{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:05:31Z","timestamp":1793833531684,"version":"4.6.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012940","name":"Universit\u00e4tsklinikum T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012940","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myxoid liposarcoma (MLPS) is a\u00a0rare subtype of soft tissue sarcoma. This entity has a\u00a0specific clinical behavior, characterized with a\u00a0distinct pattern of hematogenous spread, as well as with a\u00a0unique radiosensitivity and chemosensitivity. Oncologic results, metastatic patterns and treatment response after multimodal therapy were evaluated in a\u00a0unicentric patient cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with myxoid liposarcoma were retrospectively analyzed in a\u00a0single institution analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u200931). Oncologic outcomes were evaluated in 28\u00a0patients with localized MLPS treated with multimodal therapy in curative intent. Metastatic pattern was analyzed in additional 3\u00a0patients with initially metastatic disease. In patients treated with concomitant MR-guided hyperthermia in the preoperative setting (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u20097), tumor size response was evaluated longitudinally during radio(-chemo)therapy in thermometry MRIs and before surgery (based on preoperative imaging).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median follow-up was 4.1\u202f\u00b1\u20091.0\u00a0years. The most common anatomic localization was the lower extremity (78.6%). The 5\u2011year rates for oncologic outcomes in 28\u00a0patients treated in curative intent were 91.7% (\u00b1\u202f8.0%) for overall survival (OS), 77.4% (\u00b1\u202f11.0%) for local control (LC), 60.1% (\u00b1\u202f10.6%) for distant metastasis-free survival (DMFS) and 55.4% (\u00b1\u202f11.1%) for disease free survival (DFS). Excellent 5\u2011year LC (94.7\u202f\u00b1\u20095.1%) was demonstrated for the cohort excluding 5\u00a0patients treated for local recurrences. Most patients had good pathologic response (&lt;\u202f10% vital tumor tissue) following neoadjuvant treatment (82.4%, 14\/17). However, this did not correlate with oncologic outcomes. A\u00a0specific pattern of distant metastases has been observed, with predilection for soft tissues as the most common metastatic site. Furthermore, no isolated pulmonary metastases were observed. The MR analysis demonstrated a\u00a0significant tumor size reduction (\u2265\u202f25%) of the initial tumor volume in 85.7% (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u20096\/7) patients. No local recurrences and no distant metastases were observed in patients with significant MR size reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sequential MRIs during preoperative radiotherapy of myxoid liposarcoma show distinct patterns of the known size reduction of this specific subentity. Our analysis of metastatic patterns demonstrate mostly soft tissue metastases, no patient experienced isolated pulmonary metastases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00066-025-02366-3","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T15:20:05Z","timestamp":1738596005000},"page":"1239-1248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Myxoid liposarcoma: treatment outcomes, metastatic pattern and volumetric analysis"],"prefix":"10.1007","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-413X","authenticated-orcid":false,"given":"Vlatko","family":"Potkrajcic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merle","family":"Zschiegner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Niyazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Warm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes Tobias","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph K. W.","family":"Deinzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Szelat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elgin","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"2366_CR1","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2015.35.213","author":"G Abbas Manji","year":"2015","unstructured":"Abbas Manji\u00a0G, Singer\u00a0S, Koff\u00a0A, Schwartz\u00a0GK (2015) Application of molecular biology to individualize therapy for patients with liposarcoma. Am Soc Clin Oncol Educ Book. https:\/\/doi.org\/10.14694\/EdBook_AM.2015.35.213","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"2366_CR2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ctrv.2018.11.003","volume":"72","author":"T Assi","year":"2019","unstructured":"Assi\u00a0T, Kattan\u00a0J, El Rassy\u00a0E, Honore\u00a0C, Dumont\u00a0S, Mir\u00a0O, Le Cesne\u00a0A (2019) A comprehensive review of the current evidence for trabectedin in advanced myxoid liposarcoma. Cancer Treat Rev 72:37\u201344. https:\/\/doi.org\/10.1016\/j.ctrv.2018.11.003","journal-title":"Cancer Treat Rev"},{"key":"2366_CR3","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s00066-021-01847-5","volume":"197","author":"J Attal","year":"2021","unstructured":"Attal\u00a0J, Cabarrou\u00a0B, Valentin\u00a0T, Nesseler\u00a0JP, Stoeckle\u00a0E, Ducassou\u00a0A, Filleron\u00a0T, Le Guellec\u00a0S, Boulet\u00a0B, Vogin\u00a0G, Ferron\u00a0G, Moyal\u00a0EC, Delannes\u00a0M, Chevreau\u00a0C (2021) Evaluation of two modalities of perioperative treatment in the management of extremity and truncal soft tissue sarcomas: neoadjuvant concurrent chemoradiotherapy and sequential treatment. Strahlenther Onkol 197:1051\u20131062. https:\/\/doi.org\/10.1007\/s00066-021-01847-5","journal-title":"Strahlenther Onkol"},{"key":"2366_CR4","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/(SICI)1097-0142(19990115)85:2<389::AID-CNCR17>3.0.CO;2-J","volume":"85","author":"KG Billingsley","year":"1999","unstructured":"Billingsley\u00a0KG, Lewis\u00a0JJ, Leung\u00a0DH, Casper\u00a0ES, Woodruff\u00a0JM, Brennan\u00a0MF (1999) Multifactorial analysis of the survival of patients with distant metastasis arising from primary extremity sarcoma. Cancer 85:389\u2013395","journal-title":"Cancer"},{"key":"2366_CR5","doi-asserted-by":"publisher","first-page":"8029157","DOI":"10.1155\/2018\/8029157","volume":"2018","author":"V Chowdhry","year":"2018","unstructured":"Chowdhry\u00a0V, Goldberg\u00a0S, DeLaney\u00a0TF, Cote\u00a0GM, Chebib\u00a0I, Kim\u00a0J, Lozano-Calder\u00f3n\u00a0SA, De Amorim Bernstein\u00a0K (2018) Myxoid Liposarcoma: treatment outcomes from chemotherapy and radiation therapy. Sarcoma 2018:8029157. https:\/\/doi.org\/10.1155\/2018\/8029157","journal-title":"Sarcoma"},{"key":"2366_CR6","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1002\/cncr.24375","volume":"115","author":"PW Chung","year":"2009","unstructured":"Chung\u00a0PW, Deheshi\u00a0BM, Ferguson\u00a0PC, Wunder\u00a0JS, Griffin\u00a0AM, Catton\u00a0CN, Bell\u00a0RS, White\u00a0LM, Kandel\u00a0RA, O\u2019Sullivan\u00a0B (2009) Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma: a\u00a0comparison with other soft tissue sarcomas. Cancer 115:3254\u20133261. https:\/\/doi.org\/10.1002\/cncr.24375","journal-title":"Cancer"},{"key":"2366_CR7","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1200\/jco.1996.14.3.869","volume":"14","author":"JM Coindre","year":"1996","unstructured":"Coindre\u00a0JM, Terrier\u00a0P, Bui\u00a0NB, Bonichon\u00a0F, Collin\u00a0F, Le Doussal\u00a0V, Mandard\u00a0AM, Vilain\u00a0MO, Jacquemier\u00a0J, Duplay\u00a0H, Sastre\u00a0X, Barlier\u00a0C, Henry-Amar\u00a0M, Mace-Lesech\u00a0J, Contesso\u00a0G (1996) Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A\u00a0study of 546 patients from the French Federation of Cancer Centers Sarcoma Group. J\u00a0Clin Oncol 14:869\u2013877. https:\/\/doi.org\/10.1200\/jco.1996.14.3.869","journal-title":"J Clin Oncol"},{"key":"2366_CR8","doi-asserted-by":"publisher","first-page":"e699","DOI":"10.1097\/scs.0000000000006613","volume":"31","author":"T Daralioti","year":"2020","unstructured":"Daralioti\u00a0T, Petruzzi\u00a0G, Zocchi\u00a0J, Moretto\u00a0S, Pichi\u00a0B, Pellini\u00a0R, De Virgilio\u00a0A, Covello\u00a0R (2020) Myxoid Liposarcoma Metastasizing to the Parotid Gland. J\u00a0Craniofac Surg 31:e699\u2013e701. https:\/\/doi.org\/10.1097\/scs.0000000000006613","journal-title":"J Craniofac Surg"},{"key":"2366_CR9","doi-asserted-by":"publisher","first-page":"e20294","DOI":"10.1371\/journal.pone.0020294","volume":"6","author":"F Ducimeti\u00e8re","year":"2011","unstructured":"Ducimeti\u00e8re\u00a0F, Lurkin\u00a0A, Ranch\u00e8re-Vince\u00a0D, Decouvelaere\u00a0AV, P\u00e9oc\u2019h\u00a0M, Istier\u00a0L, Chalabreysse\u00a0P, Muller\u00a0C, Alberti\u00a0L, Bringuier\u00a0PP, Scoazec\u00a0JY, Schott\u00a0AM, Bergeron\u00a0C, Cellier\u00a0D, Blay\u00a0JY, Ray-Coquard\u00a0I (2011) Incidence of sarcoma histotypes and molecular subtypes in a\u00a0prospective epidemiological study with central pathology review and molecular testing. Plos One 6:e20294. https:\/\/doi.org\/10.1371\/journal.pone.0020294","journal-title":"Plos One"},{"key":"2366_CR10","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1186\/s12885-018-4226-8","volume":"18","author":"HR D\u00fcrr","year":"2018","unstructured":"D\u00fcrr\u00a0HR, Rauh\u00a0J, Baur-Melnyk\u00a0A, Kn\u00f6sel\u00a0T, Lindner\u00a0L, Roeder\u00a0F, Jansson\u00a0V, Klein\u00a0A (2018) Myxoid liposarcoma: local relapse and metastatic pattern in 43\u00a0patients. BMC Cancer 18:304. https:\/\/doi.org\/10.1186\/s12885-018-4226-8","journal-title":"BMC Cancer"},{"key":"2366_CR11","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1080\/02656736.2017.1369174","volume":"34","author":"F Eckert","year":"2018","unstructured":"Eckert\u00a0F, Braun\u00a0LH, Traub\u00a0F, Kopp\u00a0HG, Sipos\u00a0B, Lamprecht\u00a0U, M\u00fcller\u00a0AC, Paulsen\u00a0F, Zips\u00a0D (2018) Radiotherapy and hyperthermia with curative intent in recurrent high risk soft tissue sarcomas. Int J Hyperthermia 34:980\u2013987. https:\/\/doi.org\/10.1080\/02656736.2017.1369174","journal-title":"Int J Hyperthermia"},{"key":"2366_CR12","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1097\/01.sla.0000141710.74073.0d","volume":"240","author":"FC Eilber","year":"2004","unstructured":"Eilber\u00a0FC, Eilber\u00a0FR, Eckardt\u00a0J, Rosen\u00a0G, Riedel\u00a0E, Maki\u00a0RG, Brennan\u00a0MF, Singer\u00a0S (2004) The impact of chemotherapy on the survival of patients with high-grade primary extremity liposarcoma. Ann Surg 240:686\u2013695. https:\/\/doi.org\/10.1097\/01.sla.0000141710.74073.0d (discussion 695\u2013687)","journal-title":"Ann Surg"},{"key":"2366_CR13","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1200\/jco.2001.19.13.3203","volume":"19","author":"FC Eilber","year":"2001","unstructured":"Eilber\u00a0FC, Rosen\u00a0G, Eckardt\u00a0J, Forscher\u00a0C, Nelson\u00a0SD, Selch\u00a0M, Dorey\u00a0F, Eilber\u00a0FR (2001) Treatment-induced pathologic necrosis: a\u00a0predictor of local recurrence and survival in patients receiving neoadjuvant therapy for high-grade extremity soft tissue sarcomas. J\u00a0Clin Oncol 19:3203\u20133209. https:\/\/doi.org\/10.1200\/jco.2001.19.13.3203","journal-title":"J Clin Oncol"},{"key":"2366_CR14","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1080\/02841860601080415","volume":"46","author":"K Engstr\u00f6m","year":"2007","unstructured":"Engstr\u00f6m\u00a0K, Bergh\u00a0P, Cederlund\u00a0CG, Hultborn\u00a0R, Willen\u00a0H, Aman\u00a0P, Kindblom\u00a0LG, Meis-Kindblom\u00a0JM (2007) Irradiation of myxoid\/round cell liposarcoma induces volume reduction and lipoma-like morphology. Acta Oncol 46:838\u2013845. https:\/\/doi.org\/10.1080\/02841860601080415","journal-title":"Acta Oncol"},{"key":"2366_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/jso.10093","volume":"80","author":"SH Estourgie","year":"2002","unstructured":"Estourgie\u00a0SH, Nielsen\u00a0GP, Ott\u00a0MJ (2002) Metastatic patterns of extremity myxoid liposarcoma and their outcome. J\u00a0Surg Oncol 80:89\u201393. https:\/\/doi.org\/10.1002\/jso.10093","journal-title":"J Surg Oncol"},{"key":"2366_CR16","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1002\/cncr.22720","volume":"109","author":"M Fiore","year":"2007","unstructured":"Fiore\u00a0M, Grosso\u00a0F, Vullo\u00a0LS, Pennacchioli\u00a0E, Stacchiotti\u00a0S, Ferrari\u00a0A, Collini\u00a0P, Lozza\u00a0L, Mariani\u00a0L, Casali\u00a0PG, Gronchi\u00a0A (2007) Myxoid\/round cell and pleomorphic liposarcomas: prognostic factors and survival in a\u00a0series of patients treated at a\u00a0single institution. Cancer 109:2522\u20132531. https:\/\/doi.org\/10.1002\/cncr.22720","journal-title":"Cancer"},{"key":"2366_CR17","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.ijrobp.2007.07.2337","volume":"70","author":"BA Guadagnolo","year":"2008","unstructured":"Guadagnolo\u00a0BA, Zagars\u00a0GK, Ballo\u00a0MT, Patel\u00a0SR, Lewis\u00a0VO, Benjamin\u00a0RS, Pollock\u00a0RE (2008) Excellent local control rates and distinctive patterns of failure in myxoid liposarcoma treated with conservation surgery and radiotherapy. Int J Radiat Oncol Biol Phys 70:760\u2013765. https:\/\/doi.org\/10.1016\/j.ijrobp.2007.07.2337","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2366_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12703\/r\/10-1","volume":"10","author":"CL Haddox","year":"2021","unstructured":"Haddox\u00a0CL, Riedel\u00a0RF (2021) Recent advances in the understanding and management of liposarcoma. Fac Rev 10:1. https:\/\/doi.org\/10.12703\/r\/10-1","journal-title":"Fac Rev"},{"key":"2366_CR19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/978-3-642-04939-2_17","volume-title":"Weichgewebetumoren: Interdisziplin\u00e4res Management","author":"JT Hartmann","year":"2011","unstructured":"Hartmann\u00a0JT, Sch\u00fctte\u00a0J (2011) (Neo-)adjuvante medikament\u00f6se Therapie. In: Weichgewebetumoren: Interdisziplin\u00e4res Management. Springer, Berlin, Heidelberg, pp\u00a0217\u2013225 https:\/\/doi.org\/10.1007\/978-3-642-04939-2_17"},{"key":"2366_CR20","first-page":"3045","volume":"23","author":"H Hatano","year":"2003","unstructured":"Hatano\u00a0H, Ogose\u00a0A, Hotta\u00a0T, Kawashima\u00a0H, Sugita\u00a0T, Sasamoto\u00a0R, Endo\u00a0N (2003) Treatment of myxoid liposarcoma by marginal or intralesional resection combined with radiotherapy. Anticancer Res 23:3045\u20133049","journal-title":"Anticancer Res"},{"key":"2366_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-023-01064-5","author":"TP Ho","year":"2023","unstructured":"Ho\u00a0TP (2023) Myxoid liposarcoma: how to stage and follow. Curr Treat Options Oncol. https:\/\/doi.org\/10.1007\/s11864-023-01064-5","journal-title":"Curr Treat Options Oncol"},{"key":"2366_CR22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2214\/ajr.164.1.7998525","volume":"164","author":"MJ Kransdorf","year":"1995","unstructured":"Kransdorf\u00a0MJ (1995) Malignant soft-tissue tumors in a\u00a0large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol 164:129\u2013134. https:\/\/doi.org\/10.2214\/ajr.164.1.7998525","journal-title":"AJR Am J Roentgenol"},{"key":"2366_CR23","doi-asserted-by":"publisher","first-page":"e205865","DOI":"10.1001\/jamaoncol.2020.5865","volume":"7","author":"J Lansu","year":"2021","unstructured":"Lansu\u00a0J, Bov\u00e9e\u00a0J, Braam\u00a0P, van Boven\u00a0H, Flucke\u00a0U, Bonenkamp\u00a0JJ, Miah\u00a0AB, Zaidi\u00a0SH, Thway\u00a0K, Bruland \u00d8S, Baldini\u00a0EH, Jebsen\u00a0NL, Scholten\u00a0AN, van den Ende\u00a0PLA, Krol\u00a0ADG, Ubbels\u00a0JF, van der Hage\u00a0JA, van Werkhoven\u00a0E, Klomp\u00a0HM, van der Graaf\u00a0WTA, van Coevorden\u00a0F, Schrage\u00a0Y, van Houdt\u00a0WJ, Haas\u00a0RL (2021) Dose reduction of preoperative radiotherapy in myxoid liposarcoma: a\u00a0nonrandomized controlled trial. JAMA Oncol 7:e205865. https:\/\/doi.org\/10.1001\/jamaoncol.2020.5865","journal-title":"JAMA Oncol"},{"key":"2366_CR24","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1200\/jco.2017.74.9598","volume":"36","author":"ATJ Lee","year":"2018","unstructured":"Lee\u00a0ATJ, Thway\u00a0K, Huang\u00a0PH, Jones\u00a0RL (2018) Clinical and molecular spectrum of liposarcoma. J\u00a0Clin Oncol 36:151\u2013159. https:\/\/doi.org\/10.1200\/jco.2017.74.9598","journal-title":"J Clin Oncol"},{"key":"2366_CR25","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.3892\/ol.2015.3585","volume":"10","author":"S Lin","year":"2015","unstructured":"Lin\u00a0S, Gan\u00a0Z, Han\u00a0K, Yao\u00a0Y, Min\u00a0D (2015) Metastasis of myxoid liposarcoma to fat-bearing areas: a\u00a0case report of unusual metastatic sites and a\u00a0hypothesis. Oncol Lett 10:2543\u20132546. https:\/\/doi.org\/10.3892\/ol.2015.3585","journal-title":"Oncol Lett"},{"key":"2366_CR26","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1245\/s10434-011-2127-z","volume":"19","author":"LC Moreau","year":"2012","unstructured":"Moreau\u00a0LC, Turcotte\u00a0R, Ferguson\u00a0P, Wunder\u00a0J, Clarkson\u00a0P, Masri\u00a0B, Isler\u00a0M, Dion\u00a0N, Werier\u00a0J, Ghert\u00a0M, Deheshi\u00a0B (2012) Myxoid\\round cell liposarcoma (MRCLS) revisited: an analysis of 418 primarily managed cases. Ann Surg Oncol 19:1081\u20131088. https:\/\/doi.org\/10.1245\/s10434-011-2127-z","journal-title":"Ann Surg Oncol"},{"key":"2366_CR27","doi-asserted-by":"publisher","first-page":"8928706","DOI":"10.1155\/2018\/8928706","volume":"2018","author":"F Muratori","year":"2018","unstructured":"Muratori\u00a0F, Bettini\u00a0L, Frenos\u00a0F, Mondanelli\u00a0N, Greto\u00a0D, Livi\u00a0L, Franchi\u00a0A, Roselli\u00a0G, Scorianz\u00a0M, Capanna\u00a0R, Campanacci\u00a0D (2018) Myxoid Liposarcoma: prognostic factors and metastatic pattern in a\u00a0series of 148 patients treated at a\u00a0single institution. Int J Surg Oncol 2018:8928706. https:\/\/doi.org\/10.1155\/2018\/8928706","journal-title":"Int J Surg Oncol"},{"key":"2366_CR28","doi-asserted-by":"publisher","first-page":"262361","DOI":"10.1155\/2010\/262361","volume":"2010","author":"JL Noble","year":"2010","unstructured":"Noble\u00a0JL, Moskovic\u00a0E, Fisher\u00a0C, Judson\u00a0I (2010) Imaging of skeletal metastases in myxoid liposarcoma. Sarcoma 2010:262361. https:\/\/doi.org\/10.1155\/2010\/262361","journal-title":"Sarcoma"},{"key":"2366_CR29","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/jjco\/hye094","volume":"31","author":"A Ogose","year":"2001","unstructured":"Ogose\u00a0A, Hotta\u00a0T, Inoue\u00a0Y, Sakata\u00a0S, Takano\u00a0R, Yamamura\u00a0S (2001) Myxoid liposarcoma metastatic to the thoracic epidural space without bone involvement: report of two cases. Jpn J Clin Oncol 31:447\u2013449. https:\/\/doi.org\/10.1093\/jjco\/hye094","journal-title":"Jpn J Clin Oncol"},{"key":"2366_CR30","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1002\/1097-0142(19940815)74:4<1265::AID-CNCR2820740414>3.0.CO;2-X","volume":"74","author":"SR Patel","year":"1994","unstructured":"Patel\u00a0SR, Burgess\u00a0MA, Plager\u00a0C, Papadopoulos\u00a0NE, Linke\u00a0KA, Benjamin\u00a0RS (1994) Myxoid liposarcoma. Experience with chemotherapy. Cancer 74:1265\u20131269. https:\/\/doi.org\/10.1002\/1097-0142(19940815)74:4\u30081265::aid-cncr2820740414\u30093.0.co;2\u2011x","journal-title":"Cancer"},{"key":"2366_CR31","doi-asserted-by":"publisher","first-page":"6015","DOI":"10.1038\/sj.onc.1204018","volume":"19","author":"J P\u00e9rez-Losada","year":"2000","unstructured":"P\u00e9rez-Losada\u00a0J, S\u00e1nchez-Mart\u00edn\u00a0M, Rodr\u00edguez-Garc\u00eda\u00a0MA, P\u00e9rez-Mancera\u00a0PA, Pintado\u00a0B, Flores\u00a0T, Battaner\u00a0E, S\u00e1nchez-Garc\u00eda\u00a0I (2000) Liposarcoma initiated by FUS\/TLS-CHOP: the FUS\/TLS domain plays a\u00a0critical role in the pathogenesis of liposarcoma. Oncogene 19:6015\u20136022. https:\/\/doi.org\/10.1038\/sj.onc.1204018","journal-title":"Oncogene"},{"key":"2366_CR32","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.ijrobp.2004.03.009","volume":"60","author":"G Pitson","year":"2004","unstructured":"Pitson\u00a0G, Robinson\u00a0P, Wilke\u00a0D, Kandel\u00a0RA, White\u00a0L, Griffin\u00a0AM, Bell\u00a0RS, Catton\u00a0CN, Wunder\u00a0JS, O\u2019Sullivan\u00a0B (2004) Radiation response: an additional unique signature of myxoid liposarcoma. Int J Radiat Oncol Biol Phys 60:522\u2013526. https:\/\/doi.org\/10.1016\/j.ijrobp.2004.03.009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2366_CR33","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-1898999\/v1","author":"V Potkrajcic","year":"2022","unstructured":"Potkrajcic\u00a0V, Kolbenschlag\u00a0J, Sachsenmaier\u00a0S, Daigeler\u00a0A, Ladurner\u00a0R, Golf\u00a0A, Zips\u00a0D, Paulsen\u00a0F, Eckert\u00a0F (2022) Postoperative complications and oncologic outcomes after multimodal therapy of localized high risk soft tissue sarcoma. Res Sq. https:\/\/doi.org\/10.21203\/rs.3.rs-1898999\/v1","journal-title":"Res Sq"},{"key":"2366_CR34","doi-asserted-by":"publisher","first-page":"459","DOI":"10.2478\/raon-2021-0038","volume":"55","author":"V Potkrajcic","year":"2021","unstructured":"Potkrajcic\u00a0V, Traub\u00a0F, Hermes\u00a0B, Scharpf\u00a0M, Kolbenschlag\u00a0J, Zips\u00a0D, Paulsen\u00a0F, Eckert\u00a0F (2021) Hypofractionated preoperative radiotherapy for high risk soft tissue sarcomas in a\u00a0geriatric patient population. Radiol Oncol 55:459\u2013466. https:\/\/doi.org\/10.2478\/raon-2021-0038","journal-title":"Radiol Oncol"},{"key":"2366_CR35","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1200\/jco.1985.3.3.353","volume":"3","author":"DA Potter","year":"1985","unstructured":"Potter\u00a0DA, Glenn\u00a0J, Kinsella\u00a0T, Glatstein\u00a0E, Lack\u00a0EE, Restrepo\u00a0C, White\u00a0DE, Seipp\u00a0CA, Wesley\u00a0R, Rosenberg\u00a0SA (1985) Patterns of recurrence in patients with high-grade soft-tissue sarcomas. J\u00a0Clin Oncol 3:353\u2013366. https:\/\/doi.org\/10.1200\/jco.1985.3.3.353","journal-title":"J Clin Oncol"},{"key":"2366_CR36","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201910470","author":"C Regina","year":"2019","unstructured":"Regina\u00a0C, Hettmer\u00a0S (2019) Myxoid liposarcoma: it\u2019s a\u00a0hippo\u2019s world. EMBO Mol Med. https:\/\/doi.org\/10.15252\/emmm.201910470","journal-title":"EMBO Mol Med"},{"key":"2366_CR37","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.radonc.2010.10.007","volume":"97","author":"D Roberge","year":"2010","unstructured":"Roberge\u00a0D, Skamene\u00a0T, Nahal\u00a0A, Turcotte\u00a0RE, Powell\u00a0T, Freeman\u00a0C (2010) Radiological and pathological response following pre-operative radiotherapy for soft-tissue sarcoma. Radiother Oncol 97:404\u2013407. https:\/\/doi.org\/10.1016\/j.radonc.2010.10.007","journal-title":"Radiother Oncol"},{"key":"2366_CR38","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2407-3-17","volume":"3","author":"A Rydholm","year":"2003","unstructured":"Rydholm\u00a0A, Gustafson\u00a0P (2003) Should tumor depth be included in prognostication of soft tissue sarcoma? Bmc Cancer 3:17. https:\/\/doi.org\/10.1186\/1471-2407-3-17","journal-title":"Bmc Cancer"},{"key":"2366_CR39","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.aott.2017.03.009","volume":"51","author":"A Salduz","year":"2017","unstructured":"Salduz\u00a0A, Alpan\u00a0B, Valiyev\u00a0N, \u00d6zmen\u00a0E, \u0130riba\u015f\u00a0A, A\u011fao\u011flu\u00a0F, Bayram\u00a0A, Bilgi\u00e7\u00a0B, \u00d6zger\u00a0H (2017) Neoadjuvant radiotherapy for myxoid liposarcomas: oncologic outcomes and histopathologic correlations. Acta Orthop Traumatol Turc 51:355\u2013361. https:\/\/doi.org\/10.1016\/j.aott.2017.03.009","journal-title":"Acta Orthop Traumatol Turc"},{"key":"2366_CR40","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1245\/s10434-006-9306-3","volume":"14","author":"JH Schwab","year":"2007","unstructured":"Schwab\u00a0JH, Boland\u00a0P, Guo\u00a0T, Brennan\u00a0MF, Singer\u00a0S, Healey\u00a0JH, Antonescu\u00a0CR (2007) Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread. Ann Surg Oncol 14:1507\u20131514. https:\/\/doi.org\/10.1245\/s10434-006-9306-3","journal-title":"Ann Surg Oncol"},{"key":"2366_CR41","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3322\/caac.21254","volume":"65","author":"RL Siegel","year":"2015","unstructured":"Siegel\u00a0RL, Miller\u00a0KD, Jemal\u00a0A (2015) Cancer statistics, 2015. CA Cancer J Clin 65:5\u201329. https:\/\/doi.org\/10.3322\/caac.21254","journal-title":"CA Cancer J Clin"},{"key":"2366_CR42","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s10434-999-0389-5","volume":"6","author":"AJ Spillane","year":"1999","unstructured":"Spillane\u00a0AJ, Fisher\u00a0C, Thomas\u00a0JM (1999) Myxoid liposarcoma\u2014the frequency and the natural history of nonpulmonary soft tissue metastases. Ann Surg Oncol 6:389\u2013394. https:\/\/doi.org\/10.1007\/s10434-999-0389-5","journal-title":"Ann Surg Oncol"},{"key":"2366_CR43","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.ejso.2015.12.011","volume":"42","author":"JD Stevenson","year":"2016","unstructured":"Stevenson\u00a0JD, Watson\u00a0JJ, Cool\u00a0P, Cribb\u00a0GL, Jenkins\u00a0JP, Leahy\u00a0M, Gregory\u00a0JJ (2016) Whole-body magnetic resonance imaging in myxoid liposarcoma: a\u00a0useful adjunct for the detection of extra-pulmonary metastatic disease. Eur J Surg Oncol 42:574\u2013580. https:\/\/doi.org\/10.1016\/j.ejso.2015.12.011","journal-title":"Eur J Surg Oncol"},{"key":"2366_CR44","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1245\/s10434-006-9043-7","volume":"14","author":"SE ten Heuvel","year":"2007","unstructured":"ten Heuvel\u00a0SE, Hoekstra\u00a0HJ, van Ginkel\u00a0RJ, Bastiaannet\u00a0E, Suurmeijer\u00a0AJ (2007) Clinicopathologic prognostic factors in myxoid liposarcoma: a\u00a0retrospective study of 49\u00a0patients with long-term follow-up. Ann Surg Oncol 14:222\u2013229. https:\/\/doi.org\/10.1245\/s10434-006-9043-7","journal-title":"Ann Surg Oncol"},{"key":"2366_CR45","doi-asserted-by":"publisher","first-page":"7903","DOI":"10.1245\/s10434-021-10091-1","volume":"28","author":"JD Visgauss","year":"2021","unstructured":"Visgauss\u00a0JD, Wilson\u00a0DA, Perrin\u00a0DL, Colglazier\u00a0R, French\u00a0R, Mattei\u00a0JC, Griffin\u00a0AM, Wunder\u00a0JS, Ferguson\u00a0PC (2021) Staging and surveillance of myxoid liposarcoma: follow-up assessment and the metastatic pattern of 169 patients suggests inadequacy of current practice standards. Ann Surg Oncol 28:7903\u20137911. https:\/\/doi.org\/10.1245\/s10434-021-10091-1","journal-title":"Ann Surg Oncol"},{"key":"2366_CR46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4103\/ortho.IJOrtho_220_17","volume":"52","author":"DA Vodanovich","year":"2018","unstructured":"Vodanovich\u00a0DA, PF MC (2018) Soft-tissue Sarcomas. Indian J Orthop 52:35\u201344. https:\/\/doi.org\/10.4103\/ortho.IJOrtho_220_17","journal-title":"Indian J Orthop"},{"key":"2366_CR47","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s00066-022-02041-x","volume":"199","author":"U Yilmaz","year":"2023","unstructured":"Yilmaz\u00a0U, Kamer\u00a0S, Kaya\u00a0H, Sabah\u00a0D, Sanli\u00a0UA, Tamsel\u00a0I, Yaman\u00a0B, Akalin\u00a0T, Anacak\u00a0Y (2023) Preoperative radiotherapy with concomitant chemotherapy in extremity soft tissue sarcomas: long-term results of a\u00a0single center. Strahlenther Onkol 199:585\u2013594. https:\/\/doi.org\/10.1007\/s00066-022-02041-x","journal-title":"Strahlenther Onkol"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-025-02366-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00066-025-02366-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-025-02366-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:52:27Z","timestamp":1765543947000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00066-025-02366-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,3]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2366"],"URL":"https:\/\/doi.org\/10.1007\/s00066-025-02366-3","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,3]]},"assertion":[{"value":"21 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"V.\u00a0Potkrajcic, M.\u00a0Niyazi, F.\u00a0Szelat, E.\u00a0Hoffmann, F.\u00a0Paulsen and F.\u00a0Eckert have research and educational grants from Elekta, Philips, Siemens, Sennewald. V.\u00a0Potkrajcic is supported as a\u00a0Clinician Scientist by the German Sarcoma Foundation. E.\u00a0Hoffmann is supported as a\u00a0Clinician Scientist by the Else-Kr\u00f6ner Fresenius Foundation. C.K.W.\u00a0Deinzer has educational grants and lecture honoraria from Boehringer Ingelheim Pharma GmbH & Co. KG and PharmaMar GmbH. M.\u00a0Zschiegner, V.\u00a0Warm, J.T.\u00a0Thiel and S.\u00a0Frantz declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was approved by the local Ethics Committee in University Hospital T\u00fcbingen in accordance with the Declaration of Helsinki (Nr. 909\/2019BO2). Informed consent was obtained from all subjects and\/or their legal guardian(s).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}