{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:08:43Z","timestamp":1790248123112,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"DOI":"10.1007\/s00066-026-02597-y","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:35:11Z","timestamp":1790246111000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Re-irradiation in central lung cancer\u2014a\u00a0monocentric detailed analysis"],"prefix":"10.1007","author":[{"given":"Florian","family":"Farnik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Szkitsak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Fietkau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Corradini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7986-2169","authenticated-orcid":false,"given":"Marlen","family":"Haderlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"issue":"2","key":"2597_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S1470-2045(14)71207-0","volume":"16","author":"JD Bradley","year":"2015","unstructured":"Bradley\u00a0JD, Paulus\u00a0R, Komaki\u00a0R, Masters\u00a0G, Blumenschein\u00a0G, Schild\u00a0S et\u00a0al (2015) Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol 16(2):187\u2013199. https:\/\/doi.org\/10.1016\/S1470-2045(14)71207-0 (PubMed PMID: 25601342; PubMed Central PMCID: PMC4419359)","journal-title":"Lancet Oncol"},{"issue":"13","key":"2597_CR2","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1200\/JCO.2009.26.2543","volume":"28","author":"A Aup\u00e9rin","year":"2010","unstructured":"Aup\u00e9rin\u00a0A, Le P\u00e9choux\u00a0C, Rolland\u00a0E, Curran\u00a0WJ, Furuse\u00a0K, Fournel\u00a0P et\u00a0al (2010) Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J\u00a0Clin Oncol 28(13):2181\u20132190. https:\/\/doi.org\/10.1200\/JCO.2009.26.2543 (PubMed PMID: 20351327)","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"19","key":"2597_CR3","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1093\/jnci\/djr325","volume":"103","author":"WJ Curran","year":"2011","unstructured":"Curran\u00a0WJ, Paulus\u00a0R, Langer\u00a0CJ, Komaki\u00a0R, Lee\u00a0JS, Hauser\u00a0S et\u00a0al (2011) Sequential vs. concurrent chemoradiation for stage\u00a0III non-small cell lung cancer: randomized phase\u00a0III trial RTOG 9410. JNCI Cancer Spectr 103(19):1452\u20131460. https:\/\/doi.org\/10.1093\/jnci\/djr325 (PubMed PMID: 21903745; PubMed Central PMCID: PMC3186782)","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"2597_CR4","first-page":"1042","volume":"1","author":"J Noble","year":"2006","unstructured":"Noble\u00a0J, Ellis\u00a0PM, Mackay\u00a0JA, Evans\u00a0WK, Lung Cancer Disease Site Group of Cancer Care Ontario\u2019s Program in Evidence-based Care (2006) Second-line or subsequent systemic therapy for recurrent or progressive non-small cell lung cancer: a\u00a0systematic review and practice guideline. J\u00a0Thorac Oncol Off Publ Int Assoc Study Lung Cancer 1(9):1042\u20131058 (PubMed PMID: 17409993)","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"issue":"2","key":"2597_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1056\/NEJMoa1504627","volume":"373","author":"J Brahmer","year":"2015","unstructured":"Brahmer\u00a0J, Reckamp\u00a0KL, Baas\u00a0P, Crin\u00f2\u00a0L, Eberhardt\u00a0WEE, Poddubskaya\u00a0E et\u00a0al (2015) Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med 373(2):123\u2013135. https:\/\/doi.org\/10.1056\/NEJMoa1504627 (PubMed PMID: 26028407; PubMed Central PMCID: PMC4681400)","journal-title":"N Engl J Med"},{"issue":"17","key":"2597_CR6","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1056\/NEJMoa1507643","volume":"373","author":"H Borghaei","year":"2015","unstructured":"Borghaei\u00a0H, Paz-Ares\u00a0L, Horn\u00a0L, Spigel\u00a0DR, Steins\u00a0M, Ready\u00a0NE et\u00a0al (2015) Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. N Engl J Med 373(17):1627\u20131639. https:\/\/doi.org\/10.1056\/NEJMoa1507643 (PubMed PMID: 26412456; PubMed Central PMCID: PMC5705936)","journal-title":"N Engl J Med"},{"key":"2597_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.111003","author":"K D\u00e4hler","year":"2025","unstructured":"D\u00e4hler\u00a0K, Day\u00a0M, Kefer\u00a0K, Torelli\u00a0N, von der Gr\u00fcn\u00a0J, Joye\u00a0A et\u00a0al (2025) Evaluation of the prognostic value of the ESTRO\/EORTC classification of reirradiation in patients with non-small cell lung cancer. Clin Transl Radiat Oncol. https:\/\/doi.org\/10.1016\/j.radonc.2025.111003 (PubMed PMID: 40555298)","journal-title":"Radiother Oncol"},{"issue":"8","key":"2597_CR8","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1002\/cncr.35128","volume":"130","author":"TB Kratzer","year":"2024","unstructured":"Kratzer\u00a0TB, Bandi\u00a0P, Freedman\u00a0ND, Smith\u00a0RA, Travis\u00a0WD, Jemal\u00a0A et\u00a0al (2024) Lung cancer statistics, 2023. Cancer Cytopathol 130(8):1330\u20131348. https:\/\/doi.org\/10.1002\/cncr.35128 (PubMed PMID: 38279776)","journal-title":"Cancer"},{"issue":"10","key":"2597_CR9","doi-asserted-by":"publisher","first-page":"e469","DOI":"10.1016\/S1470-2045(22)00447-8","volume":"23","author":"N Andratschke","year":"2022","unstructured":"Andratschke\u00a0N, Willmann\u00a0J, Appelt\u00a0AL, Alyamani\u00a0N, Balermpas\u00a0P, Baumert\u00a0BG et\u00a0al (2022) European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer consensus on re-irradiation: definition, reporting, and clinical decision making. Lancet Oncol 23(10):e469\u2013e478. https:\/\/doi.org\/10.1016\/S1470-2045(22)00447-8 (PubMed PMID: 36174633)","journal-title":"Lancet Oncol"},{"issue":"1","key":"2597_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-017-0897-6","volume":"12","author":"MC Repka","year":"2017","unstructured":"Repka\u00a0MC, Aghdam\u00a0N, Kataria\u00a0SK, Campbell\u00a0L, Suy\u00a0S, Collins\u00a0SP et\u00a0al (2017) Five-fraction SBRT for ultra-central NSCLC in-field recurrences following high-dose conventional radiation. Radiat Oncol 12(1):162. https:\/\/doi.org\/10.1186\/s13014-017-0897-6 (PubMed PMID: 29052514; PubMed Central PMCID: PMC5649069)","journal-title":"Radiat Oncol Lond Engl"},{"issue":"3","key":"2597_CR11","doi-asserted-by":"publisher","first-page":"e301","DOI":"10.1016\/j.cllc.2020.05.010","volume":"22","author":"S Sood","year":"2021","unstructured":"Sood\u00a0S, Ganju\u00a0R, Shen\u00a0X, Napel\u00a0MT, Wang\u00a0F (2021) Ultra-central Thoracic Re-irradiation Using 10-fraction Stereotactic Body Radiotherapy for Recurrent Non-small-cell Lung Cancer Tumors: Preliminary Toxicity and Efficacy Outcomes. Clin Lung Cancer 22(3):e301\u2013e312. https:\/\/doi.org\/10.1016\/j.cllc.2020.05.010 (PubMed PMID: 33132058)","journal-title":"Clin Lung Cancer"},{"issue":"3","key":"2597_CR12","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3390\/cancers14030573","volume":"14","author":"B Grambozov","year":"2022","unstructured":"Grambozov\u00a0B, Stana\u00a0M, Kaiser\u00a0B, Karner\u00a0J, Gerum\u00a0S, Ruznic\u00a0E et\u00a0al (2022) High Dose Thoracic Re-Irradiation and Chemo-Immunotherapy for Centrally Recurrent NSCLC. Cancers 14(3):573. https:\/\/doi.org\/10.3390\/cancers14030573 (PubMed PMID: 35158841; PubMed Central PMCID: PMC8833516)","journal-title":"Cancers"},{"issue":"1","key":"2597_CR13","doi-asserted-by":"publisher","first-page":"e226","DOI":"10.1016\/j.ijrobp.2025.06.3790","volume":"123","author":"J Willmann","year":"2025","unstructured":"Willmann\u00a0J, D\u00e4hler\u00a0K, Day\u00a0M, Kefer\u00a0K, Torelli\u00a0N, von der Gr\u00fcn\u00a0J et\u00a0al (2025) Reirradiation or Repeat Organ Irradiation for Non-Small Cell Lung Cancer: Oncological Outcomes and Toxicities. Adv Radiat Oncol 123(1):e226\u2013e227. https:\/\/doi.org\/10.1016\/j.ijrobp.2025.06.3790","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"2597_CR14","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ijrobp.2025.03.056","volume":"123","author":"CB Simone","year":"2025","unstructured":"Simone\u00a0CB, Amini\u00a0A, Chetty\u00a0IJ, Choi\u00a0JI, Chun\u00a0SG, Donington\u00a0J et\u00a0al (2025) American Radium Society Appropriate Use Criteria Systematic Review and Guidelines on Reirradiation for Non-Small Cell Lung Cancer Executive Summary. Adv Radiat Oncol 123(1):204\u2013220. https:\/\/doi.org\/10.1016\/j.ijrobp.2025.03.056 (PubMed PMID: 40185207)","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"30","key":"2597_CR15","doi-asserted-by":"publisher","first-page":"4833","DOI":"10.1200\/JCO.2006.07.5937","volume":"24","author":"R Timmerman","year":"2006","unstructured":"Timmerman\u00a0R, McGarry\u00a0R, Yiannoutsos\u00a0C, Papiez\u00a0L, Tudor\u00a0K, DeLuca\u00a0J et\u00a0al (2006) Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J\u00a0Clin Oncol 24(30):4833\u20134839. https:\/\/doi.org\/10.1200\/JCO.2006.07.5937 (PubMed PMID: 17050868)","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"7","key":"2597_CR16","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s00066-023-02062-0","volume":"199","author":"R Werner","year":"2023","unstructured":"Werner\u00a0R, Szkitsak\u00a0J, Madesta\u00a0F, B\u00fcttgen\u00a0L, Wimmert\u00a0L, Sentker\u00a0T et\u00a0al (2023) Clinical application of breathing-adapted 4D CT: image quality comparison to conventional 4D CT. Strahlenther Onkol 199(7):686\u2013691. https:\/\/doi.org\/10.1007\/s00066-023-02062-0","journal-title":"Strahlenther Onkol Organ Dtsch Rontgengesellschaft Al"},{"issue":"7","key":"2597_CR17","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.jtho.2021.03.019","volume":"16","author":"K Lindberg","year":"2021","unstructured":"Lindberg\u00a0K, Grozman\u00a0V, Karlsson\u00a0K, Lindberg\u00a0S, Lax\u00a0I, Wers\u00e4ll\u00a0P et\u00a0al (2021) The HILUS-Trial\u2011a Prospective Nordic Multicenter Phase 2 Study of Ultracentral Lung Tumors Treated With Stereotactic Body Radiotherapy. JTO Clin Res Rep 16(7):1200\u20131210. https:\/\/doi.org\/10.1016\/j.jtho.2021.03.019 (PubMed PMID: 33823286)","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"issue":"12","key":"2597_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2024.101626","volume":"9","author":"C Rock","year":"2024","unstructured":"Rock\u00a0C, Kane\u00a0K, Sood\u00a0S, Cao\u00a0Y, Chen\u00a0RC, Wang\u00a0F (2024) Reirradiation of Utracentrally Located Thoracic Tumors Using a\u00a010-Fraction Hypofractionated Stereotactic Body Radiation Therapy Course: A\u00a0Detailed Dosimetric Analysis. Adv Radiat Oncol 9(12):101626. https:\/\/doi.org\/10.1016\/j.adro.2024.101626 (PubMed PMID: 39474010; PubMed Central PMCID: PMC11513450)","journal-title":"Adv Radiat Oncol"},{"issue":"5","key":"2597_CR19","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.ijrobp.2014.01.012","volume":"88","author":"M Trovo","year":"2014","unstructured":"Trovo\u00a0M, Minatel\u00a0E, Durofil\u00a0E, Polesel\u00a0J, Avanzo\u00a0M, Baresic\u00a0T et\u00a0al (2014) Stereotactic body radiation therapy for re-irradiation of persistent or recurrent non-small cell lung cancer. Adv Radiat Oncol 88(5):1114\u20131119. https:\/\/doi.org\/10.1016\/j.ijrobp.2014.01.012 (PubMed PMID: 24661664)","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2597_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.111001","volume":"209","author":"SS Butler","year":"2025","unstructured":"Butler\u00a0SS, Raclin\u00a0T, Lau\u00a0B, Raja\u00a0N, Skinner\u00a0L, Kastelowitz\u00a0N et\u00a0al (2025) Efficacy and toxicity of hyperfractionated thoracic reirradiation. Clin Transl Radiat Oncol 209:111001. https:\/\/doi.org\/10.1016\/j.radonc.2025.111001 (PubMed PMID: 40555297)","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"issue":"1","key":"2597_CR21","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12885-019-5542-3","volume":"19","author":"S Sumodhee","year":"2019","unstructured":"Sumodhee\u00a0S, Bondiau\u00a0PY, Poudenx\u00a0M, Cohen\u00a0C, Naghavi\u00a0AO, Padovani\u00a0B et\u00a0al (2019) Long term efficacy and toxicity after stereotactic ablative reirradiation in locally relapsed stage III non-small cell lung cancer. BMC Cancer 19(1):305\u2013305. https:\/\/doi.org\/10.1186\/s12885-019-5542-3 (PubMed PMID: 30943943; PubMed Central PMCID: PMC6448259)","journal-title":"BMC Cancer"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-026-02597-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00066-026-02597-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-026-02597-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:35:12Z","timestamp":1790246112000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00066-026-02597-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":21,"alternative-id":["2597"],"URL":"https:\/\/doi.org\/10.1007\/s00066-026-02597-y","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"22 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"F.\u00a0Farnik, J.\u00a0Szkitsak, J.\u00a0Brand, T.\u00a0Brandt, R.\u00a0Fietkau, S.\u00a0Corradini, P.\u00a0Schubert and M.\u00a0Haderlein declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}