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Orthopaedic trauma is one of the main indications for opioid prescription. We aimed to assess the risk for long-term opioid use in a healthy patient cohort.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this matched cohort study, bicycle trauma patients from a Swedish Level-I-Trauma Centre in 2006\u20132015 were matched with comparators on age, sex, and municipality. Information about dispensed opioids 6\u00a0months prior until 18\u00a0months following the trauma, data on injuries, comorbidity, and socioeconomic factors were received from national registers. Among bicycle trauma patients, the associations between two exposures (educational level and injury to the lower extremities) and the risk of long-term opioid use (&gt;\u20093\u00a0months after the trauma) were assessed in multivariable logistic regression models.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 907 bicycle trauma patients, 419 (46%) received opioid prescriptions, whereof 74 (8%) became long-term users. In the first quarter after trauma, the mean opioid use was significantly higher in the trauma patients than in the comparators (253.2\u00a0mg vs 35.1\u00a0mg, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and fell thereafter to the same level as in the comparators. Severe injury to the lower extremities was associated with an increased risk of long-term opioid use [OR 4.88 (95% CI 2.34\u201310.15)], whereas high educational level had a protecting effect [OR 0.42 (95% CI 0.20\u20130.88)].<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The risk of long-term opioid use after a bicycle trauma was low. However, opioids should be prescribed with caution, especially in those with injury to lower extremities or low educational level.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00068-022-02103-w","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T13:11:27Z","timestamp":1662988287000},"page":"531-538","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-term opioid use following bicycle trauma: a register-based cohort study"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-0733","authenticated-orcid":false,"given":"Evelyne","family":"Zibung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"von Oelreich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Buchli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Nordenvall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Oldner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"issue":"5","key":"2103_CR1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.7326\/M17-0865","volume":"167","author":"B Han","year":"2017","unstructured":"Han B, et al. 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