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Prostate shifts in anterior\u2013posterior (AP) and superior\u2013inferior (SI) directions were extracted separately. Using the static dose cloud approximation, the planned fractional dose was shifted according to the 2D gated motion (residual motion in gating window) to estimate the delivered dose by superimposing and averaging the shifted dose volumes. The dose of a\u00a0hypothetical non-gated delivery was reconstructed similarly using the non-gated motion. For the clinical target volume (CTV), rectum, and bladder, dose\u2013volume histogram parameters of the planned and reconstructed doses were compared.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 174 fractions (15.7\u202fh of cine-MRI) from 10\u00a0patients were evaluated. The average (\u00b11\u202f\u03c3) non-gated prostate motion was 0.6\u202f\u00b1\u20091.0\u202fmm in the AP and 0.0\u202f\u00b1\u20090.6\u202fmm in the SI direction with respect to the centroid position of the gating boundary. 95% of the shifts were within [\u22123.5, 2.7]\u00a0mm in the AP and [\u22122.9, 3.2]\u00a0mm in the SI direction. For the gated treatment and averaged over all fractions, CTV D<jats:sub>98%<\/jats:sub> decreased by less than 2% for all patients. The rectum and the bladder D<jats:sub>2%<\/jats:sub> increased by less than 3% and 0.5%, respectively. Doses reconstructed for gated and non-gated delivery were similar for most fractions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A\u00a0pipeline for extraction of prostate motion during gated MRI-guided radiotherapy based on 2D cine-MRI was implemented. The 2D motion data enabled an approximate estimation of the delivered dose. For the majority of fractions, the benefit of gating was negligible, and clinical dosimetric constraints were met, indicating safety of the currently adopted gated MRI-guided treatment workflow.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00066-022-02005-1","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T17:39:51Z","timestamp":1663954791000},"page":"544-553","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Assessment of intrafractional prostate motion and its dosimetric impact in MRI-guided online adaptive radiotherapy with gating"],"prefix":"10.1007","volume":"199","author":[{"given":"Yuqing","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Rabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Nierer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kawula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Corradini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Belka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Riboldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Landry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"2005_CR1","volume-title":"Cancer burden statistics 2021","author":"European Cancer Information System","year":"2022","unstructured":"European Cancer Information System (2022) Cancer burden statistics 2021 (Available from: https:\/\/ecis.jrc.ec.europa.eu\/index.php)"},{"issue":"4","key":"2005_CR2","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3322\/CA.2008.0002","volume":"58","author":"MD Michaelson","year":"2008","unstructured":"Michaelson\u00a0MD, Cotter\u00a0SE, Gargollo\u00a0PC, Zietman\u00a0AL, Dahl\u00a0DM, Smith\u00a0MR (2008) Management of complications of prostate cancer treatment. 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