{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:00:55Z","timestamp":1791644455477,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00066-025-02441-9","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T15:40:07Z","timestamp":1752594007000},"page":"1185-1190","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immune-sparing potential of isocentric lateral decubitus positioning in adjuvant whole-breast radiotherapy"],"prefix":"10.1007","volume":"201","author":[{"given":"Cezara","family":"Cheptea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlia","family":"Kirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-8110","authenticated-orcid":false,"given":"Pierre","family":"Loap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"2441_CR1","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.radonc.2020.02.015","volume":"146","author":"C Xu","year":"2020","unstructured":"Xu\u00a0C, Jin\u00a0JY, Zhang\u00a0M, Liu\u00a0A, Wang\u00a0J, Mohan\u00a0R et\u00a0al (2020) The impact of the effective dose to immune cells on lymphopenia and survival of esophageal cancer after chemoradiotherapy. Radiother Oncol 146:180\u2013186","journal-title":"Radiother Oncol"},{"key":"2441_CR2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.radonc.2021.06.020","volume":"162","author":"Y Yu","year":"2021","unstructured":"Yu\u00a0Y, Fu\u00a0P, Jin\u00a0JY, Gao\u00a0S, Wang\u00a0W, Machtay\u00a0M et\u00a0al (2021) Impact of effective dose to immune cells (EDIC) on lymphocyte nadir and survival in limited-stage SCLC. Radiother Oncol 162:26\u201333","journal-title":"Radiother Oncol"},{"issue":"4","key":"2441_CR3","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.ijrobp.2021.01.035","volume":"110","author":"C Grassberger","year":"2021","unstructured":"Grassberger\u00a0C, Shinnick\u00a0D, Yeap\u00a0BY, Tracy\u00a0M, Ellsworth\u00a0SG, Hess\u00a0CB et\u00a0al (2021) Circulating lymphocyte counts early during radiation therapy are associated with recurrence in pediatric medulloblastoma. Int J Radiat Oncol Biol Phys 110(4):1044\u20131052","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"13","key":"2441_CR4","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1001\/jama.2024.3056","volume":"331","author":"RA Leon-Ferre","year":"2024","unstructured":"Leon-Ferre\u00a0RA, Jonas\u00a0SF, Salgado\u00a0R, Loi\u00a0S, de Jong\u00a0V, Carter\u00a0JM et\u00a0al (2024) Tumor-infiltrating lymphocytes in triple-negative breast cancer. JAMA 331(13):1135\u20131144","journal-title":"JAMA"},{"key":"2441_CR5","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41523-021-00292-y","volume":"7","author":"F Liu","year":"2021","unstructured":"Liu\u00a0F, Hardiman\u00a0T, Wu\u00a0K, Quist\u00a0J, Gazinska\u00a0P, Ng\u00a0T et\u00a0al (2021) Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication. Npj Breast Cancer 7:86","journal-title":"Npj Breast Cancer"},{"issue":"20","key":"2441_CR6","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1182\/bloodadvances.2021004939","volume":"5","author":"BS Imber","year":"2021","unstructured":"Imber\u00a0BS, Chau\u00a0KW, Lee\u00a0J, Lee\u00a0J, Casey\u00a0DL, Yang\u00a0JC et\u00a0al (2021) Excellent response to very-low-dose radiation (4\u202fGy) for indolent B\u2011cell lymphomas: is 4\u202fGy suitable for curable patients? Blood Adv 5(20):4185\u20134197","journal-title":"Blood Adv"},{"issue":"4","key":"2441_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0002-9610(01)00717-6","volume":"182","author":"C Chao","year":"2001","unstructured":"Chao\u00a0C, Wong\u00a0SL, Woo\u00a0C, Edwards\u00a0MJ, Tuttle\u00a0T, Noyes\u00a0RD et\u00a0al (2001) Reliable lymphatic drainage to axillary sentinel lymph nodes regardless of tumor location within the breast. Am J Surg 182(4):307\u2013311","journal-title":"Am J Surg"},{"issue":"12","key":"2441_CR8","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1007\/s00066-024-02263-1","volume":"200","author":"P Loap","year":"2024","unstructured":"Loap\u00a0P, Vu-Bezin\u00a0J, De Marzi\u00a0L, Kirova\u00a0Y (2024) Proton therapy reduces the effective dose to immune cells in breast cancer patients. Strahlenther Onkol 200(12):1074\u20131079","journal-title":"Strahlenther Onkol"},{"issue":"2","key":"2441_CR9","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s00066-024-02240-8","volume":"201","author":"P Loap","year":"2025","unstructured":"Loap\u00a0P, Bezin\u00a0VJ, De Marzi\u00a0L, Kirova\u00a0Y (2025) Determinants of radiation dose to immune cells during breast radiotherapy. Strahlenther Onkol 201(2):106\u2013114","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"2441_CR10","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.radonc.2013.10.038","volume":"110","author":"YM Kirova","year":"2014","unstructured":"Kirova\u00a0YM, Hijal\u00a0T, Campana\u00a0F, Fournier-Bidoz\u00a0N, Stilhart\u00a0A, Dendale\u00a0R et\u00a0al (2014) Whole breast radiotherapy in the lateral decubitus position: a\u00a0dosimetric and clinical solution to decrease the doses to the organs at risk (OAR). Radiother Oncol 110(3):477\u2013481","journal-title":"Radiother Oncol"},{"key":"2441_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/bjr\/tqaf049","author":"P Loap","year":"2025","unstructured":"Loap\u00a0P, Bezin\u00a0VJ, Fourquet\u00a0A, Kirova\u00a0Y (2025) Heart and lung sparing with isocentric lateral decubitus positioning compared with dorsal decubitus positioning during adjuvant localized breast cancer radiotherapy. Br J Radiol. https:\/\/doi.org\/10.1093\/bjr\/tqaf049","journal-title":"Br J Radiol"},{"issue":"5","key":"2441_CR12","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/j.ijrobp.2004.08.051","volume":"61","author":"F Campana","year":"2005","unstructured":"Campana\u00a0F, Kirova\u00a0YM, Rosenwald\u00a0JC, Dendale\u00a0R, Vilcoq\u00a0JR, Dreyfus\u00a0H et\u00a0al (2005) Breast radiotherapy in the lateral decubitus position: a\u00a0technique to prevent lung and heart irradiation. Int J Radiat Oncol Biol Phys 61(5):1348\u20131354","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"2441_CR13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.canrad.2018.09.001","volume":"23","author":"S Krhili","year":"2019","unstructured":"Krhili\u00a0S, Costa\u00a0E, Xu\u00a0HP, Kirova\u00a0YM (2019) Whole breast radiotherapy in the isocentric lateral decubitus position: role of the immobilization device and table on clinical results. Cancer Radiother 23(3):209\u2013215","journal-title":"Cancer Radiother"},{"issue":"1","key":"2441_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.radonc.2014.11.030","volume":"114","author":"BV Offersen","year":"2015","unstructured":"Offersen\u00a0BV, Boersma\u00a0LJ, Kirkove\u00a0C, Hol\u00a0S, Aznar\u00a0MC, Sola\u00a0AB et\u00a0al (2015) ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer. Radiother Oncol 114(1):3\u201310","journal-title":"Radiother Oncol"},{"issue":"8","key":"2441_CR15","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.canrad.2020.08.044","volume":"24","author":"R Msika","year":"2020","unstructured":"Msika\u00a0R, Fourquet\u00a0A, Laki\u00a0F, Porte\u00a0B, Servois\u00a0V, Kirova\u00a0Y (2020) Institut Curie guidelines on breast target volume delineation for patients treated in lateral position. Cancer Radiother 24(8):795\u2013798","journal-title":"Cancer Radiother"},{"issue":"3","key":"2441_CR16","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/s004210100459","volume":"85","author":"JD Vescovi","year":"2001","unstructured":"Vescovi\u00a0JD, Zimmerman\u00a0SL, Miller\u00a0WC, Hildebrandt\u00a0L, Hammer\u00a0RL, Fernhall\u00a0B (2001) Evaluation of the BOD POD for estimating percentage body fat in a\u00a0heterogeneous group of adult humans. Eur J Appl Physiol 85(3):326\u2013332","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"2441_CR17","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1002\/1097-0142(19850901)56:5<979::AID-CNCR2820560502>3.0.CO;2-N","volume":"56","author":"R Holland","year":"1985","unstructured":"Holland\u00a0R, Veling\u00a0SH, Mravunac\u00a0M, Hendriks\u00a0JH (1985) Histologic multifocality of Tis, T1\u20132 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer 56(5):979\u2013990","journal-title":"Cancer"},{"issue":"9938","key":"2441_CR18","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S0140-6736(13)62422-8","volume":"384","author":"P Cortazar","year":"2014","unstructured":"Cortazar\u00a0P, Zhang\u00a0L, Untch\u00a0M, Mehta\u00a0K, Costantino\u00a0JP, Wolmark\u00a0N et\u00a0al (2014) Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 384(9938):164\u2013172","journal-title":"Lancet"},{"issue":"5","key":"2441_CR19","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.annonc.2024.02.002","volume":"35","author":"L Pusztai","year":"2024","unstructured":"Pusztai\u00a0L, Denkert\u00a0C, O\u2019Shaughnessy\u00a0J, Cortes\u00a0J, Dent\u00a0R, McArthur\u00a0H et\u00a0al (2024) Event-free survival by residual cancer burden with pembrolizumab in early-stage TNBC: exploratory analysis from KEYNOTE-522. Ann Oncol 35(5):429\u2013436","journal-title":"Ann Oncol"},{"key":"2441_CR20","doi-asserted-by":"publisher","first-page":"103146","DOI":"10.1016\/j.critrevonc.2020.103146","volume":"157","author":"E Pons-Tostivint","year":"2021","unstructured":"Pons-Tostivint\u00a0E, Alouani\u00a0E, Kirova\u00a0Y, Dalenc\u00a0F, Vaysse\u00a0C (2021) Is there a\u00a0role for locoregional treatment of the primary tumor in de novo metastatic breast cancer in the era of tailored therapies?: Evidences, unresolved questions and a\u00a0practical algorithm. Crit Rev Oncol Hematol 157:103146","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"2441_CR21","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1158\/2159-8290.CD-21-0003","volume":"12","author":"FG Herrera","year":"2022","unstructured":"Herrera\u00a0FG, Ronet\u00a0C, Ochoa de Olza\u00a0M, Barras\u00a0D, Crespo\u00a0I, Andreatta\u00a0M et\u00a0al (2022) Low-dose radiotherapy reverses tumor immune desertification and resistance to immunotherapy. Cancer Discov 12(1):108\u2013133","journal-title":"Cancer Discov"},{"issue":"18","key":"2441_CR22","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1056\/NEJMoa1609214","volume":"375","author":"DB Johnson","year":"2016","unstructured":"Johnson\u00a0DB, Balko\u00a0JM, Compton\u00a0ML, Chalkias\u00a0S, Gorham\u00a0J, Xu\u00a0Y et\u00a0al (2016) Fulminant myocarditis with combination immune checkpoint blockade. N\u00a0Engl J Med 375(18):1749\u20131755","journal-title":"N Engl J Med"},{"issue":"16","key":"2441_CR23","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/j.jacc.2018.02.037","volume":"71","author":"SS Mahmood","year":"2018","unstructured":"Mahmood\u00a0SS, Fradley\u00a0MG, Cohen\u00a0JV, Nohria\u00a0A, Reynolds\u00a0KL, Heinzerling\u00a0LM et\u00a0al (2018) Myocarditis in patients treated with immune checkpoint inhibitors. J\u00a0Am Coll Cardiol 71(16):1755\u20131764","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"2441_CR24","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ijrobp.2022.12.058","volume":"116","author":"P Loap","year":"2023","unstructured":"Loap\u00a0P, Kirova\u00a0Y (2023) In regard to Alcorn et\u00a0al. Int J Radiat Oncol Biol Phys 116(2):469\u2013470","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"2441_CR25","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1056\/NEJMoa2412063","volume":"392","author":"T Reimer","year":"2025","unstructured":"Reimer\u00a0T, Stachs\u00a0A, Veselinovic\u00a0K, K\u00fchn\u00a0T, Heil\u00a0J, Polata\u00a0S et\u00a0al (2025) Axillary surgery in breast cancer\u2014primary results of the INSEMA trial. N\u00a0Engl J Med 392(11):1051\u20131064","journal-title":"N Engl J Med"},{"issue":"11","key":"2441_CR26","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1001\/jamaoncol.2023.3759","volume":"9","author":"OD Gentilini","year":"2023","unstructured":"Gentilini\u00a0OD, Botteri\u00a0E, Sangalli\u00a0C, Galimberti\u00a0V, Porpiglia\u00a0M, Agresti\u00a0R et\u00a0al (2023) Sentinel lymph node biopsy vs no axillary surgery in patients with small breast cancer and negative results on ultrasonography of axillary lymph nodes: the SOUND randomized clinical trial. JAMA Oncol 9(11):1557\u20131564","journal-title":"JAMA Oncol"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-025-02441-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00066-025-02441-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-025-02441-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:41:19Z","timestamp":1761154879000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00066-025-02441-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["2441"],"URL":"https:\/\/doi.org\/10.1007\/s00066-025-02441-9","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"31 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"C.\u00a0Cheptea, Y.\u00a0Kirova, and P.\u00a0Loap declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}