{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:49:28Z","timestamp":1770284968867,"version":"3.49.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Diffuse intrinsic pontine glioma (DIPG) is a\u00a0lethal pediatric brain tumor. Radiation therapy (RT) is the standard treatment, with reirradiation considered in case of progression. However, the prognostic factors for reirradiation are not well understood. This study aims to investigate the outcomes of DIPG patients undergoing reirradiation and identify clinical and radiomic prognostic factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a\u00a0retrospective analysis of patients with DIPG who underwent reirradiation at our institution between January 2016 and December 2023. Using PyRadiomics, we extracted radiomic features of tumors at the time of progression from FLAIR MRI images and collected clinical data. We used the least absolute shrinkage and selection operator (lasso) for Cox\u2019s proportional hazard model with leave-one-out cross-validation to select optimal prognostic factors for survival after reirradiation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The study included 18\u00a0patients who underwent reirradiation at first progression, receiving a\u00a0total dose of 20\u202fGy or 24\u202fGy in 2\u2011Gy fractions. Reirradiation was well tolerated, with no severe toxicity. Most patients (78%) showed neurological improvement after treatment. Median survival after progression was 29.2\u00a0weeks. The Cox model demonstrated a\u00a0concordance of 0.81 (95% CI: 0.75\u20130.88), revealing that tumor sphericity and structural gray-level heterogeneity in FLAIR MRI images were associated with longer survival of reirradiated patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Reirradiation is a\u00a0safe and effective approach for patients with DIPG. MRI-based radiomic models could be helpful in predicting survival after reirradiation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00066-024-02241-7","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T11:02:03Z","timestamp":1715770923000},"page":"797-804","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reirradiation for diffuse intrinsic pontine glioma: prognostic radiomic factors at progression"],"prefix":"10.1007","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-8906","authenticated-orcid":false,"given":"Dominik","family":"Wawrzuta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzanna","family":"Chojnacka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Drogosiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"P\u0119dziwiatr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cenna","family":"Dembowska-Bagi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"issue":"9","key":"2241_CR1","doi-asserted-by":"publisher","first-page":"e30431","DOI":"10.1002\/pbc.30431","volume":"70","author":"J Robles-Castro","year":"2023","unstructured":"Robles-Castro\u00a0J, Niembro-Z\u00fa\u00f1iga\u00a0A, Ortiz-Azpilcueta\u00a0M, Betanzos-Cabrera\u00a0Y, Arregu\u00edn-Gonz\u00e1lez\u00a0F, Barrera-Villegas\u00a0G, Ortiz-Morales\u00a0D, Arroyo-Acosta\u00a0JB, Zapata-Tarr\u00e9s\u00a0M (2023) Diffuse intrinsic pontine gliomas: First registry effort in Mexico. 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