{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:07:02Z","timestamp":1782122822857,"version":"3.54.5"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:00:00Z","timestamp":1367452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s00066-013-0314-5","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T19:41:24Z","timestamp":1367350884000},"page":"486-494","source":"Crossref","is-referenced-by-count":27,"title":["Chronic adverse events and quality of life after radiochemotherapy in anal cancer patients","Chronische Nebenwirkungen und Lebensqualit\u00e4t nach Radiochemotherapie bei Analkarzinompatienten"],"prefix":"10.1007","volume":"189","author":[{"given":"K.","family":"Fakhrian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Klemm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Molls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Geinitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,2]]},"reference":[{"key":"314_CR1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1634\/theoncologist.12-5-524","volume":"12","author":"Uronis","year":"2007","unstructured":"Uronis HE, Bendell JC (2007) Anal cancer: an overview. Oncologist 12:524\u2013534","journal-title":"Oncologist"},{"key":"314_CR2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s00066-011-0057-0","volume":"188","author":"Fakhrian","year":"2012","unstructured":"Fakhrian K, Sauer T, Klemm S et al (2012) Radiotherapy with or without chemotherapy in the treatment of anal cancer: 20-year experience from a single institute. Strahlenther Onkol 188(6):464\u2013470","journal-title":"Strahlenther Onkol"},{"key":"314_CR3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0167-8140(99)00096-1","volume":"52","author":"Vordermark","year":"1999","unstructured":"Vordermark D, Sailer M, Flentje M et al (1999) Curative-intent radiation therapy in anal carcinoma: quality of life and sphincter function. Radiother Oncol 52:239\u2013243","journal-title":"Radiother Oncol"},{"key":"314_CR4","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1038\/sj.bjc.6690567","volume":"80","author":"Allal","year":"1999","unstructured":"Allal AS, Sprangers MA, Laurencet F et al (1999) Assessment of long-term quality of life in patients with anal carcinomas treated by radiotherapy with or without chemotherapy. Br J Cancer 80(10):1588","journal-title":"Br J Cancer"},{"key":"314_CR5","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/cncr.24906","volume":"116","author":"Das","year":"2010","unstructured":"Das P, Cantor SB, Parker CL et al (2010) Long-term quality of life after radiotherapy for the treatment of anal cancer. Cancer 116(4):822","journal-title":"Cancer"},{"key":"314_CR6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00066-010-2175-5","volume":"187","author":"Welzel","year":"2011","unstructured":"Welzel G, H\u00e4gele V, Wenz F, Mai SK (2011) Quality of life outcomes in patients with anal cancer after combined radiochemotherapy. Strahlenther Onkol 187:175\u2013182","journal-title":"Strahlenther Onkol"},{"key":"314_CR7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1023\/A:1008821826499","volume":"8","author":"Ward","year":"1999","unstructured":"Ward WL, Hahn EA, Mo F et al (1999) Reliability and validity of the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) quality of life instrument. Qual Life Res 8(3):181\u2013195","journal-title":"Qual Life Res"},{"key":"314_CR8","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.jclinepi.2005.07.008","volume":"58","author":"Yost","year":"2005","unstructured":"Yost KJ, Cella D, Chawla A et al (2005) Minimally important differences were estimated for the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) instrument using a combination of distribution- and anchor-based approaches. J Clin Epidemiol 58(12):1241\u20131251","journal-title":"J Clin Epidemiol"},{"key":"314_CR9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpainsymman.2004.12.009","volume":"30","author":"Yoo","year":"2005","unstructured":"Yoo HJ, Kim JC, Eremenco S (2005) Quality of life in colorectal cancer patients with colectomy and the validation of the Functional Assessment of Cancer Therapy-Colorectal (FACT-C), Version 4. J Pain Symptom Manage 30(1):24\u201332","journal-title":"J Pain Symptom Manage"},{"key":"314_CR10","first-page":"530","volume":"Oncol","author":"Jephcott","year":"2004","unstructured":"Jephcott CR, Paltiel C, Hay J (2004) Quality of life after non-surgical treatment of anal carcinoma: a case control study of long-term survivors. Clin Oncol (R Coll Radiol) 16(8):530","journal-title":"Clin"},{"key":"314_CR11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1748-717X-5-41","volume":"5","author":"Provencher","year":"2010","unstructured":"Provencher S, Oehler C, Lavertu S et al (2010) Quality of life and tumor control after short split-course chemoradiation for anal canal carcinoma. Radiat Oncol 5:41","journal-title":"Radiat Oncol"},{"key":"314_CR12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.radonc.2012.04.018","volume":"103","author":"Barraclough","year":"2012","unstructured":"Barraclough LH, Routledge JA, Farnell DJ et al (2012) Prospective analysis of patient-reported late toxicity following pelvic radiotherapy for gynaecological cancer. Radiother Oncol 103(3):327\u2013332","journal-title":"Radiother Oncol"},{"key":"314_CR13","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00404-011-2193-2","volume":"285","author":"G\u00fcth","year":"2012","unstructured":"G\u00fcth U, Hadwin RJ, Sch\u00f6tzau A, McCormack M (2012) Clinical outcomes and patterns of severe late toxicity in the era of chemo-radiation for cervical cancer. Arch Gynecol Obstet 285(6):1703\u20131711","journal-title":"Arch Gynecol Obstet"},{"key":"314_CR14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S1548-5315(11)70917-2","volume":"3","author":"Wolf","year":"2006","unstructured":"Wolf JK (2006) Prevention and treatment of vaginal stenosis resulting from pelvic radiation therapy. Commun Oncol 3:665\u2013671","journal-title":"Commun Oncol"},{"key":"314_CR15","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0360-3016(93)90455-5","volume":"27","author":"Bruner","year":"1993","unstructured":"Bruner DW, Lanciano R, Keegan M (1993) Vaginal stenosis and sexual function following intracavitary radiation for the treatment of cervical and endometrial carcinoma. Int J Radiat Oncol Biol Phys 27(4):825\u2013830","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"314_CR16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1055\/s-2008-1036704","volume":"44","author":"Kucera","year":"1984","unstructured":"Kucera H, Skodler W, Weghaupt K (1984) Complications of postoperative radiotherapy in uterine cancer (German). Geburtshilfe Frauenheilkd 44(8):498\u2013502","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"314_CR17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/bjc.2011.339","volume":"105","author":"White","year":"2011","unstructured":"White ID, Allan H, Faithfull S (2011) Assessment of treatment-induced female sexual morbidity in oncology: is this a part of routine medical follow-up after radical pelvic radiotherapy? Br J Cancer 105(7):903\u2013910","journal-title":"Br J Cancer"},{"key":"314_CR18","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ijrobp.2005.05.052","volume":"63","author":"Chen","year":"2005","unstructured":"Chen YJ, Liu A, Tsai PT et al (2005) Organ sparing by conformal avoidance intensity-modulated radiation therapy for anal cancer: dosimetric evaluation of coverage of pelvis and inguinal\/femoral nodes. Int J Radiat Oncol Biol Phys 63:274\u2013281","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"314_CR19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1748-717X-2-41","volume":"2","author":"Menkarios","year":"2007","unstructured":"Menkarios C, Azria D, Laliberte B et al (2007) Optimal organsparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans. Radiat Oncol 2:41","journal-title":"Radiat Oncol"},{"key":"314_CR20","doi-asserted-by":"crossref","first-page":"S280","DOI":"10.1016\/j.ijrobp.2006.07.530","volume":"66","author":"Kachnic","year":"2006","unstructured":"Kachnic L, Tsai HK, Willins J et al (2006) Dose-painted intensity modulated radiation therapy for anal cancer: dosimetric comparison and acute toxicity [abstract]. Int J Radiat Oncol Biol Phys 66:S280 (Abstract 2126)","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"314_CR21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ijrobp.2005.02.030","volume":"63","author":"Milano","year":"2005","unstructured":"Milano MT, Jani AB, Farrey KJ et al (2005) Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 63:354\u2013361","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"314_CR22","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s00066-009-1944-5","volume":"185","author":"Mai","year":"2009","unstructured":"Mai SK, Welzel G, Hermann B et al (2009) Can the radiation dose to CT-enlarged but FDG-PET-negative inguinal lymph nodes in anal cancer be reduced? Strahlenther Onkol 185(4):254\u2013259","journal-title":"Strahlenther Onkol"},{"key":"314_CR23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00066-011-4001-0","volume":"187","author":"Brocker","year":"2011","unstructured":"Brocker KA, Alt CD, Eichbaum M et al (2011) Imaging of female pelvic malignancies regarding MRI, CT, and PET\/CT: part 1. Strahlenther Onkol 187(10):611\u2013618","journal-title":"Strahlenther Onkol"},{"key":"314_CR24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00066-011-4002-z","volume":"187","author":"Alt","year":"2011","unstructured":"Alt CD, Brocker KA, Eichbaum M, Sohn C et al (2011) Imaging of female pelvic malignancies regarding MRI, CT, and PET\/CT: part 2. Strahlenther Onkol 187(11):705\u2013714","journal-title":"Strahlenther Onkol"},{"key":"314_CR25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00066-010-2162-x","volume":"186","author":"Fraunholz","year":"2010","unstructured":"Fraunholz I, Rabeneck D, Wei\u00df CH, R\u00f6del C (2010) Combined-modality treatment for anal cancer. current strategies and future directions. Strahlenther Onkol 186:361\u2013366","journal-title":"Strahlenther Onkol"},{"key":"314_CR26","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1471-0528.2010.02502.x","volume":"117","author":"Johnson","year":"2010","unstructured":"Johnson N, Miles TP, Cornes P (2010) Dilating the vagina to prevent damage from radiotherapy: systematic review of the literature. BJOG 117(5):522\u2013531","journal-title":"BJOG"},{"key":"314_CR27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ijrobp.2005.12.009","volume":"65","author":"Jeffries","year":"2006","unstructured":"Jeffries SA, Robinson JW, Craighead PS, Keats MR (2006) An effective group psychoeducational intervention for improving compliance with vaginal dilation: a randomized controlled trial. Int J Radiat Oncol Biol Phys 65(2):404\u2013411","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"314_CR28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3747\/co.v18i5.767","volume":"18","author":"Craighead","year":"2011","unstructured":"Craighead P, Shea-Budgell A, Nation J et al (2011) Hyperbaric oxygen therapy for late radiation tissue injury in gynecologic malignancies. Curr Oncol 18(5):220\u2013227","journal-title":"Curr Oncol"},{"key":"314_CR29","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ijrobp.2004.04.019","volume":"60","author":"Bui","year":"2004","unstructured":"Bui QC, Lieber M, Withers HR et al (2004) The efficacy of hyperbaric oxygen therapy in the treatment of radiation-induced late side effects. Int J Radiat Oncol Biol Phys 60(3):871\u2013878","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"314_CR30","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0959-8049(00)00447-0","volume":"37","author":"Schwarz","year":"2001","unstructured":"Schwarz R, Hinz A (2001) Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population. Eur J Cancer 37:1345\u20131351","journal-title":"Eur J Cancer"},{"key":"314_CR31","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/bjs.1800820229","volume":"82","author":"Eypasch","year":"1995","unstructured":"Eypasch E, Williams JI, Wood-Dauphinee S et al (1995) Gastrointestinal quality of life index: development, validation and application of a new instrument. Br J Surg 82:216\u2013222","journal-title":"Br J Surg"},{"key":"314_CR32","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1046\/j.1365-2168.1998.00958.x","volume":"85","author":"Sailer","year":"1998","unstructured":"Sailer M, Bussen D, Debus ES et al (1998) Quality of life in patients with benign anorectal disorders. Br J Surg 85:1716\u20131719","journal-title":"Br J Surg"},{"key":"314_CR33","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.brachy.2007.02.152","volume":"6","author":"Oehler-J\u00e4nne","year":"2007","unstructured":"Oehler-J\u00e4nne C, Seifert B, L\u00fctolf UM et al (2007) Clinical outcome after treatment with a brachytherapy boost versus external beam boost for anal carcinoma. Brachytherapy 6:218\u2013226","journal-title":"Brachytherapy"},{"key":"314_CR34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.radonc.2007.12.004","volume":"87","author":"Tournier-Rangeard","year":"2008","unstructured":"Tournier-Rangeard L, Mercier M, Peiffert D et al (2008) Radiochemotherapy of locally advanced anal canal carcinoma: prospective assessment of early impact on the quality of life (randomized trial ACCORD 03). Radiother Oncol 87:391\u2013397","journal-title":"Radiother Oncol"},{"key":"314_CR35","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/0163278705275341","volume":"28","author":"Brucker","year":"2005","unstructured":"Brucker PS, Yost K, Cashy J et al (2005) General population and cancer patient norms for the functional assessment of cancer therapy-general (FACT-G). Eval Health Prof 28(2):192\u2013211","journal-title":"Eval Health Prof"},{"key":"314_CR36","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/pon.1428","volume":"18","author":"Janda","year":"2009","unstructured":"Janda M, DiSipio T, Hurst C et al (2009) The Queensland Cancer Risk Study: general population norms for the Functional Assessment of Cancer Therapy-General (FACT-G). Psychooncology 18(6):606\u2013614","journal-title":"Psychooncology"},{"key":"314_CR37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/02841860310023453","volume":"43","author":"Holzner","year":"2004","unstructured":"Holzner B, Kemmler G, Cella D et al (2004) Normative data for functional assessment of cancer therapy\u2014general scale and its use for the interpretation of quality of life scores in cancer survivors. Acta Oncol 43(2):153\u2013160","journal-title":"Acta Oncol"},{"key":"314_CR38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3802\/jgo.2011.22.2.103","volume":"22","author":"Wilailak","year":"2011","unstructured":"Wilailak S, Lertkhachonsuk AA, Lohacharoenvanich N et al (2011) Quality of life in gynecologic cancer survivors compared to healthy check-up women. J Gynecol Oncol 22(2):103\u2013109","journal-title":"J Gynecol Oncol"},{"key":"314_CR39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijrobp.2006.03.055","volume":"66","author":"Heemsbergen","year":"2006","unstructured":"Heemsbergen WD, Peeters ST, Koper PC et al (2006) Acute and late gastrointestinal toxicity after radiotherapy in prostate cancer patients: consequential late damage. Int J Radiat Oncol Biol Phys 66:3\u201310","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"314_CR40","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0360-3016(01)02591-3","volume":"52","author":"Jereczek-Fossa","year":"2002","unstructured":"Jereczek-Fossa BA, Jassem J, Badzio A (2002) Relationship between acute and late normal tissue injury after postoperative radiotherapy in endometrial cancer. Int J Radiat Oncol Biol Phys 52:476\u2013482","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"314_CR41","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.radonc.2004.09.016","volume":"74","author":"Liu","year":"2005","unstructured":"Liu M, Pickles T, Berthelet E et al (2005) Urinary incontinence in prostate cancer patients treated with external beam radiotherapy. Radiother Oncol 74:197\u2013201","journal-title":"Radiother Oncol"},{"key":"314_CR42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0167-8140(91)90092-U","volume":"20","author":"Bentzen","year":"1991","unstructured":"Bentzen SM, Overgaard M (1991) Relationship between early and late normal-tissue injury after postmastectomy radiotherapy. Radiother Oncol 20:159\u2013165","journal-title":"Radiother Oncol"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-013-0314-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-013-0314-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-013-0314-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T22:31:10Z","timestamp":1558564270000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-013-0314-5"}},"subtitle":["A single institution experience and review of the literature","Die Erfahrungen einer Klinik und ein Literatur\u00fcberblick"],"short-title":[],"issued":{"date-parts":[[2013,5,2]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["314"],"URL":"https:\/\/doi.org\/10.1007\/s00066-013-0314-5","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,2]]}}}