{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:02:55Z","timestamp":1767139375656,"version":"build-2238731810"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Trauma Emerg Surg"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s00068-024-02513-y","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:01:37Z","timestamp":1712793697000},"page":"2569-2577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond expectations: safinamide\u2019s unprecedented neuroprotective impact on acute spinal cord injury"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-4763","authenticated-orcid":false,"given":"Murat","family":"G\u00f6kten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-6078","authenticated-orcid":false,"given":"Selim","family":"Z\u0131rh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4840-6769","authenticated-orcid":false,"given":"Can","family":"Sezer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-2365","authenticated-orcid":false,"given":"Elham Bahador","family":"Z\u0131rh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9226-7532","authenticated-orcid":false,"given":"Dilara Bulut","family":"G\u00f6kten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"issue":"7","key":"2513_CR1","doi-asserted-by":"publisher","first-page":"5160","DOI":"10.1002\/jcp.26287","volume":"233","author":"K Mortezaee","year":"2018","unstructured":"Mortezaee K, et al. Inflammasome: its role in traumatic brain and spinal cord injury. J Cell Physiol. 2018;233(7):5160\u20139.","journal-title":"J Cell Physiol"},{"issue":"1","key":"2513_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.5312\/wjo.v6.i1.34","volume":"6","author":"S Dalbayrak","year":"2015","unstructured":"Dalbayrak S, Yaman O, Y\u0131lmaz T. Current and future surgery strategies for spinal cord injuries. World J Orthop. 2015;6(1):34\u201341.","journal-title":"World J Orthop"},{"key":"2513_CR3","doi-asserted-by":"publisher","first-page":"113143","DOI":"10.1016\/j.expneurol.2019.113143","volume":"325","author":"O Bloom","year":"2020","unstructured":"Bloom O, Herman PE, Spungen AM. Systemic inflammation in traumatic spinal cord injury. Exp Neurol. 2020;325:113143.","journal-title":"Exp Neurol"},{"key":"2513_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neures.2013.10.004","volume":"79","author":"M Lyman","year":"2014","unstructured":"Lyman M, et al. Neuroinflammation: the role and consequences. Neurosci Res. 2014;79:1\u201312.","journal-title":"Neurosci Res"},{"issue":"2","key":"2513_CR5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10863-015-9600-5","volume":"48","author":"ED Hall","year":"2016","unstructured":"Hall ED, et al. Lipid peroxidation in brain or spinal cord mitochondria after injury. J Bioenerg Biomembr. 2016;48(2):169\u201374.","journal-title":"J Bioenerg Biomembr"},{"issue":"4","key":"2513_CR6","doi-asserted-by":"publisher","first-page":"558","DOI":"10.5798\/dicletip.1220732","volume":"49","author":"PB Boz","year":"2022","unstructured":"Boz PB, et al. The effect of neutrophil to lymphocyte and neutrophil to platelet ratios on prognosis in stroke patients. Dicle T\u0131p Dergisi. 2022;49(4):558\u201364.","journal-title":"Dicle T\u0131p Dergisi"},{"issue":"3","key":"2513_CR7","first-page":"305","volume":"32","author":"LD Hachem","year":"2021","unstructured":"Hachem LD, Fehlings MG. Pathophysiology of spinal cord injury. Neurosurgery Clinics. 2021;32(3):305\u201313.","journal-title":"Neurosurgery Clinics"},{"issue":"5","key":"2513_CR8","doi-asserted-by":"publisher","first-page":"349","DOI":"10.2217\/nmt-2016-0022","volume":"6","author":"M Fabbri","year":"2016","unstructured":"Fabbri M, Rosa MM, Ferreira JJ. Clinical pharmacology review of opicapone for the treatment of Parkinson\u2019s disease. Neurodegener Dis Manag. 2016;6(5):349\u201362.","journal-title":"Neurodegener Dis Manag"},{"key":"2513_CR9","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.2147\/TCRM.S86393","volume":"12","author":"T M\u00fcller","year":"2016","unstructured":"M\u00fcller T. Emerging approaches in Parkinson\u2019s disease - adjunctive role of safinamide. Ther Clin Risk Manag. 2016;12:1151\u201360.","journal-title":"Ther Clin Risk Manag"},{"issue":"3","key":"2513_CR10","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s40262-016-0449-5","volume":"56","author":"T M\u00fcller","year":"2017","unstructured":"M\u00fcller T, Foley P. Clinical pharmacokinetics and pharmacodynamics of safinamide. Clin Pharmacokinet. 2017;56(3):251\u201361.","journal-title":"Clin Pharmacokinet"},{"key":"2513_CR11","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s40261-021-01011-y","volume":"41","author":"R Giossi","year":"2021","unstructured":"Giossi R, et al. Overall efficacy and safety of safinamide in Parkinson\u2019s disease: a systematic review and a meta-analysis. Clin Drug Investig. 2021;41:321\u201339.","journal-title":"Clin Drug Investig"},{"key":"2513_CR12","doi-asserted-by":"publisher","first-page":"108006","DOI":"10.1016\/j.neuropharm.2020.108006","volume":"167","author":"CA Pisan\u00f2","year":"2020","unstructured":"Pisan\u00f2 CA, et al. Safinamide inhibits in vivo glutamate release in a rat model of Parkinson\u2019s disease. Neuropharmacology. 2020;167:108006.","journal-title":"Neuropharmacology"},{"issue":"5","key":"2513_CR13","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/nan.12263","volume":"42","author":"M Sadeghian","year":"2016","unstructured":"Sadeghian M, et al. Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson\u2019s disease. Neuropathol Appl Neurobiol. 2016;42(5):423\u201335.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2513_CR14","doi-asserted-by":"publisher","first-page":"667511","DOI":"10.3389\/fneur.2021.667511","volume":"12","author":"X Shi","year":"2021","unstructured":"Shi X, et al. Behavioral assessment of sensory, motor, emotion, and cognition in rodent models of intracerebral hemorrhage. Front Neurol. 2021;12:667511.","journal-title":"Front Neurol"},{"key":"2513_CR15","doi-asserted-by":"crossref","unstructured":"Hausser N., et al., Detecting behavioral deficits in rats after traumatic brain injury. J Vis Exp, 2018;(131).","DOI":"10.3791\/56044-v"},{"issue":"10","key":"2513_CR16","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1136\/jclinpath-2015-203590","volume":"69","author":"WJ Tan","year":"2016","unstructured":"Tan WJ, et al. MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression. J Clin Pathol. 2016;69(10):858\u201365.","journal-title":"J Clin Pathol"},{"key":"2513_CR17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.brainres.2014.09.036","volume":"1619","author":"R Nardone","year":"2015","unstructured":"Nardone R, et al. Descending motor pathways and cortical physiology after spinal cord injury assessed by transcranial magnetic stimulation: a systematic review. Brain Res. 2015;1619:139\u201354.","journal-title":"Brain Res"},{"key":"2513_CR18","doi-asserted-by":"publisher","first-page":"e225","DOI":"10.1016\/j.wneu.2020.12.021","volume":"147","author":"D Arac","year":"2021","unstructured":"Arac D, et al. Neuroprotective effects of milrinone on experimental acute spinal cord injury: rat model. World Neurosurgery. 2021;147:e225\u201333.","journal-title":"World Neurosurgery"},{"issue":"2","key":"2513_CR19","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1124\/jpet.117.245100","volume":"364","author":"M Morari","year":"2018","unstructured":"Morari M, et al. Safinamide differentially modulates in vivo glutamate and GABA release in the rat hippocampus and basal ganglia. J Pharmacol Exp Ther. 2018;364(2):198\u2013206.","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"2513_CR20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s40263-017-0408-1","volume":"31","author":"HA Blair","year":"2017","unstructured":"Blair HA, Dhillon S. Safinamide: a review in Parkinson\u2019s disease. CNS Drugs. 2017;31(2):169\u201376.","journal-title":"CNS Drugs"},{"issue":"4","key":"2513_CR21","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1177\/1091581815584918","volume":"34","author":"T Ramani","year":"2015","unstructured":"Ramani T, et al. Cytokines: the good, the bad, and the deadly. Int J Toxicol. 2015;34(4):355\u201365.","journal-title":"Int J Toxicol"},{"key":"2513_CR22","doi-asserted-by":"publisher","first-page":"155684","DOI":"10.1016\/j.cyto.2021.155684","volume":"148","author":"RH Jenkins","year":"2021","unstructured":"Jenkins RH, et al. Unravelling the broader complexity of IL-6 involvement in health and disease. Cytokine. 2021;148:155684.","journal-title":"Cytokine"},{"issue":"3","key":"2513_CR23","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s12640-020-00246-5","volume":"38","author":"T Xu","year":"2020","unstructured":"Xu T, et al. The protective effect of safinamide in ischemic stroke mice and a brain endothelial cell line. Neurotox Res. 2020;38(3):733\u201340.","journal-title":"Neurotox Res"},{"issue":"2","key":"2513_CR24","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.expneurol.2011.09.030","volume":"234","author":"JA Black","year":"2012","unstructured":"Black JA, Waxman SG. Sodium channels and microglial function. Exp Neurol. 2012;234(2):302\u201315.","journal-title":"Exp Neurol"}],"updated-by":[{"DOI":"10.1007\/s00068-024-02554-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000}}],"container-title":["European Journal of Trauma and Emergency Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-024-02513-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00068-024-02513-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-024-02513-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T07:06:26Z","timestamp":1732604786000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00068-024-02513-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,11]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["2513"],"URL":"https:\/\/doi.org\/10.1007\/s00068-024-02513-y","relation":{},"ISSN":["1863-9933","1863-9941"],"issn-type":[{"value":"1863-9933","type":"print"},{"value":"1863-9941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,11]]},"assertion":[{"value":"23 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00068-024-02554-3","URL":"https:\/\/doi.org\/10.1007\/s00068-024-02554-3","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol received approval from the ethical committee of the Saki Local Animal Ethics and Research Committee on 23\/05\/2022 (Approval No.: 03.05.7\/2022). The reported experiments were in accordance with the ethical standards of the committee responsible for experimentation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Submission for publication has been approved by all of the coauthors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}