{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:02:10Z","timestamp":1790787730928,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00066-021-01800-6","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T07:02:49Z","timestamp":1624431769000},"page":"847-853","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inoperable CASTLE of the thyroid gland treated with radical radiotherapy with complete remission"],"prefix":"10.1007","volume":"197","author":[{"given":"Petra","family":"Kov\u00e1\u0159ov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-7927","authenticated-orcid":false,"given":"Radovan","family":"Vojt\u00ed\u0161ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kr\u010dma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Daum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Baxa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Em\u00edlia","family":"Sukovsk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jind\u0159ich","family":"F\u00ednek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"issue":"1","key":"1800_CR1","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1002\/hed.24985","volume":"40","author":"EHC Wong","year":"2018","unstructured":"Wong\u00a0EHC, Tetter\u00a0N, Tzankov\u00a0A, Muller\u00a0L (2018) CASTLE tumor of the parotid: first documented case, literature review, and genetic analysis of the cancer. Head Neck 40(1):E1\u2013E4","journal-title":"Head Neck"},{"issue":"1","key":"1800_CR2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s12253-014-9772-z","volume":"21","author":"G Zhang","year":"2015","unstructured":"Zhang\u00a0G, Liu\u00a0X, Huang\u00a0W et al (2015) Carcinoma showing thymus-like elements of the thyroid gland: report of three cases including one case with breast cancer history. Pathol Oncol Res 21(1):45\u201351","journal-title":"Pathol Oncol Res"},{"issue":"4","key":"1800_CR3","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0046-8177(91)90083-2","volume":"22","author":"JK Chan","year":"1991","unstructured":"Chan\u00a0JK, Rosai\u00a0J (1991) Tumors of the neck showing thymic or related branchial pouch differentiation: a\u00a0unifying concept. Hum Pathol 22(4):349\u2013367","journal-title":"Hum Pathol"},{"issue":"1","key":"1800_CR4","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/BF01656263","volume":"9","author":"A Miyauchi","year":"1985","unstructured":"Miyauchi\u00a0A, Kuma\u00a0K, Matsuzuka\u00a0F et\u00a0al (1985) Intrathyroidal epithelial thymoma: an entity distinct from squamous cell carcinoma of the thyroid. World J Surg 9(1):128\u2013135","journal-title":"World J Surg"},{"issue":"5","key":"1800_CR5","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1001\/archotol.134.5.536","volume":"134","author":"KT Robbins","year":"2008","unstructured":"Robbins\u00a0KT, Shaha\u00a0AR, Medina\u00a0JE et\u00a0al (2008) Consensus statement on the classification and terminology of neck dissection. Arch Otolaryngol Head Neck Surg 134(5):536\u2013538","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1800_CR6","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3389\/fonc.2018.00477","volume":"8","author":"R Gao","year":"2018","unstructured":"Gao\u00a0R, Jia\u00a0X, Ji\u00a0T et al (2018) Management and prognostic factors for thyroid carcinoma showing thymus-like elements (CASTLE): a\u00a0case series study. Front Oncol 8:477","journal-title":"Front Oncol"},{"issue":"10","key":"1800_CR7","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/hed.20237","volume":"27","author":"CM Luo","year":"2005","unstructured":"Luo\u00a0CM, Hsueh\u00a0C, Chen\u00a0TM (2005) Extrathyroid carcinoma showing thymus-like differentiation (CASTLE) tumor\u2011a new case report and review of literature. Head Neck 27(10):927\u2013933","journal-title":"Head Neck"},{"key":"1800_CR8","first-page":"96","volume-title":"Pathology and genetics of tumours of endocrine organs","author":"W Cheuk","year":"2004","unstructured":"Cheuk\u00a0W, Chan\u00a0JKC, Dorfman\u00a0DM, Giordano\u00a0T (2004) Carcinoma showing thymus-like differentiation. In: Delellis\u00a0RA, Lloyd\u00a0RV, Heitz\u00a0PU, Eng\u00a0C (eds) Pathology and genetics of tumours of endocrine organs. IARC Press, Lyon, pp 96\u201397"},{"key":"1800_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4103\/0973-0354.168895","volume":"13","author":"VR Patil","year":"2016","unstructured":"Patil\u00a0VR, Patel\u00a0K, Muzumdar\u00a0G (2016) Carcinoma showing thymus like differentiation (CASTLE)\u2014A rare thyroid neoplasm. Thyroid Res Pract 13:71\u201373","journal-title":"Thyroid Res Pract"},{"issue":"2","key":"1800_CR10","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1309\/VM7E52B6U9Q729DQ","volume":"127","author":"Y Ito","year":"2007","unstructured":"Ito\u00a0Y, Miyauchi\u00a0A, Nakamura\u00a0Y et al (2007) Clinicopathologic significance of intrathyroidal epithelial thymoma\/carcinoma showing thymus-like differentiation: a\u00a0collaborative study with Member Institutes of The Japanese Society of Thyroid Surgery. Am J Clin Pathol 127(2):230\u2013236","journal-title":"Am J Clin Pathol"},{"key":"1800_CR11","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.06.2009.1937","author":"CM Steger","year":"2009","unstructured":"Steger\u00a0CM, von Frankenberg\u00a0M, Kahlert\u00a0C et\u00a0al (2009) CASTLE tumour of the neck: a\u00a0rare location of a\u00a0malignant tumour of the thymus. BMJ Case Rep. https:\/\/doi.org\/10.1136\/bcr.06.2009.1937","journal-title":"BMJ Case Rep"},{"issue":"2","key":"1800_CR12","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.3892\/ol.2015.4055","volume":"11","author":"W Ge","year":"2016","unstructured":"Ge\u00a0W, Yao\u00a0YZ, Chen\u00a0G, Ding\u00a0YT (2016) Clinical analysis of 82\u00a0cases of carcinoma showing thymus-like differentiation of the thyroid. Oncol Lett 11(2):1321\u20131326","journal-title":"Oncol Lett"},{"issue":"1060","key":"1800_CR13","doi-asserted-by":"publisher","first-page":"20150726","DOI":"10.1259\/bjr.20150726","volume":"89","author":"B Wu","year":"2016","unstructured":"Wu\u00a0B, Sun\u00a0T, Gu\u00a0Y et al (2016) CT and MR imaging of thyroid carcinoma showing thymus-like differentiation (CASTLE): a\u00a0report of ten cases. Br J Radiol 89(1060):20150726","journal-title":"Br J Radiol"},{"issue":"2","key":"1800_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.9738\/INTSURG-D-12-00034.1","volume":"98","author":"Z Liu","year":"2013","unstructured":"Liu\u00a0Z, Teng\u00a0XY, Sun\u00a0DX et al (2013) Clinical analysis of thyroid carcinoma showing thymus-like differentiation: report of 8\u00a0cases. Int Surg 98(2):95\u2013100","journal-title":"Int Surg"},{"issue":"12","key":"1800_CR15","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1089\/thy.2005.15.1383","volume":"15","author":"N Kusada","year":"2005","unstructured":"Kusada\u00a0N, Hara\u00a0Y, Kobayashi\u00a0S et al (2005) A case of aggressive carcinoma showing thymus-like differentiation with distant metastases. Thyroid 15(12):1383\u20131388","journal-title":"Thyroid"},{"issue":"10","key":"1800_CR16","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/hed.20237","volume":"27","author":"CM Luo","year":"2005","unstructured":"Luo\u00a0CM, Hsueh\u00a0C, Chen\u00a0TM (2005) Extrathyroid carcinoma showing thymus-like differentiation (CASTLE) tumor\u2014A new case report and review of literature. Head Neck 27(10):927\u2013933","journal-title":"Head Neck"},{"issue":"9","key":"1800_CR17","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/j.0303-6987.2004.00235.x","volume":"31","author":"IB Bayer-Garner","year":"2004","unstructured":"Bayer-Garner\u00a0IB, Kozovska\u00a0ME, Schwartz\u00a0MR, Reed\u00a0JA (2004) Carcinoma with thymus-like differentiation arising in the dermis of the head and neck. J\u00a0Cutan Pathol 31(9):625\u2013629","journal-title":"J Cutan Pathol"},{"key":"1800_CR18","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00066-014-0740-z","volume":"191","author":"M H\u00e4fner","year":"2015","unstructured":"H\u00e4fner\u00a0M, Roeder\u00a0F, Sterzing\u00a0F et\u00a0al (2015) Postoperative radiotherapy of patients with thymic epithelial tumors (TET). Strahlenther Onkol 191:133\u2013140","journal-title":"Strahlenther Onkol"},{"issue":"20","key":"1800_CR19","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.12659\/AJCR.919208","volume":"10","author":"ACH Fung","year":"2019","unstructured":"Fung\u00a0ACH, Tsang\u00a0JS, Lang\u00a0BHH (2019) Thyroid carcinoma showing thymus-like differentiation (CASTLE) with tracheal invasion: a case report. Am J Case Rep 10(20):1845\u20131851","journal-title":"Am J Case Rep"},{"issue":"49","key":"1800_CR20","doi-asserted-by":"publisher","first-page":"81899","DOI":"10.18632\/oncotarget.11914","volume":"7","author":"F Kong","year":"2016","unstructured":"Kong\u00a0F, Ying\u00a0H, Zhai\u00a0R et al (2016) Clinical outcome of intensity modulated radiotherapy for carcinoma showing thymus-like differentiation. Oncotarget 7(49):81899\u201381905","journal-title":"Oncotarget"},{"issue":"1","key":"1800_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ejso.2006.09.016","volume":"33","author":"SM Chow","year":"2007","unstructured":"Chow\u00a0SM, Chan\u00a0JK, Tse\u00a0LL et al (2007) Carcinoma showing thymus-like element (CASTLE) of thyroid: combined modality treatment in 3\u00a0patients with locally advanced disease. Eur J Surg Oncol 33(1):83\u201385","journal-title":"Eur J Surg Oncol"},{"key":"1800_CR22","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.12659\/AJCR.917982","volume":"20","author":"J Kropf","year":"2019","unstructured":"Kropf\u00a0J, Castaneira\u00a0G, Luc\u00a0LT et\u00a0al (2019) A case of thymic carcinoma with bone and cerebral metastases treated with stereotactic radiosurgery and chemotherapy. Am J Case Rep 20:1669\u20131674","journal-title":"Am J Case Rep"},{"issue":"11","key":"1800_CR23","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1007\/s00595-013-0560-2","volume":"43","author":"H Tsutsui","year":"2013","unstructured":"Tsutsui\u00a0H, Hoshi\u00a0M, Kubota\u00a0M et al (2013) Management of thyroid carcinoma showing thymus-like differentiation (CASTLE) invading the trachea. Surg Today 43(11):1261\u20131268","journal-title":"Surg Today"},{"key":"1800_CR24","unstructured":"NCCN NCCN guidelines version 1.2021. Thymomas and thymic carcinomas. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/thymic.pdf. Accessed: 20 Feb 2021"},{"issue":"2","key":"1800_CR25","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/bjs.4510","volume":"91","author":"S Roka","year":"2004","unstructured":"Roka\u00a0S, Kornek\u00a0G, Sch\u00fcller\u00a0J et al (2004) Carcinoma showing thymic-like elements\u2014A rare malignancy of the thyroid gland. Br J Surg 91(2):142\u2013145","journal-title":"Br J Surg"},{"issue":"8","key":"1800_CR26","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1089\/thy.2015.0155","volume":"25","author":"T Hanamura","year":"2015","unstructured":"Hanamura\u00a0T, Ito\u00a0K, Uehara\u00a0T et al (2015) Chemosensitivity in carcinoma showing thymus-like differentiation: a case report and review of the literature. Thyroid 25(8):969\u2013972","journal-title":"Thyroid"},{"issue":"36","key":"1800_CR27","doi-asserted-by":"publisher","first-page":"4820","DOI":"10.1200\/JCO.2011.36.0487","volume":"29","author":"RJ Kelly","year":"2011","unstructured":"Kelly\u00a0RJ, Petrini\u00a0I, Rajan\u00a0A et\u00a0al (2011) Thymic malignancies: from clinical management to targeted therapies. J\u00a0Clin Oncol 29(36):4820\u20134827","journal-title":"J Clin Oncol"},{"issue":"6","key":"1800_CR28","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/modpathol.2017.6","volume":"30","author":"A Weissferdt","year":"2017","unstructured":"Weissferdt\u00a0A, Fujimoto\u00a0J, Kalhor\u00a0N et al (2017) Expression of PD\u20111 and PD-L1 in thymic epithelial neoplasms. Mod Pathol 30(6):826\u2013833","journal-title":"Mod Pathol"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-021-01800-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00066-021-01800-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-021-01800-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T15:59:51Z","timestamp":1631894391000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00066-021-01800-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,23]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["1800"],"URL":"https:\/\/doi.org\/10.1007\/s00066-021-01800-6","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,23]]},"assertion":[{"value":"26 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"P.\u00a0Kov\u00e1\u0159ov\u00e1, R.\u00a0Vojt\u00ed\u0161ek, M.\u00a0Kr\u010dma, O.\u00a0Daum, J.\u00a0Baxa,E.\u00a0Sukovsk\u00e1 and J.\u00a0F\u00ednek declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}