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For the remaining authors, no conflicts were declared.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For MP isolation, 20 trauma patients admitted to our trauma centre (Cologne-Merheim Medical Centre, CMMC) (median ISS 24, range ISS 18\u201336) were included meeting the following inclusion criteria: (1) adult patient (age\u2009\u2265\u200918\u00a0years), (2) injury severity score (ISS)\u2009\u2265\u200916, (3) less than 2 h between injury and hospital admission, (4) less than 2000 ml of pre-hospital fluid administration, (5) no hospital transfer, (6) exclusion of patients with severe liver disease, bleeding abnormalities and\/or anticoagulant medication (excluding aspirin), (7) patient\u2019s\/consultee\u2019s informed written consent.For simulating in vitro the lethal triad conditions, the participation of five healthy blood donors from the Institute for Transfusion Medicine (CMMC) was requested. All donors and patients gave their informed and written consent to participating in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The study design and protocol was approved by the Central Ethics Committee of the University Witten\/Herdecke (nos. 37\/2005 and 168\/2014).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}