{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:46:35Z","timestamp":1772117195660,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s00066-017-1135-8","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T05:39:59Z","timestamp":1493098799000},"page":"589-592","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypopharyngeal and upper esophageal ulceration after cervical spine radiotherapy concurrent with crizotinib","Ulzeration des Hypopharynx und des oberen \u00d6sophagus nach Bestrahlung der Halswirbels\u00e4ule und simultaner Crizotinib-Therapie"],"prefix":"10.1007","volume":"193","author":[{"given":"Marcus H.","family":"Zimmermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pius","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Flentje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"1135_CR1","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.cell.2007.11.025","volume":"131","author":"K Rikova","year":"2007","unstructured":"Rikova K, Guo A, Zeng Q et\u00a0al (2007) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131:1190\u20131203","journal-title":"Cell"},{"key":"1135_CR2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature05945","volume":"448","author":"M Soda","year":"2007","unstructured":"Soda M, Choi YL, Enomoto M et al (2007) Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448:561\u2013566","journal-title":"Nature"},{"key":"1135_CR3","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1056\/NEJMoa1408440","volume":"371","author":"BJ Solomon","year":"2014","unstructured":"Solomon BJ, Mok T, Kim DW et al (2014) First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N\u00a0Engl J Med 371:2167\u20132177","journal-title":"N Engl J Med"},{"key":"1135_CR4","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1214886","volume":"368","author":"AT Shaw","year":"2013","unstructured":"Shaw AT, Kim DW, Nakagawa K et al (2013) Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N\u00a0Engl J Med 368:2385\u20132394","journal-title":"N Engl J Med"},{"key":"1135_CR5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s004050100368","volume":"258","author":"RJ Bensadoun","year":"2001","unstructured":"Bensadoun RJ, Magne N, Marcy PY et al (2001) Chemotherapy- and radiotherapy-induced mucositis in head and neck cancer patients: new trends in pathophysiology, prevention and treatment. Eur Arch Otorhinolaryngol 258:481\u2013487","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1135_CR6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cncr.21622","volume":"106","author":"M Vera-Llonch","year":"2006","unstructured":"Vera-Llonch M, Oster G, Hagiwara M et al (2006) Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer 106:329\u2013336","journal-title":"Cancer"},{"key":"1135_CR7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1200\/JCO.2009.24.7353","volume":"28","author":"DR Spigel","year":"2010","unstructured":"Spigel DR, Hainsworth JD, Yardley DA et\u00a0al (2010) Tracheoesophageal fistula formation in patients with lung cancer treated with chemoradiation and bevacizumab. J\u00a0Clin Oncol 28:43\u201348","journal-title":"J Clin Oncol"},{"key":"1135_CR8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijrobp.2013.05.012","volume":"87","author":"BM Barney","year":"2013","unstructured":"Barney BM, Markovic SN, Laack NN et\u00a0al (2013) Increased bowel toxicity in patients treated with a\u00a0vascular endothelial growth factor inhibitor (VEGFI) after stereotactic body radiation therapy (SBRT). Int J Radiat Oncol Biol Phys 87:73\u201380","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1135_CR9","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00066-014-0698-x","volume":"190","author":"R Merten","year":"2014","unstructured":"Merten R, Hecht M, Haderlein M et\u00a0al (2014) Increased skin and mucosal toxicity in the combination of vemurafenib with radiation therapy. Strahlenther Onkol 190:1169\u20131172","journal-title":"Strahlenther Onkol"},{"key":"1135_CR10","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S1470-2045(12)70344-3","volume":"13","author":"DR Camidge","year":"2012","unstructured":"Camidge DR, Bang YJ, Kwak EL et al (2012) Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a\u00a0phase 1 study. Lancet Oncol 13:1011\u20131019","journal-title":"Lancet Oncol"},{"key":"1135_CR11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.lungcan.2014.12.010","volume":"87","author":"F Cappuzzo","year":"2015","unstructured":"Cappuzzo F, Moro-Sibilot D, Gautschi O et al (2015) Management of crizotinib therapy for ALK-rearranged non-small cell lung carcinoma: an expert consensus. Lung Cancer 87:89\u201395","journal-title":"Lung Cancer"},{"key":"1135_CR12","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1158\/1535-7163.MCT-12-0868","volume":"12","author":"Y Sun","year":"2013","unstructured":"Sun Y, Nowak KA, Zaorsky NG et al (2013) ALK inhibitor PF02341066 (crizotinib) increases sensitivity to radiation in non-small cell lung cancer expressing EML4-ALK. Mol Cancer Ther 12:696\u2013704","journal-title":"Mol Cancer Ther"},{"key":"1135_CR13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.radonc.2014.12.009","volume":"114","author":"Y Dai","year":"2015","unstructured":"Dai Y, Wei Q, Schwager C et al (2015) Synergistic effects of crizotinib and radiotherapy in experimental EML4-ALK fusion positive lung cancer. Radiother Oncol 114:173\u2013181","journal-title":"Radiother Oncol"},{"key":"1135_CR14","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.ijrobp.2013.11.010","volume":"88","author":"GN Gan","year":"2014","unstructured":"Gan GN, Weickhardt AJ, Scheier B et al (2014) Stereotactic radiation therapy can safely and durably control sites of extra-central nervous system oligoprogressive disease in anaplastic lymphoma kinase-positive lung cancer patients receiving crizotinib. Int J Radiat Oncol Biol Phys 88:892\u2013898","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-017-1135-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-017-1135-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-017-1135-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T10:01:30Z","timestamp":1498125690000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-017-1135-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,25]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["1135"],"URL":"https:\/\/doi.org\/10.1007\/s00066-017-1135-8","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,25]]}}}