{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:52:34Z","timestamp":1787237554268,"version":"build-2736575974"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Innsbruck and Medical University of Innsbruck"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Klin Intensivmed Notfmed"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Saline vs. Albumin Fluid Evaluation (SAFE) Studie hat gezeigt, dass der Einsatz von Albumin als Infusionsl\u00f6sung im Bereich der Volumentherapie fast \u00fcberall sicher ist. Eine Ausnahme stellt hypoonkotisches Albumin beim Sch\u00e4del-Hirn-Trauma dar. W\u00e4hrend f\u00fcr Patientinnen und Patienten mit Leberzirrhose klare Indikationen existieren, fehlen f\u00fcr andere Einsatzgebiete noch gro\u00dfe Studien, die einen klinisch relevanten Vorteil jenseits der h\u00e4modynamischen Wirksamkeit zweifelsfrei zeigen konnten und damit einen breiteren Einsatz rechtfertigen w\u00fcrden. Bei der \u201eLarge-volume\u201c-Parazentese, der spontanen bakteriellen Peritonitis, aber auch beim hepatorenalen Syndrom ist der Einsatz von Albumin aufgrund eines klinischen Benefits in randomisierten kontrollierten Studien klar empfohlen und etabliert. Beim septischen Schock kann ein Einsatz von Albumin in Erw\u00e4gung gezogen werden, wobei sich zwei gro\u00dfe Studien zu dieser Fragestellung in Deutschland und Italien noch in der Rekrutierungsphase befinden. F\u00fcr viele Einsatzgebiete in der Volumentherapie gilt, dass Albumin vor allem dann eingesetzt werden kann, wenn andere Ma\u00dfnahmen zur h\u00e4modynamischen Stabilisierung bereits ausgesch\u00f6pft sind. Das gilt sowohl f\u00fcr die Volumengabe bei Hypovol\u00e4mie als auch f\u00fcr das konservative Volumenmanagement einschlie\u00dflich der sog. Deresuscitation-Phase. Inwieweit die Korrektur einer ausgepr\u00e4gten Hypoalbumin\u00e4mie durch Gabe von exogenem Albumin auch das schlechtere Outcome solcher Patientinnen und Patienten verbessert, ist ebenfalls Teil laufender Studien. Auf dem Weg zu einem Mehr an individualisierter Therapie kann in Zukunft die Hypoalbumin\u00e4mie bei Entscheidungen f\u00fcr oder gegen einen Einsatz von intraven\u00f6sen Albuminl\u00f6sungen in der Volumentherapie eine wichtige Rolle einnehmen.<\/jats:p>","DOI":"10.1007\/s00063-021-00875-4","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:48:34Z","timestamp":1633654114000},"page":"655-664","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Einsatz von Albumin","Use of albumin"],"prefix":"10.1007","volume":"116","author":[{"given":"Timo","family":"Mayerh\u00f6fer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Wiedermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joannidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"issue":"3","key":"875_CR1","doi-asserted-by":"publisher","first-page":"e219","DOI":"10.1097\/CCM.0000000000004899","volume":"49","author":"W Alhazzani","year":"2021","unstructured":"Alhazzani\u00a0W, Evans\u00a0L, Alshamsi\u00a0F et al (2021) Surviving sepsis campaign guidelines on the management of adults with coronavirus disease 2019 (COVID-19) in the ICU: first update. Crit Care Med 49(3):e219\u2013e234. https:\/\/doi.org\/10.1097\/CCM.0000000000004899","journal-title":"Crit Care Med"},{"key":"875_CR2","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13054-018-2053-6","volume":"22","author":"M Amouzandeh","year":"2018","unstructured":"Amouzandeh\u00a0M, Nowak\u00a0G, Januszkiewicz\u00a0A et\u00a0al (2018) Albumin mass balance and kinetics in liver transplantation. Crit Care 22:152","journal-title":"Crit Care"},{"key":"875_CR3","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1136\/gutjnl-2014-308874","volume":"64","author":"P Angeli","year":"2015","unstructured":"Angeli\u00a0P, Gines\u00a0P, Wong\u00a0F et\u00a0al (2015) Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the international club of ascites. Gut 64:531","journal-title":"Gut"},{"key":"875_CR4","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1002\/hep.30208","volume":"71","author":"V Arora","year":"2020","unstructured":"Arora\u00a0V, Maiwall\u00a0R, Rajan\u00a0V et\u00a0al (2020) Terlipressin is superior to noradrenaline in the management of acute kidney injury in acute on chronic liver failure. Hepatology 71:600\u2013610","journal-title":"Hepatology"},{"key":"875_CR5","unstructured":"AWMF online (2021) Behandlung thermischer Verletzungen des Erwachsenen. https:\/\/www.awmf.org\/uploads\/tx_szleitlinien\/044-001l_S2k_Behandlung-thermischer-Verletzungen-des-Erwachsenen_2021-07.pdf. Zugegriffen: 23. Juli 2021"},{"key":"875_CR6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s13054-020-02995-3","volume":"24","author":"M Aziz","year":"2020","unstructured":"Aziz\u00a0M, Fatima\u00a0R, Lee-Smith\u00a0W et al (2020) The association of low serum albumin level with severe COVID-19: a\u00a0systematic review and meta-analysis. Crit Care 24:255","journal-title":"Crit Care"},{"key":"875_CR7","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1002\/hep.24786","volume":"55","author":"M Bernardi","year":"2012","unstructured":"Bernardi\u00a0M, Caraceni\u00a0P, Navickis\u00a0RJ et al (2012) Albumin infusion in patients undergoing large-volume paracentesis: a\u00a0meta-analysis of randomized trials. Hepatology 55:1172\u20131181","journal-title":"Hepatology"},{"key":"875_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31884","author":"SW Biggins","year":"2021","unstructured":"Biggins\u00a0SW, Angeli\u00a0P, Garcia-Tsao\u00a0G et al (2021) Diagnosis, evaluation, and management of ascites and hepatorenal syndrome. Hepatology. https:\/\/doi.org\/10.1002\/hep.31884","journal-title":"Hepatology"},{"key":"875_CR9","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1056\/NEJMoa1305727","volume":"370","author":"P Caironi","year":"2014","unstructured":"Caironi\u00a0P, Tognoni\u00a0G, Masson\u00a0S et\u00a0al (2014) Albumin replacement in patients with severe sepsis or septic shock. N\u00a0Engl J Med 370:1412\u20131421","journal-title":"N Engl J Med"},{"key":"875_CR10","first-page":"8","volume":"14","author":"P Caraceni","year":"2016","unstructured":"Caraceni\u00a0P, Angeli\u00a0P, Prati\u00a0D et al (2016) AISF-SIMTI position paper: the appropriate use of albumin in patients with liver cirrhosis. Blood Transfus 14:8\u201322","journal-title":"Blood Transfus"},{"key":"875_CR11","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1016\/S0140-6736(18)30840-7","volume":"391","author":"P Caraceni","year":"2018","unstructured":"Caraceni\u00a0P, Riggio\u00a0O, Angeli\u00a0P et al (2018) Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial. Lancet 391:2417\u20132429","journal-title":"Lancet"},{"key":"875_CR12","first-page":"S115","volume-title":"Efficacy and tolerance of hyperoncotic albumin administration in septic shock patients: the EARSS study","author":"J Charpentier","year":"2011","unstructured":"Charpentier\u00a0J, Mira\u00a0J\u2010P (2011) Efficacy and tolerance of hyperoncotic albumin administration in septic shock patients: the EARSS study, S S115"},{"key":"875_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11894-021-00813-6","volume":"23","author":"CB Chen","year":"2021","unstructured":"Chen\u00a0CB, Hammo\u00a0B, Barry\u00a0J et\u00a0al (2021) Overview of albumin physiology and its role in pediatric diseases. Curr Gastroenterol Rep 23:11","journal-title":"Curr Gastroenterol Rep"},{"key":"875_CR14","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1056\/NEJMoa2022166","volume":"384","author":"L China","year":"2021","unstructured":"China\u00a0L, Freemantle\u00a0N, Forrest\u00a0E et\u00a0al (2021) A randomized trial of albumin infusions in hospitalized patients with cirrhosis. N\u00a0Engl J Med 384:808\u2013817","journal-title":"N Engl J Med"},{"key":"875_CR15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1136\/bmj.317.7153.235","volume":"317","author":"Cochrane Injuries Group Albumin Reviewers","year":"1998","unstructured":"Cochrane Injuries Group Albumin Reviewers (1998) Human albumin administration in critically ill patients: systematic review of randomised controlled trials. BMJ 317:235\u2013240","journal-title":"BMJ"},{"key":"875_CR16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/liv.13968","volume":"39","author":"M Di Pascoli","year":"2019","unstructured":"Di Pascoli\u00a0M, Fasolato\u00a0S, Piano\u00a0S et al (2019) Long-term administration of human albumin improves survival in patients with cirrhosis and refractory ascites. Liver Int 39:98\u2013105","journal-title":"Liver Int"},{"issue":"10","key":"875_CR17","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1097\/01.CCM.0000239119.57544.0C","volume":"34","author":"M-J Dubois","year":"2006","unstructured":"Dubois\u00a0M\u2011J, Orellana-Jimenez\u00a0C, Melot\u00a0C et al (2006) Albumin administration improves organ function in critically ill hypoalbuminemic patients: a prospective, randomized, controlled, pilot study. Crit Care Med 34(10):2536\u20132540","journal-title":"Crit Care Med"},{"key":"875_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.burns.2016.08.001","volume":"43","author":"R Eljaiek","year":"2017","unstructured":"Eljaiek\u00a0R, Heylbroeck\u00a0C, Dubois\u00a0M\u2011J (2017) Albumin administration for fluid resuscitation in burn patients: a systematic review and meta-analysis. Burns 43:17\u201324","journal-title":"Burns"},{"key":"875_CR19","unstructured":"EMA (2018) Hydroxyethyl starch (HES) containing medicinal products. https:\/\/www.ema.europa.eu\/en\/medicines\/human\/referrals\/hydroxyethyl-starch-hes-containing-medicinal-products. Zugegriffen: 19. Juli 2021"},{"key":"875_CR20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1159\/000446043","volume":"43","author":"Executive Committee of the German Medical Association on the Recommendation of the Scientific Advisory Board","year":"2016","unstructured":"Executive Committee of the German Medical Association on the Recommendation of the Scientific Advisory Board (2016) Cross-sectional guidelines for therapy with blood components and plasma derivatives: chapter 5 human albumin \u2013 revised. Transfus Med Hemother 43:223\u2013232","journal-title":"Transfus Med Hemother"},{"key":"875_CR21","unstructured":"FDA (2021) Labeling changes on mortality, kidney injury, and excess bleeding with hydroxyethyl starch products. https:\/\/www.fda.gov\/vaccines-blood-biologics\/safety-availability-biologics\/labeling-changes-mortality-kidney-injury-and-excess-bleeding-hydroxyethyl-starch-products. Zugegriffen: 19. Juli 2021"},{"key":"875_CR22","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1136\/bmj.39017.459907.BE","volume":"333","author":"S Finfer","year":"2006","unstructured":"Finfer\u00a0S, Bellomo\u00a0R, McEvoy\u00a0S et\u00a0al (2006) Effect of baseline serum albumin concentration on outcome of resuscitation with albumin or saline in patients in intensive care units: analysis of data from the saline versus albumin fluid evaluation (SAFE) study. BMJ 333:1044","journal-title":"BMJ"},{"key":"875_CR23","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1002\/hep.26338","volume":"58","author":"R Garcia-Martinez","year":"2013","unstructured":"Garcia-Martinez\u00a0R, Caraceni\u00a0P, Bernardi\u00a0M et al (2013) Albumin: pathophysiologic basis of its role in the treatment of cirrhosis and its complications. Hepatology 58:1836\u20131846","journal-title":"Hepatology"},{"key":"875_CR24","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1055\/a-0873-4641","volume":"57","author":"AL Gerbes","year":"2019","unstructured":"Gerbes\u00a0AL, Labenz\u00a0J (2019) Leitlinie Komplikationen der Leberzirrhose. Z\u00a0Gastroenterol 57:571\u2013573","journal-title":"Z Gastroenterol"},{"key":"875_CR25","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1111\/j.1399-6576.2008.01688.x","volume":"52","author":"P-O Gr\u00e4nde","year":"2008","unstructured":"Gr\u00e4nde\u00a0P\u2011O (2008) Time out for albumin or a\u00a0valuable therapeutic component in severe head injury? Acta Anaesthesiol Scand 52:738\u2013741","journal-title":"Acta Anaesthesiol Scand"},{"key":"875_CR26","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jcrc.2020.10.013","volume":"61","author":"P Hansrivijit","year":"2021","unstructured":"Hansrivijit\u00a0P, Yarlagadda\u00a0K, Cheungpasitporn\u00a0W et al (2021) Hypoalbuminemia is associated with increased risk of acute kidney injury in hospitalized patients: a meta-analysis. J\u00a0Crit Care 61:96\u2013102","journal-title":"J Crit Care"},{"key":"875_CR27","doi-asserted-by":"publisher","first-page":"820","DOI":"10.2215\/CJN.09670620","volume":"16","author":"N Hryciw","year":"2021","unstructured":"Hryciw\u00a0N, Joannidis\u00a0M, Hiremath\u00a0S et\u00a0al (2021) Intravenous albumin for mitigating hypotension and augmenting ultrafiltration during kidney replacement therapy. Clin J Am Soc Nephrol 16:820","journal-title":"Clin J Am Soc Nephrol"},{"key":"875_CR28","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1378\/chest.07-1121","volume":"133","author":"X Jia","year":"2008","unstructured":"Jia\u00a0X, Malhotra\u00a0A, Saeed\u00a0M et\u00a0al (2008) Risk factors for ARDS in patients receiving mechanical ventilation for \u3009 48\u202fh. Chest 133:853\u2013861","journal-title":"Chest"},{"key":"875_CR29","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1007\/s00134-019-05869-7","volume":"46","author":"M Joannidis","year":"2020","unstructured":"Joannidis\u00a0M, Forni\u00a0LG, Klein\u00a0SJ et al (2020) Lung-kidney interactions in critically ill patients: consensus report of the acute disease quality initiative (ADQI) 21 workgroup. Intensive Care Med 46:654\u2013672","journal-title":"Intensive Care Med"},{"key":"875_CR30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jcrc.2013.10.004","volume":"29","author":"GD Kitsios","year":"2014","unstructured":"Kitsios\u00a0GD, Mascari\u00a0P, Ettunsi\u00a0R et al (2014) Co-administration of furosemide with albumin for overcoming diuretic resistance in patients with hypoalbuminemia: a\u00a0meta-analysis. J\u00a0Crit Care 29:253\u2013259","journal-title":"J Crit Care"},{"key":"875_CR31","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1186\/s13054-016-1536-6","volume":"20","author":"A Kom\u00e1romi","year":"2016","unstructured":"Kom\u00e1romi\u00a0A, Estenberg\u00a0U, Hammarqvist\u00a0F et\u00a0al (2016) Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery. Crit Care 20:370","journal-title":"Crit Care"},{"key":"875_CR32","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1111\/jgh.14791","volume":"34","author":"GS Le\u00e3o","year":"2019","unstructured":"Le\u00e3o\u00a0GS, John Neto\u00a0G, Jotz\u00a0RDF et al (2019) Albumin for cirrhotic patients with extraperitoneal infections: a meta-analysis. J\u00a0Gastroenterol Hepatol 34:2071\u20132076","journal-title":"J Gastroenterol Hepatol"},{"key":"875_CR33","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1097\/ALN.0000000000001051","volume":"124","author":"EH Lee","year":"2016","unstructured":"Lee\u00a0EH, Kim\u00a0WJ, Kim\u00a0JY et al (2016) Effect of exogenous albumin on the incidence of postoperative acute kidney injury in patients undergoing off-pump coronary artery bypass surgery with a\u00a0preoperative albumin level of less than 4.0\u202fg\/dl. Anesthesiology 124:1001\u20131011","journal-title":"Anesthesiology"},{"key":"875_CR34","first-page":"216","volume":"7","author":"GM Liumbruno","year":"2009","unstructured":"Liumbruno\u00a0GM, Bennardello\u00a0F, Lattanzio\u00a0A et\u00a0al (2009) Recommendations for the use of albumin and immunoglobulins. Blood Transfus 7:216\u2013234","journal-title":"Blood Transfus"},{"key":"875_CR35","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","volume":"69","author":"European Association for the Study of the Liver","year":"2018","unstructured":"European Association for the Study of the Liver (2018) EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. J\u00a0Hepatol 69:406\u2013460","journal-title":"J Hepatol"},{"key":"875_CR36","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13054-020-03441-0","volume":"25","author":"E Macedo","year":"2021","unstructured":"Macedo\u00a0E, Karl\u00a0B, Lee\u00a0E et\u00a0al (2021) A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients. Crit Care 25:18","journal-title":"Crit Care"},{"key":"875_CR37","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13613-020-00679-3","volume":"10","author":"MLNG Malbrain","year":"2020","unstructured":"Malbrain\u00a0MLNG, Langer\u00a0T, Annane\u00a0D et\u00a0al (2020) Intravenous fluid therapy in the perioperative and critical care setting: executive summary of the international fluid academy (IFA). Ann Intensive Care 10:64","journal-title":"Ann Intensive Care"},{"key":"875_CR38","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1007\/s00134-018-5253-2","volume":"44","author":"J M\u00e5rtensson","year":"2018","unstructured":"M\u00e5rtensson\u00a0J, Bihari\u00a0S, Bannard-Smith\u00a0J et al (2018) Small volume resuscitation with 20\u202f% albumin in intensive care: physiological effects : the SWIPE randomised clinical trial. Intensive Care Med 44:1797\u20131806","journal-title":"Intensive Care Med"},{"key":"875_CR39","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jcrc.2018.11.031","volume":"50","author":"GS Martin","year":"2019","unstructured":"Martin\u00a0GS, Bassett\u00a0P (2019) Crystalloids vs. colloids for fluid resuscitation in the intensive care unit: a systematic review and meta-analysis. J\u00a0Crit Care 50:144\u2013154","journal-title":"J Crit Care"},{"issue":"8","key":"875_CR40","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1097\/01.ccm.0000171539.47006.02","volume":"33","author":"GS Martin","year":"2005","unstructured":"Martin\u00a0GS, Moss\u00a0M, Wheeler\u00a0AP et\u00a0al (2005) A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. Crit Care Med 33(8):1681\u20131687. https:\/\/doi.org\/10.1097\/01.ccm.0000171539.47006.02","journal-title":"Crit Care Med"},{"key":"875_CR41","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3389\/fphys.2014.00299","volume":"5","author":"AM Merlot","year":"2014","unstructured":"Merlot\u00a0AM, Kalinowski\u00a0DS, Richardson\u00a0DR (2014) Unraveling the mysteries of serum albumin-more than just a\u00a0serum protein. Front Physiol 5:299","journal-title":"Front Physiol"},{"key":"875_CR42","doi-asserted-by":"publisher","first-page":"e268","DOI":"10.1097\/BCR.0000000000000201","volume":"37","author":"RJ Navickis","year":"2016","unstructured":"Navickis\u00a0RJ, Greenhalgh\u00a0DG, Wilkes\u00a0MM (2016) Albumin in burn shock resuscitation: a meta-analysis of controlled clinical studies. J\u00a0Burn Care Res 37:e268\u2013e278","journal-title":"J Burn Care Res"},{"key":"875_CR43","doi-asserted-by":"publisher","DOI":"10.1159\/000517957","author":"Z O\u2019Brien","year":"2021","unstructured":"O\u2019Brien\u00a0Z, Finnis\u00a0M, Gallagher\u00a0M et\u00a0al (2021) Hyperoncotic albumin solution in continuous renal replacement therapy patients. Blood Purif. https:\/\/doi.org\/10.1159\/000517957","journal-title":"Blood Purif"},{"key":"875_CR44","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s00134-018-5086-z","volume":"44","author":"M Oddo","year":"2018","unstructured":"Oddo\u00a0M, Poole\u00a0D, Helbok\u00a0R et\u00a0al (2018) Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations. Intensive Care Med 44:449\u2013463","journal-title":"Intensive Care Med"},{"key":"875_CR45","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.accpm.2019.06.014","volume":"39","author":"C Paugam-Burtz","year":"2020","unstructured":"Paugam-Burtz\u00a0C, Levesque\u00a0E, Louvet\u00a0A et al (2020) Management of liver failure in general intensive care unit. Anaesth Crit Care Pain Med 39:143\u2013161","journal-title":"Anaesth Crit Care Pain Med"},{"key":"875_CR46","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s00134-017-4817-x","volume":"43","author":"A Perner","year":"2017","unstructured":"Perner\u00a0A, Prowle\u00a0J, Joannidis\u00a0M et\u00a0al (2017) Fluid management in acute kidney injury. Intensive Care Med 43:807\u2013815","journal-title":"Intensive Care Med"},{"key":"875_CR47","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/0016-5085(94)90706-4","volume":"106","author":"M Pozzi","year":"1994","unstructured":"Pozzi\u00a0M, Osculati\u00a0G, Boari\u00a0G et\u00a0al (1994) Time course of circulatory and humoral effects of rapid total paracentesis in cirrhotic patients with tense, refractory ascites. Gastroenterology 106:709\u2013719","journal-title":"Gastroenterology"},{"issue":"3","key":"875_CR48","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","volume":"43","author":"A Rhodes","year":"2017","unstructured":"Rhodes\u00a0A, Evans\u00a0LE, Alhazzani\u00a0W et\u00a0al (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43(3):304\u2013377","journal-title":"Intensive Care Med"},{"key":"875_CR49","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1053\/j.jvca.2004.05.019","volume":"18","author":"JA Russell","year":"2004","unstructured":"Russell\u00a0JA, Navickis\u00a0RJ, Wilkes\u00a0MM (2004) Albumin versus crystalloid for pump priming in cardiac surgery: meta-analysis of controlled trials. J\u00a0Cardiothorac Vasc Anesth 18:429\u2013437","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"875_CR50","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1056\/NEJMoa040232","volume":"350","author":"SAFE Study Investigators","year":"2004","unstructured":"SAFE Study Investigators (2004) A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N\u00a0Engl J Med 350:2247\u20132256","journal-title":"N Engl J Med"},{"key":"875_CR51","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1056\/NEJMoa067514","volume":"357","author":"SAFE Study Investigators","year":"2007","unstructured":"SAFE Study Investigators (2007) Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N\u00a0Engl J Med 357:874\u2013884","journal-title":"N Engl J Med"},{"key":"875_CR52","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1186\/s13063-020-04921-y","volume":"21","author":"Y Sakr","year":"2020","unstructured":"Sakr\u00a0Y, Bauer\u00a0M, Nierhaus\u00a0A et\u00a0al (2020) Randomized controlled multicentre study of albumin replacement therapy in septic shock (ARISS): protocol for a\u00a0randomized controlled trial. Trials 21:1002","journal-title":"Trials"},{"key":"875_CR53","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12876-015-0389-9","volume":"15","author":"F Salerno","year":"2015","unstructured":"Salerno\u00a0F, Navickis\u00a0RJ, Wilkes\u00a0MM (2015) Albumin treatment regimen for type 1 hepatorenal syndrome: a\u00a0dose-response meta-analysis. BMC Gastroenterol 15:167","journal-title":"BMC Gastroenterol"},{"key":"875_CR54","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.jhep.2018.08.006","volume":"69","author":"E Sol\u00e0","year":"2018","unstructured":"Sol\u00e0\u00a0E, Sol\u00e9\u00a0C, Sim\u00f3n-Talero\u00a0M et al (2018) Midodrine and albumin for prevention of complications in patients with cirrhosis awaiting liver transplantation. A randomized placebo-controlled trial. J\u00a0Hepatol 69:1250\u20131259","journal-title":"J Hepatol"},{"key":"875_CR55","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1056\/NEJM199908053410603","volume":"341","author":"P Sort","year":"1999","unstructured":"Sort\u00a0P, Navasa\u00a0M, Arroyo\u00a0V et\u00a0al (1999) Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N\u00a0Engl J Med 341:403\u2013409","journal-title":"N Engl J Med"},{"key":"875_CR56","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1086\/514940","volume":"27","author":"J Such","year":"1998","unstructured":"Such\u00a0J, Runyon\u00a0BA (1998) Spontaneous bacterial peritonitis. Clin Infect Dis 27:669\u2013674","journal-title":"Clin Infect Dis"},{"key":"875_CR57","doi-asserted-by":"publisher","first-page":"R10","DOI":"10.1186\/cc13187","volume":"18","author":"C Uhlig","year":"2014","unstructured":"Uhlig\u00a0C, Silva\u00a0PL, Deckert\u00a0S et al (2014) Albumin versus crystalloid solutions in patients with the acute respiratory distress syndrome: a\u00a0systematic review and meta-analysis. Crit Care 18:R10","journal-title":"Crit Care"},{"key":"875_CR58","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1007\/s00134-020-06310-0","volume":"46","author":"P Vignon","year":"2020","unstructured":"Vignon\u00a0P, Evrard\u00a0B, Asfar\u00a0P et\u00a0al (2020) Fluid administration and monitoring in ARDS: which management? Intensive Care Med 46:2252\u20132264","journal-title":"Intensive Care Med"},{"key":"875_CR59","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/00005373-198702000-00006","volume":"27","author":"K Waxman","year":"1987","unstructured":"Waxman\u00a0K, Rebello\u00a0T, Pinderski\u00a0L et\u00a0al (1987) Protein loss across burn wounds. J\u00a0Trauma 27:136\u2013140","journal-title":"J Trauma"},{"key":"875_CR60","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1055\/s-0038-1667328","volume":"67","author":"P Weiler","year":"2019","unstructured":"Weiler\u00a0P, Hamiko\u00a0M, Mellert\u00a0F et\u00a0al (2019) Impact of crystalloid or albumin priming of the heart\u2013lung machine on inhospital outcome after coronary artery bypass surgery. Thorac Cardiovasc Surg 67:475\u2013483","journal-title":"Thorac Cardiovasc Surg"},{"key":"875_CR61","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1007\/s00134-018-5443-y","volume":"44","author":"T Wengenmayer","year":"2018","unstructured":"Wengenmayer\u00a0T, Schroth\u00a0F, Biever\u00a0PM et al (2018) Albumin fluid resuscitation in patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy is associated with improved survival. Intensive Care Med 44:2312\u20132314","journal-title":"Intensive Care Med"},{"key":"875_CR62","doi-asserted-by":"publisher","first-page":"4496","DOI":"10.3390\/ijms22094496","volume":"22","author":"CJ Wiedermann","year":"2021","unstructured":"Wiedermann\u00a0CJ (2021) Hypoalbuminemia as surrogate and culprit of infections. IJMS 22:4496","journal-title":"IJMS"},{"key":"875_CR63","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1080\/03007995.2020.1840970","volume":"36","author":"CJ Wiedermann","year":"2020","unstructured":"Wiedermann\u00a0CJ (2020) Phases of fluid management and the roles of human albumin solution in perioperative and critically ill patients. Curr Med Res Opin 36:1961\u20131973","journal-title":"Curr Med Res Opin"},{"key":"875_CR64","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1056\/NEJMc1405675","volume":"371","author":"CJ Wiedermann","year":"2014","unstructured":"Wiedermann\u00a0CJ, Joannidis\u00a0M (2014) Albumin replacement in severe sepsis or septic shock. N\u00a0Engl J Med 371:83","journal-title":"N Engl J Med"},{"key":"875_CR65","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1007\/s00134-018-5289-3","volume":"44","author":"CJ Wiedermann","year":"2018","unstructured":"Wiedermann\u00a0CJ, Joannidis\u00a0M (2018) The Boldt scandal still in need of action: the example of colloids 10\u00a0years after initial suspicion of fraud. Intensive Care Med 44:1735\u20131737","journal-title":"Intensive Care Med"}],"container-title":["Medizinische Klinik - Intensivmedizin und Notfallmedizin"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-021-00875-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00063-021-00875-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-021-00875-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T12:04:24Z","timestamp":1635941064000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00063-021-00875-4"}},"subtitle":["State of the art"],"short-title":[],"issued":{"date-parts":[[2021,10,7]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["875"],"URL":"https:\/\/doi.org\/10.1007\/s00063-021-00875-4","relation":{},"ISSN":["2193-6218","2193-6226"],"issn-type":[{"value":"2193-6218","type":"print"},{"value":"2193-6226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,7]]},"assertion":[{"value":"13 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"T.\u00a0Mayerh\u00f6fer  gibt an, dass kein Interessenkonflikt besteht. C.J.\u00a0Wiedermann hat Honorare f\u00fcr Vortrags- und\/oder Beratungst\u00e4tigkeit von CSL Behring und Biotest erhalten. M. Joannidis hat Honorare\u00a0f\u00fcr Vortr\u00e4ge von CSL Behring erhalten.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}