{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:31:36Z","timestamp":1793068296790,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein - Campus Kiel"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Single-session cardiac stereotactic radiation therapy (SBRT) has demonstrated promising results for patients with refractory ventricular tachycardia (VT). However, the full safety profile of this novel treatment remains unknown and very limited data from prospective clinical multicenter trials are available.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The prospective multicenter multiplatform RAVENTA (radiosurgery for ventricular tachycardia) study assesses high-precision image-guided cardiac SBRT with 25\u202fGy delivered to the VT substrate determined by high-definition endocardial and\/or epicardial electrophysiological mapping in patients with refractory VT ineligible for catheter ablation and an implanted cardioverter defibrillator (ICD). Primary endpoint is the feasibility of full-dose application and procedural safety (defined as an incidence of serious [grade \u2265\u202f3] treatment-related complications \u2264\u202f5% within 30\u00a0days after therapy). Secondary endpoints comprise VT burden, ICD interventions, treatment-related toxicity, and quality of life. We present the results of a\u00a0protocol-defined interim analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Between 10\/2019 and 12\/2021, a\u00a0total of five patients were included at three university medical centers. In all cases, the treatment was carried out without complications. There were no serious potentially treatment-related adverse events and no deterioration of left ventricular ejection fraction upon echocardiography. Three patients had a\u00a0decrease in VT episodes during follow-up. One patient underwent subsequent catheter ablation for a\u00a0new VT with different morphology. One patient with local VT recurrence died 6\u00a0weeks after treatment in cardiogenic shock.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The interim analysis of the RAVENTA trial demonstrates early initial feasibility of this new treatment without serious complications within 30\u00a0days after treatment in five patients. Recruitment will continue as planned and the study has been expanded to further university medical centers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration number<\/jats:title>\n                <jats:p>NCT03867747 (clinicaltrials.gov). Registered March\u00a08, 2019. Study start: October\u00a01, 2019.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00066-023-02091-9","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T12:03:24Z","timestamp":1686139404000},"page":"621-630","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Radiosurgery for ventricular tachycardia (RAVENTA): interim analysis of a\u00a0multicenter multiplatform feasibility trial"],"prefix":"10.1007","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8811-5416","authenticated-orcid":false,"given":"David","family":"Krug","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Eidinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Grehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Boda-Heggemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Rudic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mehrhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif-Hendrik","family":"Boldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Hohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Merten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Buergy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Fleckenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kluge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Rogge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Both","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Rades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Richard","family":"Tilz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Olbrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inke R.","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank-Andre","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Schweikard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Vonthein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Bonnemeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Dunst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Blanck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"2091_CR1","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.1016\/j.hrthm.2019.03.002","volume":"17","author":"EM Cronin","year":"2020","unstructured":"Cronin\u00a0EM, Bogun\u00a0FM, Maury\u00a0P et\u00a0al (2020) 2019 HRS\/EHRA\/APHRS\/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias. 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Eur Heart J Qual Care Clin Outcomes 6:qcaa49. https:\/\/doi.org\/10.1093\/ehjqcco\/qcaa049","journal-title":"Eur Heart J Qual Care Clin Outcomes"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-023-02091-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00066-023-02091-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-023-02091-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T16:04:01Z","timestamp":1687277041000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00066-023-02091-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["2091"],"URL":"https:\/\/doi.org\/10.1007\/s00066-023-02091-9","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"assertion":[{"value":"9 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D.\u00a0Buergy reports personal fees from Siemens AG, NB Capital Research GmbH, NB Capital ApS, b.e. Imaging GmbH, and PharmaMar, all outside the submitted work. D.\u00a0Krug has received honoraria from MSD Sharp & Dohme and Pfizer as well as research funding from Merck KGaA, outside the submitted work. B.\u00a0Rudic received travel grants and personal fees from Boston Scientific Medizintechnik GmbH, outside of the submitted work. J.\u00a0Boda-Heggemann reports personal fees from EBAMed SA, outside the submitted work. S.\u00a0Hohmann received travel grants from Boston Scientific Medizintechnik GmbH, outside of the submitted work. L.-H.\u00a0Boldt received honoraria from Biotronik, Boston Scientific, and Pfizer, outside of the submitted work. O.\u00a0Blanck is the section editor for medical physics of the <i>Strahlentherapie und Onkologie<\/i> journal. A.\u00a0Zaman, L.\u00a0Eidinger, M.\u00a0Grehn, F.\u00a0Mehrhof, R.\u00a0Merten, J.\u00a0Fleckenstein, A.\u00a0Kluge, A.\u00a0Rogge, M.\u00a0Both, D.\u00a0Rades, R.\u00a0R.\u00a0Tilz, D.\u00a0Olbrich, I.\u00a0R.\u00a0K\u00f6nig, F.-A.\u00a0Siebert, A.\u00a0Schweikard, R.\u00a0Vonthein, H.\u00a0Bonnemeier, and J.\u00a0Dunst declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the German Radiation Protection Agency (<i>Bundesamt f\u00fcr Strahlenschutz<\/i>, reference number Z5-22463\/2-2018-054) and by the leading independent ethics committee at the Christian-Albrechts-University of Kiel (reference number 555\/18) as well as by the respective independent ethics committees of the participating centers. All treated patients gave their written informed consent for participation in the study and hence for publication of their anonymized data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}