{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:47:00Z","timestamp":1777441620137,"version":"3.51.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Martin-Luther-Universit\u00e4t Halle-Wittenberg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Merkel cell carcinoma (MCC) is a\u00a0radiosensitive tumor and the role of radiotherapy in the management of this disease was newly defined in the recently published update of the S2k guideline on Merkel cell carcinoma of the Association of Scientific Medical Societies in Germany (AWMF). While adjuvant radiotherapy of the tumor bed is broadly recommended, irradiation of the regional nodal region can be performed in patients with negative sentinel lymph nodes and high-risk factors. In patients with positive sentinel lymph nodes, it is an alternative to completion lymphadenectomy. The standard dose for adjuvant radiotherapy remains 50\u202fGy.<\/jats:p>","DOI":"10.1007\/s00066-023-02068-8","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T07:02:45Z","timestamp":1679986965000},"page":"433-435","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of radiotherapy in the updated German S2k guideline for management of Merkel cell carcinoma"],"prefix":"10.1007","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8816-0508","authenticated-orcid":false,"given":"Dirk","family":"Vordermark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"H\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"2068_CR1","first-page":"305","volume":"21","author":"JC Becker","year":"2023","unstructured":"Becker\u00a0JC, Beer\u00a0AJ, DeTemple\u00a0VK et al (2023)  S2k Guideline - Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) - Update 2022. J Dtsch Dermatol Ges 21:305\u2013320","journal-title":"J Dtsch Dermatol Ges"},{"key":"2068_CR2","first-page":"562","volume":"17","author":"JC Becker","year":"2019","unstructured":"Becker\u00a0JC, Eigentler\u00a0T, Frerich\u00a0B et\u00a0al (2019) S2k guidelines for Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin)\u2014update 2018. J\u00a0Dtsch Dermatol Ges 17:562\u2013576","journal-title":"J Dtsch Dermatol Ges"},{"key":"2068_CR3","doi-asserted-by":"publisher","first-page":"djw042","DOI":"10.1093\/jnci\/djw042","volume":"108","author":"S Bhatia","year":"2016","unstructured":"Bhatia\u00a0S, Storer\u00a0BE, Iyer\u00a0JG et\u00a0al (2016) Adjuvant radiation therapy and chemotherapy in Merkel cell carcinoma: survival analyses of 6908\u00a0cases from the national cancer data base. J\u00a0Natl Cancer Inst 108:djw42","journal-title":"J Natl Cancer Inst"},{"key":"2068_CR4","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1200\/JCO.2006.07.9319","volume":"25","author":"P Mojica","year":"2007","unstructured":"Mojica\u00a0P, Smith\u00a0D, Ellenhorn\u00a0JDI (2007) Adjuvant radiation therapy is associated with improved survival in Merkel cell carcinoma of the skin. J\u00a0Clin Oncol 25:1043\u20131047","journal-title":"J Clin Oncol"},{"key":"2068_CR5","doi-asserted-by":"publisher","first-page":"554","DOI":"10.3390\/cancers12030554","volume":"12","author":"S Naseri","year":"2020","unstructured":"Naseri\u00a0S, Steiniche\u00a0T, Ladekarl\u00a0M et\u00a0al (2020) Management recommendations for Merkel cell carcinoma\u2014a\u00a0Danish perspective. Cancers 12:554","journal-title":"Cancers"},{"key":"2068_CR6","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.adro.2016.10.003","volume":"1","author":"SR Takagishi","year":"2016","unstructured":"Takagishi\u00a0SR, Marx\u00a0TE, Lewis\u00a0C et\u00a0al (2016) Postoperative radiation therapy is associated with a\u00a0reduced risk of local recurrence among low risk Merkel cell carcinomas of the head and neck. Adv Radiat Oncol 1:244\u2013251","journal-title":"Adv Radiat Oncol"},{"key":"2068_CR7","unstructured":"Schmults CD Merkel cell carcinoma\u2014NCCN guidelines 2022. https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1444. Accessed 27 June 2022"},{"key":"2068_CR8","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2340\/00015555-2895","volume":"98","author":"E Fiedler","year":"2018","unstructured":"Fiedler\u00a0E, Vordermark\u00a0D (2018) Outcome of combined treatment of surgery and adjuvant radiotherapy in Merkel cell carcinoma. Acta Derm Venereol 98:699\u2013703","journal-title":"Acta Derm Venereol"},{"key":"2068_CR9","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1093\/annonc\/mdr318","volume":"23","author":"T Jouary","year":"2012","unstructured":"Jouary\u00a0T, Leyral\u00a0C, Dreno\u00a0B et\u00a0al (2012) Adjuvant prophylactic regional radiotherapy versus observation in stage I Merkel cell carcinoma: a\u00a0multicentric prospective randomized study. Ann Oncol 23:1074\u20131080","journal-title":"Ann Oncol"},{"key":"2068_CR10","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00066-014-0756-4","volume":"191","author":"U Hoeller","year":"2015","unstructured":"Hoeller\u00a0U, Mueller\u00a0T, Schubert\u00a0T et\u00a0al (2015) Regional nodal relapse in surgically staged Merkel cell carcinoma. Strahlenther Onkol 191:51\u201358","journal-title":"Strahlenther Onkol"},{"key":"2068_CR11","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/annonc\/mdw035","volume":"27","author":"A Servy","year":"2016","unstructured":"Servy\u00a0A, Maubec\u00a0E, Sugier\u00a0PE et al (2016) Merkel cell carcinoma: value of sentinel lymph-node status and adjuvant radiation therapy. Ann Oncol 27:914\u2013919","journal-title":"Ann Oncol"},{"key":"2068_CR12","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1007\/s00066-022-01944-z","volume":"198","author":"LA Ursini","year":"2022","unstructured":"Ursini\u00a0LA, Nuzzo\u00a0M, Rosa\u00a0C et\u00a0al (2022) Whole breast radiotherapy in cN0 early breast cancer patients with pathological sentinel lymph nodes (pN1mic, pN1a) without axillary dissection: preliminary results of the observational LISEN trial. Strahlenther Onkol 198:612\u2013621","journal-title":"Strahlenther Onkol"},{"key":"2068_CR13","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s00066-022-01922-5","volume":"198","author":"S Marnitz","year":"2022","unstructured":"Marnitz\u00a0S, Bereuter\u00a0AS (2022) Radiotherapy versus inguinofemoral lymphadenectomy in vulvar cancer patients with micrometastases in the sentinel node. Strahlenther Onkol 198:595\u2013597","journal-title":"Strahlenther Onkol"},{"key":"2068_CR14","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1245\/s10434-018-7072-7","volume":"26","author":"JS Lee","year":"2019","unstructured":"Lee\u00a0JS, Durham\u00a0AB, Bichakjian\u00a0CK et\u00a0al (2019) Completion lymph node dissection or radiation therapy for sentinel node metastasis in Merkel cell carcinoma. Ann Surg Oncol 26:386\u2013394","journal-title":"Ann Surg Oncol"},{"key":"2068_CR15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1245\/s10434-018-6810-1","volume":"26","author":"MC Perez","year":"2019","unstructured":"Perez\u00a0MC, Oliver\u00a0DE, Weitman\u00a0ES et\u00a0al (2019) Management of sentinel lymph node metastasis in Merkel cell carcinoma: completion lymphadenectomy, radiation, or both? Ann Surg Oncol 26:379\u2013385","journal-title":"Ann Surg Oncol"},{"key":"2068_CR16","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3389\/fonc.2019.00223","volume":"9","author":"BC Bloom","year":"2019","unstructured":"Bloom\u00a0BC, Augustyn\u00a0A, Pezzi\u00a0TA et al (2019) Rescue of immunotherapy-refractory metastatic Merkel cell carcinoma with conventionally fractionated radiotherapy and concurrent pembrolizumab. Front Oncol 9:223","journal-title":"Front Oncol"},{"key":"2068_CR17","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s00066-020-01582-3","volume":"196","author":"AD Sherry","year":"2020","unstructured":"Sherry\u00a0AD, Bezzerides\u00a0M, Khattab\u00a0MH et al (2020) An autoimmune-based, paraneoplastic neurologic syndrome following checkpoint inhibition and concurrent radiotherapy for merkel cell carcinoma: case report. Strahlenther Onkol 196:664\u2013670","journal-title":"Strahlenther Onkol"},{"key":"2068_CR18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.5826\/dpc.0802a15","volume":"8","author":"P Patel","year":"2018","unstructured":"Patel\u00a0P, Modi\u00a0C, McLellan\u00a0B, Ohri\u00a0N (2018) Radiotherapy for inoperable Merkel cell carcinoma: a\u00a0systematic review and pooled analysis. Dermatol Pract Concept 8:149\u2013157","journal-title":"Dermatol Pract Concept"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-023-02068-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00066-023-02068-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-023-02068-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T09:04:08Z","timestamp":1682499848000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00066-023-02068-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,28]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["2068"],"URL":"https:\/\/doi.org\/10.1007\/s00066-023-02068-8","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,28]]},"assertion":[{"value":"23 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D.\u00a0Vordermark and U.\u00a0H\u00f6ller declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}