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However, epidemiological studies have revealed an increase in cardiac diseases approximately a\u00a0decade after exposure of the thorax to ionizing irradiation, which might be related to vascular inflammation. Therefore, chronic inflammatory effects were examined in primary heart and lung endothelial cells (ECs) of mice after local heart irradiation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Long-lasting effects on primary ECs of the heart and lung were studied 20\u201350\u00a0weeks after local irradiation of the heart of mice (8 and 16\u202fGy) in vivo by multiparameter flow cytometry using antibodies directed against cell surface markers related to proliferation, stemness, lipid metabolism, and inflammation, and compared to those induced by occlusion of the left anterior descending coronary artery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In vivo irradiation of the complete heart caused long-lasting persistent upregulation of inflammatory (HCAM, ICAM\u20111, VCAM-1), proliferation (CD105), and lipid (CD36) markers on primary heart ECs and an upregulation of ICAM\u20111 and VCAM\u20111 on primary ECs of the partially irradiated lung lobe. An artificially induced heart infarction induces similar effects with respect to inflammatory markers, albeit in a\u00a0shorter time period.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The long-lasting upregulation of prominent inflammatory markers on primary heart and lung ECs suggests that local heart irradiation induces chronic inflammation in the microvasculature of the heart and partially irradiated lung that leads to cardiac injury which might be related to altered lipid metabolism in the heart.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00066-023-02130-5","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T12:01:27Z","timestamp":1693656087000},"page":"1214-1224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic inflammatory effects of in vivo irradiation of the murine heart on endothelial cells mimic mechanisms involved in atherosclerosis"],"prefix":"10.1007","volume":"199","author":[{"given":"Andrea","family":"Wittmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayan","family":"Alkotub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza Hasanzadeh","family":"Kafshgari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2616-3137","authenticated-orcid":false,"given":"Gabriele","family":"Multhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"key":"2130_CR1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.5604\/17322693.1101572","volume":"68","author":"K Milowska","year":"2014","unstructured":"Milowska\u00a0K, Grabowska\u00a0K, Gabryelak\u00a0T (2014) Applications of electromagnetic radiation in medicine. 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