{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:55:13Z","timestamp":1791244513835,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00066-017-1116-y","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T09:29:51Z","timestamp":1488187791000},"page":"483-490","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Radiotherapy of painful heel spur with two fractionation regimens","Strahlentherapie des Fersensporns mit 2\u00a0Fraktionierungsschemata"],"prefix":"10.1007","volume":"193","author":[{"given":"Benjamin","family":"Prokein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Holtmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias G.","family":"Hautmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"R\u00f6sler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Graeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Dzierma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ruebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Fleckenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6266-0993","authenticated-orcid":false,"given":"Marcus","family":"Niewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"1116_CR1","volume-title":"Exostosen des Fersenbeins. Jahresbericht der Gesellschaft f\u00fcr Natur und Heilkunde in Dresden","author":"P Plettner","year":"1900","unstructured":"Plettner P (1900) Exostosen des Fersenbeins. Jahresbericht der Gesellschaft f\u00fcr Natur und Heilkunde in Dresden"},{"key":"1116_CR2","unstructured":"Schreiber A, Zollinger H (1985) Entz\u00fcndungen\/Fersenbeinsporne. In: Witt A, Becker F, Baumarter-Ritter RF, Enderle A (eds) Orthop\u00e4die in Praxis und Klinik\/Bd 7 Spezielle Orthop\u00e4die \u2013 H\u00fcftgelenk und untere Extremit\u00e4t Teil 2 Fu\u00df. Thieme, Stuttgart, New York, p\u00a0441\u2013445"},{"issue":"1","key":"1116_CR3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1148\/radiology.200.1.8657925","volume":"200","author":"MH Seegenschmiedt","year":"1996","unstructured":"Seegenschmiedt MH, Keilholz L, Katalinic A, Stecken A, Sauer R (1996) Heel spur: radiation therapy for refractory pain \u2013 results with three treatment concepts. Radiology 200(1):271\u2013276","journal-title":"Radiology"},{"issue":"1","key":"1116_CR4","first-page":"26","volume":"52","author":"R Heyd","year":"1999","unstructured":"Heyd R, Uhder K, Strassmann G, Schneider L, Zamboglou N (1999) Results of analgetic radiotherapy of inflammation of the calcaneus using 6 MV photons. Rontgenpraxis 52(1):26\u201332","journal-title":"Rontgenpraxis"},{"issue":"1","key":"1116_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13014-015-0327-6","volume":"10","author":"H Holtmann","year":"2015","unstructured":"Holtmann H, Niewald M, Prokein B, Graeber S, Ruebe C (2015) Randomized multicenter follow-up trial on the effect of radiotherapy for plantar fasciitis (painful heels spur) depending on dose and fractionation \u2013 a\u00a0study protocol. Radiat Oncol 10(1):23. doi:\n                        10.1186\/s13014-015-0327-6","journal-title":"Radiat Oncol"},{"issue":"1","key":"1116_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1757-1146-1-7","volume":"1","author":"HB Menz","year":"2008","unstructured":"Menz HB, Zammit GV, Landorf KB, Munteanu SE (2008) Plantar calcaneal spurs in older people: longitudinal traction or vertical compression? J\u00a0Foot Ankle Res 1(1):7. doi:\n                        10.1186\/1757-1146-1-7","journal-title":"J Foot Ankle Res"},{"issue":"4","key":"1116_CR7","doi-asserted-by":"publisher","first-page":"e455","DOI":"10.1016\/j.ijrobp.2012.06.022","volume":"84","author":"M Niewald","year":"2012","unstructured":"Niewald M, Seegenschmiedt MH, Micke O, Graeber S, Muecke R, Schaefer V, Scheid C, Fleckenstein J, Licht N, Ruebe C, German Cooperative Group on Radiotherapy for Benign Diseases of the German Society for Radiation Oncology (2012) Randomized, multicenter trial on the effect of radiation therapy on plantar fasciitis (painful heel spur) comparing a\u00a0standard dose with a\u00a0very low dose: mature results after 12\u00a0months\u2019 follow-up. Int J Radiat Oncol Biol Phys 84(4):e455\u2013462. doi:\n                        10.1016\/j.ijrobp.2012.06.022","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"4","key":"1116_CR8","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/09553000110106027","volume":"78","author":"G Hildebrandt","year":"2002","unstructured":"Hildebrandt G, Maggiorella L, Rodel F, Rodel V, Willis D, Trott KR (2002) Mononuclear cell adhesion and cell adhesion molecule liberation after X\u2011irradiation of activated endothelial cells in vitro. Int J Radiat Biol 78(4):315\u2013325. doi:\n                        10.1080\/09553000110106027","journal-title":"Int. J. Radiat. Biol."},{"issue":"2","key":"1116_CR9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1080\/09553000310001654701","volume":"80","author":"F Rodel","year":"2004","unstructured":"Rodel F, Hantschel M, Hildebrandt G, Schultze-Mosgau S, Rodel C, Herrmann M, Sauer R, Voll RE (2004) Dose-dependent biphasic induction and transcriptional activity of nuclear factor kappa B (NF-kappaB) in EA.hy.926 endothelial cells after low-dose X\u2011irradiation. Int J Radiat Biol 80(2):115\u2013123. doi:\n                        10.1080\/09553000310001654701","journal-title":"Int. J. Radiat. Biol."},{"issue":"1","key":"1116_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00066-002-0901-3","volume":"178","author":"F Rodel","year":"2002","unstructured":"Rodel F, Kamprad F, Sauer R, Hildebrandt G (2002) Functional and molecular aspects of anti-inflammatory effects of low-dose radiotherapy. Strahlenther Onkol 178(1):1\u20139","journal-title":"Strahlenther Onkol"},{"issue":"8","key":"1116_CR11","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1080\/09553000210137671","volume":"78","author":"F Roedel","year":"2002","unstructured":"Roedel F, Kley N, Beuscher HU, Hildebrandt G, Keilholz L, Kern P, Voll R, Herrmann M, Sauer R (2002) Anti-inflammatory effect of low-dose X\u2011irradiation and the involvement of a\u00a0TGF-beta1-induced down-regulation of leukocyte\/endothelial cell adhesion. Int J Radiat Biol 78(8):711\u2013719. doi:\n                        10.1080\/09553000210137671","journal-title":"Int. J. Radiat. Biol."},{"issue":"4","key":"1116_CR12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/08916930902831233","volume":"42","author":"US Gaipl","year":"2009","unstructured":"Gaipl US, Meister S, Lodermann B, Rodel F, Fietkau R, Herrmann M, Kern PM, Frey B (2009) Activation-induced cell death and total Akt content of granulocytes show a\u00a0biphasic course after low-dose radiation. Autoimmunity 42(4):340\u2013342","journal-title":"Autoimmunity"},{"issue":"3","key":"1116_CR13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/095530098141500","volume":"74","author":"G Hildebrandt","year":"1998","unstructured":"Hildebrandt G, Seed MP, Freemantle CN, Alam CA, Colville-Nash PR, Trott KR (1998) Mechanisms of the anti-inflammatory activity of low-dose radiation therapy. Int J Radiat Biol 74(3):367\u2013378","journal-title":"Int. J. Radiat. Biol."},{"issue":"1","key":"1116_CR14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00066-008-1776-8","volume":"184","author":"F Rodel","year":"2008","unstructured":"Rodel F, Hofmann D, Auer J, Keilholz L, Rollinghoff M, Sauer R, Beuscher HU (2008) The anti-inflammatory effect of low-dose radiation therapy involves a\u00a0diminished CCL20 chemokine expression and granulocyte\/endothelial cell adhesion. Strahlenther Onkol 184(1):41\u201347. doi:\n                        10.1007\/s00066-008-1776-8","journal-title":"Strahlenther Onkol"},{"issue":"4","key":"1116_CR15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/08916930902831597","volume":"42","author":"F Rodel","year":"2009","unstructured":"Rodel F, Keilholz L, Herrmann M, Weiss C, Frey B, Voll R, Gaipl U, Rodel C (2009) Activator protein 1 shows a\u00a0biphasic induction and transcriptional activity after low dose X\u2011irradiation in EA.hy.926 endothelial cells. Autoimmunity 42(4):343\u2013345","journal-title":"Autoimmunity"},{"issue":"2","key":"1116_CR16","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.radonc.2010.01.013","volume":"97","author":"F Rodel","year":"2010","unstructured":"Rodel F, Frey B, Capalbo G, Gaipl U, Keilholz L, Voll R, Hildebrandt G, Rodel C (2010) Discontinuous induction of X\u2011linked inhibitor of apoptosis in EA.hy.926 endothelial cells is linked to NF-kappaB activation and mediates the anti-inflammatory properties of low-dose ionising-radiation. Radiother Oncol 97(2):346\u2013351. doi:\n                        10.1016\/j.radonc.2010.01.013","journal-title":"Radiother Oncol"},{"issue":"12","key":"1116_CR17","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.2174\/092986712800099866","volume":"19","author":"F Rodel","year":"2012","unstructured":"Rodel F, Frey B, Gaipl U, Keilholz L, Fournier C, Manda K, Schollnberger H, Hildebrandt G, Rodel C (2012) Modulation of inflammatory immune reactions by low-dose ionizing radiation: molecular mechanisms and clinical application. Curr Med Chem 19(12):1741\u20131750","journal-title":"Curr. Med. Chem."},{"issue":"9","key":"1116_CR18","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1007\/s00066-015-0848-9","volume":"191","author":"M Large","year":"2015","unstructured":"Large M, Hehlgans S, Reichert S, Gaipl US, Fournier C, Rodel C, Weiss C, Rodel F (2015) Study of the anti-inflammatory effects of low-dose radiation: the contribution of biphasic regulation of the antioxidative system in endothelial cells. Strahlenther Onkol 191(9):742\u2013749. doi:\n                        10.1007\/s00066-015-0848-9","journal-title":"Strahlenther Onkol"},{"issue":"9","key":"1116_CR19","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1080\/09553000500385556","volume":"81","author":"D Schaue","year":"2005","unstructured":"Schaue D, Jahns J, Hildebrandt G, Trott KR (2005) Radiation treatment of acute inflammation in mice. Int J Radiat Biol 81(9):657\u2013667. doi:\n                        10.1080\/09553000500385556","journal-title":"Int. J. Radiat. Biol."},{"key":"1116_CR20","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1001\/jama.1963.03700250056007","volume":"184","author":"C Rowe","year":"1963","unstructured":"Rowe C, Sakellarides HT, Freeman PA, Sorbie C (1963) Fractures of the os calcis. JAMA 184:920\u2013923","journal-title":"JAMA"},{"issue":"4","key":"1116_CR21","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1055\/s-2003-41645","volume":"42","author":"M Bullinger","year":"2003","unstructured":"Bullinger M, Morfeld M, Kohlmann T, Nantke J, van den Bussche H, Dodt B, Dunkelberg S, Kirchberger I, Kruger-Bodecker A, Lachmann A, Lang K, Mathis C, Mittag O, Peters A, Raspe HH, Schulz H (2003) SF-36 Health Survey in Rehabilitation Research. Findings from the North German Network for Rehabilitation Research, NVRF, within the rehabilitation research funding program. Rehabilitation (Stuttg) 42(4):218\u2013225. doi:\n                        10.1055\/s-2003-41645","journal-title":"Rehabilitation (Stuttg)"},{"key":"1116_CR22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1748-717x-3-27","volume":"3","author":"M Niewald","year":"2008","unstructured":"Niewald M, Seegenschmiedt MH, Micke O, Graber S, German Cooperative Group on the Radiotherapy for Benign Diseases of the DGSfRO (2008) Randomized multicenter trial on the effect of radiotherapy for plantar Fasciitis (painful heel spur) using very low doses \u2013 a study protocol. Radiat Oncol 3:27. doi:\n                        10.1186\/1748-717x-3-27","journal-title":"Radiat Oncol"},{"key":"1116_CR23","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13014-015-0471-z","volume":"10","author":"M Niewald","year":"2015","unstructured":"Niewald M, Holtmann H, Prokein B, Hautmann MG, Rosler HP, Graeber S, Dzierma Y, Ruebe C, Fleckenstein J (2015) Randomized multicenter follow-up trial on the effect of radiotherapy on painful heel spur (plantar fasciitis) comparing two fractionation schedules with uniform total dose: first results after three months\u2019 follow-up. Radiat Oncol 10:174. doi:\n                        10.1186\/s13014-015-0471-z","journal-title":"Radiat Oncol"},{"issue":"1","key":"1116_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00066-014-0757-3","volume":"191","author":"OJ Ott","year":"2015","unstructured":"Ott OJ, Niewald M, Weitmann HD, Jacob I, Adamietz IA, Schaefer U, Keilholz L, Heyd R, Muecke R, German Cooperative Group on Radiotherapy for Benign Diseases (2015) DEGRO guidelines for the radiotherapy of non-malignant disorders. Part II: Painful degenerative skeletal disorders. Strahlenther Onkol 191(1):1\u20136. doi:\n                        10.1007\/s00066-014-0757-3","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"1116_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00066-007-1589-1","volume":"183","author":"R Heyd","year":"2007","unstructured":"Heyd R, Tselis N, Ackermann H, Roddiger SJ, Zamboglou N (2007) Radiation therapy for painful heel spurs: results of a\u00a0prospective randomized study. Strahlenther Onkol 183(1):3\u20139. doi:\n                        10.1007\/s00066-007-1589-1","journal-title":"Strahlenther Onkol"},{"issue":"4","key":"1116_CR26","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00066-012-0256-3","volume":"189","author":"OJ Ott","year":"2013","unstructured":"Ott OJ, Jeremias C, Gaipl US, Frey B, Schmidt M, Fietkau R (2013) Radiotherapy for calcaneodynia. Results of a\u00a0single center prospective randomized dose optimization trial. Strahlenther Onkol 189(4):329\u2013334. doi:\n                        10.1007\/s00066-012-0256-3","journal-title":"Strahlenther Onkol"},{"issue":"7","key":"1116_CR27","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00066-014-0618-0","volume":"190","author":"OJ Ott","year":"2014","unstructured":"Ott OJ, Jeremias C, Gaipl US, Frey B, Schmidt M, Fietkau R (2014) Radiotherapy for benign calcaneodynia: long-term results of the Erlangen Dose Optimization (EDO) trial. Strahlenther Onkol 190(7):671\u2013675. doi:\n                        10.1007\/s00066-014-0618-0","journal-title":"Strahlenther Onkol"},{"issue":"4","key":"1116_CR28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/02841867009129108","volume":"9","author":"I Goldie","year":"1970","unstructured":"Goldie I, Rosengren B, Moberg E, Hedelin E (1970) Evaluation of radiation treatment of painful conditions of the locomotor system. A double blind study. Acta Radiol Ther Phys Biol 9(4):311\u2013322","journal-title":"Acta Radiol Ther Phys Biol"},{"issue":"3","key":"1116_CR29","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s00066-013-0462-7","volume":"190","author":"MG Hautmann","year":"2014","unstructured":"Hautmann MG, Neumaier U, Kolbl O (2014) Re-irradiation for painful heel spur syndrome. Retrospective analysis of 101 heels. Strahlenther Onkol 190(3):298\u2013303. doi:\n                        10.1007\/s00066-013-0462-7","journal-title":"Strahlenther Onkol"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-017-1116-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-017-1116-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-017-1116-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T10:07:57Z","timestamp":1495188477000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-017-1116-y"}},"subtitle":["Results of a\u00a0randomized multicenter trial after 48\u00a0weeks\u2019 follow-up","Ergebnisse einer randomisierten Multizenterstudie nach 48\u00a0Wochen Follow-up"],"short-title":[],"issued":{"date-parts":[[2017,2,27]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["1116"],"URL":"https:\/\/doi.org\/10.1007\/s00066-017-1116-y","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,27]]}}}