{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:56:38Z","timestamp":1790758598271,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s00066-021-01870-6","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T17:02:34Z","timestamp":1637082154000},"page":"150-158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adjuvant brachytherapy for oral squamous cell carcinomas: a\u00a0single-center experience comparing low-dose and pulsed-dose-rate techniques"],"prefix":"10.1007","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2302-9992","authenticated-orcid":false,"given":"Pierre","family":"Mattei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilien","family":"Chabrillac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastien","family":"Cabarrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Dupret-Bories","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Vergez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Sarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Piram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouchka","family":"Modesto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"1870_CR1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","volume":"45","author":"S Warnakulasuriya","year":"2009","unstructured":"Warnakulasuriya\u00a0S (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45:309\u2013316. https:\/\/doi.org\/10.1016\/j.oraloncology.2008.06.002","journal-title":"Oral Oncol"},{"key":"1870_CR2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3322\/caac.21384","volume":"67","author":"KD Shield","year":"2017","unstructured":"Shield\u00a0KD, Ferlay\u00a0J, Jemal\u00a0A, Sankaranarayanan\u00a0R, Chaturvedi\u00a0AK, Bray\u00a0F et\u00a0al (2017) The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin 67:51\u201364. https:\/\/doi.org\/10.3322\/caac.21384","journal-title":"CA Cancer J Clin"},{"key":"1870_CR3","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1002\/cncr.31531","volume":"124","author":"E Fridman","year":"2018","unstructured":"Fridman\u00a0E, Na\u2019ara\u00a0S, Agarwal\u00a0J, Amit\u00a0M, Bachar\u00a0G, Villaret\u00a0AB et al (2018) The role of adjuvant treatment in early-stage oral cavity squamous cell carcinoma: an international collaborative study. Cancer 124:2948\u20132955. https:\/\/doi.org\/10.1002\/cncr.31531","journal-title":"Cancer"},{"key":"1870_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1177\/0194599819839006","volume":"161","author":"MG Bulbul","year":"2019","unstructured":"Bulbul\u00a0MG, Tarabichi\u00a0O, Sethi\u00a0RK, Parikh\u00a0AS, Varvares\u00a0MA (2019) Does clearance of positive margins improve local control in oral cavity cancer? A meta-analysis. Otolaryngol Head Neck Surg 161:235\u2013244. https:\/\/doi.org\/10.1177\/0194599819839006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"1870_CR5","doi-asserted-by":"publisher","first-page":"581","DOI":"10.5114\/jcb.2017.72607","volume":"9","author":"J Skowronek","year":"2017","unstructured":"Skowronek\u00a0J (2017) Current status of brachytherapy in cancer treatment\u2014short overview. J\u00a0Contemp Brachytherapy 9:581\u2013589. https:\/\/doi.org\/10.5114\/jcb.2017.72607","journal-title":"J Contemp Brachytherapy"},{"key":"1870_CR6","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.canrad.2013.01.007","volume":"17","author":"M Lapeyre","year":"2013","unstructured":"Lapeyre\u00a0M, Coche-Dequ\u00e9ant\u00a0B, Moreira\u00a0J\u2011F, Le Bourhis\u00a0J, Peiffert\u00a0D (2013) Brachytherapy for head and neck cancers. Cancer Radiother 17:130\u2013135. https:\/\/doi.org\/10.1016\/j.canrad.2013.01.007","journal-title":"Cancer Radiother"},{"key":"1870_CR7","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.semradonc.2020.02.002","volume":"30","author":"CC Foster","year":"2020","unstructured":"Foster\u00a0CC, Fan\u00a0M, Lee\u00a0NY, Yom\u00a0SS, Heaton\u00a0CM, Deraniyagala\u00a0R et\u00a0al (2020) Is it worth it? Consequences of definitive head and neck reirradiation. Semin Radiat Oncol 30:212\u2013217. https:\/\/doi.org\/10.1016\/j.semradonc.2020.02.002","journal-title":"Semin Radiat Oncol"},{"key":"1870_CR8","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.semradonc.2019.08.007","volume":"30","author":"CC Vu","year":"2020","unstructured":"Vu\u00a0CC, Jawad\u00a0MS, Krauss\u00a0DJ (2020) The cost-effectiveness and value proposition of brachytherapy. Semin Radiat Oncol 30:87\u201393. https:\/\/doi.org\/10.1016\/j.semradonc.2019.08.007","journal-title":"Semin Radiat Oncol"},{"key":"1870_CR9","doi-asserted-by":"publisher","first-page":"323","DOI":"10.5114\/jcb.2017.69806","volume":"9","author":"A Kazemian","year":"2017","unstructured":"Kazemian\u00a0A, Babaei\u00a0M, Lashkari\u00a0M, Ghalehtaki\u00a0R, Garajei\u00a0A, Motiee-Langroudi\u00a0M et al (2017) Adjuvant high-dose-rate brachytherapy in the management of oral cavity cancers: 5\u00a0years of experience in Iran. J\u00a0Contemp Brachytherapy 9:323\u2013329. https:\/\/doi.org\/10.5114\/jcb.2017.69806","journal-title":"J Contemp Brachytherapy"},{"key":"1870_CR10","doi-asserted-by":"publisher","first-page":"813","DOI":"10.7314\/apjcp.2014.15.2.813","volume":"15","author":"BK Mohanti","year":"2014","unstructured":"Mohanti\u00a0BK, Sahai\u00a0P, Thakar\u00a0A, Sikka\u00a0K, Bhasker\u00a0S, Sharma\u00a0A et al (2014) Institutional experience of interstitial brachytherapy for head and neck cancer with a\u00a0comparison of high- and low dose rate practice. Asian Pac J Cancer Prev 15:813\u2013818. https:\/\/doi.org\/10.7314\/apjcp.2014.15.2.813","journal-title":"Asian Pac J Cancer Prev"},{"key":"1870_CR11","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.brachy.2009.08.007","volume":"9","author":"J Skowronek","year":"2010","unstructured":"Skowronek\u00a0J, Malicki\u00a0J, Piotrowski\u00a0T (2010) Values of biologically equivalent doses in healthy tissues: comparison of PDR and HDR brachytherapy techniques. Brachytherapy 9:165\u2013170. https:\/\/doi.org\/10.1016\/j.brachy.2009.08.007","journal-title":"Brachytherapy"},{"key":"1870_CR12","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/s0167-8140(03)00055-0","volume":"68","author":"N Kakimoto","year":"2003","unstructured":"Kakimoto\u00a0N, Inoue\u00a0T, Inoue\u00a0T, Murakami\u00a0S, Furukawa\u00a0S, Yoshida\u00a0K et al (2003) Results of low- and high-dose-rate interstitial brachytherapy for T3 mobile tongue cancer. Radiother Oncol 68:123\u2013128. https:\/\/doi.org\/10.1016\/s0167-8140(03)00055-0","journal-title":"Radiother Oncol"},{"key":"1870_CR13","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.brachy.2013.07.002","volume":"12","author":"V Strnad","year":"2013","unstructured":"Strnad\u00a0V, Lotter\u00a0M, Kreppner\u00a0S, Fietkau\u00a0R (2013) Interstitial pulsed-dose-rate brachytherapy for head and neck cancer\u2014single-institution long-term results of 385\u00a0patients. Brachytherapy 12:521\u2013527. https:\/\/doi.org\/10.1016\/j.brachy.2013.07.002","journal-title":"Brachytherapy"},{"key":"1870_CR14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00066-014-0809-8","volume":"191","author":"V Strnad","year":"2015","unstructured":"Strnad\u00a0V, Lotter\u00a0M, Kreppner\u00a0S, Fietkau\u00a0R (2015) Reirradiation for recurrent head and neck cancer with salvage interstitial pulsed-dose-rate brachytherapy: long-term results. Strahlenther Onkol 191:495\u2013500. https:\/\/doi.org\/10.1007\/s00066-014-0809-8","journal-title":"Strahlenther Onkol"},{"key":"1870_CR15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.critrevonc.2019.08.003","volume":"143","author":"E Ivaldi","year":"2019","unstructured":"Ivaldi\u00a0E, Di Mario\u00a0D, Paderno\u00a0A, Piazza\u00a0C, Bossi\u00a0P, Iacovelli\u00a0NA et al (2019) Postoperative radiotherapy (PORT) for early oral cavity cancer (pT1\u20112,N0-1): a review. Crit Rev Oncol Hematol 143:67\u201375. https:\/\/doi.org\/10.1016\/j.critrevonc.2019.08.003","journal-title":"Crit Rev Oncol Hematol"},{"key":"1870_CR16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.brachy.2014.09.011","volume":"14","author":"A Goineau","year":"2015","unstructured":"Goineau\u00a0A, Piot\u00a0B, Malard\u00a0O, Ferron\u00a0C, Lisbona\u00a0A, Cassagnau\u00a0E et\u00a0al (2015) Postoperative interstitial brachytherapy for resectable squamous cell carcinoma of the tongue. Brachytherapy 14:71\u201376. https:\/\/doi.org\/10.1016\/j.brachy.2014.09.011","journal-title":"Brachytherapy"},{"key":"1870_CR17","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.brachy.2014.08.050","volume":"14","author":"J Petera","year":"2015","unstructured":"Petera\u00a0J, Sir\u00e1k\u00a0I, Laco\u00a0J, Ka\u0161aov\u00e1\u00a0L, Tu\u010dek\u00a0L, Dole\u017ealov\u00e1\u00a0H (2015) High-dose-rate brachytherapy in early oral cancer with close or positive margins. Brachytherapy 14:77\u201383. https:\/\/doi.org\/10.1016\/j.brachy.2014.08.050","journal-title":"Brachytherapy"},{"key":"1870_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2020.10.008","author":"\u00d6 Ferenczi","year":"2020","unstructured":"Ferenczi \u00d6, Major\u00a0T, Akiyama\u00a0H, Fr\u00f6hlich\u00a0G, Oberna\u00a0F, R\u00e9v\u00e9sz\u00a0M et\u00a0al (2020) Results of postoperative interstitial brachytherapy of resectable floor of mouth tumors. Brachytherapy. https:\/\/doi.org\/10.1016\/j.brachy.2020.10.008","journal-title":"Brachytherapy"},{"key":"1870_CR19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00066-007-1613-5","volume":"183","author":"F Ayukawa","year":"2007","unstructured":"Ayukawa\u00a0F, Shibuya\u00a0H, Yoshimura\u00a0R, Watanabe\u00a0H, Miura\u00a0M (2007) Curative brachytherapy for recurrent\/residual tongue cancer. Strahlenther Onkol 183:133\u2013137. https:\/\/doi.org\/10.1007\/s00066-007-1613-5","journal-title":"Strahlenther Onkol"},{"key":"1870_CR20","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1002\/hed.23387","volume":"36","author":"S Ch\u2019ng","year":"2014","unstructured":"Ch\u2019ng\u00a0S, Oates\u00a0J, Gao\u00a0K, Foo\u00a0K, Davies\u00a0S, Brunner\u00a0M et\u00a0al (2014) Prospective quality of life assessment between treatment groups for oral cavity squamous cell carcinoma. Head Neck 36:834\u2013840. https:\/\/doi.org\/10.1002\/hed.23387","journal-title":"Head Neck"},{"key":"1870_CR21","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/s0360-3016(00)00538-1","volume":"48","author":"M Lapeyre","year":"2000","unstructured":"Lapeyre\u00a0M, Hoffstetter\u00a0S, Peiffert\u00a0D, Gu\u00e9rif\u00a0S, Maire\u00a0F, Dolivet\u00a0G et al (2000) Postoperative brachytherapy alone for T1\u20112 N0 squamous cell carcinomas of the oral tongue and floor of mouth with close or positive margins. Int J Radiat Oncol Biol Phys 48:37\u201342. https:\/\/doi.org\/10.1016\/s0360-3016(00)00538-1","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1870_CR22","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1002\/hed.26176","volume":"42","author":"LL de Souza","year":"2020","unstructured":"de Souza\u00a0LL, Pontes\u00a0HAR, Santos-Silva\u00a0AR, Fernandes\u00a0LA, Batista\u00a0LAL, Lopes\u00a0MA et al (2020) Oral radiation-induced sarcomas: systematic review. Head Neck 42:2660\u20132668. https:\/\/doi.org\/10.1002\/hed.26176","journal-title":"Head Neck"},{"key":"1870_CR23","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1159\/000366294","volume":"7","author":"H Horiguchi","year":"2014","unstructured":"Horiguchi\u00a0H, Takada\u00a0K, Kamihara\u00a0Y, Ibata\u00a0S, Iyama\u00a0S, Sato\u00a0T et al (2014) Radiation-induced leiomyosarcoma of the prostate after brachytherapy for prostatic adenocarcinoma. Case Rep Oncol 7:565\u2013570. https:\/\/doi.org\/10.1159\/000366294","journal-title":"Case Rep Oncol"},{"key":"1870_CR24","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s13246-021-01002-5","volume":"44","author":"M Mazonakis","year":"2021","unstructured":"Mazonakis\u00a0M, Lyraraki\u00a0E, Damilakis\u00a0J (2021) Lifetime radiation-induced sarcoma risk in patients subjected to IMRT or VMAT for uterine cervix carcinoma. Phys Eng Sci Med 44:573\u2013579. https:\/\/doi.org\/10.1007\/s13246-021-01002-5","journal-title":"Phys Eng Sci Med"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-021-01870-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00066-021-01870-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-021-01870-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T13:05:55Z","timestamp":1643115955000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00066-021-01870-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,16]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["1870"],"URL":"https:\/\/doi.org\/10.1007\/s00066-021-01870-6","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,16]]},"assertion":[{"value":"27 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"P.\u00a0Mattei, E.\u00a0Chabrillac, B.\u00a0Cabarrou, A.\u00a0Dupret-Bories, S.\u00a0Vergez, J.\u00a0Sarini, R.\u00a0Lopez, L.\u00a0Piram, and T.\u00a0Brun declare that they have no competing interests. A.\u00a0Modesto received research funding from Astra Zeneca, participated in advisory boards of Merck Serono and Astra Zeneca, received honoraria from BMS and Bayer, and travel accommodations from BMS and Merck Serono.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}