{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:53:05Z","timestamp":1772761985951,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Fakult\u00e4t Mannheim der Universit\u00e4t Heidelberg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To assess acute cardiac toxicity caused by intraoperative radiotherapy (IORT) with low-energy x\u2011rays for early breast cancer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We prospectively analyzed pre- and postoperative troponin\u00a0I and NT-proBNP in 94\u00a0women who underwent breast-conserving surgery between 2013 and 2017\u202fat the Department of Gynecology and Obstetrics of the University Medical Center Mannheim, Germany. Thirty-nine women received IORT using low-energy x\u2011rays during breast-conserving surgery while 55\u00a0patients without IORT formed the control group. Demographic and surgical parameters as well as cardiac markers were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were no significant differences concerning age and side of breast cancer between the groups. Furthermore, no significant difference between the troponin\u00a0I assays of the IORT and control groups could be found (preoperatively: 0.017\u202f\u00b1\u20090.006\u202fng\/ml vs. 0.018\u202f\u00b1\u20090.008\u202fng\/ml; <jats:italic>p<\/jats:italic>\u202f=\u20090.5105; postoperatively: 0.019\u202f\u00b1\u20090.012\u202fng\/ml vs. 0.018\u202f\u00b1\u20090.010\u202fng\/ml; <jats:italic>p<\/jats:italic>\u202f=\u20090.6225). N\u2011terminal fragment of B\u2011type natriuretic peptide (NT-proBNP) was significantly higher in the control group 24\u202fh after surgery (preoperatively: 158.154\u202f\u00b1\u2009169.427\u202fpg\/ml vs. 162.109\u202f\u00b1\u2009147.343\u202fpg\/ml; <jats:italic>p<\/jats:italic>\u202f=\u20090.56; postoperatively: 168.846\u202f\u00b1\u2009160.227\u202fpg\/ml vs. 232.527\u202f\u00b1\u2009188.957\u202fpg\/ml; <jats:italic>p<\/jats:italic>\u202f=\u20090.0279).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Troponin\u00a0I levels as a\u00a0marker of acute cardiac toxicity did not show any significant differences in patients who received IORT during breast-conserving surgery compared to those who did not.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00066-020-01671-3","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T11:02:41Z","timestamp":1597834961000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac serum marker alterations after intraoperative radiotherapy with low-energy x-rays in early breast cancer as an indicator of possible cardiac toxicity"],"prefix":"10.1007","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9652-6036","authenticated-orcid":false,"given":"Stefan","family":"Stefanovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-4480","authenticated-orcid":false,"given":"Sebastian","family":"Berlit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8771-8124","authenticated-orcid":false,"given":"Elena","family":"Sperk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6037-0853","authenticated-orcid":false,"given":"Frederik","family":"Wenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-5690","authenticated-orcid":false,"given":"Christel","family":"Wei\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5877-877X","authenticated-orcid":false,"given":"Frederik","family":"Trinkmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-2552","authenticated-orcid":false,"given":"Marc","family":"S\u00fctterlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9179-3277","authenticated-orcid":false,"given":"Benjamin","family":"Tuschy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"issue":"S3","key":"1671_CR1","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1245\/s10434-010-1265-z","volume":"17","author":"E Blank","year":"2010","unstructured":"Blank\u00a0E, Kraus-Tiefenbacher\u00a0U, Welzel\u00a0G et al (2010) Single-center long-term follow-up after Intraoperative radiotherapy as a\u00a0boost during breast-conserving surgery using low-kilovoltage X\u2011rays. 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