{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:10:14Z","timestamp":1791155414220,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:00:00Z","timestamp":1293062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1007\/s00066-010-2149-7","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T19:35:31Z","timestamp":1294947331000},"page":"32-38","source":"Crossref","is-referenced-by-count":31,"title":["IMRT Reirradiation with Concurrent Cetuximab Immunotherapy in Recurrent Head and Neck Cancer","IMRT-Re-Bestrahlung mit simultaner Cetuximab-Immuntherapie bei rezidivierten Kopf-Hals-Tumoren"],"prefix":"10.1007","volume":"187","author":[{"given":"Felix","family":"Zwicker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Roeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Thieke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Timke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc W.","family":"M\u00fcnter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,12,23]]},"reference":[{"key":"2149_CR1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1288\/00005537-199209000-00002","volume":"102","author":"Bailet","year":"1992","unstructured":"Bailet JW, Mark RJ, Abemayor E, et al. Nasopharyngeal carcinoma: treatment and results with primary radiation therapy. Laryngoscope 1992;102:965\u201372.","journal-title":"Laryngoscope"},{"key":"2149_CR2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00066-009-2092-7","volume":"185","author":"Balermpas","year":"2009","unstructured":"Balermpas P, Hambek M, Seitz O, et al. Combined cetuximab and reirradiation for locoregional recurrent and inoperable squamous cell carcinoma of the head and neck. Strahlenther Onkol 2009;185:775\u201381.","journal-title":"Strahlenther Onkol"},{"key":"2149_CR3","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.ijrobp.2007.04.057","volume":"69","author":"Biagioli","year":"2007","unstructured":"Biagioli MC, Harvey M, Roman E, et al. Intensity-modulated radiotherapywith concurrent chemotherapy for previously irradiated, recurrent head and neck cancer. Int J Radiat Biol Phys 2007;69:1076\u20133.","journal-title":"Int J Radiat Biol Phys"},{"key":"2149_CR4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00066-008-1829-z","volume":"184","author":"B\u00f6lke","year":"2008","unstructured":"B\u00f6lke E, Gerber PA, Lammering G, et al. Development and management of severe cutaneous side effects in head-and-neck cancer patients during concurrent radiotherapy and cetuximab. Strahlenther Onkol 2008;184:105\u201310.","journal-title":"Strahlenther Onkol"},{"key":"2149_CR5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa053422","volume":"354","author":"Bonner","year":"2006","unstructured":"Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous- cell carcinoma of head and neck. NEJM 2006;354:567\u201378.","journal-title":"NEJM"},{"key":"2149_CR6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0958-3947(02)00100-0","volume":"27","author":"Chen","year":"2002","unstructured":"Chen YJ, Kuo JV, Ramsinghani NS, et al. Intensity-modulated radiotherapy for previously irradiated recurrent head-and-neck cancer. Med Dosim 2002;27:171\u20136.","journal-title":"Med Dosim"},{"key":"2149_CR7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.radonc.2005.10.010","volume":"77","author":"Chua","year":"2005","unstructured":"Chua DT, Sham JS, Leung LH, et al. Re-irradiation of nasopharyngeal carcinoma with intensity-modulated radiotherapy. Radiother Oncol 2005;77:290\u20134.","journal-title":"Radiother Oncol"},{"key":"2149_CR8","unstructured":"Common Terminology Criteria for Adverse Events v3.0 (CTCAE). Publish Date: August 9, 2006."},{"key":"2149_CR9","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1002\/1097-0142(20010601)91:11<2071::AID-CNCR1234>3.0.CO;2-Z","volume":"91","author":"Crevoisier De","year":"2001","unstructured":"De Crevoisier R, Domenge C, Wibault P, et al. Full dose reirradiation combined with chemotherapy after salvage surgery in head and neck carcinoma. Cancer 2001;91:2071\u20136.","journal-title":"Cancer"},{"key":"2149_CR10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00066-010-2130-5","volume":"186","author":"Farrag","year":"2010","unstructured":"Farrag A, Voordeckers M, Tournel K, et al. Pattern of failure after helical tomotherapy in head and neck cancer. Strahlenther Onkol 2010;186:511\u20136.","journal-title":"Strahlenther Onkol"},{"key":"2149_CR11","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1200\/JCO.1992.10.8.1245","volume":"10","author":"Forastiere","year":"1992","unstructured":"Forastiere AA, Metch B, Schuller DE, et al. Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: A Southwest Oncology Group study. J Clin Oncol 1992;10:1245\u201351.","journal-title":"J Clin Oncol"},{"key":"2149_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005537-200003001-00001","volume":"110","author":"Goodwin","year":"2000","unstructured":"Goodwin WJ Jr. Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means? Laryngoscope 2000;110:1\u20138.","journal-title":"Laryngoscope"},{"key":"2149_CR13","unstructured":"ICRU Report 50. Prescribing, recording, and reporting photon beam therapy. International Commission on Radiation Units and Measurements, Bethesda, Maryland, USA, 1993."},{"key":"2149_CR14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1200\/JCO.2006.06.1143","volume":"24","author":"Janot","year":"2006","unstructured":"Janot F, De Raucourt M, Castaing E, et al. Re-irradiation combined with chemotherapy after salvage surgery in head and neck carcinoma: a randomized trial from the GETTEC and GORTEC groups. J Clin Oncol 2006;24:18.","journal-title":"J Clin Oncol"},{"key":"2149_CR15","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/hed.20163","volume":"27","author":"Kramer","year":"2005","unstructured":"Kramer NM, Horwitz EM, Cheng J, et al. Toxicity and outcome analysis of patients with recurrent head and neck cancer treated with hyperfractionated split-course reirradiation and concurrent cisplatin and paclitaxel chemotherapy from two prospective phase I and II studies. Head Neck 2005;27:406\u201314.","journal-title":"Head Neck"},{"key":"2149_CR16","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1200\/JCO.2006.07.9194","volume":"25","author":"Langer","year":"2007","unstructured":"Langer CJ, Harris J, Horwitz EM, et al. Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: results of the radiation therapy oncology group protocol 9911. J Clin Oncol 2007;25:4800\u20135.","journal-title":"J Clin Oncol"},{"key":"2149_CR17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijrobp.2003.10.056","volume":"59","author":"Machtay","year":"2004","unstructured":"Machtay M, Rosenthal DI, Chalian AA, et al. Pilot study of postoperative reirradiation, chemotherapy, and amifostine after surgical salvage for recurrent head-and-neck cancer. Int J Radiat Oncol Biol Phys 2004; 59:72\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2149_CR18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0167-8140(03)00021-5","volume":"66","author":"M\u00fcnter","year":"2003","unstructured":"M\u00fcnter MW, Thilmann C, Hof H, et al. Stereotactic intensity modulated radiation therapy and inverse treatment planning for tumors of the head and neck region: clinical implementation of the step and shoot approach and first clinical results. Radiother Oncol 2003;66:313\u201321.","journal-title":"Radiother Oncol"},{"key":"2149_CR19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3322\/canjclin.55.4.242","volume":"55","author":"Patel","year":"2005","unstructured":"Patel S, Shah J. TNM staging of cancers of the head and neck: striving for uniformity among diversity. CA Cancer J Clin 2005;55:242\u201358.","journal-title":"CA Cancer J Clin"},{"key":"2149_CR20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0360-3016(92)90741-Y","volume":"23","author":"Perez","year":"1992","unstructured":"Perez CA, Devineni VR, Marcial-Vega V, et al. Carcinoma of the nasopharynx: factors affecting prognosis. Int J Radiat Oncol Biol Phys 1992;23:271\u201380.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2149_CR21","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.ijrobp.2008.10.042","volume":"74","author":"Popovitzer","year":"2009","unstructured":"Popovitzer A, Gluck I, Chepeha DB, et al. The pattern of failure after reirradiation of recurrent squamous cell head and neck cancer: implications for defining the targets. Int J Radiat Oncol Biol Phys 2009;74:1342\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2149_CR22","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0360-3016(92)90792-G","volume":"22","author":"Pryzant","year":"1992","unstructured":"Pryzant RM, Wendt L., Delclos et al. Retreatment of nasopharyngeal carcinoma in 53 patients. Int J Radiat Oncol Biol Phys 1992;22:941\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2149_CR23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijrobp.2005.07.005","volume":"64","author":"Salama","year":"2006","unstructured":"Salama JK, Vokes EE, Chmura SJ, et al. Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-andneck squamous cell carcinoma. Int J Radiat Biol Phys 2006;64:382\u201391.","journal-title":"Int J Radiat Biol Phys"},{"key":"2149_CR24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02742396","volume":"175","author":"Schlegel","year":"1999","unstructured":"Schlegel W, Kneschaurek P. Inverse radiotherapy planning. Strahlenther Onkol 1999;175:197\u2013207.","journal-title":"Strahlenther Onkol"},{"key":"2149_CR25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0959-8049(09)70044-9","volume":"45","author":"Segaert","year":"2009","unstructured":"Segaert S, Chiritescu G, Lemmens L, et al. Skin toxicities of targeted therapies. Eur J Cancer 2009;45:295\u2013308.","journal-title":"Eur J Cancer"},{"key":"2149_CR26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/hed.10178","volume":"25","author":"Spencer","year":"2003","unstructured":"Spencer S, Wheeler R, Peters G, et al. Phase 1 trial of combined chemotherapy and reirradiation for recurrent unresectable head and neck cancer. Head Neck 2003;25:118\u201322.","journal-title":"Head Neck"},{"key":"2149_CR27","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0360-3016(01)01745-X","volume":"51","author":"Spencer","year":"2001","unstructured":"Spencer SA, Harris J, Wheeler RH, et al. RTOG 96-10Reirradiation with concurrent hydroxyurea and 5-fluouracil in patients with aquamous cell cancer of the head and neck. Int J Radiat Oncol Biol Phys 2001;51:1299\u2013304.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2149_CR28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1007\/s00066-009-1989-5","volume":"185","author":"Steinmann","year":"2009","unstructured":"Steinmann D, Cerny B, Karstens JH, et al. Chemoradiotherapy with weekly cisplatin 40 mg\/m(2) in 103 head-and-neck cancer patients: a cumulative dose-effect analysis. Strahlenther Onkol 2009;185:682\u20138.","journal-title":"Strahlenther Onkol"},{"key":"2149_CR29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1748-717X-3-43","volume":"3","author":"Studer","year":"2008","unstructured":"Studer G, Graetz KW, Glanzmann C, et al. Outcome in recurrent head and neck cancer treated with salvage-IMRT. Radiation Oncology 2008;3:43.","journal-title":"Radiation Oncology"},{"key":"2149_CR30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ijrobp.2008.04.021","volume":"73","author":"Sulman","year":"2009","unstructured":"Sulman EP, Schwartz DL, Le T, et al. IMRT reirradiation of head and neck cancer \u2013 disease control and morbidity outcomes. Int J Radiat Biol Phys 2009;73:399\u2013409.","journal-title":"Int J Radiat Biol Phys"},{"key":"2149_CR31","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00066-009-1992-x","volume":"185","author":"Tribius","year":"2009","unstructured":"Tribius S, Kronemann S, Kilic Y, et al. Radiochemotherapy including cisplatin alone versus cisplatin + 5-fluorouracil for locally advanced unresectable stage IV squamous cell carcinoma of the head and neck. Strahlenther Onkol 2009;185:675\u201381.","journal-title":"Strahlenther Onkol"},{"key":"2149_CR32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/ijc.21479","volume":"117","author":"Cruijsen Van","year":"2005","unstructured":"Van Cruijsen H, Giaccone G, Hoelman K. Epidermal growth factor recptor and angiogenesis: Opportunities for combined anticancer strategies. Int J Cancer 2005;117:883\u20138.","journal-title":"Int J Cancer"},{"key":"2149_CR33","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1056\/NEJMoa0802656","volume":"359","author":"Vermorken","year":"2008","unstructured":"Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. NEJM 2008;359(11):1116\u201327.","journal-title":"NEJM"},{"key":"2149_CR34","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00066-010-2136-z","volume":"186","author":"Wolff","year":"2010","unstructured":"Wolff HA, Bosch J, Jung K, et al. High-grade acute organ toxicity as positive prognostic factor in primary radio(chemo)therapy for locally advanced, inoperable head and neck cancer. Strahlenther Onkol 2010;186:262\u20138.","journal-title":"Strahlenther Onkol"},{"key":"2149_CR35","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0360-3016(00)00585-X","volume":"48","author":"Xia","year":"2000","unstructured":"Xia P, Fu KK, Wong GW, et al. Comparison of treatment plans involving intensit\u00e0-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2000;48:329\u201337.","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-010-2149-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-010-2149-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-010-2149-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T02:49:13Z","timestamp":1712112553000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-010-2149-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,23]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["2149"],"URL":"https:\/\/doi.org\/10.1007\/s00066-010-2149-7","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,23]]}}}