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Consequently, exsanguination and traumatic brain injury (TBI) have become the most common causes of death. Exsanguination decreased by early hemorrhage control strategies, whereas TBI has become a global health problem. The aim of this study was to investigate trends in injury severity,physiology, treatment and mortality in the last decade.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In 2014, a prospective cohort study was started including consecutive severely injured trauma patients\u2009&gt;\u200915\u00a0years admitted to a Level-1 Trauma Center ICU. Demographics,\u00a0physiology,\u00a0resuscitation, and outcome parameters were prospectively collected.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Five hundred and seventy-eight severely injured patients with predominantly blunt injuries (94%) were included. Seventy-two percent were male with a median age of 46 (28\u201361) years, and ISS of 29 (22\u201338). Overall mortality rate was 18% (106\/578) with TBI (66%, 70\/106) being the largest cause of death. Less than 1% (5\/578) died of exsanguination. Trend analysis of the 10-year period revealed similar mortality rates despite an ISS increase in the last 2\u00a0years. No significant differences in demographics,and physiology in ED were noted. Resuscitation strategy changed to less crystalloids and more FFP. Risk factors for mortality were age,\u00a0brain injury severity,\u00a0base deficit,\u00a0hypoxia,\u00a0and crystalloid resuscitation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>TBI was the single largest cause of death in severely injured patients in the last decade. With an aging population TBI will increase and become the next epidemic in trauma. Future research should focus on brain injury prevention and decreasing the inflammatory response in brain tissue causing secondary damage, as was previously done in other parts of the body.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00068-024-02653-1","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T13:43:13Z","timestamp":1726666993000},"page":"3083-3094","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["TBI related death has become the new epidemic in polytrauma: a 10-year prospective cohort analysis in severely injured patients"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-0990","authenticated-orcid":false,"given":"Karlijn J. P.","family":"van Wessem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim E. 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