{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:36:27Z","timestamp":1791333387465,"version":"4.3.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019559","name":"Carl von Ossietzky Universit\u00e4t Oldenburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019559","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Klin Intensivmed Notfmed"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Desorientierung kann ein fr\u00fches Merkmal eines Delirs sein. F\u00fcr die \u00dcberwachung eines Delirs testet die im deutschsprachigen Raum weit verbreitete \u201eConfusion Assessment Method for Intensive Care Unit\u201c (CAM-ICU) die Orientierung nicht, da intubierte Intensivpatienten sich nicht verbal \u00e4u\u00dfern k\u00f6nnen. Die Mehrheit der Patienten auf deutschen Intensivstationen ist aber nicht beatmet, sie k\u00f6nnten hinsichtlich ihrer Orientiertheit befragt werden. Die vorliegende Studie untersuchte, ob sich durch das Kriterium \u201eDesorientierung\u201c bei extubierten Patienten im Vergleich zur CAM-ICU divergierende Befunde ergeben und ob sich die Sensitivit\u00e4t der CAM-ICU durch Kombination mit dem Merkmal \u201eDesorientierung\u201c (\u201eCAM-IMC\u201c) erh\u00f6hen lassen. Insgesamt 86\u00a0gepaarte Untersuchungen fanden bei 50\u00a0extubierten Patienten statt. Ein Delir fand sich bei 19,8\u202f% (<jats:italic>n<\/jats:italic>\u202f=\u200917) aller Untersuchungen. Die CAM-ICU hatte eine Sensitivit\u00e4t von 71\u202f% (95%-KI: 44\u201390\u202f%) und eine Spezifit\u00e4t von 100\u202f% (95\u2013100\u202f%). F\u00fcr \u201eDesorientierung\u201c als alleiniges Delir-Merkmal fand sich eine Sensitivit\u00e4t von 77\u202f% (50\u201393\u202f%) und eine Spezifit\u00e4t von 93\u202f% (89\u2013100\u202f%). Die CAM-IMC erreichte eine Sensitivit\u00e4t von 88\u202f% (64\u201399\u202f%) bei einer Spezifit\u00e4t von 100\u202f% (95\u2013100\u202f%). Die \u201eReceiver-Operating-Characteristics(ROC)-Analyse\u201c fand mit einer \u201earea under the curve\u201c (AUC) von 0,941 (95%-KI: 0,851\u20131,000) f\u00fcr die CAM-IMC den h\u00f6chsten Wert im Vergleich zu den anderen Delir-Tests (CAM-ICU, AUC 0,853 [0,720\u20130,986]; Desorientierung, AUC 0,868 [0,745\u20130,991]). Diese Arbeit unterstreicht die Wertigkeit des Merkmals \u201eDesorientierung\u201c f\u00fcr Delir-Tests bei verbal kommunikationsf\u00e4higen Patienten und erkl\u00e4rt einige diskrepante Beurteilungen schwierig einzusch\u00e4tzender Patienten in der t\u00e4glichen Praxis. Die CAM-IMC scheint als Delir-Test f\u00fcr extubierte Patienten g\u00fcnstigere Eigenschaften als die CAM-ICU zu haben und sollte eingehender \u00fcberpr\u00fcft werden.<\/jats:p>","DOI":"10.1007\/s00063-021-00850-z","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T10:46:33Z","timestamp":1629888393000},"page":"419-427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bedeutung der Desorientierung bei der Delireinsch\u00e4tzung","Disorientation and delirium assessment"],"prefix":"10.1007","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4068-3849","authenticated-orcid":false,"given":"Ulf","family":"Guenther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Wolke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Christian","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Feldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Diers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Dewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Wesley","family":"Ely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Weyland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"850_CR1","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1111\/ggi.12592","volume":"16","author":"D Adamis","year":"2016","unstructured":"Adamis\u00a0D, Meagher\u00a0D, Murray\u00a0O et\u00a0al (2016) Evaluating attention in delirium: A comparison of bedside tests of attention. Geriatr Gerontol Int 16:1028\u20131035","journal-title":"Geriatr Gerontol Int"},{"key":"850_CR2","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/ageing\/afu021","volume":"43","author":"G Bellelli","year":"2014","unstructured":"Bellelli\u00a0G, Morandi\u00a0A, Davis\u00a0DH et\u00a0al (2014) Validation of the 4AT, a\u00a0new instrument for rapid delirium screening: a\u00a0study in 234 hospitalised older people. Age Ageing 43:496\u2013502","journal-title":"Age Ageing"},{"key":"850_CR3","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s001340100909","volume":"27","author":"N Bergeron","year":"2001","unstructured":"Bergeron\u00a0N, Dubois\u00a0MJ, Dumont\u00a0M et\u00a0al (2001) Intensive Care Delirium Screening Checklist: evaluation of a\u00a0new screening tool. Intensive Care Med 27:859\u2013864","journal-title":"Intensive Care Med"},{"key":"850_CR4","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/1099-1166(200011)15:11<1021::AID-GPS234>3.0.CO;2-6","volume":"15","author":"S Borson","year":"2000","unstructured":"Borson\u00a0S, Scanlan\u00a0J, Brush\u00a0M et al (2000) The mini-cog: a\u00a0cognitive \u201evital signs\u201c measure for dementia screening in multi-lingual elderly. Int J Geriatr Psychiatry 15:1021\u20131027","journal-title":"Int J Geriatr Psychiatry"},{"key":"850_CR5","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1007\/s00134-009-1590-5","volume":"35","author":"G Chanques","year":"2009","unstructured":"Chanques\u00a0G, Payen\u00a0JF, Mercier\u00a0G et al (2009) Assessing pain in non-intubated critically ill patients unable to self report: an adaptation of the Behavioral Pain Scale. Intensive Care Med 35:2060\u20132067","journal-title":"Intensive Care Med"},{"key":"850_CR6","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1002\/jhm.1003","volume":"7","author":"JG Chester","year":"2012","unstructured":"Chester\u00a0JG, Beth Harrington\u00a0M, Rudolph\u00a0JL et\u00a0al (2012) Serial administration of a\u00a0modified Richmond Agitation and Sedation Scale for delirium screening. J\u00a0Hosp Med 7:450\u2013453","journal-title":"J Hosp Med"},{"key":"850_CR7","first-page":"Doc19","volume":"13","author":"R Baron","year":"2015","unstructured":"DAS-Taskforce 2015, Baron\u00a0R, Binder\u00a0A et al (2015) Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015)\u2014short version. Ger Med Sci 13:Doc19","journal-title":"Ger Med Sci"},{"key":"850_CR8","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1007\/s00134-001-1132-2","volume":"27","author":"EW Ely","year":"2001","unstructured":"Ely\u00a0EW, Gautam\u00a0S, Margolin\u00a0R et\u00a0al (2001) The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med 27:1892\u20131900","journal-title":"Intensive Care Med"},{"key":"850_CR9","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1001\/jama.286.21.2703","volume":"286","author":"EW Ely","year":"2001","unstructured":"Ely\u00a0EW, Inouye\u00a0SK, Bernard\u00a0GR et al (2001) Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 286:2703\u20132710","journal-title":"JAMA"},{"key":"850_CR10","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1001\/jama.291.14.1753","volume":"291","author":"EW Ely","year":"2004","unstructured":"Ely\u00a0EW, Shintani\u00a0A, Truman\u00a0B et\u00a0al (2004) Delirium as a\u00a0predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291:1753\u20131762","journal-title":"JAMA"},{"key":"850_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00063-015-0056-5","volume":"111","author":"U Guenther","year":"2016","unstructured":"Guenther\u00a0U, Koegl\u00a0F, Theuerkauf\u00a0N et al (2016) Pflegeaufwandsscores TISS-10, TISS-28 und NEMS. Erh\u00f6hter Arbeitsaufwand bei Agitation und Delir wird nicht erfasst. Med Klin Intensivmed Notfmed 111:57\u201364","journal-title":"Med Klin Intensivmed Notfmed"},{"key":"850_CR12","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jcrc.2009.08.005","volume":"25","author":"U Guenther","year":"2010","unstructured":"Guenther\u00a0U, Popp\u00a0J, Koecher\u00a0L et al (2010) Validity and reliability of the CAM-ICU Flowsheet to diagnose delirium in surgical ICU patients. J\u00a0Crit Care 25:144\u2013151","journal-title":"J Crit Care"},{"key":"850_CR13","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.4037\/ajcc2012735","volume":"21","author":"U Guenther","year":"2012","unstructured":"Guenther\u00a0U, Weykam\u00a0J, Andorfer\u00a0U et\u00a0al (2012) Implications of objective vs subjective delirium assessment in surgical intensive care patients. Am J Crit Care 21:e12\u201320","journal-title":"Am J Crit Care"},{"key":"850_CR14","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1097\/EJA.0000000000001430","volume":"38","author":"U Guenther","year":"2021","unstructured":"Guenther\u00a0U, Wolke\u00a0M, Schelling\u00a0R et\u00a0al (2021) Low cholinesterase activity is a\u00a0risk factor for delirium after cardiac surgery. Eur J Anaesthesiol 38:554\u2013556","journal-title":"Eur J Anaesthesiol"},{"key":"850_CR15","first-page":"592","volume":"50","author":"U G\u00fcnther","year":"2009","unstructured":"G\u00fcnther\u00a0U, Wrigge\u00a0H, Popp\u00a0J et al (2009) Deutsche Kurzversion: Confusion Assessment Method for Intensive Care Unit (CAM-ICU) zur routinem\u00e4\u00dfigen Kontrolle des Delirs auf Intensivstation. Anaesthesiol Intensivmed 50:592\u2013600","journal-title":"Anaesthesiol Intensivmed"},{"key":"850_CR16","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/acem.12706","volume":"22","author":"JH Han","year":"2015","unstructured":"Han\u00a0JH, Vasilevskis\u00a0EE, Schnelle\u00a0JF et\u00a0al (2015) The diagnostic performance of the richmond agitation sedation scale for detecting delirium in older emergency department patients. Acad Emerg Med 22:878\u2013882","journal-title":"Acad Emerg Med"},{"key":"850_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-36915-5","volume-title":"Bewusstseinsst\u00f6rungen und Enzephalopathien","author":"H-C Hansen","year":"2013","unstructured":"Hansen\u00a0H\u2011C (2013) Bewusstseinsst\u00f6rungen und Enzephalopathien. Springer, Berlin Heidelberg"},{"key":"850_CR18","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1177\/147323001003800503","volume":"38","author":"A Heymann","year":"2010","unstructured":"Heymann\u00a0A, Radtke\u00a0F, Schiemann\u00a0A et\u00a0al (2010) Delayed treatment of delirium increases mortality rate in intensive care unit patients. J\u00a0Int Med Res 38:1584\u20131595","journal-title":"J Int Med Res"},{"key":"850_CR19","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S2215-0366(14)00006-6","volume":"1","author":"CM Kosar","year":"2014","unstructured":"Kosar\u00a0CM, Tabloski\u00a0PA, Travison\u00a0TG et\u00a0al (2014) Effect of preoperative pain and depressive symptoms on the development of postoperative delirium. Lancet Psychiatry 1:431\u2013436","journal-title":"Lancet Psychiatry"},{"key":"850_CR20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s00134-017-4945-3","volume":"44","author":"S Krotsetis","year":"2018","unstructured":"Krotsetis\u00a0S, Nydahl\u00a0P, Dubb\u00a0R et al (2018) Status quo of delirium management in German-speaking countries: comparison between intensive care units and wards. Intensive Care Med 44:252\u2013253","journal-title":"Intensive Care Med"},{"key":"850_CR21","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1176\/ajp.113.2.174","volume":"113","author":"M Levin","year":"1956","unstructured":"Levin\u00a0M (1956) Spatial disorientation in delirium. Am J Psychiatry 113:174\u2013175","journal-title":"Am J Psychiatry"},{"key":"850_CR22","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s11739-019-02258-2","volume":"15","author":"M Loritz","year":"2020","unstructured":"Loritz\u00a0M, Busch\u00a0HJ, Helbing\u00a0T et\u00a0al (2020) Prospective evaluation of the quickSOFA score as a\u00a0screening for sepsis in the emergency department. Intern Emerg Med 15:685\u2013693","journal-title":"Intern Emerg Med"},{"key":"850_CR23","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/CCM.0b013e3181cabb42","volume":"38","author":"A Luetz","year":"2010","unstructured":"Luetz\u00a0A, Heymann\u00a0A, Radtke\u00a0FM et\u00a0al (2010) Different assessment tools for intensive care unit delirium: which score to use? Crit Care Med 38:409\u2013418","journal-title":"Crit Care Med"},{"key":"850_CR24","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jcrc.2016.05.028","volume":"35","author":"A Luetz","year":"2016","unstructured":"Luetz\u00a0A, Weiss\u00a0B, Boettcher\u00a0S et\u00a0al (2016) Routine delirium monitoring is independently associated with a\u00a0reduction of hospital mortality in critically ill surgical patients: A prospective, observational cohort study. J\u00a0Crit Care 35:168\u2013173","journal-title":"J Crit Care"},{"key":"850_CR25","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.jamda.2016.05.010","volume":"17","author":"A Morandi","year":"2016","unstructured":"Morandi\u00a0A, Han\u00a0JH, Meagher\u00a0D et\u00a0al (2016) Detecting delirium superimposed on dementia: evaluation of the diagnostic performance of the richmond agitation and sedation scale. J\u00a0Am Med Dir Assoc 17:828\u2013833","journal-title":"J Am Med Dir Assoc"},{"key":"850_CR26","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1097\/00003246-200112000-00004","volume":"29","author":"JF Payen","year":"2001","unstructured":"Payen\u00a0JF, Bru\u00a0O, Bosson\u00a0JL et\u00a0al (2001) Assessing pain in critically ill sedated patients by using a\u00a0behavioral pain scale. Crit Care Med 29:2258\u20132263","journal-title":"Crit Care Med"},{"key":"850_CR27","unstructured":"Radtke R Behandlungsf\u00e4lle in der intensivmedizinischen Versorgung in Deutschland in den Jahren 2010 bis 2017. In: Destatis \u2013 Grunddaten der Krankenh\u00e4user 2017. Statista 2021. https:\/\/de.statista.com\/statistik\/daten\/studie\/1105287\/umfrage\/intensivmedizinische-behandlungsfaelle-in-deutschland\/ (Erstellt: 28. Sept. 2020). Zugegriffen: 1. Febr. 2021"},{"key":"850_CR28","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s12028-018-0649-y","volume":"30","author":"D Robinson","year":"2019","unstructured":"Robinson\u00a0D, Thompson\u00a0S, Bauerschmidt\u00a0A et\u00a0al (2019) Dispersion in scores on the richmond agitation and sedation scale as a\u00a0measure of delirium in patients with Subdural hematomas. Neurocrit Care 30:626\u2013634","journal-title":"Neurocrit Care"},{"key":"850_CR29","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1532-5415.2010.02762.x","volume":"58","author":"JL Rudolph","year":"2010","unstructured":"Rudolph\u00a0JL, Inouye\u00a0SK, Jones\u00a0RN et\u00a0al (2010) Delirium: an independent predictor of functional decline after cardiac surgery. J\u00a0Am Geriatr Soc 58:643\u2013649","journal-title":"J Am Geriatr Soc"},{"key":"850_CR30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1056\/NEJMoa1112923","volume":"367","author":"JS Saczynski","year":"2012","unstructured":"Saczynski\u00a0JS, Marcantonio\u00a0ER, Quach\u00a0L et\u00a0al (2012) Cognitive trajectories after postoperative delirium. N\u00a0Engl J Med 367:30\u201339","journal-title":"N Engl J Med"},{"issue":"3","key":"850_CR31","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s10877-020-00516-9","volume":"35","author":"T Saller","year":"2020","unstructured":"Saller T, Hofmann-Kiefer KF, Saller I et al (2020) Implementation of strategies to prevent and treat postoperative delirium in the post-anesthesia caring unit : A German survey of current practice. J Clin Monit Comput 35(3):599\u2013605. https:\/\/doi.org\/10.1007\/s10877-020-00516-9","journal-title":"J Clin Monit Comput"},{"issue":"10","key":"850_CR32","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1111\/anae.14682","volume":"74","author":"T Saller","year":"2019","unstructured":"Saller T, Maclullich AMJ, Schafer ST et al (2019) Screening for delirium after surgery: validation of the 4\u202fA\u2019s test (4AT) in the post-anaesthesia care unit. Anaesthesia 74(10):1260\u20131266. https:\/\/doi.org\/10.1111\/anae.14682","journal-title":"Anaesthesia"},{"key":"850_CR33","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s00101-016-0218-8","volume":"65","author":"T Saller","year":"2016","unstructured":"Saller\u00a0T, Von Dossow\u00a0V, Hofmann-Kiefer\u00a0K (2016) Knowledge and implementation of the S3 guideline on delirium management in Germany. Anaesthesist 65:755\u2013762","journal-title":"Anaesthesist"},{"key":"850_CR34","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1164\/rccm.2107138","volume":"166","author":"CN Sessler","year":"2002","unstructured":"Sessler\u00a0CN, Gosnell\u00a0MS, Grap\u00a0MJ et al (2002) The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 166:1338\u20131344","journal-title":"Am J Respir Crit Care Med"},{"key":"850_CR35","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer\u00a0M, Deutschman\u00a0CS, Seymour\u00a0CW et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:801\u2013810","journal-title":"JAMA"},{"key":"850_CR36","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1177\/026921559701100308","volume":"11","author":"DG Swain","year":"1997","unstructured":"Swain\u00a0DG, Nightingale\u00a0PG (1997) Evaluation of a\u00a0shortened version of the abbreviated mental test in a\u00a0series of elderly patients. Clin Rehabil 11:243\u2013248","journal-title":"Clin Rehabil"}],"container-title":["Medizinische Klinik - Intensivmedizin und Notfallmedizin"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-021-00850-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00063-021-00850-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-021-00850-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T19:03:17Z","timestamp":1662577397000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00063-021-00850-z"}},"subtitle":["Sekund\u00e4ranalyse einer prospektiven, observationellen Studie","A secondary analysis of a\u00a0prospective, observational study"],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["850"],"URL":"https:\/\/doi.org\/10.1007\/s00063-021-00850-z","relation":{},"ISSN":["2193-6218","2193-6226"],"issn-type":[{"value":"2193-6218","type":"print"},{"value":"2193-6226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,25]]},"assertion":[{"value":"2 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"U.\u00a0Guenther erhielt Vortragshonorare von MT Monitortechnik, Orion Pharma und Getinge und Honorare f\u00fcr Vortr\u00e4ge und Advisory-Board-T\u00e4tigkeiten von Sedana Medical, au\u00dferhalb der vorliegenden Arbeit. H.-C.\u00a0Hansen erhielt Vortragshonorare von Orion Pharma, au\u00dferhalb der vorliegenden Arbeit. E.\u00a0W.\u00a0Ely erhielt Honorare von Pfizer und Orion Pharma f\u00fcr Fortbildungsveranstaltungen. M.\u00a0Wolke, N.\u00a0Feldmann, A.\u00a0Diers, O.\u00a0Dewald und A.\u00a0Weyland geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Die Studie wurde von der Ethikkommission der Universit\u00e4t Oldenburg (Vorsitzender: Prof. Dr. F.\u00a0Griesinger) mit der Nr.\u00a02019-001 am 28.\u00a0Februar 2019 genehmigt. REGISTER: German Clinical Trials Register, DRKS 00017144.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}