{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:49:21Z","timestamp":1791586161177,"version":"4.3.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Klin Intensivmed Notfmed"],"DOI":"10.1007\/s00063-026-01500-y","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:40:24Z","timestamp":1791538824000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impella in infarction-related cardiogenic shock: evidence, complications, and implementation of microaxial LV unloading","Impella beim infarktbedingten kardiogenen Schock: Evidenz, Komplikationen und klinische Umsetzung des linksventrikul\u00e4ren Unloadings"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0534-132X","authenticated-orcid":false,"given":"P.","family":"Boettger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lemm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Geppert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Russ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Werdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Buerke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"1500_CR1","doi-asserted-by":"publisher","first-page":"e232","DOI":"10.1161\/CIR.0000000000000525","volume":"136","author":"S van Diepen","year":"2017","unstructured":"van Diepen S, Katz JN, Albert NM et al (2017) Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association","journal-title":"Circulation"},{"key":"1500_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3233\/CH-2009-1194","volume":"42","author":"C Jung","year":"2009","unstructured":"Jung\u00a0C et\u00a0al (2009) Evaluation of the sublingual microcirculation in cardiogenic shock. Clin Hemorheol Microcirc 42:141\u2013148. https:\/\/doi.org\/10.3233\/CH-2009-1194","journal-title":"Clin Hemorheol Microcirc"},{"key":"1500_CR3","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1056\/NEJM199908263410901","volume":"341","author":"JS Hochman","year":"1999","unstructured":"Hochman\u00a0JS et\u00a0al (1999) Early revascularization in acute myocardial infarction complicated by cardiogenic shock (SHOCK). N Engl J Med 341:625\u2013634","journal-title":"N Engl J Med"},{"key":"1500_CR4","doi-asserted-by":"publisher","first-page":"e771","DOI":"10.1161\/CIR.0000000000001309","volume":"151","author":"SV Rao","year":"2025","unstructured":"Rao\u00a0SV, O\u2019Donoghue\u00a0ML, Ruel\u00a0M et\u00a0al (2025) 2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes. Circulation 151:e771\u2013e862. https:\/\/doi.org\/10.1161\/CIR.0000000000001309","journal-title":"Circulation"},{"key":"1500_CR5","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1056\/NEJMoa12084104.","volume":"367","author":"H Thiele","year":"2012","unstructured":"Thiele\u00a0H et\u00a0al (2012) Intraaortic balloon support for myocardial infarction with cardiogenic shock (IABP-SHOCK II). N Engl J Med 367:1287\u20131296","journal-title":"N Engl J Med"},{"key":"1500_CR6","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/CCM.0b013e3181b78671","volume":"38","author":"R Prondzinsky","year":"2010","unstructured":"Prondzinsky\u00a0R, Lemm\u00a0H, Swyter\u00a0M et\u00a0al (2010) Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCK Trial for attenuation of multiorgan dysfunction syndrome. Crit Care Med 38:152\u2013160. https:\/\/doi.org\/10.1097\/CCM.0b013e3181b78671","journal-title":"Crit Care Med"},{"key":"1500_CR7","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1056\/NEJMoa1710261","volume":"377","author":"H Thiele","year":"2017","unstructured":"Thiele\u00a0H et\u00a0al (2017) Culprit lesion only versus multivessel PCI in cardiogenic shock (CULPRIT-SHOCK). N Engl J Med 377:2419\u20132432","journal-title":"N Engl J Med"},{"key":"1500_CR8","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1186\/s13054-018-1967-3","volume":"44","author":"B Levy","year":"2018","unstructured":"Levy\u00a0B et\u00a0al (2018) Vasoplegia and catecholamine-resistant shock. Intensive Care Med 44:2285\u20132297","journal-title":"Intensive Care Med"},{"key":"1500_CR9","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1161\/CIRCULATIONAHA.112.000029","volume":"128","author":"NK Kapur","year":"2013","unstructured":"Kapur\u00a0NK et\u00a0al (2013) Mechanically unloading the left ventricle before coronary reperfusion reduces left ventricular wall stress and myocardial infarct size. Circulation 128:328\u2013336. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.000029","journal-title":"Circulation"},{"key":"1500_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1161\/CIRCULATIONAHA.118.038269","volume":"139","author":"NK Kapur","year":"2019","unstructured":"Kapur\u00a0NK et\u00a0al (2019) Unloading the Left Ventricle Before Reperfusion in Patients With Anterior ST-Segment\u2013Elevation Myocardial Infarction. Circulation 139:337\u2013346. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.038269","journal-title":"Circulation"},{"key":"1500_CR11","doi-asserted-by":"publisher","unstructured":"Kapur\u00a0NK et\u00a0al (2026) Left Ventricular Unloading in Anterior ST-Segment Elevation Myocardial Infarction Without Shock: The STEMI Door-to-Unload (STEMI-DTU) Randomized Controlled Trial. JACC Adv. https:\/\/doi.org\/10.1016\/j.jacc.2026.03.071","DOI":"10.1016\/j.jacc.2026.03.071"},{"key":"1500_CR12","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1007\/s00134-020-06296-9","volume":"8","author":"MA Matthay","year":"2020","unstructured":"Matthay\u00a0MA et\u00a0al (2020) Clinical phenotypes and precision medicine in critical care. Lancet Respir Med 8:658\u2013668. https:\/\/doi.org\/10.1007\/s00134-020-06296-9","journal-title":"Lancet Respir Med"},{"key":"1500_CR13","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.jacc.2016.10.022","volume":"69","author":"DM Ouweneel","year":"2017","unstructured":"Ouweneel\u00a0DM et\u00a0al (2017) Percutaneous Mechanical Circulatory Support Versus Intra-Aortic Balloon Pump in Cardiogenic Shock After Acute Myocardial Infarction: IMPRESS in Severe Shock. JACC Adv 69:278\u2013287. https:\/\/doi.org\/10.1016\/j.jacc.2016.10.022","journal-title":"J Am Coll Cardiol"},{"key":"1500_CR14","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1097\/SHK.0b013e31824a67af","volume":"37","author":"R Prondzinsky","year":"2012","unstructured":"Prondzinsky\u00a0R, Unverzagt\u00a0S, Russ\u00a0M et\u00a0al (2012) Hemodynamic effects of intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCK Trial. Shock 37:378\u2013384. https:\/\/doi.org\/10.1097\/SHK.0b013e31824a67af","journal-title":"Shock"},{"key":"1500_CR15","first-page":"2128","volume":"130","author":"R Stretch","year":"2014","unstructured":"Stretch\u00a0R et\u00a0al (2014) National trends in use and outcomes of mechanical circulatory support. Circulation 130:2128\u20132136","journal-title":"Circulation"},{"key":"1500_CR16","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.118.036614","volume":"139","author":"B Schrage","year":"2019","unstructured":"Schrage\u00a0B et\u00a0al (2019) Impella Support for Acute Myocardial Infarction Complicated by Cardiogenic Shock. Circulation 139:1249\u20131258. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.036614","journal-title":"Circulation"},{"key":"1500_CR17","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/j.jacc.2018.12.084","volume":"73","author":"BN Tehrani","year":"2019","unstructured":"Tehrani\u00a0BN et\u00a0al (2019) Implementation of a\u00a0cardiogenic shock team and clinical outcomes. J\u00a0Am Coll Cardiol 73:1659\u20131669","journal-title":"J Am Coll Cardiol"},{"key":"1500_CR18","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1002\/ccd.28307","volume":"93","author":"MB Basir","year":"2019","unstructured":"Basir\u00a0MB et\u00a0al (2019) Improved outcomes associated with the use of shock protocols: updates from the National Cardiogenic Shock Initiative. Catheter Cardiovasc Interv 93:1173\u20131183. https:\/\/doi.org\/10.1002\/ccd.28307","journal-title":"Catheterization and Cardiovascular Interventions"},{"key":"1500_CR19","volume":"14","author":"TD Henry","year":"2021","unstructured":"Henry\u00a0TD et\u00a0al (2021) A\u00a0regional system of care for cardiogenic shock. Circulation: Cardiovascular Interventions 14:e010284","journal-title":"Circulation: Cardiovascular Interventions"},{"key":"1500_CR20","first-page":"2923","volume":"74","author":"DA Baran","year":"2019","unstructured":"Baran\u00a0DA et\u00a0al (2019) SCAI clinical expert consensus statement on the classification of cardiogenic shock. J\u00a0Am Coll Cardiol 74:2923\u20132944","journal-title":"J Am Coll Cardiol"},{"key":"1500_CR21","first-page":"1454","volume":"141","author":"S Vallabhajosyula","year":"2020","unstructured":"Vallabhajosyula\u00a0S et\u00a0al (2020) SCAI shock stages and outcomes in contemporary cardiogenic shock. Circulation 141:1454\u20131467","journal-title":"Circulation"},{"key":"1500_CR22","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019015","volume":"10","author":"JC Jentzer","year":"2021","unstructured":"Jentzer\u00a0JC et\u00a0al (2021) Cardiac power output and prognosis in cardiogenic shock. J\u00a0Am Heart Assoc 10:e019467","journal-title":"J Am Heart Assoc"},{"key":"1500_CR23","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1056\/NEJMoa2312572","volume":"390","author":"JE M\u00f8ller","year":"2024","unstructured":"M\u00f8ller\u00a0JE, Engstr\u00f8m\u00a0T, Jensen\u00a0LO et\u00a0al (2024) Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock. N Engl J Med 390:1382\u20131393. https:\/\/doi.org\/10.1056\/NEJMoa2312572","journal-title":"N Engl J Med"},{"key":"1500_CR24","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1056\/NEJMoa2307227","volume":"389","author":"H Thiele","year":"2023","unstructured":"Thiele\u00a0H et\u00a0al (2023) Extracorporeal Life Support in Infarct-Related Cardiogenic Shock. N Engl J Med 389:1286\u20131297. https:\/\/doi.org\/10.1056\/NEJMoa2307227","journal-title":"N Engl J Med"},{"key":"1500_CR25","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1016\/j.jacc.2025.02.018","volume":"85","author":"SS Sinha","year":"2025","unstructured":"Sinha\u00a0SS, Morrow\u00a0DA, Kapur\u00a0NK, Kataria\u00a0R, Roswell\u00a0RO (2025) 2025 Concise Clinical Guidance: An ACC Expert Consensus Statement on the Evaluation and Management of Cardiogenic Shock. JACC Adv 85:1618\u20131641. https:\/\/doi.org\/10.1016\/j.jacc.2025.02.018","journal-title":"J Am Coll Cardiol"},{"key":"1500_CR26","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s00063-024-01213-0","volume":"120","author":"M Buerke","year":"2025","unstructured":"Buerke\u00a0M, Geppert\u00a0A (2025) Mechanical support with Impella decreases mortality in cardiogenic shock (DanGer Shock trial). Med Klin Intensivmed Notfmed 120:162\u2013165. https:\/\/doi.org\/10.1007\/s00063-024-01213-0","journal-title":"Med Klin Intensivmed Notfmed"},{"key":"1500_CR27","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1016\/j.jacc.2025.04.025","volume":"85","author":"K Murugiah","year":"2025","unstructured":"Murugiah\u00a0K, McDonagh\u00a0TA, Cohen\u00a0DJ, Dhruva\u00a0SS (2025) Mechanical Circulatory Support in Acute Myocardial Infarction\u2013Cardiogenic Shock: 2025 Acute Coronary Syndrome Guideline in Context. JACC Adv 85:2103\u20132106. https:\/\/doi.org\/10.1016\/j.jacc.2025.04.025","journal-title":"J Am Coll Cardiol"},{"key":"1500_CR28","volume":"1","author":"SS Naidu","year":"2022","unstructured":"Naidu\u00a0SS et\u00a0al (2022) SCAI expert consensus update on cardiogenic shock. JSCAI 1:100032","journal-title":"JSCAI"},{"key":"1500_CR29","first-page":"463","volume":"76","author":"AR Garan","year":"2020","unstructured":"Garan\u00a0AR et\u00a0al (2020) Hemodynamic predictors of outcomes in cardiogenic shock. J\u00a0Am Coll Cardiol 76:463\u2013473","journal-title":"J Am Coll Cardiol"},{"key":"1500_CR30","doi-asserted-by":"publisher","unstructured":"Klein A, Beske RP, Hassager C et al \u00a0(2024) Treating Older Patients in Cardiogenic Shock With a\u00a0Microaxial Flow Pump: Is it DANGERous? JACC Adv. https:\/\/doi.org\/10.1016\/j.jacc.2024.11.003","DOI":"10.1016\/j.jacc.2024.11.003"},{"key":"1500_CR31","first-page":"586","volume":"43","author":"F Pappalardo","year":"2017","unstructured":"Pappalardo\u00a0F et\u00a0al (2017) Concomitant left ventricular unloading during venoarterial ECMO. Intensive Care Med 43:586\u2013598","journal-title":"Intensive Care Med"},{"key":"1500_CR32","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/S0140-6736(20)30164-1","volume":"395","author":"M Schmidt","year":"2020","unstructured":"Schmidt\u00a0M et\u00a0al (2020) Extracorporeal membrane oxygenation complications and management. Lancet 395:1078\u20131090","journal-title":"Lancet"}],"container-title":["Medizinische Klinik - Intensivmedizin und Notfallmedizin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-026-01500-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00063-026-01500-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00063-026-01500-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:02:07Z","timestamp":1791583327000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00063-026-01500-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":32,"alternative-id":["1500"],"URL":"https:\/\/doi.org\/10.1007\/s00063-026-01500-y","relation":{},"ISSN":["2193-6218","2193-6226"],"issn-type":[{"value":"2193-6218","type":"print"},{"value":"2193-6226","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"8 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethics approval and consent to participate: Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"P.\u00a0Boettger, H.\u00a0Lemm, A.\u00a0Geppert, M.\u00a0Russ, K.\u00a0Werdan and M.\u00a0Buerke declare that they have no competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}