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External-beam radiotherapy and systemic treatment were given according to the German S3 guideline for breast cancer and local tumor board recommendations. Outcome parameters were death, local recurrence, metastasis, local lymph node recurrence, and ipsilateral and contralateral invasive breast cancer. Kaplan\u2013Meier estimates were used to calculate overall survival, metastasis-free survival, local recurrence-free survival, and disease-free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 10\u00a0centers, 1133 patients were recruited. This analysis included 871 patients with 879 cancers, with a\u00a0median follow-up of 36\u00a0months (up to 12\u00a0years). An IORT boost was performed in 82% and whole-breast irradiation in 84%. Overall survival was 98.4% after 3\u00a0years, 96.8% after 5\u00a0years, and 95.4% after 10\u00a0years (16\u00a0deaths; 1.8%). Metastasis and local recurrence occurred in 11\u00a0patients each (1.3%). At 5\u00a0years, the local control rate was 97.4% and local recurrence-free survival was 94.4%. Ipsilateral breast cancer occurred in 2\u00a0patients, contralateral breast cancer in 3\u00a0patients, and local lymph node recurrence in 2\u00a0patients. Disease-free survival was 92.9% after 5\u00a0years and 82.6% after 10\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This phase\u00a0IV trial confirms previously reported outcomes on upfront IORT boost, with excellent disease-control outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00066-025-02412-0","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T05:54:29Z","timestamp":1747634069000},"page":"169-177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oncological outcomes of breast cancer patients after planned IORT boost with low-kV x-rays\u2014results of the TARGIT BQR prospective phase\u00a0IV trial"],"prefix":"10.1007","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7102-3350","authenticated-orcid":false,"given":"Lukas","family":"Goerdt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"P\u00f6msl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Kraus-Tiefenbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Br\u00fcck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Keymer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Abo-Madyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Fleckenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Berlit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Tuschy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"S\u00fctterlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Wenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sperk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"issue":"1","key":"2412_CR1","first-page":"17","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel\u00a0RL et\u00a0al (2023) Cancer statistics, 2023. 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E.\u00a0Sperk received speaker honoraria and travel assistance from Carl Zeiss Meditec AG. All other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. The study was reviewed and approved by the regional ethics committee (2011-319N-MA). All patients consented to the research use of their data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}