{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:13:22Z","timestamp":1786979602898,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Klin Intensivmed Notfmed"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>\n                    Das akute Atemnotsyndrom (ARDS) ist ein heterogenes klinisches Syndrom, das sich durch eine variable Pathophysiologie und unterschiedliche therapeutische Ans\u00e4tze auszeichnet. Die j\u00fcngsten Leitlinien betonen die Bedeutung der Bauchlagerung und der venoven\u00f6sen extrakorporalen Membranoxygenierung (vv-ECMO) f\u00fcr schwerste F\u00e4lle, w\u00e4hrend routinem\u00e4\u00dfige Recruitmentman\u00f6ver und extrakorporale CO\n                    <jats:sub>2<\/jats:sub>\n                    -Eliminationsverfahren nicht mehr empfohlen werden. Um die Personalisierung der ARDS-Therapie weiter voranzutreiben, zeigt die Identifikation von ARDS-Ph\u00e4notypen mittels \u201elatent class analysis\u201c vielversprechende Ans\u00e4tze zur personalisierten Therapie. Zudem k\u00f6nnten adaptive Plattformstudien und auf k\u00fcnstlicher Intelligenz (KI) basierende Entscheidungsunterst\u00fctzungssysteme die ARDS-Behandlung optimieren. Die zuk\u00fcnftige ARDS-Therapie wird zunehmend individualisiert sein und auf einer verbesserten Patientenstratifizierung, neuen Studiendesigns und dem gezielten Einsatz moderner Technologien basieren. Dieser Artikel fasst die aktuellen Entwicklungen in der ARDS-Therapie zusammen, insbesondere im Hinblick auf individuelle Behandlungsstrategien, neue Studiendesigns und den Einsatz von k\u00fcnstlicher Intelligenz.\n                  <\/jats:p>","DOI":"10.1007\/s00063-025-01273-w","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:59:50Z","timestamp":1745308790000},"page":"379-388","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute Respiratory Distress Syndrome\u00a0\u2013 quo vadis","Acute respiratory distress syndrome\u2014quo vadis"],"prefix":"10.1007","volume":"120","author":[{"given":"Nina","family":"Buchtele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Staudinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"issue":"6","key":"1273_CR1","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1038\/s41591-022-01843-x","volume":"28","author":"DM Maslove","year":"2022","unstructured":"Maslove\u00a0DM, Tang\u00a0B, Shankar-Hari\u00a0M et\u00a0al (2022) Redefining critical illness. Nat Med 28(6):1141\u20131148","journal-title":"Nat Med"},{"issue":"7","key":"1273_CR2","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s00134-023-07050-7","volume":"49","author":"G Grasselli","year":"2023","unstructured":"Grasselli\u00a0G, Calfee\u00a0CS, Camporota\u00a0L et\u00a0al (2023) ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Med 49(7):727\u2013759","journal-title":"Intensive Care Med"},{"issue":"1","key":"1273_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1164\/rccm.202311-2011ST","volume":"209","author":"N Qadir","year":"2024","unstructured":"Qadir\u00a0N, Sahetya\u00a0S, Munshi\u00a0L et\u00a0al (2024) An update on management of adult patients with acute respiratory distress syndrome: an official American thoracic society clinical practice guideline. Am J Respir Crit Care Med 209(1):24\u201336","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"1273_CR4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1164\/rccm.202303-0558WS","volume":"209","author":"MA Matthay","year":"2024","unstructured":"Matthay\u00a0MA, Arabi\u00a0Y, Arroliga\u00a0AC et\u00a0al (2024) A\u00a0new global definition of acute respiratory distress syndrome. Am J Respir Crit Care Med 209(1):37\u201347","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"1273_CR5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00063-024-01218-9","volume":"120","author":"T Staudinger","year":"2025","unstructured":"Staudinger\u00a0T (2025) Acute respiratory distress syndrome : pathophysiology, definition and treatment strategies. Med Klin Intensivmed Notfmed 120(1):81\u201393","journal-title":"Med Klin Intensivmed Notfmed"},{"issue":"7","key":"1273_CR6","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1007\/s00063-021-00823-2","volume":"116","author":"B Neetz","year":"2021","unstructured":"Neetz\u00a0B, Flohr\u00a0T, Herth\u00a0FJF et\u00a0al (2021) Patient self-inflicted lung injury (P-SILI) : from pathophysiology to clinical evaluation with differentiated management. Med Klin Intensivmed Notfmed 116(7):614\u2013623","journal-title":"Med Klin Intensivmed Notfmed"},{"issue":"1","key":"1273_CR7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1164\/rccm.201606-1306OC","volume":"195","author":"G Bellani","year":"2017","unstructured":"Bellani\u00a0G, Laffey\u00a0JG, Pham\u00a0T et\u00a0al (2017) Noninvasive ventilation of patients with acute respiratory distress syndrome insights from the LUNG SAFE study. Am J Respir Crit Care Med 195(1):67\u201377","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"1273_CR8","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.23736\/S0375-9393.19.13418-9","volume":"85","author":"DL Grieco","year":"2019","unstructured":"Grieco\u00a0DL, Menga\u00a0LS, Eleuteri\u00a0D et\u00a0al (2019) Patient self-inflicted lung injury: implications for acute hypoxemic respiratory failure and ARDS patients on non-invasive support. Minerva Anestesiol 85(9):1014\u20131023","journal-title":"Minerva Anestesiol"},{"issue":"11","key":"1273_CR9","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1007\/s00134-020-06248-3","volume":"46","author":"A Combes","year":"2020","unstructured":"Combes\u00a0A, Peek\u00a0GJ, Hajage\u00a0D et\u00a0al (2020) ECMO for severe ARDS: systematic review and individual patient data meta-analysis. Intensive Care Med 46(11):2048\u20132057","journal-title":"Intensive Care Med"},{"issue":"21","key":"1273_CR10","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1056\/NEJMoa1800385","volume":"378","author":"A Combes","year":"2018","unstructured":"Combes\u00a0A, Hajage\u00a0D, Capellier\u00a0G et\u00a0al (2018) Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. N\u00a0Engl J Med 378(21):1965\u20131975","journal-title":"N Engl J Med"},{"issue":"1","key":"1273_CR11","first-page":"37","volume":"19","author":"AJC Burrell","year":"2017","unstructured":"Burrell\u00a0AJC, Lubnow\u00a0M, Enger\u00a0TB et\u00a0al (2017) The impact of venovenous extracorporeal membrane oxygenation on cytokine levels in patients with severe acute respiratory distress syndrome: a\u00a0prospective, observational study. Crit Care Resusc 19(1):37\u201344","journal-title":"Crit Care Resusc"},{"issue":"7","key":"1273_CR12","first-page":"671","volume":"389","author":"PF Dequin","year":"2023","unstructured":"Dequin\u00a0PF, Meziani\u00a0F, Le Gouge\u00a0A (2023) Hydrocortisone in severe community-acquired pneumonia. Reply. N\u00a0Engl J Med 389(7):671\u2013672","journal-title":"N Engl J Med"},{"issue":"5","key":"1273_CR13","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/S2213-2600(23)00430-7","volume":"12","author":"N Heming","year":"2024","unstructured":"Heming\u00a0N, Renault\u00a0A, Kuperminc\u00a0E et\u00a0al (2024) Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a\u00a0subgroup analysis of the APROCCHSS phase\u00a03 randomised trial. Lancet Respir Med 12(5):366\u2013374","journal-title":"Lancet Respir Med"},{"issue":"7","key":"1273_CR14","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/S2213-2600(21)00177-6","volume":"9","author":"A Supady","year":"2021","unstructured":"Supady\u00a0A, Weber\u00a0E, Rieder\u00a0M et\u00a0al (2021) Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a\u00a0single centre, open-label, randomised, controlled trial. Lancet Respir Med 9(7):755\u2013762","journal-title":"Lancet Respir Med"},{"issue":"17","key":"1273_CR15","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1056\/NEJMoa052052","volume":"354","author":"L Gattinoni","year":"2006","unstructured":"Gattinoni\u00a0L, Caironi\u00a0P, Cressoni\u00a0M et\u00a0al (2006) Lung recruitment in patients with the acute respiratory distress syndrome. N\u00a0Engl J Med 354(17):1775\u20131786","journal-title":"N Engl J Med"},{"issue":"8","key":"1273_CR16","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1056\/NEJMsa1410639","volume":"372","author":"MB Amato","year":"2015","unstructured":"Amato\u00a0MB, Meade\u00a0MO, Slutsky\u00a0AS et\u00a0al (2015) Driving pressure and survival in the acute respiratory distress syndrome. N\u00a0Engl J Med 372(8):747\u2013755","journal-title":"N Engl J Med"},{"issue":"4","key":"1273_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1056\/NEJMoa032193","volume":"351","author":"RG Brower","year":"2004","unstructured":"Brower\u00a0RG, Lanken\u00a0PN, MacIntyre\u00a0N et\u00a0al (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N\u00a0Engl J Med 351(4):327\u2013336","journal-title":"N Engl J Med"},{"issue":"6","key":"1273_CR18","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1001\/jama.299.6.646","volume":"299","author":"A Mercat","year":"2008","unstructured":"Mercat\u00a0A, Richard\u00a0JC, Vielle\u00a0B et\u00a0al (2008) Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a\u00a0randomized controlled trial. JAMA 299(6):646\u2013655","journal-title":"JAMA"},{"issue":"9","key":"1273_CR19","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1001\/jama.2010.218","volume":"303","author":"M Briel","year":"2010","unstructured":"Briel\u00a0M, Meade\u00a0M, Mercat\u00a0A et\u00a0al (2010) Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA 303(9):865\u2013873","journal-title":"JAMA"},{"issue":"11","key":"1273_CR20","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1164\/rccm.202108-1972OC","volume":"205","author":"J Dianti","year":"2022","unstructured":"Dianti\u00a0J, Tisminetzky\u00a0M, Ferreyro\u00a0BL et\u00a0al (2022) Association of positive end-expiratory pressure and lung recruitment selection strategies with mortality in acute respiratory distress syndrome: a\u00a0systematic review and network meta-analysis. Am J Respir Crit Care Med 205(11):1300\u20131310","journal-title":"Am J Respir Crit Care Med"},{"issue":"14","key":"1273_CR21","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1001\/jama.2017.14171","volume":"318","author":"AB Cavalcanti","year":"2017","unstructured":"Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial I, Cavalcanti\u00a0AB, Suzumura\u00a0EA et\u00a0al (2017) Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a\u00a0randomized clinical trial. JAMA 318(14):1335\u20131345","journal-title":"JAMA"},{"issue":"20","key":"1273_CR22","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1056\/NEJMoa0708638","volume":"359","author":"D Talmor","year":"2008","unstructured":"Talmor\u00a0D, Sarge\u00a0T, Malhotra\u00a0A et\u00a0al (2008) Mechanical ventilation guided by esophageal pressure in acute lung injury. N\u00a0Engl J Med 359(20):2095\u20132104","journal-title":"N Engl J Med"},{"issue":"9","key":"1273_CR23","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1001\/jama.2019.0555","volume":"321","author":"JR Beitler","year":"2019","unstructured":"Beitler\u00a0JR, Sarge\u00a0T, Banner-Goodspeed\u00a0VM et\u00a0al (2019) Effect of titrating positive end-expiratory pressure (PEEP) with an esophageal pressure-guided strategy vs an empirical high PEEP-Fio2 strategy on death and days free from mechanical ventilation among patients with acute respiratory distress syndrome: a\u00a0randomized clinical trial. JAMA 321(9):846\u2013857","journal-title":"JAMA"},{"key":"1273_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-024-07362-2","author":"N Songsangvorn","year":"2024","unstructured":"Songsangvorn\u00a0N, Xu\u00a0Y, Lu\u00a0C et\u00a0al (2024) Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a\u00a0systematic review and meta-analysis. Intensive Care Med. https:\/\/doi.org\/10.1007\/s00134-024-07362-2","journal-title":"Intensive Care Med"},{"issue":"11","key":"1273_CR25","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1007\/s00134-018-5375-6","volume":"44","author":"A Serpa Neto","year":"2018","unstructured":"Serpa Neto\u00a0A, Deliberato\u00a0RO, Johnson\u00a0AEW et\u00a0al (2018) Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts. Intensive Care Med 44(11):1914\u20131922","journal-title":"Intensive Care Med"},{"issue":"12","key":"1273_CR26","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1056\/NEJMoa1005372","volume":"363","author":"L Papazian","year":"2010","unstructured":"Papazian\u00a0L, Forel\u00a0JM, Gacouin\u00a0A et\u00a0al (2010) Neuromuscular blockers in early acute respiratory distress syndrome. N\u00a0Engl J Med 363(12):1107\u20131116","journal-title":"N Engl J Med"},{"issue":"5","key":"1273_CR27","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1164\/rccm.201003-0423OC","volume":"183","author":"TR Craig","year":"2011","unstructured":"Craig\u00a0TR, Duffy\u00a0MJ, Shyamsundar\u00a0M et\u00a0al (2011) A\u00a0randomized clinical trial of hydroxymethylglutaryl-coenzyme a\u00a0reductase inhibition for acute lung injury (the HARP study). Am J Respir Crit Care Med 183(5):620\u2013626","journal-title":"Am J Respir Crit Care Med"},{"issue":"21","key":"1273_CR28","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1056\/NEJMoa1901686","volume":"380","author":"M Moss","year":"2019","unstructured":"National Heart L, Blood Institute PCTN, Moss\u00a0M et\u00a0al (2019) Early neuromuscular blockade in the acute respiratory distress syndrome. N\u00a0Engl J Med 380(21):1997\u20132008","journal-title":"N Engl J Med"},{"issue":"18","key":"1273_CR29","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1056\/NEJMoa1403285","volume":"371","author":"DF McAuley","year":"2014","unstructured":"McAuley\u00a0DF, Laffey\u00a0JG, O\u2019Kane\u00a0CM et\u00a0al (2014) Simvastatin in the acute respiratory distress syndrome. N\u00a0Engl J Med 371(18):1695\u20131703","journal-title":"N Engl J Med"},{"issue":"8","key":"1273_CR30","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S2213-2600(14)70097-9","volume":"2","author":"CS Calfee","year":"2014","unstructured":"Calfee\u00a0CS, Delucchi\u00a0K, Parsons\u00a0PE et\u00a0al (2014) Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med 2(8):611\u2013620","journal-title":"Lancet Respir Med"},{"issue":"9","key":"1273_CR31","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S2213-2600(18)30177-2","volume":"6","author":"CS Calfee","year":"2018","unstructured":"Calfee\u00a0CS, Delucchi\u00a0KL, Sinha\u00a0P et\u00a0al (2018) Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a\u00a0randomised controlled trial. Lancet Respir Med 6(9):691\u2013698","journal-title":"Lancet Respir Med"},{"issue":"1","key":"1273_CR32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41581-019-0199-3","volume":"16","author":"NL Stanski","year":"2020","unstructured":"Stanski\u00a0NL, Wong\u00a0HR (2020) Prognostic and predictive enrichment in sepsis. Nat Rev Nephrol 16(1):20\u201331","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"1273_CR33","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S2213-2600(21)00157-0","volume":"10","author":"JR Beitler","year":"2022","unstructured":"Beitler\u00a0JR, Thompson\u00a0BT, Baron\u00a0RM et\u00a0al (2022) Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med 10(1):107\u2013120","journal-title":"Lancet Respir Med"},{"issue":"16","key":"1273_CR34","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1001\/jama.2015.2316","volume":"313","author":"SM Berry","year":"2015","unstructured":"Berry\u00a0SM, Connor\u00a0JT, Lewis\u00a0RJ (2015) The platform trial: an efficient strategy for evaluating multiple treatments. JAMA 313(16):1619\u20131620","journal-title":"JAMA"},{"issue":"1","key":"1273_CR35","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1056\/NEJMra1510062","volume":"377","author":"J Woodcock","year":"2017","unstructured":"Woodcock\u00a0J, LaVange\u00a0LM (2017) Master protocols to study multiple therapies, multiple diseases, or both. N\u00a0Engl J Med 377(1):62\u201370","journal-title":"N Engl J Med"},{"issue":"1","key":"1273_CR36","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/clpt.2009.68","volume":"86","author":"AD Barker","year":"2009","unstructured":"Barker\u00a0AD, Sigman\u00a0CC, Kelloff\u00a0GJ et\u00a0al (2009) I\u2011SPY 2: an adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy. Clin Pharmacol Ther 86(1):97\u2013100","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"1273_CR37","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1016\/j.jaci.2021.01.037","volume":"147","author":"E Israel","year":"2021","unstructured":"Israel\u00a0E, Denlinger\u00a0LC, Bacharier\u00a0LB et\u00a0al (2021) PrecISE: precision medicine in severe asthma: an adaptive platform trial with biomarker ascertainment. J\u00a0Allergy Clin Immunol 147(5):1594\u20131601","journal-title":"J Allergy Clin Immunol"},{"key":"1273_CR38","unstructured":"REMAP-CAP trial. https:\/\/www.remapcap.org\/"},{"key":"1273_CR39","unstructured":"RECOVERY trial. https:\/\/www.recoverytrial.net\/"},{"key":"1273_CR40","unstructured":"PANTHER trial. https:\/\/panthertrial.org\/about"},{"issue":"1","key":"1273_CR41","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s12931-024-02834-x","volume":"25","author":"TK Tran","year":"2024","unstructured":"Tran\u00a0TK, Tran\u00a0MC, Joseph\u00a0A et\u00a0al (2024) A\u00a0systematic review of machine learning models for management, prediction and classification of ARDS. Respir Res 25(1):232","journal-title":"Respir Res"},{"issue":"1","key":"1273_CR42","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41591-018-0300-7","volume":"25","author":"EJ Topol","year":"2019","unstructured":"Topol\u00a0EJ (2019) High-performance medicine: the convergence of human and artificial intelligence. Nat Med 25(1):44\u201356","journal-title":"Nat Med"},{"issue":"1","key":"1273_CR43","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41746-023-00797-9","volume":"6","author":"N Farzaneh","year":"2023","unstructured":"Farzaneh\u00a0N, Ansari\u00a0S, Lee\u00a0E et\u00a0al (2023) Collaborative strategies for deploying artificial intelligence to complement physician diagnoses of acute respiratory distress syndrome. NPJ Digit Med 6(1):62","journal-title":"NPJ Digit Med"},{"key":"1273_CR44","doi-asserted-by":"publisher","first-page":"102361","DOI":"10.1016\/j.artmed.2022.102361","volume":"131","author":"M Rashid","year":"2022","unstructured":"Rashid\u00a0M, Ramakrishnan\u00a0M, Chandran\u00a0VP et\u00a0al (2022) Artificial intelligence in acute respiratory distress syndrome: a\u00a0systematic review. Artif Intell Med 131:102361","journal-title":"Artif Intell Med"},{"key":"1273_CR45","doi-asserted-by":"publisher","first-page":"1473629","DOI":"10.3389\/fmed.2024.1473629","volume":"11","author":"BV Patel","year":"2024","unstructured":"Patel\u00a0BV, Mumby\u00a0S, Johnson\u00a0N et\u00a0al (2024) A\u00a0randomized control trial evaluating the advice of a\u00a0physiological-model\/digital twin-based decision support system on mechanical ventilation in patients with acute respiratory distress syndrome. Front Med 11:1473629","journal-title":"Front Med"}],"container-title":["Medizinische Klinik - Intensivmedizin und Notfallmedizin"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-025-01273-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00063-025-01273-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-025-01273-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T07:01:50Z","timestamp":1748242910000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00063-025-01273-w"}},"subtitle":["Innovative und individualisierte Therapieans\u00e4tze","Innovative and individualized treatment approaches"],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1273"],"URL":"https:\/\/doi.org\/10.1007\/s00063-025-01273-w","relation":{},"ISSN":["2193-6218","2193-6226"],"issn-type":[{"value":"2193-6218","type":"print"},{"value":"2193-6226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,22]]},"assertion":[{"value":"11 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"N.\u00a0Buchtele und T.\u00a0Staudinger geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}