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This is put into context with the unsuccessful treatment of the laryngeal cancer (LC) of the German emperor Frederick\u00a0III and its historical consequences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The three-step process consisted in the analysis of (1)\u00a0historical sources of the development of ORL radiotherapy from the discovery of x\u2011rays and radioactivity until World War\u00a0I, (2)\u00a0course and treatment of Frederick\u2019s\u00a0III LC, (3)\u00a0political context with a\u00a0special focus on the escalation towards World War\u00a0I. Pertinent historical illustrations of technical developments of radiotherapy were summarized in a\u00a0video.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>ORL radiotherapy initiated on 03\u00a0February\u00a01896, only 65\u00a0days after the discovery of X\u2011rays. By 1914, organ-sparing LC radiotherapy was established with a\u00a0predominance of curietherapy over roentgentherapy. Correct diagnosis of Frederick\u00a0III\u2019s primarily radiocurable cT1a glottic LC was delayed by one year, which resulted in advancement to a\u00a0fatal pT4 pN1 Mx tumour stage. Historically, his successor, William\u00a0II, was assumed to have contributed to the causes of World War\u00a0I.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>ORL radiotherapy came only eight years late to treat Frederick\u00a0III who might have impeded World War\u00a0I. This illustrates the potential impact of modern curative radiotherapy on the future course of public life beyond the personal fate of the patient himself.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00066-022-01902-9","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T11:04:41Z","timestamp":1644577481000},"page":"325-333","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["125\u00a0years of head and neck radiotherapy: could organ-sparing radiotherapy of larynx cancer have prevented World War\u00a0I?"],"prefix":"10.1007","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-2820","authenticated-orcid":false,"given":"Thomas B.","family":"Brunner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"W\u00f6rdehoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5557-7438","authenticated-orcid":false,"given":"Ahmed","family":"Gawish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Busch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"1902_CR1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.oraloncology.2018.10.004","volume":"86","author":"MR Bonomi","year":"2018","unstructured":"Bonomi\u00a0MR, Blakaj\u00a0A, Blakaj\u00a0D (2018) Organ preservation for advanced larynx cancer: A review of chemotherapy and radiation combination strategies. 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