{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T07:10:22Z","timestamp":1780125022899,"version":"3.54.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Centre of Oncology - Maria Sklodowska-Curie Memorial Institute Cracow Branch"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:p>Primary lymphoepithelioma-like carcinoma of the skin (LELCS) is a\u00a0very rare cutaneous neoplasm. Only about 70\u00a0cases have been documented in the literature. There are no prospective data regarding treatment methods. Surgical excision is sufficient therapy in the majority of cases. Radiation therapy is sometimes used in case of recurrence or positive margins after surgery. The metastatic potential of LELCS is extremely low and only five previously documented cases of lymph node spread have been reported. We present the case of an 80-year-old male with a\u00a0tumor primarily located on the lower eyelid, with two regional recurrences and cervical lymph node spread after surgery, treated with concurrent chemoradiation. According to the available data, this is the first case of lymph node spread from an eyelid location and the first nodal recurrence after surgery.<\/jats:p>","DOI":"10.1007\/s00066-019-01516-8","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T17:02:46Z","timestamp":1568048566000},"page":"1028-1032","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Radiotherapy in lymphoepithelioma-like carcinoma of the skin: review of the literature and report of a\u00a0recurrent and metastatic case","Strahlentherapie des lymphoepitheliom\u00e4hnlichen Karzinoms der Haut: Literatur\u00fcbersicht und Fallbericht mit Rezidiv und Metastasierung"],"prefix":"10.1007","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-1199","authenticated-orcid":false,"given":"A.","family":"Mucha-Ma\u0142ecka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Urbanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ambicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Majchrzak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ma\u0142ecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"issue":"5","key":"1516_CR1","first-page":"359","volume":"1","author":"SA Swanson","year":"1988","unstructured":"Swanson\u00a0SA, Cooper\u00a0PH, Mills\u00a0SE, Wick\u00a0MR (1988) Lymphoepithelioma-like carcinoma of the skin. Mod Pathol 1(5):359\u2013365","journal-title":"Mod Pathol"},{"key":"1516_CR2","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.4081\/rt.2013.e47","volume":"5","author":"S Morteza Abedi","year":"2013","unstructured":"Morteza Abedi\u00a0S, Salama\u00a0S, Alowami\u00a0S (2013) Lymphoepithelioma-like carcinoma of the skin: case report and approach to surgical pathology sign out. Rare Tumors 5:e47","journal-title":"Rare Tumors"},{"key":"1516_CR3","doi-asserted-by":"publisher","first-page":"e252","DOI":"10.1097\/GOX.0000000000000215","volume":"2","author":"CB Lassen","year":"2014","unstructured":"Lassen\u00a0CB, Lock-Andersen\u00a0J (2014) Lymphoepithelioma-like carcinoma of the skin: a\u00a0case with perineural invasion. Plast Reconstr Surg Glob Open 2:e252","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"3","key":"1516_CR4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/00000372-200606000-00007","volume":"28","author":"G Hall","year":"2006","unstructured":"Hall\u00a0G, Duncan\u00a0A, Azurdia\u00a0R, Leonard\u00a0N (2006) Lymphoepithelioma-like carcinoma of the skin: a\u00a0case with lymph node metastases at presentation. Am J Dermatopathol 28(3):211\u2013215","journal-title":"Am J Dermatopathol"},{"key":"1516_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/DAD.0b013e31806f7fa9","volume":"4","author":"DV Kazakov","year":"2007","unstructured":"Kazakov\u00a0DV, Nemcova\u00a0J, Mikyskova\u00a0I, Michal\u00a0M (2007) Absence of Epstein-Barr virus, human papillomavirus, and simian virus 40 in patients of central European origin with lymphoepithelioma-like carcinoma of the skin. Am J Dermatopathol 4:365\u2013369","journal-title":"Am J Dermatopathol"},{"issue":"7","key":"1516_CR6","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/j.1346-8138.1996.tb04058.x","volume":"23","author":"S Takayasu","year":"1996","unstructured":"Takayasu\u00a0S, Yoshiyama\u00a0M, Kurata\u00a0S, Terashi\u00a0H (1996) Lymphoepithelioma-like carcinoma of the skin. J\u00a0Dermatol 23(7):472\u2013475","journal-title":"J Dermatol"},{"issue":"5","key":"1516_CR7","doi-asserted-by":"publisher","first-page":"668","DOI":"10.5999\/aps.2015.42.5.668","volume":"42","author":"J Lee","year":"2015","unstructured":"Lee\u00a0J, Park\u00a0J, Chang\u00a0H (2015) Lymphoepithelioma-like carcinoma of the skin in the cheek with a\u00a0malignant metastatic cervical lymph node. Arch Plast Surg 42(5):668\u2013671","journal-title":"Arch Plast Surg"},{"key":"1516_CR8","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1346-8138.1995.tb03375.x","volume":"22","author":"M Maruyama","year":"1995","unstructured":"Maruyama\u00a0M, Miyauchi\u00a0S, Ohtsuka\u00a0H, Miki\u00a0Y (1995) Lymphoepithelioma-like carcinoma originating on the eyelid. J\u00a0Dermatol 22:218\u2013222","journal-title":"J Dermatol"},{"key":"1516_CR9","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1136\/bjo.2005.066589","volume":"89","author":"W Ho","year":"2005","unstructured":"Ho\u00a0W, Taylor\u00a0A, Kemp\u00a0E, Roberts\u00a0F (2005) Lymphoepithelioma-like carcinoma of the eyelid: a\u00a0report of two cases. Br J Ophthalmol 89:1222\u20131223","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"1516_CR10","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.tripleo.2010.05.075","volume":"111","author":"PQ Welch","year":"2011","unstructured":"Welch\u00a0PQ, Williams\u00a0SB, Foss\u00a0RD et al (2011) Lymphoepithelioma-like carcinoma of head and neck skin: a\u00a0systematic analysis of 11 cases and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111(1):78\u201386","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"1516_CR11","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0190-9622(08)81049-3","volume":"22","author":"AN Walker","year":"1990","unstructured":"Walker\u00a0AN, Kent\u00a0D, Mitchell\u00a0AR (1990) Lymphoepithelioma-like carcinoma of the skin. J\u00a0Am Acad Dermatol 22:691\u2013693","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"1516_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1365-2230.1993.tb00979.x","volume":"18","author":"FJ Ortiz-Frutos","year":"1993","unstructured":"Ortiz-Frutos\u00a0FJ, Zarco\u00a0C, Gil\u00a0R, Ballestin\u00a0C, Iglesias\u00a0L (1993) Lymphoepithelioma-like carcinoma of the skin. Clin Exp Dermatol 18(1):83\u201386","journal-title":"Clin Exp Dermatol"},{"key":"1516_CR13","first-page":"241816","volume":"2012","author":"TM Gille","year":"2012","unstructured":"Gille\u00a0TM, Miles\u00a0EF, Mitchell\u00a0AO et al (2012) Lymphoepithelioma-like carcinoma of the skin treated with wide local excision and chemoradiation therapy: a\u00a0case report and review of the literature. Case Rep Oncol Med 2012:241816","journal-title":"Case Rep Oncol Med"},{"issue":"8","key":"1516_CR14","first-page":"1206","volume":"119","author":"MA Ahmadi","year":"2001","unstructured":"Ahmadi\u00a0MA, Prieto\u00a0VG, Clayman\u00a0GL, Ginsberg\u00a0LE, Esmaeli\u00a0B (2001) Lymphoepitheliomalike Carcinoma of the orbit. Arch Ophthalmol 119(8):1206\u20131208","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"1516_CR15","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1093\/ajcp\/103.3.308","volume":"103","author":"JC Iezzoni","year":"1995","unstructured":"Iezzoni\u00a0JC, Gaffey\u00a0MJ, Weiss\u00a0LM (1995) The role of Epstein-Barr virus in lymphoepithelioma-like carcinomas. Am J Clin Pathol 103(3):308\u2013315","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"1516_CR16","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1097\/00000372-199610000-00006","volume":"18","author":"PS Gillum","year":"1996","unstructured":"Gillum\u00a0PS, Morgan\u00a0MB, Naylor\u00a0MF, Everett\u00a0MA (1996) Absence of Epstein-Barr virus in lymphoepitheliomalike carcinoma of the skin. Polymerase chain reaction evidence and review of five cases. Am J Dermatopathol 18(5):478\u2013482","journal-title":"Am J Dermatopathol"},{"key":"1516_CR17","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1046\/j.1365-2559.2000.00952.x","volume":"37","author":"JF Emile","year":"2000","unstructured":"Emile\u00a0JF, Adam\u00a0R, Sebagh\u00a0M et\u00a0al (2000) Hepatocellular carcinoma with lymphoid stroma: a\u00a0tumour with good prognosis after liver transplantation. Histopathology 37:523\u2013529","journal-title":"Histopathology"},{"issue":"51","key":"1516_CR18","doi-asserted-by":"publisher","first-page":"e9416","DOI":"10.1097\/MD.0000000000009416","volume":"96","author":"JK Wang","year":"2017","unstructured":"Wang\u00a0JK, Jin\u00a0YW, Hu\u00a0HJ et al (2017) Lymphoepithelioma-like hepatocellular carcinoma. A case report and brief review of literature. Medicine 96(51):e9416","journal-title":"Medicine"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-019-01516-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-019-01516-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-019-01516-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T23:05:17Z","timestamp":1599519917000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-019-01516-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,9]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["1516"],"URL":"https:\/\/doi.org\/10.1007\/s00066-019-01516-8","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,9]]},"assertion":[{"value":"9 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A.\u00a0Mucha-Ma\u0142ecka, K.\u00a0Urbanek, A.\u00a0Ambicka, P.\u00a0Majchrzak, and K.\u00a0Ma\u0142ecki declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}