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A number of complications after intramedullary femoral nailing have been reported, particularly in Asians. To understand the anatomical features of the proximal femur and their ethnic differences, we aimed to accurately calculate the femoral isthmus dimensions and proximal distance of Asians and Caucasians.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In total, 1189 Asian and Caucasian segmented 3D CT data sets of femurs were analyzed. The individual femoral isthmus diameter was precisely computed to investigate whether gender, femur length, age, ethnicity or body mass index have an influence on isthmus diameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean isthmus diameter of all femurs was 10.71\u2009\u00b1\u20092.2\u00a0mm. A significantly larger diameter was found in Asians when compared to Caucasians (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Age was a strong predictor of the isthmus diameter variability in females (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, adjusted <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.299). With every year of life, the isthmus showed a widening of 0.08\u00a0mm in women. A Matched Pair Analysis of 150 female femurs showed a significant difference between isthmus diameter in Asian and Caucasian femurs (<jats:italic>p<\/jats:italic>\u2009=\u20090.05). In 50% of the cases the isthmus was found in a range of 2.4\u00a0cm between 16.9 and 19.3\u00a0cm distal to the tip of the greater trochanter. The female Asian femur differs from Caucasians as it is wider at the isthmus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In absolute values, the proximal isthmus distance did not show much variation but is more proximal in Asians. The detailed data presented may be helpful in the development of future implant designs. The length and thickness of future standard implants may be considered based on the findings.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00068-021-01740-x","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T11:02:44Z","timestamp":1627470164000},"page":"2379-2386","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A comparison between Asians and Caucasians in the dimensions of the femoral isthmus based on a 3D-CT analysis of 1189 adult femurs"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-4953","authenticated-orcid":false,"given":"Darius M.","family":"Thiesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Ntalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Korthaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Petersik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Frosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian J.","family":"Hartel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"1740_CR1","doi-asserted-by":"publisher","first-page":"e0204961","DOI":"10.1371\/journal.pone.0204961","volume":"13","author":"DM Thiesen","year":"2018","unstructured":"Thiesen DM, et al. 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AP is employee of Stryker and receives a regular wage.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The measurements were conducted in Sch\u00f6nkirchen-Kiel at Stryker Trauma GmbH. The article was written and statistics were performed at Hamburg University Hospital. The work was reviewed by the ethics committee of Hamburg Medical Counsel.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}