{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:21:04Z","timestamp":1793852464377,"version":"4.6.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Klin Intensivmed Notfmed"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s00063-019-00621-x","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T10:21:16Z","timestamp":1571826076000},"page":"765-776","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interpretation von S\u00e4ure-Basen-St\u00f6rungen","Interpretation of acid\u2013base disorders"],"prefix":"10.1007","volume":"114","author":[{"given":"Mathis","family":"Hochrainer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg-Christian","family":"Funk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"621_CR1","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1046\/j.1523-1755.2003.00177.x","volume":"64","author":"HE Corey","year":"2003","unstructured":"Corey\u00a0HE (2003) Stewart and beyond: new models of acid-base balance. Kidney Int 64:777\u2013787","journal-title":"Kidney Int"},{"key":"621_CR2","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1213\/ANE.0000000000001261","volume":"123","author":"DA Story","year":"2016","unstructured":"Story\u00a0DA (2016) Stewart acid-base: a simplified bedside approach. Anesth Analg 123:511\u2013515","journal-title":"Anesth Analg"},{"key":"621_CR3","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/j.1523-1755.2004.501_3.x","volume":"65","author":"M Emmett","year":"2004","unstructured":"Emmett\u00a0M (2004) Clinical acid-base disorders: traditional versus \u201cnew\u201d analytical models. Kidney Int 65:1112","journal-title":"Kidney Int"},{"key":"621_CR4","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1056\/NEJMra1003327","volume":"371","author":"K Berend","year":"2014","unstructured":"Berend\u00a0K, De Vries\u00a0AP, Gans\u00a0RO (2014) Physiological approach to assessment of acid-base disturbances. N\u00a0Engl J Med 371:1434\u20131445","journal-title":"N Engl J Med"},{"key":"621_CR5","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s00134-009-1496-2","volume":"35","author":"MM Boniatti","year":"2009","unstructured":"Boniatti\u00a0MM, Cardoso\u00a0PR, Castilho\u00a0RK et al (2009) Acid-base disorders evaluation in critically ill patients: we can improve our diagnostic ability. Intensive Care Med 35:1377\u20131382","journal-title":"Intensive Care Med"},{"key":"621_CR6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0883-9441(93)90001-2","volume":"8","author":"BM Gilfix","year":"1993","unstructured":"Gilfix\u00a0BM, Bique\u00a0M, Magder\u00a0S (1993) A physical chemical approach to the analysis of acid-base balance in the clinical setting. J\u00a0Crit Care 8:187\u2013197","journal-title":"J Crit Care"},{"key":"621_CR7","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1139\/y83-207","volume":"61","author":"PA Stewart","year":"1983","unstructured":"Stewart\u00a0PA (1983) Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 61:1444\u20131461","journal-title":"Can J Physiol Pharmacol"},{"key":"621_CR8","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/bja\/aeh018","volume":"92","author":"DA Story","year":"2004","unstructured":"Story\u00a0DA, Morimatsu\u00a0H, Bellomo\u00a0R (2004) Strong ions, weak acids and base excess: a\u00a0simplified Fencl-Stewart approach to clinical acid-base disorders. Br J Anaesth 92:54\u201360","journal-title":"Br J Anaesth"},{"key":"621_CR9","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1007\/s00508-007-0811-6","volume":"119","author":"GC Funk","year":"2007","unstructured":"Funk\u00a0GC (2007) Stewart\u2019s acid-base approach. Wien Klin Wochenschr 119:390\u2013403","journal-title":"Wien Klin Wochenschr"},{"key":"621_CR10","doi-asserted-by":"publisher","first-page":"205031211880125","DOI":"10.1177\/2050312118801255","volume":"6","author":"S Kimura","year":"2018","unstructured":"Kimura\u00a0S, Shabsigh\u00a0M, Morimatsu\u00a0H (2018) Traditional approach versus Stewart approach for acid-base disorders: inconsistent evidence. SAGE Open Med 6:2050312118801255","journal-title":"SAGE Open Med"},{"key":"621_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s00063-019-0538-y","author":"S Schricker","year":"2019","unstructured":"Schricker\u00a0S, Schanz\u00a0M, Alscher\u00a0MD et\u00a0al (2019) Metabolic acidosis: diagnosis and treatment. Med Klin Intensivmed Notfmed. \n                    https:\/\/doi.org\/10.1007\/s00063-019-0538-y","journal-title":"Med Klin Intensivmed Notfmed"},{"key":"621_CR12","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1056\/NEJMra1215672","volume":"371","author":"JL Seifter","year":"2014","unstructured":"Seifter\u00a0JL (2014) Integration of acid-base and electrolyte disorders. N\u00a0Engl J Med 371:1821\u20131831","journal-title":"N Engl J Med"},{"key":"621_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000069557","volume":"93","author":"NE Madias","year":"2003","unstructured":"Madias\u00a0NE, Adrogue\u00a0HJ (2003) Cross-talk between two organs: how the kidney responds to disruption of acid-base balance by the lung. Nephron Physiol 93:61\u201366","journal-title":"Nephron Physiol"},{"key":"621_CR14","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1164\/ajrccm.162.6.9904099","volume":"162","author":"V Fencl","year":"2000","unstructured":"Fencl\u00a0V, Jabor\u00a0A, Kazda\u00a0A et al (2000) Diagnosis of metabolic acid-base disturbances in critically ill patients. Am J Respir Crit Care Med 162:2246\u20132251","journal-title":"Am J Respir Crit Care Med"},{"key":"621_CR15","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.jhep.2006.03.011","volume":"45","author":"GC Funk","year":"2006","unstructured":"Funk\u00a0GC, Doberer\u00a0D, Fuhrmann\u00a0V et al (2006) The acidifying effect of lactate is neutralized by the alkalinizing effect of hypoalbuminemia in non-paracetamol-induced acute liver failure. J\u00a0Hepatol 45:387\u2013392","journal-title":"J Hepatol"},{"key":"621_CR16","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/00003246-200201000-00046","volume":"30","author":"JA Kellum","year":"2002","unstructured":"Kellum\u00a0JA (2002) Saline-induced hyperchloremic metabolic acidosis. Crit Care Med 30:259\u2013261","journal-title":"Crit Care Med"},{"key":"621_CR17","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1056\/NEJM198803103181002","volume":"318","author":"DC Batlle","year":"1988","unstructured":"Batlle\u00a0DC, Hizon\u00a0M, Cohen\u00a0E et\u00a0al (1988) The use of the urinary anion gap in the diagnosis of hyperchloremic metabolic acidosis. N\u00a0Engl J Med 318:594\u2013599","journal-title":"N Engl J Med"},{"key":"621_CR18","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1164\/ajrccm.157.4.9705037","volume":"157","author":"J Levraut","year":"1998","unstructured":"Levraut\u00a0J, Ciebiera\u00a0JP, Chave\u00a0S et\u00a0al (1998) Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 157:1021\u20131026","journal-title":"Am J Respir Crit Care Med"},{"key":"621_CR19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0002-9343(94)90047-7","volume":"97","author":"PW Stacpoole","year":"1994","unstructured":"Stacpoole\u00a0PW, Wright\u00a0EC, Baumgartner\u00a0TG et\u00a0al (1994) Natural history and course of acquired lactic acidosis in adults. DCA \u2013 Lactic Acidosis Study Group. Am J Med 97:47\u201354","journal-title":"Am J Med"},{"key":"621_CR20","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1056\/NEJMra1309483","volume":"371","author":"JA Kraut","year":"2014","unstructured":"Kraut\u00a0JA, Madias\u00a0NE (2014) Lactic acidosis. N\u00a0Engl J Med 371:2309\u20132319","journal-title":"N Engl J Med"},{"key":"621_CR21","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00134-005-0009-1","volume":"32","author":"D Taylor","year":"2006","unstructured":"Taylor\u00a0D, Durward\u00a0A, Tibby\u00a0SM et\u00a0al (2006) The influence of hyperchloraemia on acid base interpretation in diabetic ketoacidosis. Intensive Care Med 32:295\u2013301","journal-title":"Intensive Care Med"},{"key":"621_CR22","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1056\/NEJM198212233072603","volume":"307","author":"HJ Adrogue","year":"1982","unstructured":"Adrogue\u00a0HJ, Wilson\u00a0H, Boyd\u00a0AE 3rd et al (1982) Plasma acid-base patterns in diabetic ketoacidosis. N\u00a0Engl J Med 307:1603\u20131610","journal-title":"N Engl J Med"},{"key":"621_CR23","first-page":"366","volume":"46","author":"SK Epstein","year":"2001","unstructured":"Epstein\u00a0SK, Singh\u00a0N (2001) Respiratory acidosis. Respir Care 46:366\u2013383","journal-title":"Respir Care"},{"key":"621_CR24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ccm.2010.03.002","volume":"31","author":"LK Brown","year":"2010","unstructured":"Brown\u00a0LK (2010) Hypoventilation syndromes. Clin Chest Med 31:249\u2013270","journal-title":"Clin Chest Med"},{"key":"621_CR25","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1378\/chest.109.2.516","volume":"109","author":"WN Gardner","year":"1996","unstructured":"Gardner\u00a0WN (1996) The pathophysiology of hyperventilation disorders. Chest 109:516\u2013534","journal-title":"Chest"}],"container-title":["Medizinische Klinik - Intensivmedizin und Notfallmedizin"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-019-00621-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00063-019-00621-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-019-00621-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T23:41:52Z","timestamp":1603237312000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00063-019-00621-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,22]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["621"],"URL":"https:\/\/doi.org\/10.1007\/s00063-019-00621-x","relation":{},"ISSN":["2193-6218","2193-6226"],"issn-type":[{"value":"2193-6218","type":"print"},{"value":"2193-6226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,22]]},"assertion":[{"value":"3 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"Gem\u00e4\u00df den Richtlinien des Springer Medizin Verlags werden Autoren und wissenschaftliche Leitung im Rahmen der Manuskripterstellung und Manuskriptfreigabe aufgefordert, eine vollst\u00e4ndige Erkl\u00e4rung zu ihren finanziellen und nichtfinanziellen Interessen abzugeben.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"<b>M.\u00a0Hochrainer<\/b>: A. Finanzielle Interessen: Vortragshonorar zum Thema Interstitielle Lungenerkrankungen durch die Firma Boehringer Ingelheim. \u2013 B. Nichtfinanzielle Interessen: angestellter Assistenzarzt beim Krankenanstaltenverbund der Stadt Wien, Krankenhaus Nord, Abteilung f\u00fcr Innere Medizin und Pneumologie\u00a0| Mitgliedschaft: \u00d6sterreichische Gesellschaft f\u00fcr Pneumologie (\u00d6GP). <b>G.C.\u00a0Funk<\/b>: A. Finanzielle Interessen: Forschungsf\u00f6rderung zur pers\u00f6nlichen Verf\u00fcgung: Finanziell von AstraZeneca, Roche, Vifor Pharma, Orion Pharma. \u2013 Referentenhonorar oder Kostenerstattung als passiver Teilnehmer: Boehringer Ingelheim. \u2013 Bezahlter Berater\/interner Schulungsreferent\/Gehaltsempf\u00e4nger o.\u202f\u00e4.: Actelion, Almirall, AstraZeneca, Bayer, B.\u00a0Braun Melsungen, Boehringer Ingelheim, Chiesi, CSL-Behring, Dr\u00e4ger, Fresenius, GlaxoSmithKline, Heinen\u00a0&\u00a0L\u00f6wenstein, Getinge, Menarini, Novartis, Nycomed, Orion Pharma, Pfizer, Roche Diagnostics, Roche, Takeda. \u2013 B. Nichtfinanzielle Interessen: angestellter Pneumologe, KAV Wien, niedergelassener Pneumologe, Wahlarzt in Wien, Mitgliedschaft; \u00d6sterreichische Gesellschaft f\u00fcr Pneumologie.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Autoren"}},{"value":"Die vollst\u00e4ndige Erkl\u00e4rung zum Interessenkonflikt der wissenschaftlichen Leitung finden Sie am Kurs der zertifizierten Fortbildung auf .","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Wissenschaftliche Leitung"}},{"value":"erkl\u00e4rt, dass f\u00fcr die Publikation dieser CME-Fortbildung keine Sponsorengelder an den Verlag flie\u00dfen.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Der Verlag"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Der Verlag"}}]}}