{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:57:08Z","timestamp":1791266228417,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012681","name":"Universit\u00e4tsklinikum K\u00f6ln","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012681","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Consolidation brachytherapy is a\u00a0critical treatment component for cervical cancer patients undergoing primary chemoradiation. Some patients are unsuitable for brachytherapy for a\u00a0variety of reasons. The use of alternatives (LINAC-based stereotactic radiosurgery or external beam boosts) compromise oncologic results in cervical cancer patients. Thus, we evaluated the value of brachytherapy-like doses prescriptions using robotic radiosurgery (CyberKnife\u00ae, CR, Acuuray, Sunnyvale, CA, USA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>From 06\/2011 to 06\/2015, 31\u00a0patients (median age 53\u00a0years; range 30\u201377\u00a0years) with histologically proven FIGO stages IB-IVB cervical cancer underwent primary chemoradiation. All patients were either not suitable for intracervical brachytherapy for a\u00a0variety of reasons or refused the brachytherapy. To achieve an adequate dose within the tumor, a\u00a0CK boost was applied after fiducial implantation. In 29\u00a0patients, a\u00a0dose of either five times 6\u202fGy or five times 5\u202fGy was prescribed to the target volume. Two patients received three times 5\u202fGy. The target dose was prescribed to the 70% isodose. Treatment toxicity was documented once weekly regarding vaginal mucositis, bladder, and bowel irritation according to CTCAE v.\u00a04.03. If possible 3\u00a0months after completion of treatment intracervical curettage was performed to exclude residual tumor and the patients were followed up clinically. Sparing of organs at risk (OAR) and outcome in terms of local control (LC), overall survival (OS), and progression-free survival (PFS) were assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 31\u00a0patients, 30 have completed CK boost therapy. The median follow-up time was 40\u00a0months (range 5\u201384\u00a0months). General treatment tolerability was good. Except for 1\u00a0patient, who had diarrhea grade\u00a03, no treatment related side effects above grade\u00a02 were reported. Sparing of OAR was excellent. The 1\u2011, 3\u2011, and 5\u2011year OS rates were 89, 60, and 57% respectively across all stages. Seven patients showed progression (28%), only two of them with local relapse (8%), resulting in an LC rate of 92% after 3 and 5\u00a0years. Mean PFS was 41\u00a0months (range 2\u201384\u00a0months). Patients with local recurrence had PFS of 5\u00a0and 8\u00a0months. Five patients developed distant metastases. Fifteen patients (48%) underwent intracervical curettage 3\u00a0months after completion of treatment of which 14\u00a0(93%) had complete pathologic response.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Brachytherapy remains the standard of care for patients diagnosed with cervical cancer and indication for primary chemoradiation. In terms of local control, CyberKnife\u00ae-based boost concepts provide excellent local control. It can be an alternative for patients who cannot receive adequate brachytherapy. Distant relapse still remains a\u00a0challenge in this context.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00066-020-01685-x","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T14:02:49Z","timestamp":1600956169000},"page":"474-486","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long-term results of robotic radiosurgery for non brachytherapy patients with cervical cancer"],"prefix":"10.1007","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-2170","authenticated-orcid":false,"given":"Janis","family":"Morgenthaler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christhardt","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Budach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalid","family":"Sehouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Stromberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Besserer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Trommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Baues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Marnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"issue":"2","key":"1685_CR1","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.ijrobp.2010.12.029","volume":"82","author":"P Georg","year":"2012","unstructured":"Georg\u00a0P, P\u00f6tter\u00a0R, Georg\u00a0D, Lang\u00a0S, Dimopoulos\u00a0JCA, Sturdza\u00a0AE et al (2012) Dose effect relationship for late side effects of the rectum and urinary bladder in magnetic resonance image-guided adaptive cervix cancer brachytherapy. 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