{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:01:05Z","timestamp":1792670465187,"version":"4.5.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T00:00:00Z","timestamp":1505520000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Trauma Emerg Surg"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00068-017-0833-3","type":"journal-article","created":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T08:00:11Z","timestamp":1505548811000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Fibrinolysis in trauma: a review"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5613-871X","authenticated-orcid":false,"given":"M. J.","family":"Madurska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Sachse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. O.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. E.","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-8456","authenticated-orcid":false,"given":"J. J.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,16]]},"reference":[{"issue":"6","key":"833_CR1","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1097\/01.TA.0000069184.82147.06","volume":"54","author":"K Brohi","year":"2003","unstructured":"Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54(6):1127\u201330. doi: 10.1097\/01.TA.0000069184.82147.06 .","journal-title":"J Trauma"},{"issue":"3","key":"833_CR2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1093\/bja\/aer158","volume":"107","author":"H Tauber","year":"2011","unstructured":"Tauber H, Innerhofer P, Breitkopf R, Westermann I, Beer R, El Attal R, Strasak A, Mittermayr M. Prevalence and impact of abnormal ROTEM assays in severe blunt trauma: results of the \u201cdiagnosis and treatment of trauma-induced coagulopathy (DIA-TRE-TIC) study. Br J Anaesth. 2011;107(3):378\u201387. doi: 10.1093\/bja\/aer158 .","journal-title":"Br J Anaesth"},{"issue":"6","key":"833_CR3","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1097\/TA.0000000000000341","volume":"77","author":"HB Moore","year":"2014","unstructured":"Moore HB, Moore EE, Gonzalez E, Chapman MP, Chin TL, Silliman CC, Banerjee A, Sauaia A. Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy. J Trauma Acute Care Surg. 2014;77(6):811\u20137. doi: 10.1097\/TA.0000000000000341 . (discussion 817).","journal-title":"J Trauma Acute Care Surg"},{"issue":"1","key":"833_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.hoc.2006.11.004","volume":"21","author":"M Hoffman","year":"2007","unstructured":"Hoffman M, Monroe DM. Coagulation 2006: a modern view of hemostasis. Hematol Oncol Clin North Am. 2007;21(1):1\u201311. doi: 10.1016\/j.hoc.2006.11.004 .","journal-title":"Hematol Oncol Clin North Am"},{"issue":"6","key":"833_CR5","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1182\/blood.V88.6.2093.bloodjournal8862093","volume":"88","author":"L Bajzar","year":"1996","unstructured":"Bajzar L, Nesheim ME, Tracy PB. The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood. 1996;88(6):2093\u2013100.","journal-title":"Blood"},{"issue":"5","key":"833_CR6","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1590\/S1516-84842010000500016","volume":"32","author":"CN Ferreira","year":"2010","unstructured":"Ferreira CN, Sousa MDO. A cell-based model of coagulation and its implications. Rev Bras Hematol e Hemoter. 2010;32(5):416\u201321. doi: 10.1590\/S1516-84842010000500016 .","journal-title":"Rev Bras Hematol e Hemoter"},{"issue":"1\/2","key":"833_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1023\/B:THRO.0000014588.95061.28","volume":"16","author":"M Hoffman","year":"2003","unstructured":"Hoffman M. Remodeling the blood coagulation cascade. J Thromb Thrombolysis. 2003;16(1\/2):17\u201320. doi: 10.1023\/B:THRO.0000014588.95061.28 .","journal-title":"J Thromb Thrombolysis"},{"issue":"19","key":"833_CR8","doi-asserted-by":"crossref","first-page":"11117","DOI":"10.1016\/S0021-9258(18)60437-5","volume":"264","author":"HV Jakubowski","year":"1989","unstructured":"Jakubowski HV, Owen WG. Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin. J Biol Chem. 1989;264(19):11117\u201321.","journal-title":"J Biol Chem"},{"key":"833_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/978-3-319-28308-1_9","volume-title":"Trauma induced coagulopathy","author":"H Moore","year":"2016","unstructured":"Moore H, Moore E, Gonzalez E. Fibrinolysis. In: Gonzalez E, Moore H, Moore E, editors. Trauma induced coagulopathy. 1st ed. Cham: Springer International Publishing; 2016. pp.\u00a0135\u201347. doi: 10.1007\/978-3-319-28308-1_9 .","edition":"1"},{"issue":"2","key":"833_CR10","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/TA.0b013e31825c1234","volume":"73","author":"B Cotton","year":"2012","unstructured":"Cotton B, Harvin J, Kostousouv V, Minei KM, Radwan Z, Sch\u00f6chl H, Wade CE, Holcomb JB, Matijevic N. Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration. J Trauma Acute Care Surg. 2012;73(2):365\u201370. doi: 10.1097\/TA.0b013e31825c1234 .","journal-title":"J Trauma Acute Care Surg"},{"issue":"5","key":"833_CR11","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1097\/TA.0b013e318169cd3c","volume":"64","author":"K Brohi","year":"2008","unstructured":"Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64(5):1211\u20137. doi: 10.1097\/TA.0b013e318169cd3c . 1217.","journal-title":"J Trauma"},{"issue":"3","key":"833_CR12","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/SLA.0b013e3181f09191","volume":"252","author":"JL Kashuk","year":"2010","unstructured":"Kashuk JL, Moore EE, Sawyer M, Wohlauer M, Pezold M, Barnett C, Biffl WL, Burlew CC, Johnson JL, Sauaia A. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg. 2010;252(3):434. doi: 10.1097\/SLA.0b013e3181f09191 .","journal-title":"Ann Surg"},{"issue":"5","key":"833_CR13","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1097\/01.sla.0000256862.79374.31","volume":"245","author":"K Brohi","year":"2007","unstructured":"Brohi K, Cohen MJ, Ganter MT, Matthay M a, Mackersie RC, Pittet J-F. Acute traumatic coagulopathy: initiated by hypoperfusion, modulated through the protein C pathway? Ann Surg. 2007;245(5):812\u20138. doi: 10.1097\/01.sla.0000256862.79374.31 .","journal-title":"Ann Surg"},{"issue":"6","key":"833_CR14","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/S0140-6736(10)60835-5","volume":"376","author":"JA Williams-Johnson","year":"2010","unstructured":"Williams-Johnson JA, McDonald AH, Strachan GG, Williams EW. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2) a randomised, placebo-controlled trial. The Lancet. 2010;376(6):612\u201324. doi: 10.1016\/S0140-6736(10)60835-5 .","journal-title":"The Lancet"},{"issue":"19","key":"833_CR15","doi-asserted-by":"publisher","first-page":"15567","DOI":"10.1074\/jbc.C100123200","volume":"276","author":"AR Rezaie","year":"2001","unstructured":"Rezaie AR. Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1: implications for the mechanism of profibrinolytic action of activated protein C. J Biol Chem. 2001;276(19):15567\u201370. doi: 10.1074\/jbc.C100123200 .","journal-title":"J Biol Chem"},{"issue":"1","key":"833_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/ALN.0000000000001428","volume":"126","author":"RA Davenport","year":"2017","unstructured":"Davenport RA, Guerreiro M, Frith D, Rourke C, Platton S, Cohen M, Pearse R, Thiemermann C, Brohi C. Activated protein C drives the hyperfibrinolysis of acute traumatic coagulopathy. Anesthesiology. 2017;126(1):115\u201327. doi: 10.1097\/ALN.0000000000001428 .","journal-title":"Anesthesiology"},{"issue":"2","key":"833_CR17","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1160\/TH11-03-0175","volume":"106","author":"C Solomon","year":"2011","unstructured":"Solomon C, Traintinger S, Ziegler B, Hanke A, Rahe-Meyer N, Voelckel W, Sch\u00f6chl H. Platelet function following trauma. A multiple electrode aggregometry study. Thromb Haemost. 2011;106(2):322\u201330. doi: 10.1160\/TH11-03-0175 .","journal-title":"Thromb Haemost"},{"key":"833_CR18","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001304","author":"SR Ostrowski","year":"2017","unstructured":"Ostrowski SR, Henriksen HH, Stensballe J, Gybel-Brask M, Cardenas JC, Baer LA, Cotton BA, Holcomb JB, Wade CE, Johansson PI. Sympathoadrenal activation and endotheliopathy are drivers of hypocoagulability and hyperfibrinolysis in trauma: a prospective observational study of 404 severely injured patients. J Trauma Acute Care Surg. 2017. doi: 10.1097\/TA.0000000000001304 .","journal-title":"J Trauma Acute Care Surg"},{"issue":"6","key":"833_CR19","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/jcp.22.6.659","volume":"22","author":"R Chakrabarti","year":"1969","unstructured":"Chakrabarti R, Hocking E, Fearnley G. Reaction pattern to three stresses\u2014electroplexy, surgery, and myocardial infarction\u2014of fibrinolysis and plasma fibrinogen. J Clin Pathol. 1969;22(6):659\u201362.","journal-title":"J Clin Pathol"},{"issue":"4","key":"833_CR20","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jamcollsurg.2016.01.006","volume":"222","author":"HB Moore","year":"2016","unstructured":"Moore HB, Moore EE, Liras IN, Gonzalez E, Harvin JA, Holcomb JB, Sauaia A, Cotton BA. Acute fibrinolysis shutdown after injury occurs frequently and increases mortality: a multicenter evaluation of 2540 severely injured patients. J Am Coll Surg. 2016;222(4):347\u201355. doi: 10.1016\/j.jamcollsurg.2016.01.006 .","journal-title":"J Am Coll Surg"},{"issue":"1","key":"833_CR21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/TA.0000000000001308","volume":"82","author":"C Leeper","year":"2017","unstructured":"Leeper C, Neal M, McKenna C, Sperry J, Gaines B. Abnormalities in fibrinolysis at the time of admission are associated with deep vein thrombosis, mortality, and disability in a pediatric trauma population. J Trauma Acute Care Surg. 2017;82(1):27\u201334.","journal-title":"J Trauma Acute Care Surg"},{"issue":"2","key":"833_CR22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.4315\/0362-028X.JFP-13-395.Knowledge","volume":"158","author":"HB Moore","year":"2015","unstructured":"Moore HB, Moore EE, Lawson P, Gonzalez E, Fragoso M, Morton AP, Goboni F, Chapman MP, Sauaia A, Baneree A, et al. Fibrinolysis shutdown phenotype masks changes in rodent coagulation in tissue injury versus hemorrhagic shock. Surgery. 2015;158(2):386\u201392. doi: 10.4315\/0362-028X.JFP-13-395.Knowledge .","journal-title":"Surgery"},{"issue":"4","key":"833_CR23","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1097\/TA.0000000000001379","volume":"82","author":"A Macko","year":"2017","unstructured":"Macko A, Moore H, Cap A, Meledeo M, Moore E, Sheppard F. Tissue injury suppresses fibrinolysis after hemorrhagic shock in nonhuman primates (rhesus macaque). J Trauma Acute Care Surg. 2017;82(4):750\u20137. doi: 10.1097\/TA.0000000000001379 .","journal-title":"J Trauma Acute Care Surg"},{"issue":"6","key":"833_CR24","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1055\/s-0037-1615947","volume":"85","author":"M Hoffman","year":"2001","unstructured":"Hoffman M, Monroe DMI. A cell-based model of hemostasis. Thromb Haemost. 2001;85(6):958\u201365.","journal-title":"Thromb Haemost"},{"issue":"12","key":"833_CR25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/jcp.12.3.215","volume":"215","author":"O Kowalski","year":"1959","unstructured":"Kowalski O, Kopec M, Niewiarowski S. An evaluation of the euglobulin method for the determination of fibrinolysis. J Clin Pathol. 1959;215(12):215\u20138.","journal-title":"J Clin Pathol"},{"issue":"5\u20136","key":"833_CR26","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.thromres.2004.01.001","volume":"112","author":"AA Smith","year":"2004","unstructured":"Smith AA, Jacobson LJ, Miller BI, Hathaway WE, Manco-Johnson MJ. A new euglobulin clot lysis assay for global fibrinolysis. Thromb Res. 2004;112(5\u20136):329\u201337. doi: 10.1016\/j.thromres.2004.01.001 .","journal-title":"Thromb Res"},{"issue":"6","key":"833_CR27","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1093\/bja\/aen083","volume":"100","author":"A Levrat","year":"2008","unstructured":"Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, David JS. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth. 2008;100(6):792\u20137. doi: 10.1093\/bja\/aen083 .","journal-title":"Br J Anaesth"},{"issue":"5","key":"833_CR28","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1213\/ANE.0b013e31822e183f","volume":"113","author":"OM Theusinger","year":"2011","unstructured":"Theusinger OM, Wanner G a, Emmert MY, Billeter A, Eismon J, Seifert B, Simmen HP, Spahn DR, Baulig W. Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe trauma. Anesth Analg. 2011;113(5):1003\u201312. doi: 10.1213\/ANE.0b013e31822e183f .","journal-title":"Anesth Analg"},{"issue":"6","key":"833_CR29","doi-asserted-by":"publisher","first-page":"R272","DOI":"10.1186\/cc10553","volume":"15","author":"PI Johansson","year":"2011","unstructured":"Johansson PI, S\u00f8rensen AM, Perner A, Welling KL, Wanscher M, Larsen CF. Ostrowski SR disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study. Crit Care. 2011;15(6):R272. doi: 10.1186\/cc10553 .","journal-title":"Crit Care"},{"key":"833_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1757-7241-17-45","volume":"17","author":"PI Johansson","year":"2009","unstructured":"Johansson PI, Stissing T, Bochsen L, Ostrowski SR. Thrombelastography and tromboelastometry in assessing coagulopathy in trauma. Scand J Trauma Resusc Emerg Med. 2009;17:1\u20138. doi: 10.1186\/1757-7241-17-45 .","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"2","key":"833_CR31","doi-asserted-by":"publisher","first-page":"R55","DOI":"10.1186\/cc8948","volume":"14","author":"H Sch\u00f6chl","year":"2010","unstructured":"Sch\u00f6chl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, Kozek-Langenecker S, Solomon C. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care. 2010;14(2):R55. doi: 10.1186\/cc8948 .","journal-title":"Crit Care"},{"issue":"2","key":"833_CR32","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1365-2257.2005.00681.x","volume":"27","author":"RJ Luddington","year":"2005","unstructured":"Luddington RJ. Thrombelastography\/thromboelastometry. Clin Lab Haematol. 2005;27(2):81\u201390. doi: 10.1111\/j.1365-2257.2005.00681.x .","journal-title":"Clin Lab Haematol"},{"issue":"1","key":"833_CR33","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.trsl.2009.04.001","volume":"154","author":"RC Carroll","year":"2009","unstructured":"Carroll RC, Craft RM, Langdon RJ, Clanton CR, Snider CC, Wellons DD, Dakin PA, Lawson CM, Enderson BL, Kurek SJ. Early evaluation of acute traumatic coagulopathy by thrombelastography. Transl Res. 2009;154(1):34\u20139. doi: 10.1016\/j.trsl.2009.04.001 .","journal-title":"Transl Res"},{"issue":"1","key":"833_CR34","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1399-6576.2009.02132.x","volume":"54","author":"M Brenni","year":"2010","unstructured":"Brenni M, Worn M, Br\u00fcesch M, Spahn DR, Ganter MT. Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy. Acta Anaesthesiol Scand. 2010;54(1):111\u20137. doi: 10.1111\/j.1399-6576.2009.02132.x .","journal-title":"Acta Anaesthesiol Scand"},{"issue":"3","key":"833_CR35","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/bja\/aes186","volume":"109","author":"E Schaden","year":"2012","unstructured":"Schaden E, Kimberger O, Kraincuk P, Baron DM, Metnitz PG, Kozek-Langenecker S. Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements. Br J Anaesth. 2012;109(3):376\u201381. doi: 10.1093\/bja\/aes186 .","journal-title":"Br J Anaesth"},{"issue":"2","key":"833_CR36","doi-asserted-by":"publisher","first-page":"R83","DOI":"10.1186\/cc10078","volume":"15","author":"H Sch\u00f6chl","year":"2011","unstructured":"Sch\u00f6chl H, Nienaber U, Maegele M, Hochleitner G, Primavesi F, Steitz B, Arndt C, Hanke A, Voelckel W, Solomon C. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care. 2011;15(2):R83. doi: 10.1186\/cc10078 .","journal-title":"Crit Care"},{"key":"833_CR37","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007871.pub2.Copyright","author":"A Afshari","year":"2013","unstructured":"Afshari A, Wikkels\u00f8 A, Brok J, Am M, Wetterslev J, Afshari A, Wikkels\u00f8 A, Brok J, M\u00f8ller AM, Wetterslev J. TEG or ROTEM to monitor haemotherapy versus usual care in patients with massive transfusion (review). Cochrane Database Syst Rev. 2013. doi: 10.1002\/14651858.CD007871.pub2.Copyright .","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"833_CR38","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1177\/1076029611434527","volume":"18","author":"GF Gen\u00e9t","year":"2012","unstructured":"Gen\u00e9t GF, Ostrowski SR, S\u00f8rensen AM, Johansson PI. Detection of tPA-induced hyperfibrinolysis in whole blood by RapidTEG, KaolinTEG, and functional fibrinogenTEG in healthy individuals. Clin Appl Thromb Hemost. 2012;18(6):638\u201344. doi: 10.1177\/1076029611434527 .","journal-title":"Clin Appl Thromb Hemost"},{"issue":"1","key":"833_CR39","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jamcollsurg.2017.02.018","volume":"225","author":"H Moore","year":"2017","unstructured":"Moore H, Moore E, Chapman M, Huebner BR, Einersen PM, Oushy S, Silliman CC, Banerjee A, Sauaia A. Viscoelastic tissue plasminogen activator challenge predicts massive transfusion in 15\u00a0min. J Am Coll Surg. 2017;225(1):138\u201347.","journal-title":"J Am Coll Surg"},{"issue":"4","key":"833_CR40","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.jamcollsurg.2012.06.005","volume":"215","author":"C Ives","year":"2012","unstructured":"Ives C, Inaba K, Branco BC, Okoye O, Schochl H, Talving P, Lam L, Shulman I, Nelson J, Demetriades D. Hyperfibrinolysis elicited via thromboelastography predicts mortality in trauma. J Am Coll Surg. 2012;215(4):496\u2013502. doi: 10.1016\/j.jamcollsurg.2012.06.005 .","journal-title":"J Am Coll Surg"},{"issue":"1","key":"833_CR41","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/TA.0b013e31818b2483","volume":"67","author":"H Sch\u00f6chl","year":"2009","unstructured":"Sch\u00f6chl H, Frietsch T, Pavelka M, J\u00e1mbor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma. 2009;67(1):125\u201331. doi: 10.1097\/TA.0b013e31818b2483 .","journal-title":"J Trauma"},{"issue":"12","key":"833_CR42","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1097\/CCM.0b013e3182281af5","volume":"39","author":"R Davenport","year":"2011","unstructured":"Davenport R, Manson J, De\u2019Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R, Pasi KJ, MacCallum P. Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med. 2011;39(12):2652\u20138. doi: 10.1097\/CCM.0b013e3182281af5 .","journal-title":"Crit Care Med"},{"issue":"6","key":"833_CR43","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/01.mbc.0000169225.31173.19","volume":"16","author":"T Lang","year":"2005","unstructured":"Lang T, Bauters A, Braun SL, Po B. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis. 2005;16(6):301\u201310.","journal-title":"Blood Coagul Fibrinolysis"},{"key":"833_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jss.2017.05.006","volume":"7","author":"R Sharma","year":"2016","unstructured":"Sharma R, Letson HL, Smith S, Dobson GP. Tranexamic acid leads to paradoxical coagulation changes during cardiac surgery: a pilot rotational thromboelastometry study. J Surg Res. 2016;7:1\u201313. doi: 10.1016\/j.jss.2017.05.006 .","journal-title":"J Surg Res"},{"issue":"1","key":"833_CR45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/TA.0b013e3182598c70","volume":"73","author":"ME Kutcher","year":"2012","unstructured":"Kutcher ME, Cripps MW, McCreery RC, Crane IM, Greenberg MD, Cachola LM, Redick BJ, Nelson MF, Cohen MJ. Criteria for empiric treatment of hyperfibrinolysis after trauma. J Trauma Acute Care Surg. 2012;73(1):87\u201393. doi: 10.1097\/TA.0b013e3182598c70 .","journal-title":"J Trauma Acute Care Surg"},{"issue":"6","key":"833_CR46","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1097\/TA.0b013e318292cc54","volume":"74","author":"LM Napolitano","year":"2013","unstructured":"Napolitano LM, Cohen MJ, Cotton BA, Schreiber MA, Moore EE. Tranexamic acid in trauma. J Trauma Acute Care Surg. 2013;74(6):1575\u201386. doi: 10.1097\/TA.0b013e318292cc54 .","journal-title":"J Trauma Acute Care Surg"},{"issue":"3","key":"833_CR47","first-page":"436","volume":"33","author":"JJ Morrison","year":"2013","unstructured":"Morrison JJ, Ross JD. Is viscoelastic evidence of hyperfibrinolysis the ideal indicator for tranexamic acid administration in trauma? Letters to the editor. J Trauma Acute Care Surg. 2013;33(3):436\u20137.","journal-title":"J Trauma Acute Care Surg"},{"issue":"9771","key":"833_CR48","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/S0140-6736(11)60278-X","volume":"377","author":"F Olldashi","year":"2011","unstructured":"Olldashi F, Ker\u00e7i M, Zhurda T, Ru\u00e7i K, Banushi A, Traverso MS, Jim\u00e9nez J, Balbi J, Dellera C, Svampa S. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. The Lancet. 2011;377(9771):1096\u2013101. doi: 10.1016\/S0140-6736(11)60278-X . (1101.e1\u20131101.e2).","journal-title":"The Lancet"},{"issue":"7","key":"833_CR49","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.pestbp.2011.02.012.Investigations","volume":"11","author":"GG Lin","year":"2013","unstructured":"Lin GG, Scott JG. The incidence and magnitude of fibrinolytic activation in trauma patients: a rebuttal. J Thromb Haemost. 2013;11(7):130\u20134. doi: 10.1016\/j.pestbp.2011.02.012.Investigations .","journal-title":"J Thromb Haemost"},{"issue":"3","key":"833_CR50","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1097\/SLA.0000000000002355","volume":"266","author":"CM Leeper","year":"2017","unstructured":"Leeper CM, Neal MD, McKenna CJ, Gaines BA. Trending fibrinolytic dysregulation. Ann Surg. 2017;266(3):505\u201315. doi: 10.1097\/SLA.0000000000002355 .","journal-title":"Ann Surg"},{"issue":"6","key":"833_CR51","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1160\/TH13-10-0870","volume":"111","author":"M Nagler","year":"2014","unstructured":"Nagler M, ten Cate H, Kathriner S, Casutt M, Bachmann LM, Wuillemin WA. Consistency of thromboelastometry analysis under scrutiny: results of a systematic evaluation within and between analysers. Thromb Haemost. 2014;111(6):1161\u20136. doi: 10.1160\/TH13-10-0870 .","journal-title":"Thromb Haemost"},{"issue":"12","key":"833_CR52","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1590\/S0100-879X2009001200015","volume":"42","author":"S Scarpelini","year":"2009","unstructured":"Scarpelini S, Rhind SG, Nascimento B, Tien H, Shek PN, Peng HT, Huang H, Pinto R, Speers V, Reis M. Normal range values for thromboelastography in healthy adult volunteers. Braz J Med Biol Res. 2009;42(12):1210\u20137.","journal-title":"Braz J Med Biol Res"},{"issue":"2","key":"833_CR53","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1055\/s-0036-1598001","volume":"43","author":"L Gall","year":"2017","unstructured":"Gall L, Brohi K, Davenport R. Diagnosis and treatment of hyperfibrinolysis in trauma (a European perspective). Semin Thromb Hemost. 2017;43(2):224\u201334. doi: 10.1055\/s-0036-1598001 .","journal-title":"Semin Thromb Hemost"},{"key":"833_CR54","unstructured":"TEG \u00ae 5000 Thrombelastograph \u00ae Hemostasis System User Manual. Haemoscope Corporation.\u00a02008. http:\/\/www.haemonetics.com\/en\/products\/devices\/surgical-and-diagnostic-devices\/teg-5000 . Accessed 1 Sep 2017."},{"issue":"1","key":"833_CR55","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1757-7241-19-64","volume":"19","author":"SR Ostrowski","year":"2011","unstructured":"Ostrowski SR, S\u00f8rensen AM, Larsen CF, Johansson PI. Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective study. Scand J Trauma Resusc Emerg Med. 2011;19(1):64. doi: 10.1186\/1757-7241-19-64 .","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"2","key":"833_CR56","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/jth.12078","volume":"11","author":"I Raza","year":"2013","unstructured":"Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, Khan S, De\u2019Ath HD, Allard S, Hart DP. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost. 2013;11(2):307\u201314. doi: 10.1111\/jth.12078 .","journal-title":"J Thromb Haemost"},{"issue":"5","key":"833_CR57","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1213\/ANE.0b013e31822e183f","volume":"113","author":"OM Theusinger","year":"2011","unstructured":"Theusinger OM, Wanner GA, Emmert MY, Billeter A, Eismon J, Seifert B, Simmen H-P, Spahn DR, Baulig W. Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe trauma. Anesth Analg. 2011;113(5):1003\u201312. doi: 10.1213\/ANE.0b013e31822e183f .","journal-title":"Anesth Analg"},{"key":"833_CR58","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1093\/bja\/aen270","volume":"101","author":"C Fenger-Eriksen","year":"2008","unstructured":"Fenger-Eriksen C, Lindberg-Larsen M, Christensen AQ, Ingerslev J, S\u00f8rensen B. Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations. Br J Anaesth. 2008;101:769\u201373. doi: 10.1093\/bja\/aen270 .","journal-title":"Br J Anaesth"},{"issue":"7","key":"833_CR59","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.injury.2010.12.015","volume":"42","author":"U Nienaber","year":"2011","unstructured":"Nienaber U, Innerhofer P, Westermann I, Schochl H, Attal R, Breitkopf R, Maegele M. The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion. Injury. 2011;42(7):697\u2013701. doi: 10.1016\/j.injury.2010.12.015 .","journal-title":"Injury"},{"key":"833_CR60","doi-asserted-by":"publisher","unstructured":"Huebner BR, Moore EE, Moore HB, Sauaia A, Stettler G, Dzieciatkowska M, Hansen K. Freeze-dried plasma enhances clot formation and inhibits fibrinolysis in the presence of tissue plasminogen activator similar to pooled liquid plasma. Transfusion. doi: 10.1111\/trf.14149 .","DOI":"10.1111\/trf.14149"},{"issue":"5","key":"833_CR61","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/MBC.0b013e32835e4246","volume":"24","author":"V Kostousov","year":"2013","unstructured":"Kostousov V, Wang Y-WW, Cotton BA, Wade CE, Holcomb JB, Matijevic N. Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model. Blood Coagul Fibrinolysis. 2013;24(5):489\u201397. doi: 10.1097\/MBC.0b013e32835e4246 .","journal-title":"Blood Coagul Fibrinolysis"},{"key":"833_CR62","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jss.2015.04.077","volume":"213","author":"A Morton","year":"2017","unstructured":"Morton A, Moore E, Moore H, Gonzalez E, Chapman MP, Peltz E, Banerjee A, Silliman C. Hemoglobin-based oxygen carriers promote systemic hyperfibrinolysis that is both dependent and independent of plasmin. J Surg Res. 2017;213:166\u201370. doi: 10.1016\/j.jss.2015.04.077 .","journal-title":"J Surg Res"},{"issue":"2","key":"833_CR63","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1001\/archsurg.2011.287","volume":"147","author":"JJ Morrison","year":"2012","unstructured":"Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military application of tranexamic acid in trauma emergency resuscitation (MATTERs) study. Arch Surg. 2012;147(2):113\u20139. doi: 10.1001\/archsurg.2011.287 .","journal-title":"Arch Surg"},{"issue":"2","key":"833_CR64","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/SLA.0000000000000717","volume":"261","author":"E Cole","year":"2015","unstructured":"Cole E, Davenport R, Willett K, Brohi K. Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study. Ann Surg. 2015;261(2):390\u20134. doi: 10.1097\/SLA.0000000000000717 .","journal-title":"Ann Surg"},{"issue":"5","key":"833_CR65","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1213\/XAA.0000000000000550","volume":"9","author":"J Louro","year":"2017","unstructured":"Louro J, Andersen K, Dudaryk R. Correction of severe coagulopathy and hyperfibrinolysis by tranexamic acid and recombinant factor VIIa in a cirrhotic patient after trauma: a case report. A A Case Rep. 2017;9(5):144\u20137. doi: 10.1213\/XAA.0000000000000550 .","journal-title":"A A Case Rep"},{"key":"833_CR66","doi-asserted-by":"publisher","DOI":"10.4172\/2167-1222.1000179","author":"H Swendsen","year":"2013","unstructured":"Swendsen H, Galante JM, Utter GH, Bateni S, Scherer LA, Schermer CR. Tranexamic acid use in trauma: effective but not without consequences. Trauma Treat. 2013. doi: 10.4172\/2167-1222.1000179 .","journal-title":"Trauma Treat"},{"issue":"9\u201310","key":"833_CR67","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00508-017-1194-y","volume":"129","author":"I Pabinger","year":"2017","unstructured":"Pabinger I, Fries D, Sch\u00f6chl H, Streif W, Toller W. Tranexamic acid for treatment and prophylaxis of bleeding and hyperfibrinolysis. Wien Klin Wochenschr. 2017;129(9\u201310):303\u201316. doi: 10.1007\/s00508-017-1194-y .","journal-title":"Wien Klin Wochenschr"},{"issue":"2","key":"833_CR68","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1055\/s-0036-1597900","volume":"43","author":"M Walsh","year":"2017","unstructured":"Walsh M, Shreve J, Thomas S, Moore E, Moore H, Hake D, Pohlman T, Davis P, Ploplis V, Piscoya A, et al. Fibrinolysis in Trauma: \u201cmyth,\u201d \u201creality,\u201d or \u201csomething in between\u201d. Semin Thromb Hemost. 2017;43(2):200\u201312. doi: 10.1055\/s-0036-1597900 .","journal-title":"Semin Thromb Hemost"},{"key":"833_CR69","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3109\/00365528709089756","volume":"137","author":"B Astedt","year":"1987","unstructured":"Astedt B. Clinical pharmacology of tranexamic acid. Scand J Gastroenterol Suppl. 1987;137:22\u20135.","journal-title":"Scand J Gastroenterol Suppl"},{"key":"833_CR70","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004896.pub4.Copyright","author":"I Roberts","year":"2015","unstructured":"Roberts I, Shakur H, Ker K, Coats T. Antifibrinolytic drugs for acute traumatic injury (review). Cochrane Database Syst Rev. 2015. doi: 10.1002\/14651858.CD004896.pub4.Copyright .","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"833_CR71","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00101-017-0277-5","volume":"66","author":"V Zickenrott","year":"2017","unstructured":"Zickenrott V, Greb I, Henkelmann A, Balzer F, Casu S, Kaufne L, von Heymann C, Zacharowski K, Weber CF. Tranexamic acid in the German emergency medical service: a national survey. Anaesthesist. 2017;66(4):249\u201355. doi: 10.1007\/s00101-017-0277-5 .","journal-title":"Anaesthesist"},{"issue":"2S","key":"833_CR72","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1016\/j.wem.2016.12.006","volume":"28","author":"BR Huebner","year":"2017","unstructured":"Huebner BR, Dorlac WC, Cribari C. Tranexamic acid use in prehospital uncontrolled hemorrhage. Wilderness Environ Med. 2017;28(2S):S50\u2013S60. doi: 10.1016\/j.wem.2016.12.006 .","journal-title":"Wilderness Environ Med"},{"issue":"6","key":"833_CR73","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1186\/s13054-014-0685-8","volume":"18","author":"I Roberts","year":"2014","unstructured":"Roberts I, Prieto-Merino D, Manno D. Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial. Crit Care. 2014;18(6):685. doi: 10.1186\/s13054-014-0685-8 .","journal-title":"Crit Care"},{"issue":"Supple1","key":"833_CR74","doi-asserted-by":"publisher","first-page":"S195","DOI":"10.1111\/jth.12878","volume":"13","author":"I Roberts","year":"2015","unstructured":"Roberts I. Tranexamic acid in trauma: how should we use it? J Thromb Haemost. 2015;13(Supple1):S195\u20139. doi: 10.1111\/jth.12878 .","journal-title":"J Thromb Haemost"},{"key":"833_CR75","doi-asserted-by":"publisher","first-page":"e5839","DOI":"10.1136\/bmj.e5839","volume":"345","author":"I Roberts","year":"2012","unstructured":"Roberts I, Perel P, Prieto-Merino D, Shakur H, Coats T, Hunt B, Lecky F, Brohi K, Willett K. CRASH-2 collaborators. Effect of tranexamic acid on mortlity in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. Bmj. 2012;345:e5839. doi: 10.1136\/bmj.e5839 .","journal-title":"Bmj"},{"issue":"6","key":"833_CR76","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1592\/phco.27.6.860","volume":"27","author":"R MacLaren","year":"2007","unstructured":"MacLaren R, Stringer K. Emerging role of anticoagulants and fibrinolytics in the treatment of acute respiratory distress syndrome. Pharmacotherapy. 2007;27(6):860\u201373.","journal-title":"Pharmacotherapy"},{"issue":"4","key":"833_CR77","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/000313480106700417","volume":"67","author":"R Hardaway","year":"2001","unstructured":"Hardaway R, Harkey H, Tyroch A, WIlliams C, Vazquez Y, Krause G. Treatment of severe acute respiratory distress syndrome: a final report on a phase I study. Am Surg. 2001;67(4):377\u201382.","journal-title":"Am Surg"},{"key":"833_CR78","unstructured":"ClinicalTrials.gov\u2014a service of the US National Institutes of Health.\u00a0 https:\/\/clinicaltrials.gov . Accessed 4 Sep 2017."},{"issue":"1","key":"833_CR79","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.athoracsur.2011.07.085","volume":"93","author":"D Kalavrouziotis","year":"2012","unstructured":"Kalavrouziotis D, Voisine P, Mohammadi S, Dionne S, Dagenais F. High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass. Ann Thorac Surg. 2012;93(1):148\u201354. doi: 10.1016\/j.athoracsur.2011.07.085 .","journal-title":"Ann Thorac Surg"},{"issue":"2","key":"833_CR80","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1053\/j.jvca.2010.08.004","volume":"25","author":"GRW Hunter","year":"2011","unstructured":"Hunter GRW, Young GB. Seizures after cardiac surgery. J Cardiothorac Vasc Anesth. 2011;25(2):299\u2013305. doi: 10.1053\/j.jvca.2010.08.004 .","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"833_CR81","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-87","author":"Y Dewan","year":"2012","unstructured":"Dewan Y, O Komolafe E, Mejia-Mantilla J, Perel P, Roberts I, Shakur H. CRASH-3\u2014tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial. Trials. 2012. doi: 10.1186\/1745-6215-13-87 .","journal-title":"Trials"},{"key":"833_CR82","unstructured":"PATCH\u2014trauma study. The pre-hospital anti-fibrinolytics for traumatic coagulopathy and haemorrhage study. https:\/\/www.patchtrauma.org . Accessed 4 September 2017."}],"container-title":["European Journal of Trauma and Emergency Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00068-017-0833-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-017-0833-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-017-0833-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:33:40Z","timestamp":1693006420000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00068-017-0833-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,16]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["833"],"URL":"https:\/\/doi.org\/10.1007\/s00068-017-0833-3","relation":{},"ISSN":["1863-9933","1863-9941"],"issn-type":[{"value":"1863-9933","type":"print"},{"value":"1863-9941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,16]]}}}