{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:51:08Z","timestamp":1790545868216,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00066-018-1379-y","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T02:20:11Z","timestamp":1539051611000},"page":"175-185","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A\u00a0density assignment method for dose monitoring in head-and-neck radiotherapy","Dichtezuordnungsmethode zur Dosis\u00fcberwachung bei der Strahlentherapie von Kopf-Hals-Tumoren"],"prefix":"10.1007","volume":"195","author":[{"given":"A.","family":"Barateau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Perichon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Castelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Schick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Chajon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lafond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"De Crevoisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"1379_CR1","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.ijrobp.2003.12.024","volume":"59","author":"JL Barker","year":"2004","unstructured":"Barker JL, Garden AS, Ang KK, O\u2019Danierl JC, Wang H, Court LE (2004) Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT\/linear accelerator system. Int J Radiat Oncol Biol Phys 59:960\u2013970","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"1379_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.radonc.2012.11.005","volume":"106","author":"T Nishi","year":"2013","unstructured":"Nishi T, Nishimura Y, Shibata T, Tamura M, Nishigaito N, Okumura M (2013) Volume and dosimetric changes and initial clinical experience of a\u00a0two-step adaptive intensity modulated radiation therapy (IMRT) scheme for head and neck cancer. Radiother Oncol 106:85\u201389","journal-title":"Radiother Oncol"},{"key":"1379_CR3","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1016\/j.clon.2011.11.006","volume":"24","author":"S Marzi","year":"2012","unstructured":"Marzi S, Pinnaro P, D\u2019Alessio D, Strigari L, Bruzzaniti V, Giordano C (2012) Anatomical and dose changes of gross tumour volume and parotid glands for head and neck cancer patients during intensity-modulated radiotherapy: effect on the probability of xerostomia incidence. Clin Oncol 24:e54\u2013e62","journal-title":"Clin Oncol"},{"key":"1379_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-016-0650-6","author":"J Castelli","year":"2016","unstructured":"Castelli J, Simon A, Rigaud B, Lafond C, Chajon E, Ospina JD (2016) A nomogram to predict parotid gland overdose in head and neck IMRT. Radiat Oncol. \n                    https:\/\/doi.org\/10.1186\/s13014-016-0650-6","journal-title":"Radiat Oncol"},{"key":"1379_CR5","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00066-011-0041-8","volume":"188","author":"MN Duma","year":"2012","unstructured":"Duma MN, Kampfer S, Schuster T, Winkler C, Geinitz H (2012) Adaptive radiotherapy for soft tissue changes during helical tomotherapy for head and neck cancer. Strahlenther Onkol 188:243\u2013247","journal-title":"Strahlenther Onkol"},{"key":"1379_CR6","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.radonc.2015.05.018","volume":"115","author":"CL Brouwer","year":"2015","unstructured":"Brouwer CL, Steenbakkers RJHM, Langendijk JA, Sijtsema NM (2015) Identifying patients who may benefit from adaptive radiotherapy: Does the literature on anatomic and dosimetric changes in head and neck organs at risk during radiotherapy provide information to help? Radiother Oncol 115:285\u2013294","journal-title":"Radiother Oncol"},{"key":"1379_CR7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.radonc.2016.05.028","volume":"120","author":"P Zhang","year":"2016","unstructured":"Zhang P, Simon A, Rigaud B, Castelli J, Ospina Arango JD, Nassef M (2016) Optimal adaptive IMRT strategy to spare the parotid glands in oropharyngeal cancer. Radiother Oncol 120:41\u201347","journal-title":"Radiother Oncol"},{"key":"1379_CR8","doi-asserted-by":"publisher","DOI":"10.1118\/1.4864240","author":"C Veiga","year":"2014","unstructured":"Veiga C, McClelland J, Moinuddin S, Louren\u00e7o A, Ricketts K, Annkah J (2014) Toward adaptive radiotherapy for head and neck patients: feasibility study on using CT-to-CBCT deformable registration for \u2018dose of the day\u2019 calculations. Med Phys. \n                    https:\/\/doi.org\/10.1118\/1.4864240","journal-title":"Med Phys"},{"key":"1379_CR9","doi-asserted-by":"publisher","first-page":"908","DOI":"10.3109\/0284186X.2011.590525","volume":"50","author":"UV Elstr\u00f8m","year":"2011","unstructured":"Elstr\u00f8m UV, Muren LP, Petersen JBB, Grau C (2011) Evaluation of image quality for different kV cone-beam CT acquisition and reconstruction methods in the head and neck region. Acta Oncol 50:908\u2013917","journal-title":"Acta Oncol"},{"key":"1379_CR10","doi-asserted-by":"publisher","DOI":"10.1118\/1.4865788","author":"SJ Gardner","year":"2014","unstructured":"Gardner SJ, Studenski MT, Giaddui T, Cui Y, Galvin J, Yu Y (2014) Investigation into image quality and dose for different patient geometries with multiple cone-beam CT systems. Med Phys. \n                    https:\/\/doi.org\/10.1118\/1.4865788","journal-title":"Med Phys"},{"key":"1379_CR11","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.radonc.2012.06.007","volume":"104","author":"I Fotina","year":"2012","unstructured":"Fotina I, Hopfgartner J, Stock M, Steininger T, L\u00fctgendorf-Caucig C, Georg D (2012) Feasibility of CBCT-based dose calculation: comparative analysis of HU adjustment techniques. Radiother Oncol 104:249\u2013256","journal-title":"Radiother Oncol"},{"key":"1379_CR12","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1007\/s00066-015-0890-7","volume":"191","author":"A Dunlop","year":"2015","unstructured":"Dunlop A, McQuaid D, Nill S, Murray J, Poludniowski G, Hansen VN (2015) Comparison of CT number calibration techniques for CBCT-based dose calculation. Strahlenther Onkol 191:970\u2013978","journal-title":"Strahlenther Onkol"},{"key":"1379_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.radonc.2015.07.041","volume":"117","author":"CL Brouwer","year":"2015","unstructured":"Brouwer CL, Steenbakkers RJHM, Langendijk JA, Sijtsema NM (2015) CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines. Radiother Oncol 117:83\u201390","journal-title":"Radiother Oncol"},{"key":"1379_CR14","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.radonc.2011.12.010","volume":"103","author":"I Toledano","year":"2012","unstructured":"Toledano I, Graff P, Serre A, Boisselier P, Bensadoun RJ, Ortholan C (2012) Intensity-modulated radiotherapy in head and neck cancer: results of the prospective study GORTEC 2004\u201303. Radiother Oncol 103:57\u201362","journal-title":"Radiother Oncol"},{"key":"1379_CR15","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1118\/1.598248","volume":"25","author":"DA Low","year":"1998","unstructured":"Low DA, Harms WB, Mutic S, Purdy JA (1998) A technique for the quantitative evaluation of dose distributions. Med Phys 25:656\u2013661","journal-title":"Med Phys"},{"key":"1379_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejmp.2017.03.001","volume":"36","author":"M Hussein","year":"2017","unstructured":"Hussein M, Clark CH, Nisbet A (2017) Challenges in calculation of the gamma index in radiotherapy \u2013 towards good practice. Phys Med 36:1\u201311","journal-title":"Phys Med"},{"key":"1379_CR17","doi-asserted-by":"publisher","first-page":"6239","DOI":"10.1088\/0031-9155\/54\/20\/013","volume":"54","author":"H Guan","year":"2009","unstructured":"Guan H, Dong H (2009) Dose calculation accuracy using cone-beam CT (CBCT) for pelvic adaptive radiotherapy. Phys Med Biol 54:6239\u20136250","journal-title":"Phys Med Biol"},{"key":"1379_CR18","doi-asserted-by":"publisher","first-page":"N329","DOI":"10.1088\/0031-9155\/54\/15\/N01","volume":"54","author":"J Hatton","year":"2009","unstructured":"Hatton J, McCurdy B, Greer PB (2009) Cone beam computerized tomography: the effect of calibration of the Hounsfield unit number to electron density on dose calculation accuracy for adaptive radiation therapy. Phys Med Biol 54:N329\u2013N346","journal-title":"Phys Med Biol"},{"key":"1379_CR19","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1259\/bjr.72.860.10624344","volume":"72","author":"SJ Thomas","year":"1999","unstructured":"Thomas SJ (1999) Relative electron density calibration of CT scanners for radiotherapy treatment planning. Br J Radiol 72:781\u2013786","journal-title":"Br J Radiol"},{"key":"1379_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0167-8140(98)00072-3","volume":"48","author":"L Cozzi","year":"1998","unstructured":"Cozzi L, Fogliata A, Buffa F, Bieri S (1998) Dosimetric impact of computed tomography calibration on a\u00a0commercial treatment planning system for external radiation therapy. Radiother Oncol 48:335\u2013338","journal-title":"Radiother Oncol"},{"key":"1379_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1259\/dmfr\/30642039","volume":"40","author":"R Schulze","year":"2011","unstructured":"Schulze R (2011) Artefacts in CBCT: a\u00a0review. Dentomaxillofac Radiol 40:265\u2013273","journal-title":"Dentomaxillofac. Radiol."},{"key":"1379_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717x-3-42","author":"A Richter","year":"2008","unstructured":"Richter A, Hu Q, Steglich D, Baier K, Wilbert J, Guckenberger M, Flentje M (2008) Investigation of the usability of conebeam CT data sets for dose calculation. Radiat Oncol. \n                    https:\/\/doi.org\/10.1186\/1748-717x-3-42","journal-title":"Radiat Oncol"},{"key":"1379_CR23","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.radonc.2007.08.010","volume":"85","author":"M Zijtveld van","year":"2007","unstructured":"van Zijtveld M, Dirkx M, Heijmen B (2007) Correction of conebeam CT values using a\u00a0planning CT for derivation of the \u2019dose of the day. Radiother Oncol 85:195\u2013200","journal-title":"Radiother Oncol"},{"key":"1379_CR24","doi-asserted-by":"publisher","first-page":"e375","DOI":"10.1016\/j.ijrobp.2011.07.004","volume":"82","author":"KF Ho","year":"2012","unstructured":"Ho KF, Marchant T, Moore C, Webster G, Rowbottom C, Penington H (2012) Monitoring dosimetric impact of weight loss with kilovoltage (KV) cone beam CT (CBCT) during parotid-sparing IMRT and concurrent chemotherapy. Int J Radiat Oncol Biol Phys 82:e375\u2013e382","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"1379_CR25","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.ijrobp.2014.02.007","volume":"89","author":"Y Onozato","year":"2014","unstructured":"Onozato Y, Kadoya N, Fujita Y, Arai K, Dobashi S, Takeda K (2014) Evaluation of on-board kV cone beam computed tomography\u2013based dose calculation with deformable image registration using Hounsfield unit modifications. Int J Radiat Oncol Biol Phys 89:416\u2013423","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"1379_CR26","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1088\/0031-9155\/58\/12\/4157","volume":"58","author":"B Disher","year":"2013","unstructured":"Disher B, Hajdok G, Wang A, Craig J, Gaede S, Battista JJ (2013) Correction for \u2018artificial\u2019 electron disequilibrium due to cone-beam CT density errors: implications for on-line adaptive stereotactic body radiation therapy of lung. Phys Med Biol 58:4157\u20134174","journal-title":"Phys Med Biol"},{"key":"1379_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1120\/jacmp.v12i4.3522","volume":"12","author":"A Karotki","year":"2011","unstructured":"Karotki A, Mah K, Meijer G, Meltsner M (2011) Comparison of bulk electron density and voxel-based electron density treatment planning. J\u00a0Appl Clin Med Phys 12:97\u2013104","journal-title":"J Appl Clin Med Phys"},{"key":"1379_CR28","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aab0f0","author":"TE Marchant","year":"2018","unstructured":"Marchant TE, Joshi KD, Moore CJ (2018) Accuracy of radiotherapy dose calculations based on cone-beam CT: comparison of deformable registration and image correction based methods. Phys Med Biol. \n                    https:\/\/doi.org\/10.1088\/1361-6560\/aab0f0","journal-title":"Phys Med Biol"},{"key":"1379_CR29","doi-asserted-by":"publisher","DOI":"10.1088\/2057-1976\/aad546","author":"D Brivio","year":"2018","unstructured":"Brivio D, Hu YD, Margalit DN, Zygmanski P (2018) Selection of head and neck cancer patients for adaptive replanning of radiation treatment using kV-CBCT. Biomed Phys Eng Express. \n                    https:\/\/doi.org\/10.1088\/2057-1976\/aad546","journal-title":"Biomed. Phys. Eng. Express"},{"key":"1379_CR30","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/726268","author":"B Rigaud","year":"2015","unstructured":"Rigaud B, Simon A, Castelli J, Gobeli M, Ospina Arango JD, Cazoulat G (2015) Evaluation of deformable image registration methods for dose monitoring in head and neck radiotherapy. Biomed Res Int. \n                    https:\/\/doi.org\/10.1155\/2015\/726268","journal-title":"Biomed Res Int"},{"key":"1379_CR31","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1120\/jacmp.v17i3.5735","volume":"17","author":"J Pukala","year":"2016","unstructured":"Pukala J, Johnson PB, Shah AP, Langen KM, Bova FJ, Staton RB (2016) Benchmarking of five commercial deformable image registration algorithms for head and neck patients. J\u00a0Appl Clin Med Phys 17:25\u201340","journal-title":"J Appl Clin Med Phys"},{"key":"1379_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.radonc.2008.04.010","volume":"89","author":"P Castadot","year":"2008","unstructured":"Castadot P, Lee JA, Parraga A, Geets X, Macq B, Gr\u00e9goire V (2008) Comparison of 12 deformable registration strategies in adaptive radiation therapy for the treatment of head and neck tumors. Radiother Oncol 89:1\u201312","journal-title":"Radiother Oncol"},{"key":"1379_CR33","doi-asserted-by":"publisher","first-page":"e0175906","DOI":"10.1371\/journal.pone.0175906","volume":"12","author":"X Li","year":"2017","unstructured":"Li X, Zhang Y, Shi Y, Wu S, Xiao Y, Gu X (2017) Comprehensive evaluation of ten deformable image registration algorithms for contour propagation between CT and cone-beam CT images in adaptive head & neck radiotherapy. PLoS ONE 12:e175906","journal-title":"PLoS ONE"},{"key":"1379_CR34","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/1748-717X-7-160","volume":"7","author":"M Macchia La","year":"2012","unstructured":"La Macchia M, Fellin F, Amichetti M, Cianchetti M, Gianolini S, Paola V (2012) Systematic evaluation of three different commercial software solutions for automatic segmentation for adaptive therapy in head-and-neck, prostate and pleural cancer. Radiat Oncol 7:160","journal-title":"Radiat Oncol"},{"key":"1379_CR35","doi-asserted-by":"publisher","DOI":"10.1118\/1.3554647","author":"J Hou","year":"2011","unstructured":"Hou J, Guerrero M, Chen W, D\u2019Souza WD (2011) Deformable planning CT to cone-beam CT image registration in head-and-neck cancer. Med Phys. \n                    https:\/\/doi.org\/10.1118\/1.3554647","journal-title":"Med Phys"},{"key":"1379_CR36","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.3109\/0284186X.2010.500304","volume":"49","author":"UV Elstr\u00f8m","year":"2010","unstructured":"Elstr\u00f8m UV, Wysocka BA, Muren LP, Petersen JBB, Grau C (2010) Daily kV cone-beam CT and deformable image registration as a\u00a0method for studying dosimetric consequences of anatomic changes in adaptive IMRT of head and neck cancer. Acta Oncol 49:1101\u20131108","journal-title":"Acta Oncol"},{"key":"1379_CR37","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1080\/0284186X.2016.1185149","volume":"55","author":"CA Hvid","year":"2016","unstructured":"Hvid CA, Elstr\u00f8m UV, Jensen K, Alber M, Grau C (2016) Accuracy of software-assisted contour propagation from planning CT to cone beam CT in head and neck radiotherapy. Acta Oncol 55:1324\u20131330","journal-title":"Acta Oncol"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-018-1379-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-018-1379-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-018-1379-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T19:32:27Z","timestamp":1570563147000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-018-1379-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["1379"],"URL":"https:\/\/doi.org\/10.1007\/s00066-018-1379-y","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]},"assertion":[{"value":"16 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A.\u00a0Barateau, N.\u00a0Perichon, J.\u00a0Castelli, U.\u00a0Schick, O.\u00a0Henry, E.\u00a0Chajon, A.\u00a0Simon, C.\u00a0Lafond and, R.\u00a0De Crevoisier declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}