{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:34:19Z","timestamp":1761824059476,"version":"3.37.3"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Ministry of Science, Korea through the R&D program","award":["NRF-2017R1C1B2010379"],"award-info":[{"award-number":["NRF-2017R1C1B2010379"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00066-018-1366-3","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T07:26:19Z","timestamp":1536564379000},"page":"164-174","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Treatment outcomes of radiotherapy for primary spinal cord glioma","Behandlungsergebnisse der Strahlentherapie beim prim\u00e4ren R\u00fcckenmarksgliom"],"prefix":"10.1007","volume":"195","author":[{"given":"Seo Hee","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-6856","authenticated-orcid":false,"given":"Hong In","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JaeHo","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ah","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Seok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Koo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Hee","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Ok","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"1366_CR1","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1097\/00019052-200112000-00001","volume":"14","author":"JW Henson","year":"2001","unstructured":"Henson JW (2001) Spinal cord gliomas. Curr Opin Neurol 14:679\u2013682","journal-title":"Curr Opin Neurol"},{"key":"1366_CR2","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.6004\/jnccn.2017.0166","volume":"15","author":"LB Nabors","year":"2017","unstructured":"Nabors LB, Portnow J, Ammirati M et\u00a0al (2017) NCCN guidelines insights: central nervous system cancers, version 1.2017. J\u00a0Natl Compr Canc Netw 15:1331\u20131345","journal-title":"J Natl Compr Canc Netw"},{"key":"1366_CR3","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ijrobp.2010.05.009","volume":"81","author":"J Kahn","year":"2011","unstructured":"Kahn J, Loeffler JS, Niemierko A et al (2011) Long-term outcomes of patients with spinal cord gliomas treated by modern conformal radiation techniques. Int J Radiat Oncol Biol Phys 81:232\u2013238","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1366_CR4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00066-015-0917-0","volume":"192","author":"S Corradini","year":"2016","unstructured":"Corradini S, Hadi I, Hankel V et al (2016) Radiotherapy of spinal cord gliomas: a retrospective mono-institutional analysis. Strahlenther Onkol 192:139\u2013145","journal-title":"Strahlenther Onkol"},{"key":"1366_CR5","first-page":"972","volume":"56","author":"A Raco","year":"2005","unstructured":"Raco A, Esposito V, Lenzi J et al (2005) Long-term follow-up of intramedullary spinal cord tumors: a\u00a0series of 202 cases. Neurosurgery 56:972\u2013981 (discussion 972\u2013981)","journal-title":"Neurosurgery"},{"key":"1366_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.ijrobp.2005.09.038","volume":"64","author":"M Abdel-Wahab","year":"2006","unstructured":"Abdel-Wahab M, Etuk B, Palermo J et al (2006) Spinal cord gliomas: a multi-institutional retrospective analysis. Int J Radiat Oncol Biol Phys 64:1060\u20131071","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1366_CR7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1023\/A:1010680924975","volume":"52","author":"MS Kim","year":"2001","unstructured":"Kim MS, Chung CK, Choe G et\u00a0al (2001) Intramedullary spinal cord astrocytoma in adults: postoperative outcome. J\u00a0Neurooncol 52:85\u201394","journal-title":"J Neurooncol"},{"key":"1366_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1023\/A:1006470523052","volume":"47","author":"SR Isaacson","year":"2000","unstructured":"Isaacson SR (2000) Radiation therapy and the management of intramedullary spinal cord tumors. J\u00a0Neurooncol 47:231\u2013238","journal-title":"J Neurooncol"},{"key":"1366_CR9","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/(SICI)1520-6823(1998)6:6<276::AID-ROI5>3.0.CO;2-6","volume":"6","author":"MP McLaughlin","year":"1998","unstructured":"McLaughlin MP, Buatti JM, Marcus RB Jr. et\u00a0al (1998) Outcome after radiotherapy of primary spinal cord glial tumors. Radiat Oncol Investig 6:276\u2013280","journal-title":"Radiat Oncol Investig"},{"key":"1366_CR10","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/0360-3016(85)90274-3","volume":"11","author":"DM Garcia","year":"1985","unstructured":"Garcia DM (1985) Primary spinal cord tumors treated with surgery and postoperative irradiation. Int J Radiat Oncol Biol Phys 11:1933\u20131939","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1366_CR11","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0360-3016(86)90345-7","volume":"12","author":"EG Shaw","year":"1986","unstructured":"Shaw EG, Evans RG, Scheithauer BW et\u00a0al (1986) Radiotherapeutic management of adult intraspinal ependymomas. Int J Radiat Oncol Biol Phys 12:323\u2013327","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1366_CR12","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1148\/93.6.1351","volume":"93","author":"CH Chang","year":"1969","unstructured":"Chang CH, Housepian EM, Herbert C Jr. (1969) An operative staging system and a\u00a0megavoltage radiotherapeutic technic for cerebellar medulloblastomas. Radiology 93:1351\u20131359","journal-title":"Radiology"},{"key":"1366_CR13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s11060-007-9507-z","volume":"87","author":"KA Schellinger","year":"2008","unstructured":"Schellinger KA, Propp JM, Villano JL et\u00a0al (2008) Descriptive epidemiology of primary spinal cord tumors. J\u00a0Neurooncol 87:173\u2013179","journal-title":"J Neurooncol"},{"key":"1366_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/pbc.21806","volume":"52","author":"CS McGuire","year":"2009","unstructured":"McGuire CS, Sainani KL, Fisher PG (2009) Both location and age predict survival in ependymoma: a\u00a0SEER study. Pediatr Blood Cancer 52:65\u201369","journal-title":"Pediatr Blood Cancer"},{"key":"1366_CR15","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/S0360-3016(98)00350-2","volume":"42","author":"SE Schild","year":"1998","unstructured":"Schild SE, Nisi K, Scheithauer BW et\u00a0al (1998) The results of radiotherapy for ependymomas: the Mayo Clinic experience. Int J Radiat Oncol Biol Phys 42:953\u2013958","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1366_CR16","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/00000421-199908000-00004","volume":"22","author":"M Abdel-Wahab","year":"1999","unstructured":"Abdel-Wahab M, Corn B, Wolfson A et al (1999) Prognostic factors and survival in patients with spinal cord gliomas after radiation therapy. Am J Clin Oncol 22:344\u2013351","journal-title":"Am J Clin Oncol"},{"key":"1366_CR17","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0360-3016(95)00179-3","volume":"33","author":"H Shirato","year":"1995","unstructured":"Shirato H, Kamada T, Hida K et\u00a0al (1995) The role of radiotherapy in the management of spinal cord glioma. Int J Radiat Oncol Biol Phys 33:323\u2013328","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1366_CR18","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/0167-8140(93)90147-Z","volume":"29","author":"MC Hulshof","year":"1993","unstructured":"Hulshof MC, Menten J, Dito JJ et\u00a0al (1993) Treatment results in primary intraspinal gliomas. Radiother Oncol 29:294\u2013300","journal-title":"Radiother Oncol"},{"key":"1366_CR19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11060-009-0054-7","volume":"98","author":"MT Milano","year":"2010","unstructured":"Milano MT, Johnson MD, Sul J et\u00a0al (2010) Primary spinal cord glioma: a\u00a0surveillance, epidemiology, and end results database study. J\u00a0Neurooncol 98:83\u201392","journal-title":"J Neurooncol"},{"key":"1366_CR20","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3349\/ymj.2016.57.4.824","volume":"57","author":"J Lee","year":"2016","unstructured":"Lee J, Cho J, Chang JH et al (2016) Re-irradiation for recurrent gliomas: treatment outcomes and prognostic factors. Yonsei Med\u00a0J 57:824\u2013830","journal-title":"Yonsei Med J"},{"key":"1366_CR21","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3349\/ymj.2018.59.2.194","volume":"59","author":"J Lee","year":"2018","unstructured":"Lee J, Ahn SS, Chang JH et al (2018) Hypofractionated re-irradiation after maximal surgical resection for recurrent glioblastoma: therapeutic adequacy and its prognosticators of survival. Yonsei Med\u00a0J 59:194\u2013201","journal-title":"Yonsei Med J"},{"key":"1366_CR22","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ijrobp.2017.08.038","volume":"100","author":"W Shi","year":"2018","unstructured":"Shi W, Scannell BM, Gilbert MR et\u00a0al (2018) Investigating the effect of reirradiation or systemic therapy in patients with glioblastoma after tumor progression: a secondary analysis of NRG oncology\/radiation therapy oncology group trial 0525. Int J Radiat Oncol Biol Phys 100:38\u201344","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1366_CR23","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s11060-017-2611-9","volume":"135","author":"ND Arvold","year":"2017","unstructured":"Arvold ND, Shi DD, Aizer AA et al (2017) Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone. J\u00a0Neurooncol 135:581\u2013591","journal-title":"J Neurooncol"},{"key":"1366_CR24","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.ijrobp.2017.10.002","volume":"100","author":"DS Tsang","year":"2018","unstructured":"Tsang DS, Burghen E, Klimo P Jr. et\u00a0al (2018) Outcomes after reirradiation for recurrent pediatric intracranial ependymoma. Int J Radiat Oncol Biol Phys 100:507\u2013515","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1366_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF02341151","volume":"9","author":"HC Chun","year":"1990","unstructured":"Chun HC, Schmidt-Ullrich RK, Wolfson A et al (1990) External beam radiotherapy for primary spinal cord tumors. J\u00a0Neurooncol 9:211\u2013217","journal-title":"J Neurooncol"},{"key":"1366_CR26","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/S0360-3016(00)00690-8","volume":"48","author":"GB Rodrigues","year":"2000","unstructured":"Rodrigues GB, Waldron JN, Wong CS et\u00a0al (2000) A retrospective analysis of 52 cases of spinal cord glioma managed with radiation therapy. Int J Radiat Oncol Biol Phys 48:837\u2013842","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1366_CR27","first-page":"490","volume":"30","author":"HM Sandler","year":"1992","unstructured":"Sandler HM, Papadopoulos SM, Thornton AF Jr. et\u00a0al (1992) Spinal cord astrocytomas: results of therapy. Neurosurgery 30:490\u2013493","journal-title":"Neurosurgery"},{"key":"1366_CR28","doi-asserted-by":"publisher","first-page":"4067","DOI":"10.1007\/s00586-016-4475-7","volume":"25","author":"SJ Ryu","year":"2016","unstructured":"Ryu SJ, Kim JY, Kim KH et\u00a0al (2016) A retrospective observational study on the treatment outcomes of 26 patients with spinal cord astrocytoma including two cases of malignant transformation. Eur Spine\u00a0J 25:4067\u20134079","journal-title":"Eur Spine J"},{"key":"1366_CR29","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1007\/s00586-009-1076-8","volume":"18","author":"V Benes 3rd","year":"2009","unstructured":"Benes V 3rd, Barsa P, Benes V Jr. et\u00a0al (2009) Prognostic factors in intramedullary astrocytomas: a\u00a0literature review. Eur Spine\u00a0J 18:1397\u20131422","journal-title":"Eur Spine J"},{"key":"1366_CR30","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.clineuro.2016.03.009","volume":"144","author":"R Xiao","year":"2016","unstructured":"Xiao R, Abdullah KG, Miller JA et\u00a0al (2016) Molecular and clinical prognostic factors for favorable outcome following surgical resection of adult intramedullary spinal cord astrocytomas. Clin Neurol Neurosurg 144:82\u201387","journal-title":"Clin Neurol Neurosurg"},{"key":"1366_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0303-8467(96)00555-0","volume":"99","author":"G Innocenzi","year":"1997","unstructured":"Innocenzi G, Salvati M, Cervoni L et\u00a0al (1997) Prognostic factors in intramedullary astrocytomas. Clin Neurol Neurosurg 99:1\u20135","journal-title":"Clin Neurol Neurosurg"},{"key":"1366_CR32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.nec.2005.10.006","volume":"17","author":"C Roonprapunt","year":"2006","unstructured":"Roonprapunt C, Houten JK (2006) Spinal cord astrocytomas: presentation, management, and outcome. Neurosurg Clin N Am 17:29\u201336","journal-title":"Neurosurg Clin N Am"},{"key":"1366_CR33","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/bpa.12336","volume":"26","author":"DA Solomon","year":"2016","unstructured":"Solomon DA, Wood MD, Tihan T et al (2016) Diffuse midline gliomas with Histone H3-K27M mutation: a series of 47 cases assessing the spectrum of morphologic variation and associated genetic alterations. Brain Pathol 26:569\u2013580","journal-title":"Brain Pathol"},{"key":"1366_CR34","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","volume":"131","author":"DN Louis","year":"2016","unstructured":"Louis DN, Perry A, Reifenberger G et\u00a0al (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a\u00a0summary. Acta Neuropathol 131:803\u2013820","journal-title":"Acta Neuropathol"},{"key":"1366_CR35","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00401-015-1405-4","volume":"129","author":"A Korshunov","year":"2015","unstructured":"Korshunov A, Ryzhova M, Hovestadt V et\u00a0al (2015) Integrated analysis of pediatric glioblastoma reveals a\u00a0subset of biologically favorable tumors with associated molecular prognostic markers. Acta Neuropathol 129:669\u2013678","journal-title":"Acta Neuropathol"},{"key":"1366_CR36","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.ccr.2012.08.024","volume":"22","author":"D Sturm","year":"2012","unstructured":"Sturm D, Witt H, Hovestadt V et\u00a0al (2012) Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 22:425\u2013437","journal-title":"Cancer Cell"},{"key":"1366_CR37","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00401-012-0998-0","volume":"124","author":"DA Khuong-Quang","year":"2012","unstructured":"Khuong-Quang DA, Buczkowicz P, Rakopoulos P et al (2012) K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol 124:439\u2013447","journal-title":"Acta Neuropathol"},{"key":"1366_CR38","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/neuonc\/not144","volume":"16","author":"K Aihara","year":"2014","unstructured":"Aihara K, Mukasa A, Gotoh K et al (2014) H3F3A K27M mutations in thalamic gliomas from young adult patients. Neuro-oncology 16:140\u2013146","journal-title":"Neuro-oncology"},{"key":"1366_CR39","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1016\/j.humpath.2015.07.002","volume":"46","author":"J Feng","year":"2015","unstructured":"Feng J, Hao S, Pan C et\u00a0al (2015) The H3.3 K27M mutation results in a\u00a0poorer prognosis in brainstem gliomas than thalamic gliomas in adults. Hum Pathol 46:1626\u20131632","journal-title":"Hum Pathol"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-018-1366-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-018-1366-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-018-1366-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T19:03:39Z","timestamp":1568055819000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-018-1366-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,10]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["1366"],"URL":"https:\/\/doi.org\/10.1007\/s00066-018-1366-3","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"type":"print","value":"0179-7158"},{"type":"electronic","value":"1439-099X"}],"subject":[],"published":{"date-parts":[[2018,9,10]]},"assertion":[{"value":"14 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical guidelines"}},{"value":"S.H.\u00a0Choi, H.I.\u00a0Yoon, S.\u00a0Yi, J.W.\u00a0Park, J.\u00a0Cho, D.A.\u00a0Shin, Y.\u00a0Ha, D.-S.\u00a0Kim, S.H.\u00a0Kim, S.-K.\u00a0Lee, J.H.\u00a0Chang and C.-O.\u00a0Suh declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}