{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:21:46Z","timestamp":1740108106774,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>This study aimed to assess the margin for the planning target volume (PTV) using the Van Herk formula. We then validated the proposed margin by real-time magnetic resonance imaging (MRI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>An analysis of cone-beam computed tomography (CBCT) data from early glottic cancer patients was performed to evaluate organ motion. Deformed clinical target volumes (CTV) after rigid registration were acquired using the Velocity program (Varian Medical Systems, Palo Alto, CA, USA). Systematic (\u03a3)\u00a0and random errors (\u03c3)\u00a0were evaluated. The margin for the PTV was defined as 2.5\u202f\u03a3\u202f+\u20090.7\u202f\u03c3 according to the Van Herk formula. To validate this margin, we accrued healthy volunteers. Sagittal real-time cine MRI was conducted using the ViewRay system (ViewRay Inc., Oakwood Village, OH, USA). Within the obtained sagittal images, the vocal cord was delineated. The movement of the vocal cord was summed up and considered as the internal target volume (ITV). We then assessed the degree of overlap between the ITV and the PTV (vocal cord plus margins) by calculating the volume overlap ratio, represented as (ITV\u2229PTV)\/ITV.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>CBCTs of 17\u00a0early glottic patients were analyzed. \u03a3\u00a0and \u03c3\u00a0were 0.55 and 0.57 for left\u2013right (LR), 0.70 and 0.60 for anterior\u2013posterior (AP), and 1.84 and 1.04 for superior\u2013inferior (SI), respectively. The calculated margin was 1.8\u202fmm (LR), 2.2\u202fmm (AP), and 5.3\u202fmm (SI). Four healthy volunteers participated for validation. A\u00a0margin of 3\u202fmm (AP) and 5\u202fmm (SI) was applied to the vocal cord as the PTV. The average volume overlap ratio between ITV and PTV was 0.92 (range 0.85\u20130.99) without swallowing and 0.77 (range 0.70\u20130.88) with swallowing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>By evaluating organ motion by using CBCT, the margin was 1.8\u00a0(LR), 2.2\u00a0(AP), and 5.3\u202fmm (SI). The margin acquired using CBCT fitted well in real-time cine MRI. Given that swallowing during radiotherapy can result in a\u00a0substantial displacement, it is crucial to consider strategies aimed at minimizing swallowing and related motion.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00066-024-02204-y","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T12:01:54Z","timestamp":1710504114000},"page":"418-424","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment and validation of glottic motion using cone-beam CT and real-time cine MRI"],"prefix":"10.1007","volume":"200","author":[{"given":"Seok-Joo","family":"Chun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaeman","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonghee","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Heon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-in","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Gyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"issue":"54","key":"2204_CR1","doi-asserted-by":"publisher","first-page":"330","DOI":"10.4143\/crt.2022.128","volume":"2022","author":"MJ Kang","year":"2019","unstructured":"Kang\u00a0MJ, Won\u00a0YJ, Lee\u00a0JJ, Jung\u00a0KW, Kim\u00a0HJ, Kong\u00a0HJ et\u00a0al (2019) Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in. 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