{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:24:47Z","timestamp":1792113887074,"version":"4.4.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Concomitant chemoradiation followed by repeat (dose-deescalated) irradiation has become standard of care in treating childhood diffuse intrinsic pontine glioma (DIPG) during first line treatment and at first progression. Progression after re-irradiation (re-RT) is in most cases symptomatic and either treated systemically with chemotherapy or new innovative approaches including targeted therapy. Alternatively, the patient receives best supportive care. Data on second re-irradiation in DIPG patients with second progression and good performance status are sparse. This is a\u00a0case report of second short-term re-irradiation to shed further light on this option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case report of a\u00a06-year-old boy with DIPG receiving a\u00a0second course of re-irradiation (with 21.6\u202fGy) as part of an individual multimodal approach in a\u00a0patient with very low symptom burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The second course of re-irradiation was feasible and well tolerated. No acute neurological symptoms or radiation-induced toxicity occurred. Overall survival was 24\u00a0months after initial diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A\u00a0second course of re-irradiation can be an additional tool in patients with progressive disease after first- and second-line irradiation. It is unclear whether and to what extent it contributes to progression-free survival prolongation and if\u2014since our patient was asymptomatic\u2014progression-associated neurological deficits can be alleviated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00066-023-02057-x","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T07:03:26Z","timestamp":1677740606000},"page":"773-777","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Second course of re-irradiation in pediatric diffuse intrinsic pontine glioma"],"prefix":"10.1007","volume":"199","author":[{"given":"Paula Maria","family":"Bergengruen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Herna\u00edz Driever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Budach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-2719","authenticated-orcid":false,"given":"Arne","family":"Gr\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"issue":"17","key":"2057_CR1","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.2174\/0929867327666200806110206","volume":"28","author":"MG Perrone","year":"2021","unstructured":"Perrone\u00a0MG, Ruggiero\u00a0A, Centonze\u00a0A, Carrieri\u00a0A, Ferorelli\u00a0S, Scilimati\u00a0A (2021) Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective. Curr Med Chem 28(17):3287\u20133317","journal-title":"Curr Med Chem"},{"issue":"1","key":"2057_CR2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1023\/A:1006360222643","volume":"44","author":"RI Jakacki","year":"1999","unstructured":"Jakacki\u00a0RI, Siffert\u00a0J, Jamison\u00a0C, Velasquez\u00a0L, Allen\u00a0JC (1999) Dose-intensive, time-compressed procarbazine, CCNU, vincristine (PCV) with peripheral blood stem cell support and concurrent radiation in patients with newly diagnosed high-grade gliomas. J\u00a0Neurooncol 44(1):77\u201383","journal-title":"J Neurooncol"},{"issue":"13","key":"2057_CR3","doi-asserted-by":"publisher","first-page":"942","DOI":"10.2176\/nmc.32.942","volume":"32","author":"T Wakabayashi","year":"1992","unstructured":"Wakabayashi\u00a0T, Yoshida\u00a0J, Mizuno\u00a0M, Kito\u00a0A, Sugita\u00a0K (1992) Effectiveness of interferon-beta, ACNU, and radiation therapy in pediatric patients with brainstem glioma. Neurol Med Chir 32(13):942\u2013946","journal-title":"Neurol Med Chir"},{"key":"2057_CR4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3389\/fonc.2015.00237","volume":"5","author":"MI Vanan","year":"2015","unstructured":"Vanan\u00a0MI, Eisenstat\u00a0DD (2015) DIPG in children\u2014what Can we learn from the past? Front Oncol 5:237","journal-title":"Front Oncol"},{"key":"2057_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ejca.2016.12.007","volume":"73","author":"GO Janssens","year":"2017","unstructured":"Janssens\u00a0GO, Gandola\u00a0L, Bolle\u00a0S, Mandeville\u00a0H, Ramos-Albiac\u00a0M, van Beek\u00a0K et al (2017) Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG\/DIPG working group. Eur J Cancer 73:38\u201347","journal-title":"Eur J Cancer"},{"issue":"1","key":"2057_CR6","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/COC.0b013e318201a2b7","volume":"35","author":"HP Fontanilla","year":"2012","unstructured":"Fontanilla\u00a0HP, Pinnix\u00a0CC, Ketonen\u00a0LM, Woo\u00a0SY, Vats\u00a0TS, Rytting\u00a0ME et\u00a0al (2012) Palliative reirradiation for progressive diffuse intrinsic pontine glioma. Am J Clin Oncol 35(1):51\u201357","journal-title":"Am J Clin Oncol"},{"issue":"1","key":"2057_CR7","first-page":"68","volume":"8","author":"C Cacciotti","year":"2021","unstructured":"Cacciotti\u00a0C, Liu\u00a0KX, Haas-Kogan\u00a0DA, Warren\u00a0KE (2021) Reirradiation practices for children with diffuse intrinsic pontine glioma. 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An ethics approval was not deemed necessary as no randomization of patients was performed. This manuscript contains only anonymized imaging data. All data supporting the results reported in this article are available on a\u00a0secured data server owned by the Charit\u00e9 University Medicine, Berlin, Germany. The datasets used and analyses of all data of this manuscript are available from the corresponding author upon reasonable request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}