{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:35:00Z","timestamp":1788957300020,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00066-017-1221-y","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T09:42:21Z","timestamp":1507887741000},"page":"79-90","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Predictive and prognostic value of tumor volume and its changes during radical radiotherapy of\n\t\t\tstage\u00a0III non-small cell lung cancer","Pr\u00e4diktiver und prognostischer Wert des Tumorvolumens und seiner Ver\u00e4nderungen w\u00e4hrend radikaler Strahlentherapie beim nicht-kleinzelligen Bronchialkarzinom im Stadium\u00a0III"],"prefix":"10.1007","volume":"194","author":[{"name":"Young DEGRO Trial Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"K\u00e4smann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Niyazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Blanck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Baues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Dobiasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chukwuka","family":"Eze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fleischmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Gauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Goy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Hausmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Henkenberens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Klook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Krug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00e4urer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric M.","family":"Panje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Rosenbrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Sautter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"S\u00fc\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander H.","family":"Thieme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Trommer-Nestler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Medenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ostheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,13]]},"reference":[{"key":"1221_CR1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/JTO.0b013e31812f3c1a","volume":"2","author":"P Goldstraw","year":"2007","unstructured":"Goldstraw P, Crowley J, Chansky K et\u00a0al (2007) The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J\u00a0Thorac Oncol 2:706\u2013714","journal-title":"J Thorac Oncol"},{"key":"1221_CR2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel RL, Miller KD, Jemal A (2016) Cancer statistics 2016. CA Cancer J Clin 66:7\u201330","journal-title":"CA Cancer J Clin"},{"key":"1221_CR3","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.ijrobp.2006.05.022","volume":"66","author":"G Bosmans","year":"2006","unstructured":"Bosmans G, van Baardwijk A, Dekker A et al (2006) Intra-patient variability of tumor volume and tumor motion during conventionally fractionated radiotherapy for locally advanced non-small-cell lung cancer: a\u00a0prospective clinical study. Int J Radiat Oncol Biol Phys 66:748\u2013753","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijrobp.2008.07.063","volume":"74","author":"J Fox","year":"2009","unstructured":"Fox J, Ford E, Redmond K et al (2009) Quantification of tumor volume changes during radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 74:341\u2013348","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lungcan.2016.10.002","volume":"102","author":"V Agrawal","year":"2016","unstructured":"Agrawal V, Coroller TP, Hou Y et al (2016) Radiologic-pathologic correlation of response to chemoradiation in resectable locally advanced NSCLC. Lung Cancer 102:1\u20138","journal-title":"Lung Cancer"},{"key":"1221_CR6","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ijrobp.2008.08.052","volume":"74","author":"C Dehing-Oberije","year":"2009","unstructured":"Dehing-Oberije C, Yu S, De Ruysscher D et al (2009) Development and external validation of prognostic model for 2\u2011year survival of non\u2013small-cell lung cancer patients treated with chemoradiotherapy. Int J Radiat Oncol Biol Phys 74:355\u2013362","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00066-016-0941-8","volume":"192","author":"M Flentje","year":"2016","unstructured":"Flentje M, Huber RM, Engel-Riedel W et al (2016) GILT\u2014A randomised phase III study of oral vinorelbine and cisplatin with concomitant radiotherapy followed by either consolidation therapy with oral vinorelbine and cisplatin or best supportive care alone in stage III non-small cell lung cancer. Strahlenther Onkol 192:216\u2013222","journal-title":"Strahlenther Onkol"},{"key":"1221_CR8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s00066-014-0754-6","volume":"191","author":"F Zehentmayr","year":"2015","unstructured":"Zehentmayr F, Wurstbauer K, Deutschmann H et al (2015) DART-bid: dose-differentiated accelerated radiation therapy, 1.8\u202fGy twice daily. Strahlenther Onkol 191:256\u2013263","journal-title":"Strahlenther Onkol"},{"key":"1221_CR9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00066-015-0900-9","volume":"192","author":"J Fleckenstein","year":"2016","unstructured":"Fleckenstein J, Kremp K, Kremp S et\u00a0al (2016) IMRT and 3D conformal radiotherapy with or without elective nodal irradiation in locally advanced NSCLC. Strahlenther Onkol 192:75\u201382","journal-title":"Strahlenther Onkol"},{"key":"1221_CR10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.radonc.2012.12.003","volume":"106","author":"DL Ball","year":"2013","unstructured":"Ball DL, Fisher RJ, Burmeister BH et al (2013) The complex relationship between lung tumor volume and survival in patients with non-small cell lung cancer treated by definitive radiotherapy: a\u00a0prospective, observational prognostic factor study of the Trans-Tasman Radiation Oncology Group (TROG 99.05). Radiother Oncol 106:305\u2013311","journal-title":"Radiother Oncol"},{"key":"1221_CR11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2005.07.967","volume":"64","author":"K Basaki","year":"2006","unstructured":"Basaki K, Abe Y, Aoki M et al (2006) Prognostic factors for survival in stage III non-small-cell lung cancer treated with definitive radiation therapy: impact of tumor volume. Int J Radiat Oncol Biol Phys 64:449\u2013454","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0360-3016(01)01772-2","volume":"52","author":"JD Bradley","year":"2002","unstructured":"Bradley JD, Ieumwananonthachai N, Purdy JA et al (2002) Gross tumor volume, critical prognostic factor in patients treated with three-dimensional conformal radiation therapy for non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys 52:49\u201357","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR13","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.ijrobp.2007.07.2323","volume":"70","author":"C Dehing-Oberije","year":"2008","unstructured":"Dehing-Oberije C, De Ruysscher D, van der Weide H et al (2008) Tumor volume combined with number of positive lymph node stations is a\u00a0more important prognostic factor than TNM stage for survival of non-small-cell lung cancer patients treated with (chemo) radiotherapy. Int J Radiat Oncol Biol Phys 70:1039\u20131044","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0167-8140(97)00215-6","volume":"47","author":"H-H Dubben","year":"1998","unstructured":"Dubben H\u2011H, Thames HD, Beck-Bornholdt H\u2011P (1998) Tumor volume: a\u00a0basic and specific response predictor in radiotherapy. Radiother Oncol 47:167\u2013174","journal-title":"Radiother Oncol"},{"key":"1221_CR15","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0360-3016(02)02814-6","volume":"53","author":"D Etiz","year":"2002","unstructured":"Etiz D, Marks LB, Zhou S\u2011M et al (2002) Influence of tumor volume on survival in patients irradiated for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 53:835\u2013846","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.7785\/tcrt.2012.500310","volume":"12","author":"X Ding","year":"2013","unstructured":"Ding X, Li H, Wang Z et al (2013) A clinical study of shrinking field radiation therapy based on 18F-FDG PET\/CT for stage III non-small cell lung cancer. Technol Cancer Res Treat 12:251\u2013257","journal-title":"Technol Cancer Res Treat"},{"key":"1221_CR17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.radonc.2009.03.015","volume":"91","author":"S Bral","year":"2009","unstructured":"Bral S, Duchateau M, De Ridder M et\u00a0al (2009) Volumetric response analysis during chemoradiation as predictive tool for optimizing treatment strategy in locally advanced unresectable NSCLC. Radiother Oncol 91:438\u2013442","journal-title":"Radiother Oncol"},{"key":"1221_CR18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0167-8140(97)00081-9","volume":"44","author":"MK Martel","year":"1997","unstructured":"Martel MK, Strawderman M, Hazuka MB et al (1997) Volume and dose parameters for survival of non-small cell lung cancer patients. Radiother Oncol 44:23\u201329","journal-title":"Radiother Oncol"},{"key":"1221_CR19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0360-3016(01)01615-7","volume":"51","author":"M Werner-Wasik","year":"2001","unstructured":"Werner-Wasik M, Xiao Y, Pequignot E et al (2001) Assessment of lung cancer response after nonoperative therapy: tumor diameter, bidimensional product, and volume. A serial CT scan-based study. Int J Radiat Oncol Biol Phys 51:56\u201361","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR20","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0360-3016(01)01823-5","volume":"52","author":"J Willner","year":"2002","unstructured":"Willner J, Baier K, Caragiani E et al (2002) Dose, volume, and tumor control prediction in primary radiotherapy of non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 52:382\u2013389","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.lungcan.2005.11.008","volume":"52","author":"TE Stinchcombe","year":"2006","unstructured":"Stinchcombe TE, Morris DE, Moore DT, al at (2006) Post-chemotherapy gross tumor volume is predictive of survival in patients with stage III non-small cell lung cancer treated with combined modality therapy. Lung Cancer 52:67\u201374","journal-title":"Lung Cancer"},{"key":"1221_CR22","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijrobp.2007.06.034","volume":"70","author":"M Werner-Wasik","year":"2008","unstructured":"Werner-Wasik M, Swann RS, Bradley J et al (2008) Increasing tumor volume is predictive of poor overall and progression-free survival: secondary analysis of the Radiation Therapy Oncology Group 93\u201311 phase I\u2013II radiation dose-escalation study in patients with inoperable non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 70:385\u2013390","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1748-717X-8-49","volume":"8","author":"K Wurstbauer","year":"2013","unstructured":"Wurstbauer K, Deutschmann H, Dagn K et al (2013) DART-bid (Dose-differentiated accelerated radiation therapy, 1.8\u202fGy twice daily) \u2014 a novel approach for non-resected NSCLC: final results of a\u00a0prospective study, correlating radiation dose to tumor volume. Radiat Oncol 8:49","journal-title":"Radiat Oncol"},{"key":"1221_CR24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s13014-014-0283-6","volume":"9","author":"TR Koo","year":"2014","unstructured":"Koo TR, Moon SH, Lim YJ et al (2014) The effect of tumor volume and its change on survival in stage III non-small cell lung cancer treated with definitive concurrent chemoradiotherapy. Radiat Oncol 9:283","journal-title":"Radiat Oncol"},{"key":"1221_CR25","first-page":"2517","volume":"34","author":"J-U Jeong","year":"2014","unstructured":"Jeong J\u2011U, Chung W\u2011K, Nam T\u2011K et al (2014) Early metabolic response on 18\u202fF-Fluorodeoxyglucose \u2014 positron-emission tomography\/computed tomography after concurrent chemoradiotherapy for advanced stage III non-small cell lung cancer is correlated with local tumor control and survival. Anticancer Res 34:2517\u20132523","journal-title":"Anticancer Res"},{"key":"1221_CR26","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.2147\/OTT.S124311","volume":"9","author":"M Kong","year":"2016","unstructured":"Kong M, Hong SE (2016) Comparison of survival rates between 3D conformal radiotherapy and intensity-modulated radiotherapy in patients with stage iii non-small cell lung cancer. Onco Targets Ther 9:7227\u20137234","journal-title":"Onco Targets Ther"},{"key":"1221_CR27","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s10147-016-0982-0","volume":"21","author":"H Kanzaki","year":"2016","unstructured":"Kanzaki H, Kataoka M, Nishikawa A et al (2016) Impact of early tumor reduction on outcome differs by histological subtype in stage III non-small-cell lung cancer treated with definitive radiotherapy. Int J Clin Oncol 21:853\u2013861","journal-title":"Int J Clin Oncol"},{"key":"1221_CR28","first-page":"144","volume":"46","author":"YH Kim","year":"2006","unstructured":"Kim YH, Ahn SJ, Kim YC, al at (2006) Predictive factors for survival and correlation to toxicity in advanced stage III non-small cell lung cancer patients with concurrent chemoradiation. Jpn J Clin Oncol 46:144\u2013151","journal-title":"Jpn J Clin Oncol"},{"key":"1221_CR29","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.ijrobp.2009.12.060","volume":"79","author":"BM Alexander","year":"2011","unstructured":"Alexander BM, Othus M, Caglar HB et al (2011) Tumor volume is a\u00a0prognostic factor in non-small-cell lung cancer treated with chemoradiotherapy. Int J Radiat Oncol Biol Phys 79:1381\u20131387","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0167-8140(02)00287-6","volume":"66","author":"SC Erridge","year":"2003","unstructured":"Erridge SC, Seppenwoolde Y, Muller SH et al (2003) Portal imaging to assess set-up errors, tumor motion and tumor shrinkage during conformal radiotherapy of non-small cell lung cancer. Radiother Oncol 66:75\u201385","journal-title":"Radiother Oncol"},{"key":"1221_CR31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijrobp.2006.03.064","volume":"66","author":"ML Siker","year":"2006","unstructured":"Siker ML, Tom\u00e9 WA, Mehta MP (2006) Tumor volume changes on serial imaging with megavoltage CT for non-small-cell lung cancer during intensity-modulated radiotherapy: how reliable, consistent, and meaningful is the effect? Int J Radiat Oncol Biol Phys 66:135\u2013141","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR32","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.ijrobp.2007.07.2369","volume":"69","author":"C Woodford","year":"2007","unstructured":"Woodford C, Yartsev S, Dar AR et\u00a0al (2007) Adaptive radiotherapy planning on decreasing gross tumor volumes as seen on megavoltage computed tomography images. Int J Radiat Oncol Biol Phys 69:1316\u20131322","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.radonc.2008.05.004","volume":"88","author":"C Gillham","year":"2008","unstructured":"Gillham C, Zips D, P\u00f6nisch F et al (2008) Additional PET\/CT in week 5\u20136 of radiotherapy for patients with stage III non-small cell lung cancer as a\u00a0means of dose escalation planning? Radiother Oncol 88:335\u2013341","journal-title":"Radiother Oncol"},{"key":"1221_CR34","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.3892\/ol.2016.5104","volume":"12","author":"C Ostheimer","year":"2016","unstructured":"Ostheimer C, Schweyer F, Reese T et al (2016) The relationship between tumor volume changes and serial plasma osteopontin detection during radical radiotherapy of non-small-cell lung cancer. Oncol Lett 12:3449\u20133456","journal-title":"Oncol Lett"},{"key":"1221_CR35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00066-015-0927-y","volume":"192","author":"K Elsayad","year":"2016","unstructured":"Elsayad K, Kriz J, Reinartz G et al (2016) Cone-beam CT-guided radiotherapy in the management of lung cancer. Strahlenther Onkol 192:83\u201391","journal-title":"Strahlenther Onkol"},{"key":"1221_CR36","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.2967\/jnumed.111.102566","volume":"53","author":"W Elmpt van","year":"2012","unstructured":"van Elmpt W, \u00d6llers M, Dingemans A\u2011MC et al (2012) Response assessment using 18\u202fF-FDG PET early in the course of chemo-radiotherapy is correlated with survival in advanced stage non-small cell lung cancer. J\u00a0Nucl Med 53:1514\u20131520","journal-title":"J Nucl Med"},{"key":"1221_CR37","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2967\/jnumed.112.116921","volume":"54","author":"EA Usmanij","year":"2013","unstructured":"Usmanij EA, de Geus-Oei L\u2011F, Troost EG et al (2013) 18\u202fF-FDG PET early response evaluation of locally advanced non-small cell lung cancer treated with concomitant chemoradiotherapy. J\u00a0Nucl Med 54:1528\u20131534","journal-title":"J Nucl Med"},{"key":"1221_CR38","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00259-014-2687-9","volume":"41","author":"P Vera","year":"2014","unstructured":"Vera P, Mezzani-Saillard S, Edet-Sanson A et al (2014) FDG PET during radiochemotherapy is predictive of outcome at 1 year in non-small-cell lung cancer patients: a\u00a0prospective multicentre study (RTEP2). Eur J Nucl Med Mol Imaging 41:1057\u20131065","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1221_CR39","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ejrad.2014.11.020","volume":"84","author":"W Huang","year":"2015","unstructured":"Huang W, Liu B, Fan M et al (2015) The early predictive value of a\u00a0decrease of metabolic tumor volume in repeated 18\u202fF-FDG PET\/CT for recurrence of locally advanced non-small cell lung cancer with concurrent radiochemotherapy. Eur J Radiol 84:482\u2013488","journal-title":"Eur J Radiol"},{"key":"1221_CR40","doi-asserted-by":"crossref","first-page":"e0157836","DOI":"10.1371\/journal.pone.0157836","volume":"11","author":"X Dong","year":"2016","unstructured":"Dong X, Sun X, Sun L et al (2016) Early change in metabolic tumor heterogeneity during chemoradiotherapy and its prognostic value for patients with locally advanced non-small cell lung cancer. PLOS ONE 11:e157836","journal-title":"PLOS ONE"},{"key":"1221_CR41","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.ijrobp.2010.06.011","volume":"81","author":"C Dehing-Oberije","year":"2011","unstructured":"Dehing-Oberije C, Aerts H, Yu S et al (2011) Development and validation of a\u00a0prognostic model using blood biomarker information for prediction of survival of non-small-cell lung cancer patients treated with combined chemotherapy and radiation or radiotherapy alone (NCT00181519, NCT00573040, and NCT00572325). Int J Radiat Oncol Biol Phys 81:360\u2013368","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1221_CR42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cllc.2014.08.003","volume":"16","author":"B Jeremi\u0107","year":"2015","unstructured":"Jeremi\u0107 B (2015) Standard treatment option in stage III non-small-cell lung cancer: case against trimodal therapy and consolidation drug therapy. Clin Lung Cancer 16:80\u201385","journal-title":"Clin Lung Cancer"},{"key":"1221_CR43","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1200\/JCO.2015.62.6812","volume":"33","author":"WEE Eberhardt","year":"2015","unstructured":"Eberhardt WEE, P\u00f6ttgen C, Gauler TC et al (2015) Phase III study of surgery versus definitive concurrent chemoradiotherapy boost in patients with resectable stage IIIA (N2) and selected IIIB non-small-cell lung cancer after induction chemotherapy and concurrent chemoradiotherapy (ESPATUE). J\u00a0Clin Oncol 33:4194\u20134201","journal-title":"J Clin Oncol"},{"key":"1221_CR44","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0169-5002(03)00282-4","volume":"42","author":"J Park","year":"2003","unstructured":"Park J, Ahn YC, Kim H et al (2003) A phase II trial of concurrent chemoradiation therapy followed by consolidation chemotherapy with oral etoposide and cisplatin for locally advanced inoperable non-small cell lung cancers. Lung Cancer 42:227\u2013235","journal-title":"Lung Cancer"},{"key":"1221_CR45","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/sj.bjc.6605875","volume":"103","author":"F Oshita","year":"2010","unstructured":"Oshita F, Ohe M, Honda T et al (2010) Phase II study of nedaplatin and irinotecan with concurrent thoracic radiotherapy in patients with locally advanced non-small-cell lung cancer. Br J Cancer 103:1325\u20131330","journal-title":"Br J Cancer"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-017-1221-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-017-1221-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-017-1221-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T08:24:07Z","timestamp":1523953447000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-017-1221-y"}},"subtitle":["A\u00a0systematic review","Ein systematischer Review"],"short-title":[],"issued":{"date-parts":[[2017,10,13]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["1221"],"URL":"https:\/\/doi.org\/10.1007\/s00066-017-1221-y","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,13]]}}}