{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:54:41Z","timestamp":1791291281588,"version":"4.3.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Klin Intensivmed Notfmed"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s00063-026-01480-z","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:14:58Z","timestamp":1785172498000},"page":"530-537","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vasopressoren beim septischen Schock: Altes und Neues","Vasopressors in septic shock: the old and the new"],"prefix":"10.1007","volume":"121","author":[{"given":"Reimer","family":"Riessen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Heister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janika","family":"Briegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"1480_CR1","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s00134-016-4249-z","volume":"42","author":"DT Andreis","year":"2016","unstructured":"Andreis\u00a0DT, Singer\u00a0M (2016) Catecholamines for inflammatory shock: a\u00a0Jekyll-and-Hyde conundrum. Intensive Care Medicine 42:1387\u20131397","journal-title":"Intensive Care Medicine"},{"key":"1480_CR2","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1007\/s00134-018-5242-5","volume":"44","author":"D Annane","year":"2018","unstructured":"Annane\u00a0D, Ouanes-Besbes\u00a0L, De Backer\u00a0D et\u00a0al (2018) A global perspective on vasoactive agents in shock. Intensive Care Medicine 44:833\u2013846","journal-title":"Intensive Care Medicine"},{"key":"1480_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-025-01463-x","volume":"15","author":"C Benaroua","year":"2025","unstructured":"Benaroua\u00a0C, Pucci\u00a0F, Rooman\u00a0M et\u00a0al (2025) Alterations in the renin-angiotensin system during septic shock. Ann Intensive Care 15:40","journal-title":"Ann Intensive Care"},{"key":"1480_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00063-025-01317-1","volume":"120","author":"FM Brunkhorst","year":"2025","unstructured":"Brunkhorst\u00a0FM, Adamzik\u00a0M, Axer\u00a0H et\u00a0al (2025) S3-Leitlinie Sepsis \u2013 Pr\u00e4vention, Diagnose, Therapie und Nachsorge \u2013 Update 2025. Medizinische Klinik - Intensivmedizin und Notfallmedizin 120:163\u2013231","journal-title":"Medizinische Klinik - Intensivmedizin und Notfallmedizin"},{"key":"1480_CR5","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.cardiores.2006.07.011","volume":"72","author":"JF Buckley","year":"2006","unstructured":"Buckley\u00a0JF, Singer\u00a0M, Clapp\u00a0LH (2006) Role of KATP channels in sepsis. Cardiovasc Res 72:220\u2013230","journal-title":"Cardiovasc Res"},{"key":"1480_CR6","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1177\/0300060517743836","volume":"46","author":"AM Burgdorff","year":"2018","unstructured":"Burgdorff\u00a0AM, Bucher\u00a0M, Schumann\u00a0J (2018) Vasoplegia in patients with sepsis and septic shock: pathways and mechanisms. J\u00a0Int Med Res 46:1303\u20131310","journal-title":"J Int Med Res"},{"key":"1480_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1161\/01.HYP.35.1.155","volume":"35","author":"RM Carey","year":"2000","unstructured":"Carey\u00a0RM, Wang\u00a0ZQ, Siragy\u00a0HM (2000) Role of the Angiotensin Type 2 Receptor in the Regulation of Blood Pressure and Renal Function. Hypertension 35:155\u2013163","journal-title":"Hypertension"},{"key":"1480_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s44158-024-00150-w","volume":"4","author":"I Coloretti","year":"2024","unstructured":"Coloretti\u00a0I, Genovese\u00a0A, Teixeira\u00a0JP et\u00a0al (2024) Angiotensin II therapy in refractory septic shock: which patient can benefit most? A narrative review. J\u00a0Anesth Analg Crit Care 4:13","journal-title":"J Anesth Analg Crit Care"},{"key":"1480_CR9","doi-asserted-by":"crossref","unstructured":"Dubin A, Mugno M (2024) The Effects of Dobutamine in Septic Shock: An Updated Narrative Review of Clinical and Experimental Studies. Medicina (Kaunas) 60","DOI":"10.3390\/medicina60050751"},{"key":"1480_CR10","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-\u00c1lvarez R, Arboleda-Salazar R (2023) Vasopressin in Sepsis and Other Shock States: State of the Art. J\u00a0Pers Med\u00a013","DOI":"10.3390\/jpm13111548"},{"key":"1480_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04396-8","volume":"27","author":"B Garcia","year":"2023","unstructured":"Garcia\u00a0B, Su\u00a0F, Manicone\u00a0F et\u00a0al (2023) Angiotensin 1\u20117 in an experimental septic shock model. Crit Care 27:106","journal-title":"Crit Care"},{"key":"1480_CR12","volume":"17","author":"A Gon\u00e7alves","year":"2025","unstructured":"Gon\u00e7alves\u00a0A, Gon\u00e7alves\u00a0Pereira F, Fernandes\u00a0S et\u00a0al (2025) Insights Into the Pathophysiology of Catecholamine-Refractory Shock: A Narrative Review. Cureus 17:e86224","journal-title":"Cureus"},{"key":"1480_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00134-018-5499-8","volume":"45","author":"G Hern\u00e1ndez","year":"2019","unstructured":"Hern\u00e1ndez\u00a0G, Teboul\u00a0JL, Bakker\u00a0J (2019) Norepinephrine in septic shock. Intensive Care Medicine 45:687\u2013689","journal-title":"Intensive Care Medicine"},{"key":"1480_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/cc2338","volume":"8","author":"CL Holmes","year":"2004","unstructured":"Holmes\u00a0CL, Landry\u00a0DW, Granton\u00a0JT (2004) Science Review: Vasopressin and the cardiovascular system part 2 - clinical physiology. Crit Care 8:15\u201323","journal-title":"Crit Care"},{"key":"1480_CR15","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1161\/01.CIR.95.5.1122","volume":"95","author":"DW Landry","year":"1997","unstructured":"Landry\u00a0DW, Levin\u00a0HR, Gallant\u00a0EM et\u00a0al (1997) Vasopressin Deficiency Contributes to the Vasodilation of Septic Shock. Circulation 95:1122\u20131125","journal-title":"Circulation"},{"key":"1480_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05123-7","volume":"28","author":"M Legrand","year":"2024","unstructured":"Legrand\u00a0M, Khanna\u00a0AK, Ostermann\u00a0M et\u00a0al (2024) The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II. Crit Care 28:389","journal-title":"Crit Care"},{"key":"1480_CR17","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1097\/CCM.0000000000007124","volume":"54","author":"M Leone","year":"2026","unstructured":"Leone\u00a0M, Myatra\u00a0SN, Dugar\u00a0S et\u00a0al (2026) Clinical Criteria for the Definition of Refractory Septic Shock: A\u00a0Joint Delphi Consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM). Critical Care Medicine 54:1073\u20131091","journal-title":"Critical Care Medicine"},{"key":"1480_CR18","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00134-018-5222-9","volume":"44","author":"V L\u00e9opold","year":"2018","unstructured":"L\u00e9opold\u00a0V, Gayat\u00a0E, Pirracchio\u00a0R et\u00a0al (2018) Epinephrine and short-term survival in cardiogenic shock: an individual data meta-analysis of 2583 patients. Intensive Care Medicine 44:847\u2013856","journal-title":"Intensive Care Medicine"},{"key":"1480_CR19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s10286-018-0572-5","volume":"29","author":"AJ Miller","year":"2019","unstructured":"Miller\u00a0AJ, Arnold\u00a0AC (2019) The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications. Clin Auton Res 29:231\u2013243","journal-title":"Clin Auton Res"},{"key":"1480_CR20","volume":"16","author":"N Nagaraju","year":"2024","unstructured":"Nagaraju\u00a0N, Varma\u00a0A, Meshram\u00a0RJ (2024) Steroids in the Management of Ionotropic-Resistant Septic Shock: A Comprehensive Review of Efficacy and Outcomes. Cureus 16:e67795","journal-title":"Cureus"},{"key":"1480_CR21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jash.2014.05.014","volume":"8","author":"LG Navar","year":"2014","unstructured":"Navar\u00a0LG (2014) Physiology: hemodynamics, endothelial function, renin-angiotensin-aldosterone system, sympathetic nervous system. J\u00a0Am Soc Hypertens 8:519\u2013524","journal-title":"J Am Soc Hypertens"},{"key":"1480_CR22","volume":"6","author":"T Pitre","year":"2024","unstructured":"Pitre\u00a0T, Drover\u00a0K, Chaudhuri\u00a0D et\u00a0al (2024) Corticosteroids in Sepsis and Septic Shock: A Systematic Review, Pairwise, and Dose-Response Meta-Analysis. Crit Care Explor 6:e1000","journal-title":"Crit Care Explor"},{"key":"1480_CR23","unstructured":"Prescott HC, Antonelli M, Alhazzani W et\u00a0al. (2026) Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026. Intensive Care Medicine"},{"key":"1480_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05717-9","volume":"29","author":"M Reinikainen","year":"2025","unstructured":"Reinikainen\u00a0M, Delamarre\u00a0L, Blaser\u00a0AR et\u00a0al (2025) Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis. Critical Care 29:498","journal-title":"Critical Care"},{"key":"1480_CR25","doi-asserted-by":"crossref","unstructured":"Riessen R, Tschritter O, Janssens U et\u00a0al. (2015) Katecholamine: Pro und Kontra. Medizinische Klinik - Intensivmedizin und Notfallmedizin:1\u201310","DOI":"10.1007\/s00063-015-0011-5"},{"key":"1480_CR26","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2026.5758","volume":"57","author":"H Ruan","year":"2026","unstructured":"Ruan\u00a0H, Shen\u00a0XY, Liu\u00a0SY et\u00a0al (2026) Role of vascular smooth muscle cell pathobiology in sepsis-induced vasoplegia (Review). Int J Mol Med 57:87","journal-title":"Int J Mol Med"},{"key":"1480_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-024-00770-y","volume":"13","author":"R Sato","year":"2025","unstructured":"Sato\u00a0R, Hasegawa\u00a0D, Guo\u00a0S et\u00a0al (2025) Sepsis-induced cardiogenic shock: controversies and evidence gaps in diagnosis and management. J\u00a0Intensive Care 13:1","journal-title":"J Intensive Care"},{"key":"1480_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05400-z","volume":"29","author":"R Shi","year":"2025","unstructured":"Shi\u00a0R, Bra\u00efk\u00a0R, Monnet\u00a0X et\u00a0al (2025) Early norepinephrine for patients with septic shock: an updated systematic review and meta-analysis with trial sequential analysis. Critical Care 29:182","journal-title":"Critical Care"},{"key":"1480_CR29","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1161\/CIRCULATIONAHA.124.069508","volume":"150","author":"S Van Diepen","year":"2024","unstructured":"Van Diepen\u00a0S, P\u00f6ss\u00a0J, Senaratne\u00a0JM et\u00a0al (2024) Mixed Cardiogenic Shock: A Proposal for Standardized Classification, a Hemodynamic Definition, and Framework for Management. Circulation 150:1459\u20131468","journal-title":"Circulation"},{"key":"1480_CR30","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s00392-011-0292-5","volume":"100","author":"K Werdan","year":"2011","unstructured":"Werdan\u00a0K, Oelke\u00a0A, Hettwer\u00a0S et\u00a0al (2011) Septic cardiomyopathy: hemodynamic quantification, occurrence, and prognostic implications. Clin Res Cardiol 100:661\u2013668","journal-title":"Clin Res Cardiol"},{"key":"1480_CR31","doi-asserted-by":"crossref","unstructured":"Wieruszewski PM, Leone M, Kaas-Hansen BS et al. (2024) Position Paper on the Reporting of Norepinephrine Formulations in Critical Care from the Society of Critical Care Medicine and European Society of Intensive Care Medicine Joint Task Force. Crit Care Med 52:521\u2013530","DOI":"10.1097\/CCM.0000000000006176"},{"key":"1480_CR32","unstructured":"Bendjelid K, Cassina T, Cioccari L et al. (2025) 2nd Swiss Vasopressin Consensus: Vasopressin in Septic Shock and other Vasodilatory States. hb TIMES Schw Aerztej. 17:8-19"}],"container-title":["Medizinische Klinik - Intensivmedizin und Notfallmedizin"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-026-01480-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00063-026-01480-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-026-01480-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:10:00Z","timestamp":1791288600000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00063-026-01480-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["1480"],"URL":"https:\/\/doi.org\/10.1007\/s00063-026-01480-z","relation":{},"ISSN":["2193-6218","2193-6226"],"issn-type":[{"value":"2193-6218","type":"print"},{"value":"2193-6226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"29 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"R.\u00a0Riessen, D.J.\u00a0Heister und J.\u00a0Briegel geben an, dass kein Interessenkonflikt besteht.","order":1,"name":"Ethics","label":"Interessenkonflikt","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}}]}}