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Articles were screened independently by two reviewers, based on inclusion and exclusion criteria, and a\u00a0meta-analysis was performed using RevMan\u00a05.3 software with a\u00a0random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A\u00a0total of 18\u00a0studies (intervention group: 1794 participants, control group: 2129 participants) were included in the systematic review, with 18\u00a0studies included in the meta-analysis. Early mobilisation was found to reduce the risk of delirium in critically ill populations, with a\u00a0pooled odds ratio of 0.65 (95% confidence interval [CI] 0.49\u20130.86;\n                      <jats:italic>P<\/jats:italic>\n                      \u202f=\u20090.003; I\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u200959%). Additionally, two studies found that early mobilisation did not change the duration of delirium in critically ill populations, with a\u00a0pooled mean difference of \u22121.53 (95% CI \u22123.48 to 0.41;\n                      <jats:italic>P<\/jats:italic>\n                      \u202f=\u20090.12; I\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u200937%). Subgroup analysis revealed that early mobilisation maintained its preventive effect on delirium in the before\/after intervention studies, studies published before 2018 and studies with a\u00a0moderate methodological rating.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As a\u00a0nonpharmacological intervention, early mobilisation may help reduce the risk of delirium and shorten its duration in critically ill patients compared with standard treatment and may potentially become a\u00a0novel strategy for delirium prevention in future intensive care unit settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00063-024-01243-8","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T06:09:16Z","timestamp":1741932556000},"page":"15-28","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Preventive effects of early mobilisation on delirium incidence in critically ill patients: systematic review and meta-analysis","Pr\u00e4ventive Effekte der Fr\u00fchmobilisation auf die Delir-Inzidenz bei kritisch Kranken: systematischer Review und Metaanalyse"],"prefix":"10.1007","volume":"120","author":[{"given":"Li","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"issue":"2","key":"1243_CR1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.5603\/AIT.a2018.0011","volume":"50","author":"K Kotfis","year":"2018","unstructured":"Kotfis\u00a0K, Marra\u00a0A, Ely\u00a0EW (2018) ICU delirium\u2014a\u00a0diagnostic and therapeutic challenge in the intensive care unit. 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