{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:07:53Z","timestamp":1792782473797,"version":"4.5.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum M\u00fcnster","id":[{"id":"https:\/\/ror.org\/01856cw59","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Intravascular papillary endothelial hyperplasia (IPEH, \u201cMasson\u2019s tumor\u201d) is a\u00a0rare benign tumor of vascular origin. It may occur at various anatomical sites and is often preceded by local stress conditions such as trauma or even stereotactic radiotherapy. The treatment normally requires surgical resection, as tumors are able to grow rapidly and cause symptoms that can limit activities of daily life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We present the case of a\u00a077-year-old woman developing IPEH in the left supraorbital skull after facial trauma, leading to rapid mutilating tumor growth and causing loss of functionality of the left eye. Since a\u00a0surgical approach was initially not possible due to the bleeding risk, local radiotherapy was applied. Because radiotherapy can also be a\u00a0cause of IPEH, we discuss its use as part of a\u00a0multimodal treatment strategy based on the available literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Evidence regarding the optimal treatment of IPEH is limited. Several case reports link its appearance to prior stereotactic radiotherapy. In our case, the application of normofractionated radiotherapy resulted in a\u00a0stop of tumor growth. After additional necrosectomy, the patient regained functionality of her left eye and was less limited in everyday activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While stereotactic radiotherapy has been linked to the development of IPEH in selected reports, normofractionated radiotherapy achieved meaningful local control in this case and facilitated further surgical treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00066-026-02598-x","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:35:50Z","timestamp":1790152550000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Upfront radiotherapy as part of the multimodal treatment of intravascular papillary endothelial hyperplasia (Masson\u2019s tumor) of the neurocranium\u2014a\u00a0case report and review of the literature"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-4203","authenticated-orcid":false,"given":"Niklas Benedikt","family":"Pepper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Rene","family":"Steike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee-C\u00e4cilia","family":"Spille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"K\u00fcllenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Stummer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Theodor","family":"Eich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"4","key":"2598_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00066-014-0789-8","volume":"191","author":"G Reinartz","year":"2015","unstructured":"German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD), Reinartz\u00a0G, Eich\u00a0HT, Pohl\u00a0F (2015) DEGRO practical guidelines for the radiotherapy of non-malignant disorders \u2013 Part\u00a0IV: Symptomatic functional disorders. Strahlenther Onkol 191(4):295\u2013302. https:\/\/doi.org\/10.1007\/s00066-014-0789-8","journal-title":"Strahlenther Onkol"},{"key":"2598_CR2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","volume":"89","author":"DS Riley","year":"2017","unstructured":"Riley\u00a0DS, Barber\u00a0MS, Kienle\u00a0GS, Aronson\u00a0JK, Von Schoen-Angerer\u00a0T, Tugwell\u00a0P, Kiene\u00a0H, Helfand\u00a0M, Altman\u00a0DG, Sox\u00a0H, Werthmann\u00a0PG, Moher\u00a0D, Rison\u00a0RA, Shamseer\u00a0L, Koch\u00a0CA, Sun\u00a0GH, Hanaway\u00a0P, Sudak\u00a0NL, Kaszkin-Bettag\u00a0M, Carpenter\u00a0JE, Gagnier\u00a0JJ (2017) CARE guidelines for case reports: explanation and elaboration document. J\u00a0Clin Epidemiol 89:218\u2013235. https:\/\/doi.org\/10.1016\/j.jclinepi.2017.04.026","journal-title":"Journal of Clinical Epidemiology"},{"issue":"3","key":"2598_CR3","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3857\/roj.2017.00199","volume":"35","author":"S Park","year":"2017","unstructured":"Park\u00a0S, Yoon\u00a0SM, Lee\u00a0S, Park , Song\u00a0SY, Lee , Ahn\u00a0SD, Kim\u00a0JH, Choi\u00a0EK (2017) Role of fractionated radiotherapy in patients with hemangioma of the cavernous sinus. 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BMJ Case Rep 2013:bcr2013009549. https:\/\/doi.org\/10.1136\/bcr-2013-009549","journal-title":"BMJ Case Reports"},{"issue":"1","key":"2598_CR6","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1302\/0301-620X.90B1.19726","volume":"90-B","author":"SG Anthony","year":"2008","unstructured":"Anthony\u00a0SG, Mudgal\u00a0CS, DeLaney\u00a0TF, Shin\u00a0RD, Raskin\u00a0KA, Ring\u00a0DC (2008) Recurrent intravascular papillary endothelial hyperplasia of the right middle finger treated with radiation therapy. 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The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the Medical Association of Westphalia-Lippe and the University of M\u00fcnster on 02.06.2026 (protocol code 2026-405-f-S).","order":1,"name":"Ethics","label":"Ethical standards","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"N.B. Pepper, D.R.\u00a0Steike, D.-C.\u00a0Spille, E.\u00a0K\u00fcllenberg, W.\u00a0Stummer, and H.T.\u00a0Eich declare they have no competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}