{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T15:07:07Z","timestamp":1648652827130},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Klin"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1007\/s00063-009-1022-x","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T07:21:36Z","timestamp":1235546496000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Kollateralschaden der Cephalosporine und Chinolone und Wege zu ihrer Reduktion"],"prefix":"10.1007","volume":"104","author":[{"given":"Fuat H.","family":"Saner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Canbay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Gerken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph E.","family":"Broelsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,2,26]]},"reference":[{"issue":"Suppl1","key":"1022_CR1","doi-asserted-by":"publisher","first-page":"9S","DOI":"10.1378\/chest.115.suppl_1.9S","volume":"115","author":"J.M. Bernstein","year":"1999","unstructured":"Bernstein JM. Treatment of community-acquired pneumonia - IDSA guidelines. Infectious Diseases Society of America. Chest 1999;115:Suppl 1:9S\u201313S.","journal-title":"Chest"},{"key":"1022_CR2","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1056\/NEJMoa022139","volume":"348","author":"G.S. Martin","year":"2003","unstructured":"Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348:1546\u201354.","journal-title":"N Engl J Med"},{"key":"1022_CR3","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1086\/500319","volume":"42","author":"P. Charbonneau","year":"2006","unstructured":"Charbonneau P, Parienti JJ, Thibon P, et al. Fluoroquinolone use and methicillin-resistant Staphylococcus aureus isolation rates in hospitalized patients: a quasi experimental study. Clin Infect Dis 2006;42:778\u201384.","journal-title":"Clin Infect Dis"},{"key":"1022_CR4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.7326\/0003-4819-135-3-200108070-00009","volume":"135","author":"S.K. Fridkin","year":"2001","unstructured":"Fridkin SK, Edwards JR, Courval JM, et al. The effect of vancomycin and third-generation cephalosporins on prevalence of vancomycin-resistant enterococci in 126 U.S. adult intensive care units. Ann Intern Med 2001;135:175\u201383.","journal-title":"Ann Intern Med"},{"issue":"Suppl3","key":"1022_CR5","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1016\/S1098-3597(03)90025-1","volume":"5","author":"D.J. Hoban","year":"2003","unstructured":"Hoban DJ. Antibiotics and collateral damage. Clin Cornerstone 2003;5:Suppl 3:S12\u201320.","journal-title":"Clin Cornerstone"},{"key":"1022_CR6","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1086\/319600","volume":"32","author":"A.D. Harris","year":"2001","unstructured":"Harris AD, Karchmer TB, Carmeli Y, et al. Methodological principles of case-control studies that analyzed risk factors for antibiotic resistance: a systematic review. Clin Infect Dis 2001;32:1055\u201361.","journal-title":"Clin Infect Dis"},{"key":"1022_CR7","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1086\/338237","volume":"34","author":"A.D. Harris","year":"2002","unstructured":"Harris AD, Smith D, Johnson JA, et al. Risk factors for imipenem-resistant Pseudomonas aeruginosa among hospitalized patients. Clin Infect Dis 2002;34:340\u20135.","journal-title":"Clin Infect Dis"},{"key":"1022_CR8","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1086\/322677","volume":"33","author":"S. Harbarth","year":"2001","unstructured":"Harbarth S, Harris AD, Carmeli Y, et al. Parallel analysis of individual and aggregated data on antibiotic exposure and resistance in gram-negative bacilli. Clin Infect Dis 2001;33:1462\u20138.","journal-title":"Clin Infect Dis"},{"key":"1022_CR9","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ijantimicag.2006.08.031","volume":"29","author":"J.A. Roberts","year":"2007","unstructured":"Roberts JA, Webb SA, Lipman J. Cefepime versus ceftazidime: considerations for empirical use in critically ill patients. Int J Antimicrob Agents 2007; 29:117\u201328.","journal-title":"Int J Antimicrob Agents"},{"key":"1022_CR10","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1001\/archinte.153.13.1581","volume":"153","author":"R. Pallares","year":"1993","unstructured":"Pallares R, Pujol M, Pena C, et al. Cephalosporins as risk factor for nosocomial Enterococcus faecalis bacteremia. A matched case-control study. Arch Intern Med 1993;153:1581\u20136.","journal-title":"Arch Intern Med"},{"key":"1022_CR11","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1001\/archsurg.133.12.1343","volume":"133","author":"R.A. Dahms","year":"1998","unstructured":"Dahms RA, Johnson EM, Statz CL, et al. Third-generation cephalosporins and vancomycin as risk factors for postoperative vancomycin-resistant enterococcus infection. Arch Surg 1998;133:1343\u20136.","journal-title":"Arch Surg"},{"key":"1022_CR12","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1001\/archinte.159.13.1467","volume":"159","author":"B.E. Ostrowsky","year":"1999","unstructured":"Ostrowsky BE, Venkataraman L, D\u2019Agata EM, et al. Vancomycin-resistant enterococci in intensive care units: high frequency of stool carriage during a non-outbreak period. Arch Intern Med 1999;159:1467\u201372.","journal-title":"Arch Intern Med"},{"key":"1022_CR13","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1086\/346153","volume":"36","author":"E. Lautenbach","year":"2003","unstructured":"Lautenbach E, LaRosa LA, Marr AM, et al. Changes in the prevalence of vancomycin-resistant enterococci in response to antimicrobial formulary interventions: impact of progressive restrictions on use of vancomycin and third-generation cephalosporins. Clin Infect Dis 2003;36:440\u20136.","journal-title":"Clin Infect Dis"},{"key":"1022_CR14","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/jac\/43.2.261","volume":"43","author":"S.J. Bradley","year":"1999","unstructured":"Bradley SJ, Wilson AL, Allen MC, et al. The control of hyperendemic glycopeptide-resistant Enterococcus spp. on a haematology unit by changing antibiotic usage. J Antimicrob Chemother 1999;43: 261\u20136.","journal-title":"J Antimicrob Chemother"},{"key":"1022_CR15","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0033-3506(97)00581-7","volume":"111","author":"M. Washio","year":"1997","unstructured":"Washio M, Mizoue T, Kajioka T, et al. Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in a Japanese geriatric hospital. Public Health 1997;111:187\u201390.","journal-title":"Public Health"},{"key":"1022_CR16","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/BF01641355","volume":"11","author":"H. Knothe","year":"1983","unstructured":"Knothe H, Shah P, Krcmery V, et al. Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection 1983;11:315\u20137.","journal-title":"Infection"},{"key":"1022_CR17","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/S0140-6736(87)90891-9","volume":"2","author":"C. Brun-Buisson","year":"1987","unstructured":"Brun-Buisson C, Legrand P, Philippon A, et al. Transferable enzymatic resistance to third-generation cephalosporins during nosocomial outbreak of multiresistant Klebsiella pneumoniae. Lancet 1987;2:302\u20136.","journal-title":"Lancet"},{"key":"1022_CR18","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1345\/aph.1K213","volume":"41","author":"K Yang","year":"2007","unstructured":"Yang K, Guglielmo BJ. Diagnosis and treatment of extended-spectrum and AmpC ta-lactamase-producing organisms. Ann Pharmacother 2007;41:1427\u201335.","journal-title":"Ann Pharmacother"},{"key":"1022_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jinf.2006.11.018","volume":"55","author":"D.C. Halstead","year":"2007","unstructured":"Halstead DC, Abid J, Dowzicky MJ. Antimicrobial susceptibility among Acinetobacter calcoaceticus-baumannii complex and Enterobacteriaceae collected as part of the Tigecycline Evaluation and Surveillance Trial. J Infect 2007;55:49\u201357.","journal-title":"J Infect"},{"key":"1022_CR20","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1086\/342577","volume":"35","author":"J.M. Quale","year":"2002","unstructured":"Quale JM, Landman D, Bradford PA, et al. Molecular epidemiology of a citywide outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae infection. Clin Infect Dis 2002;35:834\u201341.","journal-title":"Clin Infect Dis"},{"key":"1022_CR21","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1001\/archinte.162.13.1515","volume":"162","author":"D. Landman","year":"2002","unstructured":"Landman D, Quale JM, Mayorga D, et al. Citywide clonal outbreak of multiresistant Acinetobacter baumannii and Pseudomonas aeruginosa in Brooklyn, NY: the preantibiotic era has returned. Arch Intern Med 2002;162:1515\u201320.","journal-title":"Arch Intern Med"},{"key":"1022_CR22","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1086\/501787","volume":"21","author":"J.E. Patterson","year":"2000","unstructured":"Patterson JE, Hardin TC, Kelly CA, et al. Association of antibiotic utilization measures and control of multiple-drug resistance in Klebsiella pneumoniae. Infect Control Hosp Epidemiol 2000;21:455\u20138.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"1022_CR23","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1001\/jama.280.14.1233","volume":"280","author":"J.J. Rahal","year":"1998","unstructured":"Rahal JJ, Urban C, Horn D, et al. Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. JAMA 1998; 280:1233\u20137.","journal-title":"JAMA"},{"key":"1022_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s100960050002","volume":"19","author":"M.J. Schwaber","year":"2000","unstructured":"Schwaber MJ, Simhon A, Block C, et al. Factors associated with nosocomial diarrhea and Clostridium difficile-associated disease on the adult wards of an urban tertiary care hospital. Eur J Clin Microbiol Infect Dis 2000;19:9\u201315.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"1022_CR25","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0195-6701(98)90257-2","volume":"39","author":"P.M. Zadik","year":"1998","unstructured":"Zadik PM, Moore AP. Antimicrobial associations of an outbreak of diarrhoea due to Clostridium difficile. J Hosp Infect 1998;39:189\u201393.","journal-title":"J Hosp Infect"},{"key":"1022_CR26","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/jac\/23.4.623","volume":"23","author":"F. De Lalla","year":"1989","unstructured":"De Lalla F, Privitera G, Ortisi G, et al. Third generation cephalosporins as a risk factor for Clostridium difficile-associated disease: a four-year survey in a general hospital. J Antimicrob Chemother 1989; 23:623\u201331.","journal-title":"J Antimicrob Chemother"},{"key":"1022_CR27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2307\/30145537","volume":"15","author":"D.E. Nelson","year":"1994","unstructured":"Nelson DE, Auerbach SB, Baltch AL, et al. Epidemic Clostridium difficile-associated diarrhea: role of second- and third-generation cephalosporins. Infect Control Hosp Epidemiol 1994;15:88\u201394.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"1022_CR28","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1046\/j.1365-2036.1998.00428.x","volume":"12","author":"C.D. Settle","year":"1998","unstructured":"Settle CD, Wilcox MH, Fawley WN, et al. Prospective study of the risk of Clostridium difficile diarrhoea in elderly patients following treatment with cefotaxime or piperacillin-tazobactam. Aliment Pharmacol Ther 1998;12:1217\u201323.","journal-title":"Aliment Pharmacol Ther"},{"key":"1022_CR29","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1093\/ageing\/28.6.578","volume":"28","author":"H. Ludlam","year":"1999","unstructured":"Ludlam H, Brown N, Sule O, et al. An antibiotic policy associated with reduced risk of Clostridium difficile-associated diarrhoea. Age Ageing 1999;28:578\u201380.","journal-title":"Age Ageing"},{"key":"1022_CR30","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.3201\/eid0911.030284","volume":"9","author":"S.G. Weber","year":"2003","unstructured":"Weber SG, Gold HS, Hooper DC, et al. Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patients. Emerg Infect Dis 2003;9:1415\u201322.","journal-title":"Emerg Infect Dis"},{"key":"1022_CR31","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1093\/jac\/dkf009","volume":"49","author":"E.M. Graffunder","year":"2002","unstructured":"Graffunder EM, Venezia RA. Risk factors associated with nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection including previous use of antimicrobials. J Antimicrob Chemother 2002;49:999\u20131005.","journal-title":"J Antimicrob Chemother"},{"key":"1022_CR32","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1017\/S0950268801006288","volume":"127","author":"B. Campillo","year":"2001","unstructured":"Campillo B, Dupeyron C, Richardet JP. Epidemiology of hospital-acquired infections in cirrhotic patients: effect of carriage of methicillin-resistant Staphylococcus aureus and influence of previous antibiotic therapy and norfloxacin prophylaxis. Epidemiol Infect 2001;127:443\u201350.","journal-title":"Epidemiol Infect"},{"key":"1022_CR33","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1053\/jhin.2000.0846","volume":"46","author":"G. Dziekan","year":"2000","unstructured":"Dziekan G, Hahn A, Thune K, et al. Methicillin-resistant Staphylococcus aureus in a teaching hospital: investigation of nosocomial transmission using a matched case-control study. J Hosp Infect 2000;46:263\u201370.","journal-title":"J Hosp Infect"},{"key":"1022_CR34","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1086\/379709","volume":"37","author":"M.J. Zervos","year":"2003","unstructured":"Zervos MJ, Hershberger E, Nicolau DP, et al. Relationship between fluoroquinolone use and changes in susceptibility to fluoroquinolones of selected pathogens in 10 United States teaching hospitals, 1991-2000. Clin Infect Dis 2003;37:1643\u20138.","journal-title":"Clin Infect Dis"},{"key":"1022_CR35","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1128\/AAC.44.6.1428-1437.2000","volume":"44","author":"C. Bisognano","year":"2000","unstructured":"Bisognano C, Vaudaux P, Rohner P, et al. Induction of fibronectin-binding proteins and increased adhesion of quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin. Antimicrob Agents Chemother 2000;44:1428\u201337.","journal-title":"Antimicrob Agents Chemother"},{"key":"1022_CR36","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1128\/AAC.38.2.340","volume":"38","author":"C. Dupeyron","year":"1994","unstructured":"Dupeyron C, Mangeney N, Sedrati L, et al. Rapid emergence of quinolone resistance in cirrhotic patients treated with norfloxacin to prevent spontaneous bacterial peritonitis. Antimicrob Agents Chemother 1994;38:340\u20134.","journal-title":"Antimicrob Agents Chemother"},{"key":"1022_CR37","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1086\/516132","volume":"25","author":"J.H. Yoo","year":"1997","unstructured":"Yoo JH, Huh DH, Choi JH, et al. Molecular epidemiological analysis of quinolone-resistant Escherichia coli causing bacteremia in neutropenic patients with leukemia in Korea. Clin Infect Dis 1997;25:1385\u201391.","journal-title":"Clin Infect Dis"},{"key":"1022_CR38","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1086\/322667","volume":"33","author":"E. Lautenbach","year":"2001","unstructured":"Lautenbach E, Strom BL, Bilker WB, et al. Epidemiological investigation of fluoroquinolone resistance in infections due to extended-spectrum beta- lactamase-producing Escherichia coli and Klebsiella pneumoniae. Clin Infect Dis 2001;33:1288\u201394.","journal-title":"Clin Infect Dis"},{"key":"1022_CR39","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1086\/313719","volume":"30","author":"D.L. Paterson","year":"2000","unstructured":"Paterson DL, Mulazimoglu L, Casellas JM, et al. Epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum beta-lactamase production in Klebsiella pneumoniae isolates causing bacteremia. Clin Infect Dis 2000;30:473\u20138.","journal-title":"Clin Infect Dis"},{"key":"1022_CR40","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1001\/jama.281.6.517","volume":"281","author":"J. Wiener","year":"1999","unstructured":"Wiener J, Quinn JP, Bradford PA, et al. Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes. JAMA 1999;281:517\u201323.","journal-title":"JAMA"},{"key":"1022_CR41","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7326\/0003-4819-129-3-199808010-00003","volume":"129","author":"D. Villers","year":"1998","unstructured":"Villers D, Espaze E, Coste-Burel M, et al. Nosocomial Acinetobacter baumannii infections: microbiological and clinical epidemiology. Ann Intern Med 1998;129:182\u20139.","journal-title":"Ann Intern Med"},{"key":"1022_CR42","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/AAC.38.3.547","volume":"38","author":"M.P. Fink","year":"1994","unstructured":"Fink MP, Snydman DR, Niederman MS, et al. Treatment of severe pneumonia in hospitalized patients: results of a multicenter, randomized, double- blind trial comparing intravenous ciprofloxacin with imipenem-cilastatin. The Severe Pneumonia Study Group. Antimicrob Agents Chemother 1994;38:547\u201357.","journal-title":"Antimicrob Agents Chemother"},{"key":"1022_CR43","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1001\/jama.289.7.885","volume":"289","author":"M.M. Neuhauser","year":"2003","unstructured":"Neuhauser MM, Weinstein RA, Rydman R, et al. Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use. JAMA 2003;289:885\u20138.","journal-title":"JAMA"},{"key":"1022_CR44","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/jac\/30.2.141","volume":"30","author":"C.L. Golledge","year":"1992","unstructured":"Golledge CL, Carson CF, O\u2019Neill GL, et al. Ciprofloxacin and Clostridium difficile-associated diarrhoea. J Antimicrob Chemother 1992;30:141\u20137.","journal-title":"J Antimicrob Chemother"},{"key":"1022_CR45","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1086\/381551","volume":"38","author":"R. Gaynes","year":"2004","unstructured":"Gaynes R, Rimland D, Killum E, et al. Outbreak of Clostridium difficile infection in a long-term care facility: association with gatifloxacin use. Clin Infect Dis 2004;38:640\u20135.","journal-title":"Clin Infect Dis"},{"key":"1022_CR46","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1086\/382084","volume":"38","author":"D.N. Gerding","year":"2004","unstructured":"Gerding DN. Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem. Clin Infect Dis 2004;38:646\u20138.","journal-title":"Clin Infect Dis"},{"key":"1022_CR47","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1086\/501954","volume":"22","author":"C. Yip","year":"2001","unstructured":"Yip C, Loeb M, Salama S, et al. Quinolone use as a risk factor for nosocomial Clostridium difficile-associated diarrhea. Infect Control Hosp Epidemiol 2001;22:572\u20135.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"1022_CR48","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1086\/647687","volume":"18","author":"K.K. Lai","year":"1997","unstructured":"Lai KK, Melvin ZS, Menard MJ, et al. Clostridium difficile-associated diarrhea: epidemiology, risk factors, and infection control. Infect Control Hosp Epidemiol 1997;18:628\u201332.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"1022_CR49","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s00134-003-1715-1","volume":"29","author":"A. Sandiumenge","year":"2003","unstructured":"Sandiumenge A, Diaz E, Bodi M, et al. Therapy of ventilator-associated pneumonia. A patient-based approach based on the ten rules of \u201cThe Tarragona Strategy\u201d. Intensive Care Med 2003;29:876\u201383.","journal-title":"Intensive Care Med"},{"key":"1022_CR50","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1001\/jama.290.19.2588","volume":"290","author":"J. Chastre","year":"2003","unstructured":"Chastre J, Wolff M, Fagon JY, et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 2003;290:2588\u201398.","journal-title":"JAMA"},{"key":"1022_CR51","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1164\/ajrccm.162.2.9909095","volume":"162","author":"N. Singh","year":"2000","unstructured":"Singh N, Rogers P, Atwood CW, et al. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med 2000;162:505\u201311.","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Medizinische Klinik"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-009-1022-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00063-009-1022-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-009-1022-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-009-1022-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T13:39:30Z","timestamp":1589809170000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00063-009-1022-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["1022"],"URL":"https:\/\/doi.org\/10.1007\/s00063-009-1022-x","relation":{},"ISSN":["0723-5003","1615-6722"],"issn-type":[{"value":"0723-5003","type":"print"},{"value":"1615-6722","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"18 October 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"114"}}