{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:35:59Z","timestamp":1780461359423,"version":"3.54.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Arbeitsgemeinschaft f\u00fcr Osteosynthesefragen","award":["S-14-14P"],"award-info":[{"award-number":["S-14-14P"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Trauma Emerg Surg"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00068-019-01098-1","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T04:40:57Z","timestamp":1552365657000},"page":"31-42","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Monotrauma is associated with enhanced remote inflammatory response and organ damage, while polytrauma intensifies both in porcine trauma model"],"prefix":"10.1007","volume":"46","author":[{"given":"Philipp","family":"St\u00f6rmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kernt","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Auner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim-P.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Pfeifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Horst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Christoph","family":"Pape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hildebrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Wutzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Marzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borna","family":"Relja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"1098_CR1","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00104-013-2477-0","volume":"84","author":"S Wutzler","year":"2013","unstructured":"Wutzler S, Lustenberger T, Relja B, Lehnert M, Marzi I. Pathophysiology of multiple trauma: intensive care medicine and timing of treatment. Chirurg. 2013;84:753\u20138. https:\/\/doi.org\/10.1007\/s00104-013-2477-0 .","journal-title":"Chirurg"},{"key":"1098_CR2","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1111\/j.1476-5381.2011.01595.x","volume":"165","author":"B Relja","year":"2012","unstructured":"Relja B, et al. Acute alcohol intoxication reduces mortality, inflammatory responses and hepatic injury after haemorrhage and resuscitation in vivo. Br J Pharmacol. 2012;165:1188\u201399. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01595.x .","journal-title":"Br J Pharmacol"},{"key":"1098_CR3","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.smim.2016.04.005","volume":"28","author":"M Huber-Lang","year":"2016","unstructured":"Huber-Lang M, et al. Complement therapeutic strategies in trauma, hemorrhagic shock and systemic inflammation\u2014closing Pandora\u2019s box? Semin Immunol. 2016;28:278\u201384. https:\/\/doi.org\/10.1016\/j.smim.2016.04.005 .","journal-title":"Semin Immunol"},{"key":"1098_CR4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/00024382-199503000-00001","volume":"3","author":"AJ Botha","year":"1995","unstructured":"Botha AJ, et al. Postinjury neutrophil priming and activation states: therapeutic challenges. Shock. 1995;3:157\u201366.","journal-title":"Shock"},{"key":"1098_CR5","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s00068-009-9123-z","volume":"35","author":"M Maier","year":"2009","unstructured":"Maier M, et al. Role of lung contusions on posttraumatic inflammatory response and organ dysfunction in traumatized patients. Eur J Trauma Emerg Surg. 2009;35:463\u20139. https:\/\/doi.org\/10.1007\/s00068-009-9123-z .","journal-title":"Eur J Trauma Emerg Surg"},{"key":"1098_CR6","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/S0168-8278(02)00025-9","volume":"36","author":"RG Nie","year":"2002","unstructured":"Nie RG, et al. The role of endogenous heme oxygenase in the initiation of liver injury following limb ischemia\/reperfusion. J Hepatol. 2002;36:624\u201330.","journal-title":"J Hepatol"},{"key":"1098_CR7","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1097\/ALN.0000000000001106","volume":"124","author":"J Ning","year":"2016","unstructured":"Ning J, et al. Therapeutic whole-body hypothermia protects remote lung, liver, and kidney injuries after blast limb trauma in rats. Anesthesiology. 2016;124:1360\u201371. https:\/\/doi.org\/10.1097\/ALN.0000000000001106 .","journal-title":"Anesthesiology"},{"key":"1098_CR8","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1097\/TA.0b013e318266013a","volume":"73","author":"JL Ning","year":"2012","unstructured":"Ning JL, et al. Lung injury following lower extremity blast trauma in rats. J Trauma Acute Care Surg. 2012;73:1537\u201344. https:\/\/doi.org\/10.1097\/TA.0b013e318266013a .","journal-title":"J Trauma Acute Care Surg"},{"key":"1098_CR9","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1097\/TA.0000000000000396","volume":"77","author":"H Zhao","year":"2014","unstructured":"Zhao H, et al. Regional traumatic limb hypothermia attenuates distant hepatic and renal injury following blast limb trauma in rats. J Trauma Acute Care Surg. 2014;77:464\u201370. https:\/\/doi.org\/10.1097\/TA.0000000000000396 .","journal-title":"J Trauma Acute Care Surg"},{"key":"1098_CR10","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/hep.510300132","volume":"30","author":"RW Brock","year":"1999","unstructured":"Brock RW, Lawlor DK, Harris KA, Potter RF. Initiation of remote hepatic injury in the rat: interactions between Kupffer cells, tumor necrosis factor-alpha, and microvascular perfusion. Hepatology. 1999;30:137\u201342. https:\/\/doi.org\/10.1002\/hep.510300132 .","journal-title":"Hepatology"},{"key":"1098_CR11","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/BOT.0b013e318175dd88","volume":"22","author":"P Kobbe","year":"2008","unstructured":"Kobbe P, Vodovotz Y, Kaczorowski DJ, Billiar TR, Pape HC. The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture. J Orthop Trauma. 2008;22:385\u201390. https:\/\/doi.org\/10.1097\/BOT.0b013e318175dd88 .","journal-title":"J Orthop Trauma"},{"key":"1098_CR12","doi-asserted-by":"publisher","first-page":"R1538","DOI":"10.1152\/ajpregu.00272.2007","volume":"293","author":"RM Levy","year":"2007","unstructured":"Levy RM, et al. Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1538\u201344. https:\/\/doi.org\/10.1152\/ajpregu.00272.2007 .","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1098_CR13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.7555\/JBR.31.20160053","volume":"31","author":"Z Jin","year":"2017","unstructured":"Jin Z, Chun Suen K, Ma D. Perioperative \u201cremote\u201d acute lung injury: recent update. J Biomed Res. 2017;31:197\u2013212. https:\/\/doi.org\/10.7555\/JBR.31.20160053 .","journal-title":"J Biomed Res"},{"key":"1098_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2017.08.041","author":"P Stormann","year":"2017","unstructured":"Stormann P, Lustenberger T, Relja B, Marzi I, Wutzler S. Role of biomarkers in acute traumatic lung injury. Injury. 2017. https:\/\/doi.org\/10.1016\/j.injury.2017.08.041 .","journal-title":"Injury"},{"key":"1098_CR15","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.imbio.2012.06.002","volume":"218","author":"B Relja","year":"2013","unstructured":"Relja B, et al. Thrombin-activatable fibrinolysis inhibitor (TAFI) is enhanced in major trauma patients without infectious complications. Immunobiology. 2013;218:470\u20136. https:\/\/doi.org\/10.1016\/j.imbio.2012.06.002 .","journal-title":"Immunobiology"},{"key":"1098_CR16","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.imbio.2016.03.005","volume":"221","author":"K Mors","year":"2016","unstructured":"Mors K, et al. Influence of gender on systemic IL-6 levels, complication rates and outcome after major trauma. Immunobiology. 2016;221:904\u201310. https:\/\/doi.org\/10.1016\/j.imbio.2016.03.005 .","journal-title":"Immunobiology"},{"key":"1098_CR17","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/shk.0b013e318123e64e","volume":"28","author":"B Maier","year":"2007","unstructured":"Maier B, et al. Early versus late onset of multiple organ failure is associated with differing patterns of plasma cytokine biomarker expression and outcome after severe trauma. Shock. 2007;28:668\u201374.","journal-title":"Shock"},{"key":"1098_CR18","first-page":"322","volume":"51","author":"L Carbone","year":"2012","unstructured":"Carbone L. Pain management standards in the eighth edition of the Guide for the Care and Use of Laboratory Animals. J Am Assoc Lab Anim Sci. 2012;51:322\u20138.","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"1098_CR19","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 2010;8:e1000412. https:\/\/doi.org\/10.1371\/journal.pbio.1000412 .","journal-title":"PLoS Biol"},{"key":"1098_CR20","doi-asserted-by":"publisher","first-page":"39659","DOI":"10.1038\/srep39659","volume":"6","author":"K Horst","year":"2016","unstructured":"Horst K, et al. Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma. Sci Rep. 2016;6:39659. https:\/\/doi.org\/10.1038\/srep39659 .","journal-title":"Sci Rep"},{"key":"1098_CR21","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3109\/00365521.2013.772228","volume":"48","author":"B Relja","year":"2013","unstructured":"Relja B, et al. Effects of acute ethanol gavage on intestinal integrity after hemorrhage\/resuscitation. Scand J Gastroenterol. 2013;48:448\u201358. https:\/\/doi.org\/10.3109\/00365521.2013.772228 .","journal-title":"Scand J Gastroenterol"},{"key":"1098_CR22","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.injury.2007.09.026","volume":"38","author":"HC Pape","year":"2007","unstructured":"Pape HC, et al. Assessment of the clinical course with inflammatory parameters. Injury. 2007;38:1358\u201364. https:\/\/doi.org\/10.1016\/j.injury.2007.09.026 .","journal-title":"Injury"},{"key":"1098_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-018-0962-3","author":"B Relja","year":"2018","unstructured":"Relja B, Mors K, Marzi I. Danger signals in trauma. Eur J Trauma Emerg Surg. 2018. https:\/\/doi.org\/10.1007\/s00068-018-0962-3 .","journal-title":"Eur J Trauma Emerg Surg"},{"key":"1098_CR24","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41590-018-0064-8","volume":"19","author":"M Huber-Lang","year":"2018","unstructured":"Huber-Lang M, Lambris JD, Ward PA. Innate immune responses to trauma. Nat Immunol. 2018;19:327\u201341. https:\/\/doi.org\/10.1038\/s41590-018-0064-8 .","journal-title":"Nat Immunol"},{"key":"1098_CR25","doi-asserted-by":"publisher","first-page":"e149","DOI":"10.1016\/j.jss.2010.11.914","volume":"166","author":"CL Menzel","year":"2011","unstructured":"Menzel CL, et al. Models of lower extremity damage in mice: time course of organ damage and immune response. J Surg Res. 2011;166:e149\u201356. https:\/\/doi.org\/10.1016\/j.jss.2010.11.914 .","journal-title":"J Surg Res"},{"key":"1098_CR26","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/jor.21214","volume":"29","author":"R Pfeifer","year":"2011","unstructured":"Pfeifer R, Kobbe P, Darwiche SS, Billiar TR, Pape HC. Role of hemorrhage in the induction of systemic inflammation and remote organ damage: analysis of combined pseudo-fracture and hemorrhagic shock. J Orthop Res. 2011;29:270\u20134. https:\/\/doi.org\/10.1002\/jor.21214 .","journal-title":"J Orthop Res"},{"key":"1098_CR27","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s00423-008-0334-2","volume":"393","author":"F Gebhard","year":"2008","unstructured":"Gebhard F, Huber-Lang M. Polytrauma\u2013pathophysiology and management principles. Langenbecks Arch Surg. 2008;393:825\u201331. https:\/\/doi.org\/10.1007\/s00423-008-0334-2 .","journal-title":"Langenbecks Arch Surg"},{"key":"1098_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1172\/JCI11830","volume":"107","author":"PP Tak","year":"2001","unstructured":"Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest. 2001;107:7\u201311. https:\/\/doi.org\/10.1172\/JCI11830 .","journal-title":"J Clin Invest"},{"key":"1098_CR29","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1017\/S000711451000560X","volume":"105","author":"B Relja","year":"2011","unstructured":"Relja B, et al. Effects of green tea catechins on the pro-inflammatory response after haemorrhage\/resuscitation in rats. Br J Nutr. 2011;105:1791\u20137. https:\/\/doi.org\/10.1017\/S000711451000560X .","journal-title":"Br J Nutr"},{"key":"1098_CR30","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1034\/j.1399-3003.2000.15e14.x","volume":"15","author":"A Aggarwal","year":"2000","unstructured":"Aggarwal A, Baker CS, Evans TW, Haslam PL. G-CSF and IL-8 but not GM-CSF correlate with severity of pulmonary neutrophilia in acute respiratory distress syndrome. Eur Respir J. 2000;15:895\u2013901.","journal-title":"Eur Respir J"},{"key":"1098_CR31","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.injury.2011.05.034","volume":"43","author":"K Raymondos","year":"2012","unstructured":"Raymondos K, et al. Early alveolar and systemic mediator release in patients at different risks for ARDS after multiple trauma. Injury. 2012;43:189\u201395. https:\/\/doi.org\/10.1016\/j.injury.2011.05.034 .","journal-title":"Injury"},{"key":"1098_CR32","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00281-016-0560-6","volume":"38","author":"CT Robb","year":"2016","unstructured":"Robb CT, Regan KH, Dorward DA, Rossi AG. Key mechanisms governing resolution of lung inflammation. Semin Immunopathol. 2016;38:425\u201348. https:\/\/doi.org\/10.1007\/s00281-016-0560-6 .","journal-title":"Semin Immunopathol"},{"key":"1098_CR33","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/BF03401959","volume":"7","author":"N Hirani","year":"2001","unstructured":"Hirani N, et al. The regulation of interleukin-8 by hypoxia in human macrophages\u2014a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS). Mol Med. 2001;7:685\u201397.","journal-title":"Mol Med"},{"key":"1098_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.plefa.2017.09.014","volume":"127","author":"P Stormann","year":"2017","unstructured":"Stormann P, et al. Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model. Prostaglandins Leukot Essent Fatty Acids. 2017;127:25\u201331. https:\/\/doi.org\/10.1016\/j.plefa.2017.09.014 .","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1098_CR35","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/TA.0b013e3181d7693c","volume":"70","author":"DH Seitz","year":"2011","unstructured":"Seitz DH, et al. Inflammatory alterations in a novel combination model of blunt chest trauma and hemorrhagic shock. J Trauma. 2011;70:189\u201396. https:\/\/doi.org\/10.1097\/TA.0b013e3181d7693c .","journal-title":"J Trauma"},{"key":"1098_CR36","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1097\/TA.0b013e31827d5f1b","volume":"74","author":"S Weckbach","year":"2013","unstructured":"Weckbach S, et al. Inflammatory and apoptotic alterations in serum and injured tissue after experimental polytrauma in mice: distinct early response compared with single trauma or \u201cdouble-hit\u201d injury. J Trauma Acute Care Surg. 2013;74:489\u201398. https:\/\/doi.org\/10.1097\/TA.0b013e31827d5f1b .","journal-title":"J Trauma Acute Care Surg"},{"key":"1098_CR37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cyto.2010.09.005","volume":"53","author":"P Mommsen","year":"2011","unstructured":"Mommsen P, et al. Productive capacity of alveolar macrophages and pulmonary organ damage after femoral fracture and hemorrhage in IL-6 knockout mice. Cytokine. 2011;53:60\u20135. https:\/\/doi.org\/10.1016\/j.cyto.2010.09.005 .","journal-title":"Cytokine"},{"key":"1098_CR38","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/jor.22857","volume":"33","author":"C Kleber","year":"2015","unstructured":"Kleber C, et al. Temporal profile of inflammatory response to fracture and hemorrhagic shock: proposal of a novel long-term survival murine multiple trauma model. J Orthop Res. 2015;33:965\u201370. https:\/\/doi.org\/10.1002\/jor.22857 .","journal-title":"J Orthop Res"},{"key":"1098_CR39","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1097\/SHK.0b013e3182699072","volume":"38","author":"S Korff","year":"2012","unstructured":"Korff S, et al. Time dependency and topography of hepatic nuclear factor kappaB activation after hemorrhagic shock and resuscitation in mice. Shock. 2012;38:486\u201392. https:\/\/doi.org\/10.1097\/SHK.0b013e3182699072 .","journal-title":"Shock"},{"key":"1098_CR40","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000925","author":"S Denk","year":"2017","unstructured":"Denk S, et al. Role of hemorrhagic shock in experimental polytrauma. Shock. 2017. https:\/\/doi.org\/10.1097\/SHK.0000000000000925 .","journal-title":"Shock"},{"key":"1098_CR41","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1111\/ans.13197","volume":"85","author":"BM Hardy","year":"2015","unstructured":"Hardy BM, Yoshino O, Quail AW, Balogh ZJ. Influence of the timing of internal fixation of femur fractures during shock resuscitation on remote organ damage. ANZ J Surg. 2015;85:966\u201371. https:\/\/doi.org\/10.1111\/ans.13197 .","journal-title":"ANZ J Surg"},{"key":"1098_CR42","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3390\/ijms15010309","volume":"15","author":"H Algattas","year":"2013","unstructured":"Algattas H, Huang JH. Traumatic brain injury pathophysiology and treatments: early, intermediate, and late phases post-injury. Int J Mol Sci. 2013;15:309\u201341. https:\/\/doi.org\/10.3390\/ijms15010309 .","journal-title":"Int J Mol Sci"},{"key":"1098_CR43","doi-asserted-by":"publisher","first-page":"e0187404","DOI":"10.1371\/journal.pone.0187404","volume":"12","author":"L Schimunek","year":"2017","unstructured":"Schimunek L, et al. Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model. PLoS One. 2017;12:e0187404. https:\/\/doi.org\/10.1371\/journal.pone.0187404 .","journal-title":"PLoS One"},{"key":"1098_CR44","doi-asserted-by":"publisher","first-page":"e0180145","DOI":"10.1371\/journal.pone.0180145","volume":"12","author":"KM Groeneveld","year":"2017","unstructured":"Groeneveld KM, et al. Early decreased neutrophil responsiveness is related to late onset sepsis in multitrauma patients: an international cohort study. PLoS One. 2017;12:e0180145. https:\/\/doi.org\/10.1371\/journal.pone.0180145 .","journal-title":"PLoS One"},{"key":"1098_CR45","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13151","author":"P Ghorbani","year":"2018","unstructured":"Ghorbani P, Strommer L. Analysis of preventable deaths and errors in trauma care in a Scandinavian trauma level-I centre. Acta Anaesthesiol Scand. 2018. https:\/\/doi.org\/10.1111\/aas.13151 .","journal-title":"Acta Anaesthesiol Scand"},{"key":"1098_CR46","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-017-0880-9","author":"Z Qiao","year":"2017","unstructured":"Qiao Z, et al. Using IL-6 concentrations in the first 24 h following trauma to predict immunological complications and mortality in trauma patients: a meta-analysis. Eur J Trauma Emerg Surg. 2017. https:\/\/doi.org\/10.1007\/s00068-017-0880-9 .","journal-title":"Eur J Trauma Emerg Surg"}],"container-title":["European Journal of Trauma and Emergency Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-019-01098-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00068-019-01098-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-019-01098-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T11:51:03Z","timestamp":1694692263000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00068-019-01098-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["1098"],"URL":"https:\/\/doi.org\/10.1007\/s00068-019-01098-1","relation":{},"ISSN":["1863-9933","1863-9941"],"issn-type":[{"value":"1863-9933","type":"print"},{"value":"1863-9941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]},"assertion":[{"value":"4 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest regarding the publication of this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The ethical approval for the study was obtained by the \u201cLandesamt f\u00fcr Natur-, Umwelt- und Verbraucherschutz, Nordrhein Westfalen\u201d (LANUV-NRW), Recklinghausen, Germany, which is the local responsible government authority (ethical permission: AZ TV-Nr.: 82-02.04.2014.A265).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Consent to submit has been received from all co-authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All data generated or analysed during this study are included in this published article. The data are available from the corresponding author on reasonable request.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}}]}}