{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:35:02Z","timestamp":1787236502294,"version":"build-2736575974"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1007\/s00066-012-0289-7","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T09:59:46Z","timestamp":1358157586000},"page":"223-229","source":"Crossref","is-referenced-by-count":56,"title":["Intensity-modulated radiotherapy vs. parotid-sparing 3D conformal radiotherapy","Intensit\u00e4tsmodulierte Strahlentherapie versus Parotis schonende 3-D- konformale Strahlentherapie"],"prefix":"10.1007","volume":"189","author":[{"given":"M.","family":"Lambrecht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Nevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nuyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,16]]},"reference":[{"key":"289_CR1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0140-6736(06)69121-6","volume":"368","author":"Bourhis","year":"2006","unstructured":"Bourhis J, Overgaard J, Audry H et al (2006) Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet 368:843\u2013854","journal-title":"Lancet"},{"key":"289_CR2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(00)90011-0","volume":"355","author":"Pignon","year":"2000","unstructured":"Pignon JP, Bourhis J, Domenge C, Designe L (2000) Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC collaborative group. Meta-analysis of chemotherapy on head and neck cancer. Lancet 355:949\u2013955","journal-title":"Lancet"},{"key":"289_CR3","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1200\/JCO.2007.14.8841","volume":"26","author":"Machtay","year":"2008","unstructured":"Machtay M, Moughan J, Trotti A et al (2008) Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol 26:3582\u20133589","journal-title":"J Clin Oncol"},{"key":"289_CR4","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1007\/s00066-011-2267-x","volume":"187","author":"Wiehle","year":"2011","unstructured":"Wiehle R, Knippen S, Grosu AL (2011) VMAT and step-and-shoot IMRT in head and neck cancer: a comparative plan analysis. Strahlenther Onkol 187:820\u2013825","journal-title":"Strahlenther Onkol"},{"key":"289_CR5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1470-2045(08)70098-6","volume":"9","author":"Veldeman","year":"2008","unstructured":"Veldeman L, Madani I, Hulstaert F et al (2008) Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies. Lancet Oncol 9:367\u2013375","journal-title":"Lancet Oncol"},{"key":"289_CR6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1053\/srao.2002.32435","volume":"12","author":"Eisbruch","year":"2002","unstructured":"Eisbruch A, Foote RL, O\u2019Sullivan B et al (2002) Intensity-modulated radiation therapy for head and neck cancer: emphasis on the selection and delineation of the targets. Semin Radiat Oncol 12:238\u2013249","journal-title":"Semin Radiat Oncol"},{"key":"289_CR7","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0360-3016(02)02881-X","volume":"53","author":"Chao","year":"2002","unstructured":"Chao KS, Wippold FJ, Ozyigit G et al (2002) Determination and delineation of nodal target volumes for head-and-neck cancer based on patterns of failure in patients receiving definitive and postoperative IMRT. Int J Radiat Oncol Biol Phys 53:1174\u20131184","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"289_CR8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.radonc.2003.09.011","volume":"69","author":"Gregoire","year":"2003","unstructured":"Gregoire V, Levendag P, Ang KK et al (2003) CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines. Radiother Oncol 69:227\u2013236","journal-title":"Radiother Oncol"},{"key":"289_CR9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.radonc.2006.03.009","volume":"79","author":"Gregoire","year":"2006","unstructured":"Gregoire V, Eisbruch A, Hamoir M, Levendag P (2006) Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck. Radiother Oncol 79:15\u201320","journal-title":"Radiother Oncol"},{"key":"289_CR10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0167-8140(02)00013-0","volume":"63","author":"Maes","year":"2002","unstructured":"Maes A, Weltens C, Flamen P et al (2002) Preservation of parotid function with uncomplicated conformal radiotherapy. Radiother Oncol 63:203\u2013211","journal-title":"Radiother Oncol"},{"key":"289_CR11","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ijrobp.2008.08.061","volume":"73","author":"Mendenhall","year":"2009","unstructured":"Mendenhall WM, Mancuso AA (2009) Radiotherapy for head and neck cancer\u2014is the \u201cnext level\u201d down? Int J Radiat Oncol Biol Phys 73:645\u2013646","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"289_CR12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","volume":"12","author":"Nutting","year":"2011","unstructured":"Nutting CM, Morden JP, Harrington KJ et al (2011) Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol 12:127\u2013136","journal-title":"Lancet Oncol"},{"key":"289_CR13","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.ijrobp.2006.06.040","volume":"66","author":"Lee","year":"2006","unstructured":"Lee NY, de Arruda FF, Puri DR et al (2006) A comparison of intensity-modulated radiation therapy and concomitant boost radiotherapy in the setting of concurrent chemotherapy for locally advanced oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 66:966\u2013974","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"289_CR14","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.ijrobp.2009.11.020","volume":"79","author":"Chen","year":"2011","unstructured":"Chen AM, Li BQ, Farwell DG et al (2011) Improved dosimetric and clinical outcomes with intensity-modulated radiotherapy for head-and-neck cancer of unknown primary origin. Int J Radiat Oncol Biol Phys 79:756\u2013762","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"289_CR15","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ijrobp.2010.10.061","volume":"82","author":"Clavel","year":"2012","unstructured":"Clavel S, Nguyen DH, Fortin B et al (2012) Simultaneous integrated boost using intensity-modulated radiotherapy compared with conventional radiotherapy in patients treated with concurrent carboplatin and 5-fluorouracil for locally advanced oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 82:582\u2013589","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"289_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijrobp.2008.07.059","volume":"74","author":"Vergeer","year":"2009","unstructured":"Vergeer MR, Doornaert PA, Rietveld DH et al (2009) Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health-related quality of life: results of a nonrandomized prospective study using a standardized follow-up program. Int J Radiat Oncol Biol Phys 74:1\u20138","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"289_CR17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.radonc.2011.12.010","volume":"103","author":"Toledano","year":"2012","unstructured":"Toledano I, Graff P, Serre A et al (2012) Intensity-modulated radiotherapy in head and neck cancer: results of the prospective study GORTEC 2004-03. Radiother Oncol 103:57\u201362","journal-title":"Radiother Oncol"},{"key":"289_CR18","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00066-012-0125-0","volume":"188","author":"Nguyen","year":"2012","unstructured":"Nguyen NP, Vock J, Chi A et al (2012) Impact of intensity-modulated and image-guided radiotherapy on elderly patients undergoing chemoradiation for locally advanced head and neck cancer. Strahlenther Onkol 188:677\u2013683","journal-title":"Strahlenther Onkol"},{"key":"289_CR19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/154411130301400306","volume":"14","author":"Vissink","year":"2003","unstructured":"Vissink A, Burlage FR, Spijkervet FK et al (2003) Prevention and treatment of the consequences of head and neck radiotherapy. Crit Rev Oral Biol Med 14:213\u2013225","journal-title":"Crit Rev Oral Biol Med"},{"key":"289_CR20","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1200\/JCO.2007.14.6647","volume":"26","author":"Langendijk","year":"2008","unstructured":"Langendijk JA, Doornaert P, Verdonck-de Leeuw IM et al (2008) Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy. J Clin Oncol 26:3770\u20133776","journal-title":"J Clin Oncol"},{"key":"289_CR21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijrobp.2008.11.041","volume":"75","author":"Dirix","year":"2009","unstructured":"Dirix P, Abbeel S, Vanstraelen B et al (2009) Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys 75:385\u2013392","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"289_CR22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.radonc.2007.07.009","volume":"85","author":"Levendag","year":"2007","unstructured":"Levendag PC, Teguh DN, Voet P et al (2007) Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose\u2013effect relationship. Radiother Oncol 85:64\u201373","journal-title":"Radiother Oncol"},{"key":"289_CR23","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S1053-4296(03)00033-X","volume":"13","author":"Eisbruch","year":"2003","unstructured":"Eisbruch A, Rhodus N, Rosenthal D et al (2003) How should we measure and report radiotherapy-induced xerostomia? Semin Radiat Oncol 13:226\u2013234","journal-title":"Semin Radiat Oncol"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-012-0289-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-012-0289-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-012-0289-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T22:31:10Z","timestamp":1558564270000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-012-0289-7"}},"subtitle":["Effect on outcome and toxicity in locally advanced head and neck cancer","Effektivit\u00e4t und Toxizit\u00e4t der Behandlung beim lokal fortgeschrittenen Kopf-Hals-Karzinoms"],"short-title":[],"issued":{"date-parts":[[2013,1,16]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["289"],"URL":"https:\/\/doi.org\/10.1007\/s00066-012-0289-7","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,16]]}}}