{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T14:15:05Z","timestamp":1794492905497,"version":"4.9.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Axillary management remains unclear when sentinel lymph node (SLN) results are positive in cN0\u00a0patients with breast cancer (BC). The trial ACOSOG Z0011 represented a\u00a0revolution with axillary lymph node dissection (ALND) omission in SLN+ patients, despite critiques regarding non-uniformity of radiation fields. We conducted an observational study (LISEN) where whole breast radiotherapy (WBRT) was planned with tangential fields without nodal irradiation in patients eligible for the Z0011 trial.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Inclusion criteria were female patients with histologically proven BC, cT1-2cN0, planned conservative surgery, no neoadjuvant therapy. Patients were stratified into two groups: micrometastatic (pN1mic, group\u00a01) and macrometastatic (pN1a, group\u00a02) lymph nodes. Tangential field WBRT was mandatory. Clinical outcomes were analysed, measured from surgery until the first event.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In all, 199\u00a0patients underwent conservative surgery and SLN biopsy; 133\u00a0patients meeting criteria were analysed: 41\u00a0patients (30.8%) pN1mic and\u00a092 (69.2%) pN1a. The 5\u2011year disease-free survival (DFS) was 95.0% (85.9\u2013100%) in group\u00a01 and 93.0% (86.3\u2013100.0%) in group\u00a02 (<jats:italic>p<\/jats:italic>\u202f=\u20090.78). Overall survival (OS) was 100% (100\u2013100%) in group\u00a01 and 97.4% (92.4\u2013100%) in group\u00a02 (<jats:italic>p<\/jats:italic>\u202f=\u20090.74). For the whole cohort DFS and OS were 93.6% (88.2\u201399.4%) and 96.9% (91.5\u2013100.0%), respectively. For groups\u00a01 and\u00a02, the 5\u2011year outcomes were 5.0% (0.0\u201314.4%) and 2.3% (0.0\u20136.1%) for local recurrence (<jats:italic>p<\/jats:italic>\u202f=\u20090.51), and 6.2% (0.0\u201317.4%) and 7.0% (0.0\u201313.7%) for distant metastasis (<jats:italic>p<\/jats:italic>\u202f=\u20090.61), respectively. In group\u00a01, regional recurrence (RR) and local regional recurrence (LRR) were 5.0% (0.0\u201314.1%; <jats:italic>p<\/jats:italic>\u202f=\u20090.13). In group\u00a02, RR and LRR were 0.0% (0.0\u20130.0%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our results showed good regional control in patients who met the Z0011 trial criteria. WBRT, without nodal surgery or RT, avoiding axillary morbidity, seems to be a\u00a0good choice.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00066-022-01944-z","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T13:11:50Z","timestamp":1651497110000},"page":"612-621","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Whole breast radiotherapy in cN0 early breast cancer patients with pathological sentinel lymph nodes (pN1mic, pN1a) without axillary dissection: preliminary results of the observational LISEN trial"],"prefix":"10.1007","volume":"198","author":[{"given":"Lucia Anna","family":"Ursini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Nuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Borgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Caravatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Di Tommaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Trignani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorella Cristina","family":"Di Guglielmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Ausili Cefaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Angelucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Muzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Cianchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Grossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saveria","family":"Tavoletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Brocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Grassadonia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Tinari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Gildetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"D\u2019Ostilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liborio","family":"Stuppia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Porreca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Di Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Genovesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"1944_CR1","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1002\/bjs.9955","volume":"102","author":"MA Beek","year":"2015","unstructured":"Beek\u00a0MA, Verheuvel\u00a0NC, Luiten\u00a0EJT, Klompenhouwer\u00a0EG, Rutten\u00a0HJT, Roumen\u00a0RMH et\u00a0al (2015) Two decades of axillary management in breast cancer. Br J Surg 102:1658\u20131664. https:\/\/doi.org\/10.1002\/bjs.9955","journal-title":"Br J Surg"},{"key":"1944_CR2","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1001\/jama.2011.90","volume":"305","author":"AE Giuliano","year":"2011","unstructured":"Giuliano\u00a0AE, Hunt\u00a0KK, Ballman\u00a0KV, Beitsch\u00a0PD, Whitworth\u00a0PW, Blumencranz\u00a0PW et\u00a0al (2011) Sentinel lymph node dissection with and without axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 305:569\u2013575. https:\/\/doi.org\/10.1001\/jama.2011.90","journal-title":"JAMA"},{"key":"1944_CR3","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1001\/jama.2017.11470","volume":"318","author":"AE Giuliano","year":"2017","unstructured":"Giuliano\u00a0AE, Ballman\u00a0KV, McCall\u00a0L, Beitsch\u00a0PD, Brennan\u00a0MB, Kelemen\u00a0PR et\u00a0al (2017) Effect of Axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis. The ACOSOG Z0011 (Alliance) randomized clinical trial. JAMA 318:918\u2013926. https:\/\/doi.org\/10.1001\/jama.2017.11470","journal-title":"JAMA"},{"issue":"7","key":"1944_CR4","doi-asserted-by":"publisher","first-page":"01004","DOI":"10.1016\/S0140-6736","volume":"9","author":"U Veronesi","year":"1997","unstructured":"Veronesi\u00a0U, Paganelli\u00a0G, Galimberti\u00a0V, Viale\u00a0G, Zurrida\u00a0S, Bedoni\u00a0M et al (1997) Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet 9(7):1004\u20131000. https:\/\/doi.org\/10.1016\/S0140-6736","journal-title":"Lancet"},{"key":"1944_CR5","doi-asserted-by":"publisher","first-page":"5220","DOI":"10.1200\/JCO.2008.16.3766","volume":"26","author":"SA McLaughlin","year":"2008","unstructured":"McLaughlin\u00a0SA, Wright\u00a0MJ, Morris\u00a0KT, Sampson\u00a0MR, Brockway\u00a0JP, Hurley\u00a0KE et\u00a0al (2008) Prevalence of Lymphoedema in women with breast cancer 5\u00a0years after sentinel lymph node biopsy or axillary dissection: patients perceptions and precautionary behaviors. J\u00a0Clin Oncol 26:5220\u20135226","journal-title":"J Clin Oncol"},{"key":"1944_CR6","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/SLA.0b013e3181f08f32","volume":"252","author":"AE Giuliano","year":"2010","unstructured":"Giuliano\u00a0AE, McCall\u00a0L, Beitsch\u00a0P, Whitworth\u00a0PW, Blumencranz\u00a0P, Leitch\u00a0AM et\u00a0al (2010) Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: The American College of Surgeons Oncology Group Z0011 Randomized Trial. Ann Surg 252:426\u2013433. https:\/\/doi.org\/10.1097\/SLA.0b013e3181f08f32","journal-title":"Ann Surg"},{"key":"1944_CR7","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1007\/s10147-018-1297-0","volume":"23","author":"N Kittaka","year":"2018","unstructured":"Kittaka\u00a0N, Tokui\u00a0R, Ota\u00a0C, Hashimoto\u00a0Y, Motomura\u00a0K, Ishitobi\u00a0M et\u00a0al (2018) A prospective feasibility study applying the ACOSOG Z0011 criteria to Japanese patients with early breast cancer undergoing breast conserving surgery. Int J Clin Oncol 23:860\u2013866. https:\/\/doi.org\/10.1007\/s10147-018-1297-0","journal-title":"Int J Clin Oncol"},{"key":"1944_CR8","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1097\/SLA.0000000000002354","volume":"266","author":"M Morrow","year":"2017","unstructured":"Morrow\u00a0M, Van Zee\u00a0KJ, Patil\u00a0S, Petruolo\u00a0O, Mamtani\u00a0A, Barrio\u00a0AV et al (2017) Axillary dissection and nodal irradiation can be avoided for most node-positive Z0011-eligible breast cancers. Ann Surg 266:457\u2013462. https:\/\/doi.org\/10.1097\/SLA.0000000000002354","journal-title":"Ann Surg"},{"key":"1944_CR9","doi-asserted-by":"publisher","first-page":"3600","DOI":"10.1200\/JCO.2014.56.5838","volume":"32","author":"R Jagsi","year":"2014","unstructured":"Jagsi\u00a0R, Chadha\u00a0M, Moni\u00a0J, Ballman\u00a0K, Laurie\u00a0F, Buchholz\u00a0T et\u00a0al (2014) Radiation field design in the ACOSOG Z0011 (Alliance) trial. J\u00a0Clin Oncol 32:3600\u20133606. https:\/\/doi.org\/10.1200\/JCO.2014.56.5838","journal-title":"J Clin Oncol"},{"key":"1944_CR10","doi-asserted-by":"publisher","first-page":"vi12","DOI":"10.1093\/annonc\/mdr371","volume":"Supplement 6","author":"S Aebi","year":"2011","unstructured":"Aebi\u00a0S, Davidson\u00a0T, Gruber\u00a0G, Cardoso\u00a0F, ESMO Guidelines Working Group (2011) Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology Supplement 6:vi12\u2013vi24. https:\/\/doi.org\/10.1093\/annonc\/mdr371","journal-title":"Annals of Oncology"},{"key":"1944_CR11","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000328054","volume":"6","author":"M Gnant","year":"2011","unstructured":"Gnant\u00a0M, Harbeck\u00a0N, Thomssenc\u00a0C (2011) St. Gallen 2011: Summary of the Consensus Discussion. Breast Care 6:136\u2013141. https:\/\/doi.org\/10.1159\/000328054","journal-title":"Breast Care"},{"key":"1944_CR12","unstructured":"NCCN 2012. www.nccn.org\u00a0\u203a physician_gls. Accessed 31 Dec 2012"},{"key":"1944_CR13","doi-asserted-by":"publisher","first-page":"4479","DOI":"10.1200\/JCO.2011.36.1667","volume":"29","author":"BG Haffty","year":"2011","unstructured":"Haffty\u00a0BG, Hunt\u00a0KK, Harris\u00a0JR, Buchholz\u00a0TA (2011) Positive sentinel nodes without axillary dissection: implications for the radiation oncologist. J\u00a0Clin Oncol 29:4479\u20134481. https:\/\/doi.org\/10.1200\/JCO.2011.36.1667","journal-title":"J Clin Oncol"},{"key":"1944_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.radonc.2014.11.030","volume":"114","author":"BV Offersen","year":"2015","unstructured":"Offersen\u00a0BV, Boersma\u00a0LJ, Kirkove\u00a0C, Hol\u00a0S, Aznar\u00a0MC, Sola\u00a0AS et\u00a0al (2015) ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer. Radiother Oncol 114:3\u201310. https:\/\/doi.org\/10.1016\/j.radonc.2014.11.030","journal-title":"Radiother Oncol"},{"key":"1944_CR15","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s10549-012-2162-x","volume":"135","author":"S Hofvind","year":"2012","unstructured":"Hofvind\u00a0S, Lee\u00a0CI, Elmore\u00a0JG (2012) Stage-specific breast cancer incidence rates among participants and non-participants of a\u00a0population-based mammographic screening program. Breast Cancer Res Treat 135:291\u2013299. https:\/\/doi.org\/10.1007\/s10549-012-2162-x","journal-title":"Breast Cancer Res Treat"},{"key":"1944_CR16","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1097\/SLA.0b013e3181c0e92a","volume":"251","author":"U Veronesi","year":"2010","unstructured":"Veronesi\u00a0U, Viale\u00a0G, Paganelli\u00a0G, Zurrida\u00a0S, Luini\u00a0A, Galimberti\u00a0V et al (2010) Sentinel lymph-node biopsy in breast cancer: ten-year results of a\u00a0randomized controlled study. Ann Surg 251:595\u2013600. https:\/\/doi.org\/10.1097\/SLA.0b013e3181c0e92a","journal-title":"Ann Surg"},{"issue":"0","key":"1944_CR17","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/S1470-2045(10)70207-2","volume":"11","author":"DN Krag","year":"2010","unstructured":"Krag\u00a0DN, Anderson\u00a0SJ, Julian\u00a0TB, Brown\u00a0AM, Harlow\u00a0SP, Costantino\u00a0JP et al (2010) Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B\u201132 randomised phase 3 trial. Lancet Oncol 11(0):927\u2013933. https:\/\/doi.org\/10.1016\/S1470-2045(10)70207-2","journal-title":"Lancet Oncol"},{"key":"1944_CR18","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1470-2045(13)70035-4","volume":"23","author":"V Galimberti","year":"2013","unstructured":"Galimberti\u00a0V, Cole\u00a0BF, Zurrida\u00a0S, Viale\u00a0G, Luini\u00a0A, Veronesi\u00a0P et\u00a0al (2013) Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a\u00a0phase\u00a03 randomised controlled trial. Lancet Oncol 14:297\u2013305. https:\/\/doi.org\/10.1016\/S1470-2045(13)70035-4","journal-title":"Lancet Oncol"},{"key":"1944_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30380-2","author":"V Galimberti","year":"2018","unstructured":"Galimberti\u00a0V, Cole\u00a0BF, Viale\u00a0G, Veronesi\u00a0P, Vicini\u00a0E, Intra\u00a0M et al (2018) Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised,controlled phase 3 trial. Lancet Oncol. https:\/\/doi.org\/10.1016\/S1470-2045(18)30380-2","journal-title":"Lancet Oncol"},{"key":"1944_CR20","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/S1470-2045(14)70460-7","volume":"15","author":"M Donker","year":"2014","unstructured":"Donker\u00a0M, van Tienhoven\u00a0G, Straver\u00a0ME, Meijnen\u00a0P, van de Velde\u00a0CJ, Mansel\u00a0RE et al (2014) Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981\u201322023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol 15:1303\u20131310. https:\/\/doi.org\/10.1016\/S1470-2045(14)70460-7","journal-title":"Lancet Oncol"},{"key":"1944_CR21","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1002\/cncr.26504","volume":"118","author":"J Setton","year":"2012","unstructured":"Setton\u00a0J, Cody\u00a0H, Tan\u00a0L, Morrow\u00a0M, Hudis\u00a0C, Catalano\u00a0J et al (2012) Radiation field design and regional control in sentinel lymph node-positive breast cancer patients with omission of axillary dissection. Cancer 118:1994\u20132003. https:\/\/doi.org\/10.1002\/cncr.26504","journal-title":"Cancer"},{"key":"1944_CR22","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jamcollsurg.2012.09.005","volume":"216","author":"M Yi","year":"2013","unstructured":"Yi\u00a0M, Kuerer\u00a0HM, Mittendorf\u00a0EA, Hwang\u00a0RF, Caudle\u00a0AS, Bedrosian\u00a0I et\u00a0al (2013) Impact of the American College of Surgeons Oncology Group Z0011 criteria applied to a contemporary patient population. Oncology 216:105\u2013113. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2012.09.005","journal-title":"Oncology"},{"key":"1944_CR23","doi-asserted-by":"publisher","first-page":"e89778","DOI":"10.1371\/journal.pone.0089778","volume":"9","author":"J Wang","year":"2014","unstructured":"Wang\u00a0J, Mittendorf\u00a0AE, Sahin\u00a0AA, Yi\u00a0M, Caudle\u00a0A, Hunt\u00a0KK et\u00a0al (2014) Outcomes of sentinel lymph node dissection alone vs. axillary lymph node dissection in early stage invasive lobular carcinoma: a retrospective study of the surveillance, epidemiology and end results (SEER) database. Plos One 9:e89778. https:\/\/doi.org\/10.1371\/journal.pone.0089778","journal-title":"Plos One"},{"key":"1944_CR24","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s10549-019-05157-4","volume":"175","author":"J Jung","year":"2019","unstructured":"Jung\u00a0J, Han\u00a0W, Lee\u00a0ES, Jung\u00a0SY, Han\u00a0JH, Noh\u00a0DY et al (2019) Retrospectively validating the results of the ACOSOG Z0011 trial in a\u00a0large Asian Z0011-eligible cohort. Breast Cancer Res Treat 175:203\u2013215. https:\/\/doi.org\/10.1007\/s10549-019-05157-4","journal-title":"Breast Cancer Res Treat"},{"key":"1944_CR25","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s10549-015-3559-0","volume":"153","author":"F Petrelli","year":"2015","unstructured":"Petrelli\u00a0F, Viale\u00a0G, Cabiddu\u00a0M, Barni\u00a0S (2015) Prognostic value of different cut-off levels of Ki-67 in breast cancer: a\u00a0systematic review and meta-analysis of 64,196\u00a0patients. Breast Cancer Res Treat 153:477\u2013491. https:\/\/doi.org\/10.1007\/s10549-015-3559-0","journal-title":"Breast Cancer Res Treat"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-022-01944-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00066-022-01944-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-022-01944-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T13:08:37Z","timestamp":1663074517000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00066-022-01944-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1944"],"URL":"https:\/\/doi.org\/10.1007\/s00066-022-01944-z","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,2]]},"assertion":[{"value":"24 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Missing Open Access funding information has been added in the Funding Note.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}]}}