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Dabei wurde das Update der \u201eSurviving sepsis campaign (SSC): international guidelines for management of sepsis and septic shock 2021\u201c vom 04.10.2021 als Referenzleitlinie zugrunde gelegt. Die DSG-Leitlinienkommission verglich jede Empfehlung zu den zugrunde liegenden PICO-Fragen der DSG-Leitlinie 2018 (Literaturrecherche bis 12\/2018) mit denen der SSC-Leitlinie 2021 (Literaturrecherche bis 07\/2019) und bewertete die in der Zwischenzeit neu verf\u00fcgbare publizierte Datenlage (Literaturrecherche bis 12\/2024) mittels systematischer Aktualisierungsrecherchen und Literaturbewertungen unter Befolgung des Regelwerkes des GRADE-Systems und der AWMF.<\/jats:p>\n <\/jats:sec>\n \n Ergebnisse<\/jats:title>\n Insgesamt wurden 88\u00a0PICO-Fragen u.\u202fa. zur Diagnose und Therapie der Infektion und des Organversagens adressiert. Davon wurden 2\u00a0als Statements, 29\u00a0als Expertenkonsens und 57\u00a0als evidenzbasierte Empfehlungen (26\u00a0mit starkem und 31\u00a0mit schwachem Empfehlungsgrad) konsentiert. Im Vergleich zur Vorg\u00e4nger-Leitlinie 2018 wurden 43\u00a0Empfehlungen \u00fcberpr\u00fcft, aber beibehalten. 16\u00a0Empfehlungen wurden ge\u00e4ndert, und 29\u00a0Empfehlungen wurden neu ausgesprochen.<\/jats:p>\n <\/jats:sec>\n \n Schlussfolgerung<\/jats:title>\n Angesichts fehlender Evidenz f\u00fcr zahlreiche Ma\u00dfnahmen zur station\u00e4ren Versorgung von Patienten mit Sepsis oder septischem Schock wurden alte und neue Wissensl\u00fccken offenbart. Bei den evidenzbasierten Empfehlungen war die zugrunde liegende Evidenzqualit\u00e4t nach GRADE nur bei 5\u00a0Empfehlungen hoch, bei 18\u00a0Empfehlungen moderat, bei 17\u00a0Empfehlungen niedrig und bei 16\u00a0sehr niedrig. Diese Evidenzl\u00fccken k\u00f6nnen nur durch zuk\u00fcnftige multizentrische, nichtkommerzielle klinische Pr\u00fcfungen geschlossen werden. Das Update der S3-Leitlinie Sepsis beinhaltet einige Aktualisierungen zu Empfehlungen der Vorg\u00e4ngerleitlinie. Diese Aktualisierungen werden in einige der fall- und einrichtungsbezogenen QS-Indikatoren des QS-Verfahrens 2025 einflie\u00dfen m\u00fcssen. Beeintr\u00e4chtigungen in der gesundheitsbezogenen Lebensqualit\u00e4t m\u00fcssen bei \u00dcberlebenden mehr in den Fokus der ambulanten Versorgung ger\u00fcckt werden.<\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s00063-025-01317-1","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T11:48:32Z","timestamp":1755517712000},"page":"163-231","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["S3-Leitlinie Sepsis \u2013\u00a0Pr\u00e4vention, Diagnose, Therapie und Nachsorge\u00a0\u2013 Update 2025","S3 guideline on sepsis\u2014prevention, diagnosis, therapy, and follow-up care\u2014update 2025"],"prefix":"10.1007","volume":"120","author":[{"given":"Frank 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