{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:14:19Z","timestamp":1789708459805,"version":"4.0.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s00066-019-01525-7","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T10:06:21Z","timestamp":1571825181000},"page":"349-355","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Long-term outcome after intraoperative radiotherapy as a\u00a0boost in breast cancer","Langzeitergebnisse nach intraoperativem Boost bei Brustkrebs"],"prefix":"10.1007","volume":"196","author":[{"given":"Matthias","family":"Pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grit","family":"Welzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Abo-Madyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Tuschy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Berlit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"S\u00fctterlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Wenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8771-8124","authenticated-orcid":false,"given":"Elena","family":"Sperk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"1525_CR1","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/0360-3016(95)90159-0","volume":"31","author":"Anonymous","year":"1995","unstructured":"Anonymous (1995) LENT SOMA scales for all anatomic sites. Int J Radiat Oncol Biol Phys 31:1049\u20131091","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1525_CR2","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/1748-717X-6-174","volume":"6","author":"MH Aziz","year":"2011","unstructured":"Aziz\u00a0MH, Schneider\u00a0F, Clausen\u00a0S et al (2011) Can the risk of secondary cancer induction after breast conserving therapy be reduced using intraoperative radiotherapy (IORT) with low-energy x\u2011rays? Radiat Oncol 6:174","journal-title":"Radiat Oncol"},{"key":"1525_CR3","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1200\/JCO.2007.11.4991","volume":"25","author":"H Bartelink","year":"2007","unstructured":"Bartelink\u00a0H, Horiot\u00a0JC, Poortmans\u00a0PM et al (2007) Impact of a\u00a0higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial. J\u00a0Clin Oncol 25:3259\u20133265","journal-title":"J Clin Oncol"},{"key":"1525_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S1470-2045(14)71156-8","volume":"16","author":"H Bartelink","year":"2015","unstructured":"Bartelink\u00a0H, Maingon\u00a0P, Poortmans\u00a0P et al (2015) Whole-breast irradiation with or without a\u00a0boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a\u00a0randomised phase 3 trial. Lancet Oncol 16:47\u201356","journal-title":"Lancet Oncol"},{"key":"1525_CR5","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/cncr.11142","volume":"97","author":"RK Benda","year":"2003","unstructured":"Benda\u00a0RK, Yasuda\u00a0G, Sethi\u00a0A et\u00a0al (2003) Breast boost: are we missing the target? Cancer 97:905\u2013909","journal-title":"Cancer"},{"issue":"Suppl 3","key":"1525_CR6","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1245\/s10434-010-1265-z","volume":"17","author":"E Blank","year":"2010","unstructured":"Blank\u00a0E, Kraus-Tiefenbacher\u00a0U, Welzel\u00a0G et al (2010) Single-center long-term follow-up after intraoperative radiotherapy as a\u00a0boost during breast-conserving surgery using low-kilovoltage x\u2011rays. Ann Surg Oncol 17(Suppl 3):352\u2013358","journal-title":"Ann Surg Oncol"},{"key":"1525_CR7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ijrobp.2013.09.049","volume":"88","author":"DW Chang","year":"2014","unstructured":"Chang\u00a0DW, Te Marvelde\u00a0L, Chua\u00a0BH (2014) Prospective study of local control and late radiation toxicity after intraoperative radiation therapy boost for early breast cancer. Int J Radiat Oncol Biol Phys 88:73\u201379","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1525_CR8","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1016\/j.ejca.2008.07.032","volume":"44","author":"S Collette","year":"2008","unstructured":"Collette\u00a0S, Collette\u00a0L, Budiharto\u00a0T et al (2008) Predictors of the risk of fibrosis at 10 years after breast conserving therapy for early breast cancer: a\u00a0study based on the EORTC Trial 22881-10882 \u2018boost versus no boost\u2019. Eur J Cancer 44:2587\u20132599","journal-title":"Eur J Cancer"},{"key":"1525_CR9","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","volume":"378","author":"S Darby","year":"2011","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group, Darby\u00a0S, Mcgale\u00a0P et al (2011) Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 378:1707\u20131716","journal-title":"Lancet"},{"key":"1525_CR10","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s00404-016-4124-8","volume":"294","author":"F Ebner","year":"2016","unstructured":"Ebner\u00a0F, Schramm\u00a0A, Bottke\u00a0D et\u00a0al (2016) Comparison of seroma production in breast conserving surgery with or without intraoperative radiotherapy as tumour bed boost. Arch Gynecol Obstet 294:861\u2013866","journal-title":"Arch Gynecol Obstet"},{"key":"1525_CR11","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.radonc.2013.05.031","volume":"108","author":"G Fastner","year":"2013","unstructured":"Fastner\u00a0G, Sedlmayer\u00a0F, Merz\u00a0F et\u00a0al (2013) IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: long term results of an ISIORT pooled analysis. Radiother Oncol 108:279\u2013286","journal-title":"Radiother Oncol"},{"key":"1525_CR12","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1002\/1097-0142(19850901)56:5<979::AID-CNCR2820560502>3.0.CO;2-N","volume":"56","author":"R Holland","year":"1985","unstructured":"Holland\u00a0R, Veling\u00a0SH, Mravunac\u00a0M et al (1985) Histologic multifocality of Tis, T1\u20132 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer 56:979\u2013990","journal-title":"Cancer"},{"key":"1525_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011987.pub2","author":"I Kindts","year":"2017","unstructured":"Kindts\u00a0I, Laenen\u00a0A, Depuydt\u00a0T et al (2017) Tumour bed boost radiotherapy for women after breast-conserving surgery. Cochrane Database Syst Rev. \nhttps:\/\/doi.org\/10.1002\/14651858.CD011987.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"1525_CR14","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s00066-018-1413-0","volume":"195","author":"I Kindts","year":"2019","unstructured":"Kindts\u00a0I, Verhoeven\u00a0K, Laenen\u00a0A et al (2019) A\u00a0comparison of a\u00a0brachytherapy and an external beam radiotherapy boost in breast-conserving therapy for breast cancer: local and any recurrences. Strahlenther Onkol 195:310\u2013317","journal-title":"Strahlenther Onkol"},{"key":"1525_CR15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s00066-016-1072-y","volume":"193","author":"HC Kolberg","year":"2017","unstructured":"Kolberg\u00a0HC, Loevey\u00a0G, Akpolat-Basci\u00a0L et al (2017) Targeted intraoperative radiotherapy tumour bed boost during breast-conserving surgery after neoadjuvant chemotherapy. Strahlenther Onkol 193:62\u201369","journal-title":"Strahlenther Onkol"},{"key":"1525_CR16","first-page":"77","volume":"29","author":"U Kraus-Tiefenbacher","year":"2006","unstructured":"Kraus-Tiefenbacher\u00a0U, Bauer\u00a0L, Kehrer\u00a0T et al (2006) Intraoperative radiotherapy (IORT) as a\u00a0boost in patients with early-stage breast cancer\u2014acute toxicity. Onkologie 29:77\u201382","journal-title":"Onkologie"},{"key":"1525_CR17","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ijrobp.2006.05.042","volume":"66","author":"U Kraus-Tiefenbacher","year":"2006","unstructured":"Kraus-Tiefenbacher\u00a0U, Bauer\u00a0L, Scheda\u00a0A et al (2006) Long-term toxicity of an intraoperative radiotherapy boost using low energy X\u2011rays during breast-conserving surgery. Int J Radiat Oncol Biol Phys 66:377\u2013381","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1525_CR18","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1016\/j.ijrobp.2005.10.025","volume":"64","author":"C Lemanski","year":"2006","unstructured":"Lemanski\u00a0C, Azria\u00a0D, Thezenas\u00a0S et al (2006) Intraoperative radiotherapy given as a\u00a0boost for early breast cancer: long-term clinical and cosmetic results. Int J Radiat Oncol Biol Phys 64:1410\u20131415","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1525_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00066-018-1378-z","volume":"195","author":"MD Piroth","year":"2019","unstructured":"Piroth\u00a0MD, Baumann\u00a0R, Budach\u00a0W et\u00a0al (2019) Heart toxicity from breast cancer radiotherapy. Strahlenther Onkol 195:1\u201312","journal-title":"Strahlenther Onkol"},{"key":"1525_CR20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/1748-717X-9-154","volume":"9","author":"E Sperk","year":"2014","unstructured":"Sperk\u00a0E, Astor\u00a0D, Keller\u00a0A et\u00a0al (2014) A cohort analysis to identify eligible patients for intraoperative radiotherapy (IORT) of early breast cancer. Radiat Oncol 9:154","journal-title":"Radiat Oncol"},{"key":"1525_CR21","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/S0360-3016(96)00426-9","volume":"36","author":"I Turesson","year":"1996","unstructured":"Turesson\u00a0I, Nyman\u00a0J, Holmberg\u00a0E et\u00a0al (1996) Prognostic factors for acute and late skin reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys 36:1065\u20131075","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1525_CR22","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/j.ijrobp.2006.07.1378","volume":"66","author":"JS Vaidya","year":"2006","unstructured":"Vaidya\u00a0JS, Baum\u00a0M, Tobias\u00a0JS et\u00a0al (2006) Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a\u00a0boost. Int J Radiat Oncol Biol Phys 66:1335\u20131338","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1525_CR23","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.ijrobp.2010.07.1996","volume":"81","author":"JS Vaidya","year":"2011","unstructured":"Vaidya\u00a0JS, Baum\u00a0M, Tobias\u00a0JS et al (2011) Long-term results of targeted intraoperative radiotherapy (Targit) boost during breast-conserving surgery. Int J Radiat Oncol Biol Phys 81:1091\u20131097","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1525_CR24","first-page":"39","volume":"8","author":"F Wenz","year":"2012","unstructured":"Wenz\u00a0F, Blank\u00a0E, Welzel\u00a0G et al (2012) Intraoperative radiotherapy during breast-conserving surgery using a\u00a0miniature x\u2011ray generator (Intrabeam(R)): theoretical and experimental background and clinical experience. Womens Health 8:39\u201347","journal-title":"Womens Health"},{"key":"1525_CR25","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.ijrobp.2009.06.085","volume":"77","author":"F Wenz","year":"2010","unstructured":"Wenz\u00a0F, Welzel\u00a0G, Blank\u00a0E et al (2010) Intraoperative radiotherapy as a\u00a0boost during breast-conserving surgery using low-kilovoltage X\u2011rays: the first 5 years of experience with a\u00a0novel approach. Int J Radiat Oncol Biol Phys 77:1309\u20131314","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1525_CR26","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.breast.2008.05.009","volume":"17","author":"F Wenz","year":"2008","unstructured":"Wenz\u00a0F, Welzel\u00a0G, Keller\u00a0A et al (2008) Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a\u00a0boost for breast cancer. Breast 17:617\u2013622","journal-title":"Breast"},{"key":"1525_CR27","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1055\/a-0646-4522","volume":"78","author":"A Wockel","year":"2018","unstructured":"Wockel\u00a0A, Festl\u00a0J, Stuber\u00a0T et al (2018) Interdisciplinary screening, diagnosis, therapy and follow-up of breast cancer. Guideline of the DGGG and the DKG (S3-level, AWMF registry number 032\/045OL, december 2017)\u2014part 1 with recommendations for the screening, diagnosis and therapy of breast cancer. Geburtshilfe Frauenheilkd 78:927\u2013948","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"1525_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/tbj.12235","volume":"20","author":"WW Wong","year":"2014","unstructured":"Wong\u00a0WW, Pockaj\u00a0BA, Vora\u00a0SA et al (2014) Six-year outcome of a\u00a0prospective study evaluating tumor bed boost with intra-operative electron irradiation followed by whole-breast irradiation for early-stage breast cancer. Breast\u00a0J 20:125\u2013130","journal-title":"Breast J"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-019-01525-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00066-019-01525-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-019-01525-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T23:09:30Z","timestamp":1603235370000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00066-019-01525-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,22]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["1525"],"URL":"https:\/\/doi.org\/10.1007\/s00066-019-01525-7","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,22]]},"assertion":[{"value":"13 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.\u00a0Pez, A.\u00a0Keller, B.\u00a0Tuschy, and S.\u00a0Berlit declare that they have no competing interests. G.\u00a0Welzel reports non-financial support from Carl Zeiss Meditec AG and personal fees from Roche Pharma AG outside the submitted work. Y.\u00a0Abo-Madyan reports honoraria from Carl-Zeiss Meditec outside the submitted work, honoraria from Merck-Serono outside the submitted work, personal fees from Elekta. M. Ehmann reports travel grants from Carl Zeiss meditec AG outside the submitted work. M. S\u00fctterlin reports personal fees and travel grants from Carl Zeiss Meditec AG outside the submitted work. F.\u00a0Wenz reports personal fees from Celgene GmbH, personal fees from Roche Pharma AG, personal fees from Eli Lilly and Company, personal fees from Ipsen Pharma GmbH, research and travel grants from Carl Zeiss Meditec AG and from ELEKTA AB outside the submitted work. F. Wenz also holds a patent in collaboration with Carl Zeiss Meditec AG. F.A.\u00a0Giordano reports grants and personal fees from NOXXON Pharma AG, grants and personal fees from CARL ZEISS MEDITEC AG, personal fees from Bristol-Myers Squibb, personal fees from Roche Pharma AG, personal fees from MSD Sharp and Dohme GmbH, personal fees from AstraZeneca GmbH, outside the submitted work; F.A. Giordano is the founder of Implacit GmbH, and reports non-financial support (using software for free) from Oncare GmbH; In addition, F.A. Giordano has a patent (US 62\/435405) pending. E. Sperk reports grants from the Ministry for Science and Arts during the conduct of the study; personal fees and travel grants from Zeiss Meditec AG, outside the submitted work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}