{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:52:18Z","timestamp":1770742338003,"version":"3.49.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Danube University Krems University for Continuing Education"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oper Orthop Traumatol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Operationsziel<\/jats:title>\n                <jats:p>Offene Therapie osteochondraler L\u00e4sionen des Kniegelenks zur vollst\u00e4ndigen Auff\u00fcllung kn\u00f6cherner Defekte und Wiederherstellung der Gelenkfl\u00e4che.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Indikationen<\/jats:title>\n                <jats:p>Fokale, symptomatische osteochondrale Defekte des Kniegelenks ab einer Knochendefekttiefe von \u2265\u202f5\u202fmm und Gr\u00f6\u00dfe von \u2265\u202f1,5\u202fcm<jats:sup>2<\/jats:sup>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Kontraindikationen<\/jats:title>\n                <jats:p>Arthrose (&gt;\u202fKL Grad\u00a02), \u201ekissing lesions\u201c (ICRS\u202f&gt;\u2009Grad\u00a02), Alter &gt;\u202f50\u00a0Jahre, unbehandelte Bandinstabilit\u00e4ten oder Beinachsenfehstellungen zum Nachteil des betroffenen Gelenkkompartiments, fehlendes Defektcontainment, entz\u00fcndliche Gelenkerkrankungen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Operationstechnik<\/jats:title>\n                <jats:p>Zweizeitiger Eingriff: Ersteingriff (arthroskopische Knorpelprobenentnahme): Defektevaluierung, Entnahme von Knorpelst\u00fccken f\u00fcr die Chondrozytenkultivierung, bei Bedarf Behandlung von Begleitpathologien. Zweiteingriff (offene Defektbehandlung): Arthrotomie, Pr\u00e4paration des kn\u00f6chernen Defekts, Auff\u00fcllung mit autologen Spongiosazylindern aus dem Beckenkamm, Knorpeldefektpr\u00e4paration (kann gr\u00f6\u00dfer als kn\u00f6cherner Defekt sein) und matrixgest\u00fctzte autologe Chondrozytentransplantation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Weiterbehandlung<\/jats:title>\n                <jats:p>Ersteingriff: fr\u00fchfunktionelle Nachbehandlung mit schmerzorientierter Vollbelastung je nach Begleiteingriffen. Zweiteingriff: keine Drainage, funktionelle Kniegelenkorthese in Streckstellung f\u00fcr 1\u00a0Woche, danach schrittweise Freigabe der Flexion, Teilbelastung f\u00fcr 6\u00a0Wochen, Motorschiene (CPM) ab dem 1.\u00a0postoperativen Tag.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Seit 2018 sind 8\u00a0Patienten (mittleres Alter 29,4\u00a0Jahre, Spanne 18 bis 36) mit der beschriebenen Technik behandelt worden. Alle Patienten konnten nach durchschnittlich 12\u00a0Monaten nachuntersucht werden. Der Gesamt-KOOS (Knee injury and Osteoarthritis Outcome Score) verbesserte sich im Mittel von 45,8 auf 81,3, und die postoperativen radiologischen Kontrollen zeigten die Einheilung der Spongiosazylinder bei allen Patienten. Der MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) Score ergab 80,4\u00a0Punkte.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00064-021-00751-6","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T09:02:31Z","timestamp":1638176551000},"page":"239-252","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Autologe Knorpelzelltransplantation mit Knochenaufbau zur Behandlung osteochondraler Defekte am Knie","Autologous chondrocyte transplantation with bone augmentation for the treatment of osteochodral defects of the knee"],"prefix":"10.1007","volume":"34","author":[{"given":"Christoph","family":"Stotter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Nehrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Klestil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"751_CR1","doi-asserted-by":"publisher","first-page":"3069","DOI":"10.1177\/0363546517717679","volume":"45","author":"J Zellner","year":"2017","unstructured":"Zellner\u00a0J, Grechenig\u00a0S, Pfeifer\u00a0CG et al (2017) Clinical and radiological regeneration of large and deep osteochondral defects of the knee by bone augmentation combined with matrix-guided Autologous Chondrocyte transplantation. 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F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}