{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:00:19Z","timestamp":1790193619191,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Strahlenther Onkol"],"DOI":"10.1007\/s00066-026-02600-6","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:06:26Z","timestamp":1790190386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anatomical\u2013molecular interaction in glioblastoma: subventricular zone involvement and MGMT-related survival benefit"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4084-3672","authenticated-orcid":false,"given":"Flavio","family":"Donnini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Bonzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Pastina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Perrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Bagnacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Chibbaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Cerase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Antonietta Mazzei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Minniti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"12 Suppl 2","key":"2600_CR1","doi-asserted-by":"publisher","first-page":"iii1","DOI":"10.1093\/neuonc\/noab200","volume":"23","author":"QT Ostrom","year":"2021","unstructured":"Ostrom\u00a0QT, Cioffi\u00a0G, Waite\u00a0K, Kruchko\u00a0C, Barnholtz-Sloan\u00a0JS (2021) CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018. Neurooncol Adv 23(12 Suppl 2):iii1\u2013iii105. https:\/\/doi.org\/10.1093\/neuonc\/noab200 (PMID: 34608945; PMCID: PMC8491279)","journal-title":"Neuro Oncol"},{"issue":"10","key":"2600_CR2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa043330","volume":"352","author":"R Stupp","year":"2005","unstructured":"Stupp\u00a0R, Mason\u00a0WP, van den Bent\u00a0MJ, Weller\u00a0M, Fisher\u00a0B, Taphoorn\u00a0MJ, Belanger\u00a0K, Brandes\u00a0AA, Marosi\u00a0C, Bogdahn\u00a0U, Curschmann\u00a0J, Janzer\u00a0RC, Ludwin\u00a0SK, Gorlia\u00a0T, Allgeier\u00a0A, Lacombe\u00a0D, Cairncross\u00a0JG, Eisenhauer\u00a0E, Mirimanoff\u00a0RO, European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups, National Cancer Institute of Canada Clinical Trials Group (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987\u2013996. https:\/\/doi.org\/10.1056\/NEJMoa043330 (PMID: 15758009)","journal-title":"N Engl J Med"},{"issue":"5","key":"2600_CR3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","volume":"10","author":"R Stupp","year":"2009","unstructured":"Stupp\u00a0R, Hegi\u00a0ME, Mason\u00a0WP, van den Bent\u00a0MJ, Taphoorn\u00a0MJ, Janzer\u00a0RC, Ludwin\u00a0SK, Allgeier\u00a0A, Fisher\u00a0B, Belanger\u00a0K, Hau\u00a0P, Brandes\u00a0AA, Gijtenbeek\u00a0J, Marosi\u00a0C, Vecht\u00a0CJ, Mokhtari\u00a0K, Wesseling\u00a0P, Villa\u00a0S, Eisenhauer\u00a0E, Gorlia\u00a0T, Weller\u00a0M, Lacombe\u00a0D, Cairncross\u00a0JG, Mirimanoff\u00a0RO, European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups, National Cancer Institute of Canada Clinical Trials Group (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a\u00a0randomised phase\u00a0III study: 5\u2011year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459\u2013466. https:\/\/doi.org\/10.1016\/S1470-2045(09)70025-7 (Epub 2009 Mar\u00a09. PMID: 19269895)","journal-title":"Lancet Oncol"},{"issue":"10","key":"2600_CR4","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1056\/NEJMoa043331","volume":"352","author":"ME Hegi","year":"2005","unstructured":"Hegi\u00a0ME, Diserens\u00a0AC, Gorlia\u00a0T, Hamou\u00a0MF, de Tribolet\u00a0N, Weller\u00a0M, Kros\u00a0JM, Hainfellner\u00a0JA, Mason\u00a0W, Mariani\u00a0L, Bromberg JE, Hau\u00a0P, Mirimanoff\u00a0RO, Cairncross\u00a0JG, Janzer\u00a0RC, Stupp\u00a0R (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352(10):997\u20131003. https:\/\/doi.org\/10.1056\/NEJMoa043331 (PMID: 15758010)","journal-title":"N Engl J Med"},{"issue":"3","key":"2600_CR5","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41571-020-00447-z","volume":"18","author":"M Weller","year":"2021","unstructured":"Weller\u00a0M, van den Bent\u00a0M, Preusser\u00a0M, Le Rhun\u00a0E, Tonn\u00a0JC, Minniti\u00a0G, Bendszus\u00a0M, Balana\u00a0C, Chinot\u00a0O, Dirven\u00a0L, French\u00a0P, Hegi\u00a0ME, Jakola\u00a0AS, Platten\u00a0M, Roth\u00a0P, Rud\u00e0\u00a0R, Short\u00a0S, Smits\u00a0M, Taphoorn\u00a0MJB, von Deimling\u00a0A, Westphal\u00a0M, Soffietti\u00a0R, Reifenberger\u00a0G, Wick\u00a0W (2021) EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat Rev Clin Oncol 18(3):170\u2013186. https:\/\/doi.org\/10.1038\/s41571-020-00447-z (Epub 2020 Dec 8. PMID: 33293629)","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"2600_CR6","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1002\/jcp.25896","volume":"233","author":"MM Binabaj","year":"2018","unstructured":"Binabaj\u00a0MM, Bahrami\u00a0A, ShahidSales\u00a0S, Joodi\u00a0M, Joudi Mashhad\u00a0M, Hassanian\u00a0SM, Anvari\u00a0K, Avan\u00a0A (2018) The prognostic value of MGMT promoter methylation in glioblastoma: A meta-analysis of clinical trials. J\u00a0Cell Physiol 233(1):378\u2013386. https:\/\/doi.org\/10.1002\/jcp.25896 (Epub 2017 May 16. PMID: 28266716)","journal-title":"J Cell Physiol"},{"issue":"3","key":"2600_CR7","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.cell.2015.12.028","volume":"164","author":"M Ceccarelli","year":"2016","unstructured":"Ceccarelli\u00a0M, Barthel\u00a0FP, Malta\u00a0TM, Sabedot\u00a0TS, Salama\u00a0SR, Murray\u00a0BA, Morozova\u00a0O, Newton\u00a0Y, Radenbaugh\u00a0A, Pagnotta\u00a0SM, Anjum\u00a0S, Wang\u00a0J, Manyam\u00a0G, Zoppoli\u00a0P, Ling\u00a0S, Rao\u00a0AA, Grifford\u00a0M, Cherniack\u00a0AD, Zhang\u00a0H, Poisson\u00a0L, Carlotti\u00a0CG Jr, Tirapelli\u00a0DP, Rao\u00a0A, Mikkelsen\u00a0T, Lau\u00a0CC, Yung\u00a0WK, Rabadan\u00a0R, Huse\u00a0J, Brat\u00a0DJ, Lehman\u00a0NL, Barnholtz-Sloan\u00a0JS, Zheng\u00a0S, Hess\u00a0K, Rao\u00a0G, Meyerson\u00a0M, Beroukhim\u00a0R, Cooper\u00a0L, Akbani\u00a0R, Wrensch\u00a0M, Haussler\u00a0D, Aldape\u00a0KD, Laird\u00a0PW, Gutmann\u00a0DH, TCGA Research Network, Noushmehr\u00a0H, Iavarone\u00a0A, Verhaak\u00a0RG (2016) Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. Device 164(3):550\u2013563. https:\/\/doi.org\/10.1016\/j.cell.2015.12.028 (PMID: 26824661; PMCID: PMC4754110)","journal-title":"Cell"},{"issue":"6976","key":"2600_CR8","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nature02301","volume":"427","author":"N Sanai","year":"2004","unstructured":"Sanai\u00a0N, Tramontin\u00a0AD, Qui\u00f1ones-Hinojosa\u00a0A, Barbaro\u00a0NM, Gupta\u00a0N, Kunwar\u00a0S, Lawton\u00a0MT, McDermott\u00a0MW, Parsa\u00a0AT, Manuel-Garc\u00eda Verdugo\u00a0J, Berger\u00a0MS, Alvarez-Buylla\u00a0A (2004) Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature 427(6976):740\u2013744. https:\/\/doi.org\/10.1038\/nature02301 (PMID: 14973487)","journal-title":"Nature"},{"issue":"4","key":"2600_CR9","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","volume":"70","author":"GL Ming","year":"2011","unstructured":"Ming\u00a0GL, Song\u00a0H (2011) Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 70(4):687\u2013702. https:\/\/doi.org\/10.1016\/j.neuron.2011.05.001 (PMID: 21609825; PMCID: PMC3106107)","journal-title":"Neuron"},{"issue":"1","key":"2600_CR10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/neuonc\/nos268","volume":"15","author":"NF Jafri","year":"2013","unstructured":"Jafri\u00a0NF, Clarke\u00a0JL, Weinberg\u00a0V, Barani\u00a0IJ, Cha\u00a0S (2013) Relationship of glioblastoma multiforme to the subventricular zone is associated with survival. Neurooncol Adv 15(1):91\u201396. https:\/\/doi.org\/10.1093\/neuonc\/nos268 (Epub 2012 Oct 24. PMID: 23095230; PMCID: PMC3534420)","journal-title":"Neuro Oncol"},{"issue":"3","key":"2600_CR11","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1007\/s12094-020-02448-x","volume":"23","author":"S Comas","year":"2021","unstructured":"Comas\u00a0S, Luguera\u00a0E, Molero\u00a0J, Bala\u00f1a\u00a0C, Estival\u00a0A, Casta\u00f1er\u00a0S, Carrato\u00a0C, Hostalot\u00a0C, Teixidor\u00a0P, Vill\u00e0\u00a0S (2021) Influence of glioblastoma contact with the subventricular zone on survival and recurrence patterns. Clin Transl Oncol 23(3):554\u2013564. https:\/\/doi.org\/10.1007\/s12094-020-02448-x (Epub 2020 Jul 29. PMID: 32728970)","journal-title":"Clin Transl Oncol"},{"issue":"10","key":"2600_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222717","volume":"14","author":"S Berendsen","year":"2019","unstructured":"Berendsen\u00a0S, van Bodegraven\u00a0E, Seute\u00a0T, Spliet\u00a0WGM, Geurts\u00a0M, Hendrikse\u00a0J, Schoysman\u00a0L, Huiszoon\u00a0WB, Varkila\u00a0M, Rouss\u00a0S, Bell\u00a0EH, Kroonen\u00a0J, Chakravarti\u00a0A, Bours\u00a0V, Snijders\u00a0TJ, Robe\u00a0PA (2019) Adverse prognosis of glioblastoma contacting the subventricular zone: Biological correlates. PLoS One 14(10):e0222717. https:\/\/doi.org\/10.1371\/journal.pone.0222717 (PMID: 31603915; PMCID: PMC6788733)","journal-title":"PLoS One"},{"issue":"1","key":"2600_CR13","doi-asserted-by":"publisher","DOI":"10.1080\/23262133.2016.1225548","volume":"3","author":"AW Smith","year":"2016","unstructured":"Smith\u00a0AW, Parashar\u00a0B, Wernicke\u00a0AG (2016) Subventricular zone-associated glioblastoma: A\u00a0call for translational research to guide clinical decision making. Neurogenesis (Austin) 3(1):e1225548. https:\/\/doi.org\/10.1080\/23262133.2016.1225548 (PMID: 27900341; PMCID: PMC5111577)","journal-title":"Neurogenesis (Austin)"},{"issue":"4","key":"2600_CR14","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.ijrobp.2014.07.027","volume":"90","author":"S Adeberg","year":"2014","unstructured":"Adeberg\u00a0S, K\u00f6nig\u00a0L, Bostel\u00a0T, Harrabi\u00a0S, Welzel\u00a0T, Debus\u00a0J, Combs\u00a0SE (2014) Glioblastoma recurrence patterns after radiation therapy with regard to the subventricular zone. Adv Radiat Oncol 90(4):886\u2013893. https:\/\/doi.org\/10.1016\/j.ijrobp.2014.07.027 (Epub 2014 Sep 11. PMID: 25220720)","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2600_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.693693","volume":"11","author":"S Zhang","year":"2021","unstructured":"Zhang\u00a0S, Zhao\u00a0F, Zhou\u00a0T, Liu\u00a0D, Yao\u00a0X, Fu\u00a0W, Liu\u00a0Z, Lan\u00a0C, Lai\u00a0Z, Liu\u00a0C, Li\u00a0H, Li\u00a0Y, Hu\u00a0S, Yin\u00a0Y, Tan\u00a0T, Li\u00a0W, Li\u00a0F, Hu\u00a0H, Feng\u00a0H (2021) Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With Glioma. Front Oncol 11:693693. https:\/\/doi.org\/10.3389\/fonc.2021.693693","journal-title":"Front. Oncol"},{"issue":"1","key":"2600_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/cancers18010063","volume":"18","author":"H Selhane","year":"2025","unstructured":"Selhane\u00a0H, Obara\u00a0T, Vogin\u00a0G, Anxionnat\u00a0R, Gauchotte\u00a0G, Taillandier\u00a0L, Blonski\u00a0M, Rech\u00a0F (2025) Prognostic Factors of IDH Wild-Type Glioblastoma After Extensive Surgery: A Multimodal Atlas of Tumor Locations, Recurrences and Management. Cancers 18(1):63. https:\/\/doi.org\/10.3390\/cancers18010063","journal-title":"Cancers (Basel)"},{"issue":"1","key":"2600_CR17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13014-017-0791-2","volume":"12","author":"J Khalifa","year":"2017","unstructured":"Khalifa\u00a0J, Tensaouti\u00a0F, Lusque\u00a0A, Plas\u00a0B, Lotterie\u00a0JA, Benouaich-Amiel\u00a0A, Uro-Coste\u00a0E, Lubrano\u00a0V, Cohen-Jonathan Moyal\u00a0E (2017) Subventricular zones: new key targets for glioblastoma treatment. Radiat Oncol 12(1):67. https:\/\/doi.org\/10.1186\/s13014-017-0791-2 (PMID: 28424082; PMCID: PMC5397708)","journal-title":"Radiat Oncol"},{"issue":"2","key":"2600_CR18","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s11060-023-04342-2","volume":"163","author":"P Tini","year":"2023","unstructured":"Tini\u00a0P, Yavoroska\u00a0M, Mazzei\u00a0MA, Miracco\u00a0C, Pirtoli\u00a0L, Tomaciello\u00a0M, Marampon\u00a0F, Minniti\u00a0G (2023) Low expression of Ki-67\/MIB\u20111 labeling index in IDH wild type glioblastoma predicts prolonged survival independently by MGMT methylation status. J\u00a0Neurooncol 163(2):339\u2013344. https:\/\/doi.org\/10.1007\/s11060-023-04342-2","journal-title":"J Neurooncol"},{"key":"2600_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109663","volume":"184","author":"M Niyazi","year":"2023","unstructured":"Niyazi\u00a0M, Andratschke\u00a0N, Bendszus\u00a0M, Chalmers\u00a0AJ, Erridge\u00a0SC, Galldiks\u00a0N, Lagerwaard\u00a0FJ, Navarria\u00a0P, Munck Af Rosensch\u00f6ld\u00a0P, Ricardi\u00a0U, van den Bent\u00a0MJ, Weller\u00a0M, Belka\u00a0C, Minniti\u00a0G (2023) ESTRO-EANO guideline on target delineation and radiotherapy details for glioblastoma. Clin Transl Radiat Oncol 184:109663. https:\/\/doi.org\/10.1016\/j.radonc.2023.109663 (Epub 2023 Apr 13. PMID: 37059335)","journal-title":"Radiother Oncol"},{"issue":"1","key":"2600_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s11060-016-2278-7","volume":"131","author":"AM Mistry","year":"2017","unstructured":"Mistry\u00a0AM, Hale\u00a0AT, Chambless\u00a0LB, Weaver\u00a0KD, Thompson\u00a0RC, Ihrie\u00a0RA (2017) Influence of glioblastoma contact with the lateral ventricle on survival: a\u00a0meta-analysis. J\u00a0Neurooncol 131(1):125\u2013133. https:\/\/doi.org\/10.1007\/s11060-016-2278-7 (Epub 2016 Sep\u00a019. PMID: 27644688; PMCID: PMC5262526)","journal-title":"J Neurooncol"},{"issue":"7120","key":"2600_CR21","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/nature05236","volume":"444","author":"S Bao","year":"2006","unstructured":"Bao\u00a0S, Wu\u00a0Q, McLendon\u00a0RE, Hao\u00a0Y, Shi\u00a0Q, Hjelmeland\u00a0AB, Dewhirst\u00a0MW, Bigner\u00a0DD, Rich\u00a0JN (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444(7120):756\u2013760. https:\/\/doi.org\/10.1038\/nature05236 (Epub 2006 Oct 18. PMID: 17051156)","journal-title":"Nature"},{"issue":"23","key":"2600_CR22","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1001\/jama.2017.18718","volume":"318","author":"R Stupp","year":"2017","unstructured":"Stupp\u00a0R, Taillibert\u00a0S, Kanner\u00a0A, Read\u00a0W, Steinberg\u00a0D, Lhermitte\u00a0B, Toms\u00a0S, Idbaih\u00a0A, Ahluwalia\u00a0MS, Fink\u00a0K, Di Meco\u00a0F, Lieberman\u00a0F, Zhu\u00a0JJ, Stragliotto\u00a0G, Tran\u00a0D, Brem\u00a0S, Hottinger\u00a0A, Kirson\u00a0ED, Lavy-Shahaf\u00a0G, Weinberg\u00a0U, Kim\u00a0CY, Paek\u00a0SH, Nicholas\u00a0G, Bruna\u00a0J, Hirte\u00a0H, Weller\u00a0M, Palti\u00a0Y, Hegi\u00a0ME, Ram\u00a0Z (2017) Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial. JAMA 318(23):2306\u20132316. https:\/\/doi.org\/10.1001\/jama.2017.18718 (PMID: 29260225)","journal-title":"JAMA"},{"issue":"10172","key":"2600_CR23","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/S0140-6736(18)31791-4","volume":"393","author":"U Herrlinger","year":"2019","unstructured":"Herrlinger\u00a0U, Tzaridis\u00a0T, Mack\u00a0F, Steinbach\u00a0JP, Schlegel\u00a0U, Sabel\u00a0M, Hau\u00a0P, Kortmann\u00a0RD, Krex\u00a0D, Grauer\u00a0O, Goldbrunner\u00a0R, Schnell\u00a0O, B\u00e4hr\u00a0O, Uhl\u00a0M, Seidel\u00a0C, Tabatabai\u00a0G, Kowalski\u00a0T, Ringel\u00a0F, Schmidt-Graf\u00a0F, Suchorska\u00a0B, Brehmer\u00a0S, Weyerbrock\u00a0A, Renovanz\u00a0M, Bullinger\u00a0L, Galldiks\u00a0N, Vajkoczy\u00a0P, Misch\u00a0M, Vatter\u00a0H, Stuplich\u00a0M, Sch\u00e4fer\u00a0N, Kebir\u00a0S, Weller\u00a0J, Schaub\u00a0C, Stummer\u00a0W, Tonn\u00a0JC, Simon\u00a0M, Keil\u00a0VC, Nelles\u00a0M, Urbach\u00a0H, Coenen\u00a0M, Wick\u00a0W, Weller\u00a0M, Fimmers\u00a0R, Schmid\u00a0M, Hattingen\u00a0E, Pietsch\u00a0T, Coch\u00a0C, Glas\u00a0M (2019) Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG\/NOA-09): a randomised, open-label, phase 3 trial. Lancet 393(10172):678\u2013688. https:\/\/doi.org\/10.1016\/S0140-6736(18)31791-4","journal-title":"Lancet"},{"issue":"4","key":"2600_CR24","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.ijrobp.2013.02.014","volume":"86","author":"L Chen","year":"2013","unstructured":"Chen\u00a0L, Guerrero-Cazares\u00a0H, Ye\u00a0X, Ford\u00a0E, McNutt\u00a0T, Kleinberg\u00a0L, Lim\u00a0M, Chaichana\u00a0K, Quinones-Hinojosa\u00a0A, Redmond\u00a0K (2013) Increased subventricular zone radiation dose correlates with survival in glioblastoma patients after gross total resection. Adv Radiat Oncol 86(4):616\u2013622. https:\/\/doi.org\/10.1016\/j.ijrobp.2013.02.014 (Epub 2013 Mar 26. PMID: 23540348; PMCID: PMC3996451)","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Strahlentherapie und Onkologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-026-02600-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00066-026-02600-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00066-026-02600-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:06:26Z","timestamp":1790190386000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00066-026-02600-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":24,"alternative-id":["2600"],"URL":"https:\/\/doi.org\/10.1007\/s00066-026-02600-6","relation":{},"ISSN":["0179-7158","1439-099X"],"issn-type":[{"value":"0179-7158","type":"print"},{"value":"1439-099X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"16 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Institutional Review Board Statement: The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Azienda Ospedaliero Universitaria Senese, Area Vasta Sud-Est (GLIOMARKERS\u00a01.1). Informed Consent Statement: Patient data were collected retrospectively; informed consent was waived by the Ethics Committee given the observational nature of the study.","order":1,"name":"Ethics","label":"Ethical standards","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"F.\u00a0Donnini, A.\u00a0Bonzani, P.\u00a0Pastina, G.\u00a0Battaglia, A.\u00a0Perrella, G.\u00a0Bagnacci, S.\u00a0Chibbaro, A.\u00a0Cerase, M.\u00a0AntoniettaMazzei, G.\u00a0Minniti and P.\u00a0Tini declare that they have no competing interests.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}