{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:34:09Z","timestamp":1769265249291,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017070426"],"award-info":[{"award-number":["2017070426"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s00066-018-1342-y","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T06:09:04Z","timestamp":1534140544000},"page":"1017-1029","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Compensatory hypertrophy of the liver after external beam radiotherapy for primary liver cancer","Kompensatorische Hypertrophie der Leber nach externer Strahlentherapie bei prim\u00e4rem Leberkrebs"],"prefix":"10.1007","volume":"194","author":[{"given":"Chai Hong","family":"Rim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangjoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong Yeol","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsil","family":"Seong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"1342_CR1","volume-title":"NCCN Clinical Practice Guidelines in Oncology, Hepatobiliary cancers","author":"National Comprehensive Cancer Network","year":"2016","unstructured":"National Comprehensive Cancer Network (2016) NCCN Clinical Practice Guidelines in Oncology, Hepatobiliary cancers. \n                    https:\/\/www.nccn.org\/professionals\/physician_gls\/default_nojava.aspx\n                    \n                  . Accessed 3 Oct 2016"},{"issue":"1","key":"1342_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ijrobp.2012.08.043","volume":"87","author":"J Klein","year":"2013","unstructured":"Klein J, Dawson LA (2013) Hepatocellular carcinoma radiation therapy: review of evidence and future opportunities. Int J Radiat Oncol Biol Phys 87(1):22\u201332","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1342_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3350\/cmh.2016.22.1.7","volume":"22","author":"SJ Yu","year":"2016","unstructured":"Yu SJ (2016) A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world: 2010\u20132016. Clin Mol Hepatol 22(1):7\u201317","journal-title":"Clin Mol Hepatol"},{"issue":"11","key":"1342_CR4","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1245\/s10434-014-3652-3","volume":"21","author":"HS Lee","year":"2014","unstructured":"Lee HS, Choi GH, Choi JS, Kim KS, Han KH, Seong J et al (2014) Surgical resection after down-staging of locally advanced hepatocellular carcinoma by localized concurrent chemoradiotherapy. Ann Surg Oncol 21(11):3646\u20133653","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"1342_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0022-4804(02)96503-0","volume":"107","author":"S Kubo","year":"2002","unstructured":"Kubo S, Shiomi S, Tanaka H, Shuto T, Takemura S, Mikami S et al (2002) Evaluation of the effect of portal vein embolization on liver function by 99mTc-galactosyl human serum albumin scintigraphy. J\u00a0Surg Res 107(1):113\u2013118","journal-title":"J Surg Res"},{"issue":"5","key":"1342_CR6","first-page":"814","volume":"17","author":"M Kudo","year":"1993","unstructured":"Kudo M, Todo A, Ikekubo K, Yamamoto K, Vera DR, Stadalnik RC (1993) Quantitative assessment of hepatocellular function through in vivo radioreceptor imaging with technetium 99m galactosyl human serum albumin. Hepatology 17(5):814\u2013819","journal-title":"Hepatology"},{"issue":"1","key":"1342_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/SLA.0b013e31815f6e5b","volume":"247","author":"A Abulkhir","year":"2008","unstructured":"Abulkhir A, Limongelli P, Healey AJ, Damrah O, Tait P, Jackson J et al (2008) Preoperative portal vein embolization for major liver resection: a\u00a0meta-analysis. Ann Surg 247(1):49\u201357","journal-title":"Ann Surg"},{"issue":"4","key":"1342_CR8","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.surg.2014.12.009","volume":"157","author":"S Pandanaboyana","year":"2015","unstructured":"Pandanaboyana S, Bell R, Hidalgo E, Toogood G, Prasad KR, Bartlett A et al (2015) A systematic review and meta-analysis of portal vein ligation versus portal vein embolization for elective liver resection. Surgery 157(4):690\u2013698","journal-title":"Surgery"},{"issue":"10","key":"1342_CR9","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1001\/archsurg.143.10.978","volume":"143","author":"L Capussotti","year":"2008","unstructured":"Capussotti L, Muratore A, Baracchi F, Lelong B, Ferrero A, Regge D et\u00a0al (2008) Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases. Arch Surg 143(10):978\u2013982","journal-title":"Arch Surg"},{"issue":"5","key":"1342_CR10","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ijsu.2014.03.009","volume":"12","author":"G-Q Zhang","year":"2014","unstructured":"Zhang G\u2011Q, Zhang Z\u2011W, Lau W\u2011Y, Chen X\u2011P (2014) Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): a\u00a0new strategy to increase resectability in liver surgery. Int J Surg 12(5):437\u2013441","journal-title":"Int J Surg"},{"issue":"5","key":"1342_CR11","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.jhep.2013.06.015","volume":"59","author":"M Vouche","year":"2013","unstructured":"Vouche M, Lewandowski RJ, Atassi R, Memon K, Gates VL, Ryu RK et al (2013) Radiation lobectomy: Time-dependent analysis of future liver remnant volume in unresectable liver cancer as a\u00a0bridge to resection. J\u00a0Hepatol 59(5):1029\u20131036","journal-title":"J Hepatol"},{"issue":"6","key":"1342_CR12","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1245\/s10434-009-0454-0","volume":"16","author":"RC Gaba","year":"2009","unstructured":"Gaba RC, Lewandowski RJ, Kulik LM, Riaz A, Ibrahim SM, Mulcahy MF et al (2009) Radiation lobectomy: preliminary findings of hepatic volumetric response to lobar yttrium-90 radioembolization. Ann Surg Oncol 16(6):1587\u20131596","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"1342_CR13","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/PL00002348","volume":"176","author":"K Tokuuye","year":"2000","unstructured":"Tokuuye K, Sumi M, Kagami Y, Murayama S, Kawashima M, Ikeda H et\u00a0al (2000) Radiotherapy for hepatocellular carcinoma. Strahlenther Onkol 176(9):406\u2013410","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"1342_CR14","doi-asserted-by":"publisher","first-page":"465","DOI":"10.3348\/kjr.2015.16.3.465","volume":"16","author":"Korean Liver Cancer Study Group","year":"2015","unstructured":"Korean Liver Cancer Study Group, National Cancer Center (2015) 2014 Korean Liver Cancer Study Group-National Cancer Center Korea practice guideline for the management of hepatocellular carcinoma. Korean J Radiol 16(3):465\u2013522","journal-title":"Korean J Radiol"},{"issue":"3","key":"1342_CR15","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3857\/roj.2016.01970","volume":"34","author":"CH Rim","year":"2016","unstructured":"Rim CH, Seong J (2016) Application of radiotherapy for hepatocellular carcinoma in current clinical practice guidelines. Radiat Oncol\u00a0J 34(3):160\u2013167","journal-title":"Radiat Oncol J"},{"issue":"3","key":"1342_CR16","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1159\/000367766","volume":"5","author":"HC Park","year":"2016","unstructured":"Park HC, Yu JI, Cheng JCH, Zeng ZC, Hong JH, Wang MLC et al (2016) Consensus for radiotherapy in hepatocellular carcinoma from the 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014): current practice and future clinical trials. Liver Cancer 5(3):162\u2013174","journal-title":"Liver Cancer"},{"issue":"1","key":"1342_CR17","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ijrobp.2006.08.015","volume":"67","author":"TH Kim","year":"2007","unstructured":"Kim TH, Kim DY, Park JW, Kim SH, Choi JI, Kim HB et al (2007) Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 67(1):225\u2013231","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"1342_CR18","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1055\/s-0030-1247132","volume":"30","author":"R Lencioni","year":"2010","unstructured":"Lencioni R, Llovet JM (2010) Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis 30(1):52\u201360","journal-title":"Semin Liver Dis"},{"issue":"1","key":"1342_CR19","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jamcollsurg.2013.03.004","volume":"217","author":"J Shindoh","year":"2013","unstructured":"Shindoh J, Vauthey JN, Zimmitti G, Curley SA, Huang SY, Mahvash A et\u00a0al (2013) Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume. J\u00a0Am Coll Surg 217(1):126\u2013133 (Including a\u00a0comparison with the associating liver partition with portal vein ligation for staged hepatectomy approach)","journal-title":"J Am Coll Surg"},{"issue":"5","key":"1342_CR20","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ijsu.2014.03.009","volume":"12","author":"GQ Zhang","year":"2014","unstructured":"Zhang GQ, Zhang ZW, Lau WY, Chen XP (2014) Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): a\u00a0new strategy to increase resectability in liver surgery. Int J Surg 12(5):437\u2013441","journal-title":"Int J Surg"},{"issue":"2","key":"1342_CR21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.radonc.2010.03.025","volume":"96","author":"H Imada","year":"2010","unstructured":"Imada H, Kato H, Yasuda S, Yamada S, Yanagi T, Hara R et\u00a0al (2010) Compensatory enlargement of the liver after treatment of hepatocellular carcinoma with carbon ion radiotherapy\u2014relation to prognosis and liver function. Radiother Oncol 96(2):236\u2013242","journal-title":"Radiother Oncol"},{"issue":"2","key":"1342_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1055\/s-0032-1312568","volume":"29","author":"BJ May","year":"2012","unstructured":"May BJ, Madoff DC (2012) Portal vein embolization: rationale, technique, and current application. Semin Intervent Radiol 29(2):81\u201389","journal-title":"Semin Intervent Radiol"},{"issue":"4","key":"1342_CR23","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.surg.2003.08.024","volume":"135","author":"EK Abdalla","year":"2004","unstructured":"Abdalla EK, Denys A, Chevalier P, Nemr RA, Vauthey JN (2004) Total and segmental liver volume variations: implications for liver surgery. Surgery 135(4):404\u2013410","journal-title":"Surgery"},{"issue":"2","key":"1342_CR24","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1055\/s-2008-1076679","volume":"25","author":"RD Kim","year":"2008","unstructured":"Kim RD, Kim JS, Watanabe G, Mohuczy D, Behrns KE (2008) Liver regeneration and the atrophy-hypertrophy complex. Semin Intervent Radiol 25(2):92\u2013103","journal-title":"Semin Intervent Radiol"},{"issue":"8","key":"1342_CR25","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1245\/s10434-010-0979-2","volume":"17","author":"T Baere de","year":"2010","unstructured":"de Baere T, Teriitehau C, Deschamps F, Catherine L, Rao P, Hakime A et\u00a0al (2010) Predictive factors for hypertrophy of the future remnant liver after selective portal vein embolization. Ann Surg Oncol 17(8):2081\u20132089","journal-title":"Ann Surg Oncol"},{"issue":"8","key":"1342_CR26","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1046\/j.0007-1323.2001.01832.x","volume":"88","author":"M Nagino","year":"2001","unstructured":"Nagino M, Ando M, Kamiya J, Uesaka K, Sano T, Nimura Y (2001) Liver regeneration after major hepatectomy for biliary cancer. Br J Surg 88(8):1084\u20131091","journal-title":"Br J Surg"},{"key":"1342_CR27","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1007\/BF00686664","volume":"33","author":"M Tani","year":"1994","unstructured":"Tani M, Tomiya T, Yamada S, Hayashi S, Yahata K, Tamura Y et\u00a0al (1994) Regulating factors of liver regeneration after hepatectomy. Cancer Chemother Pharmacol 33:S29\u2013S32","journal-title":"Cancer Chemother Pharmacol"},{"issue":"9","key":"1342_CR28","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.jvir.2011.04.014","volume":"22","author":"T Denecke","year":"2011","unstructured":"Denecke T, Seehofer D, Steffen IG, Grieser C, Stelter L, Schnapauff D et\u00a0al (2011) Arterial versus portal venous embolization for induction of hepatic hypertrophy before extended right hemihepatectomy in hilar cholangiocarcinomas: a prospective randomized study. J\u00a0Vasc Interv Radiol 22(9):1254\u20131262","journal-title":"J Vasc Interv Radiol"},{"issue":"1","key":"1342_CR29","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1148\/radiology.208.1.9646816","volume":"208","author":"TJ Vogl","year":"1998","unstructured":"Vogl TJ, Balzer JO, Dette K, Hintze R, Pegios W, Maurer J et\u00a0al (1998) Initially unresectable hilar cholangiocarcinoma: Hepatic regeneration after transarterial embolization. Radiology 208(1):217\u2013222","journal-title":"Radiology"},{"issue":"5","key":"1342_CR30","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0168-8278(97)80325-X","volume":"27","author":"K Yamakado","year":"1997","unstructured":"Yamakado K, Takeda K, Matsumura K, Nakatsuka A, Hirano T, Kato N et al (1997) Regeneration of the un-embolized liver parenchyma following portal vein embolization. J\u00a0Hepatol 27(5):871\u2013880","journal-title":"J Hepatol"},{"issue":"7","key":"1342_CR31","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1001\/archsurg.139.7.766","volume":"139","author":"T Aoki","year":"2004","unstructured":"Aoki T, Imamura H, Hasegawa K, Matsukura A, Sano K, Sugawara Y et\u00a0al (2004) Sequential preoperative arterial and portal venous embolizations in patients with hepatocellular carcinoma. Arch Surg 139(7):766\u2013774","journal-title":"Arch Surg"},{"issue":"9","key":"1342_CR32","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1002\/bjs.5341","volume":"93","author":"S Ogata","year":"2006","unstructured":"Ogata S, Belghiti J, Farges O, Varma D, Sibert A, Vilgrain V (2006) Sequential arterial and portal vein embolizations before right hepatectomy in patients with cirrhosis and hepatocellular carcinoma. Br J Surg 93(9):1091\u20131098","journal-title":"Br J Surg"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-018-1342-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-018-1342-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-018-1342-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T21:46:30Z","timestamp":1569188790000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-018-1342-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,13]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["1342"],"URL":"https:\/\/doi.org\/10.1007\/s00066-018-1342-y","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,13]]},"assertion":[{"value":"30 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical guidelines"}},{"value":"C.H.\u00a0Rim, S.\u00a0Park, J.Y.\u00a0Woo, and J.\u00a0Seong declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institutional Review Board of the relevant facility.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}