{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:38:26Z","timestamp":1792100306996,"version":"4.4.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Trauma Emerg Surg"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      In patients with traumatic brain injury (TBI), adequate oxygenation is crucial to optimize survival and neurological outcome. However, supranormal oxygen partial pressure (PaO\n                      <jats:sub>2<\/jats:sub>\n                      ) only leads to minor increase in cerebral oxygen delivery but can cause numerous pathophysiological disturbances. Therefore, we aimed to study effects of hyperoxia on patient outcome and identify optimum PaO\n                      <jats:sub>2<\/jats:sub>\n                      ranges.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective, single-center cohort study included TBI patients receiving mechanical ventilation for \u2265\u200972\u00a0h. Time-weighted mean PaO\n                      <jats:sub>2<\/jats:sub>\n                      and integrals above thresholds of 80, 100, 120, and 150 mmHg were calculated over periods of 1, 3, 7, and 14 days. The effects on in-hospital mortality and favorable functional outcome defined as Glasgow Outcome Scale (GOS)\u2009\u2265\u20094 were explored at discharge and after 3\u20136 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 01\/2013 until 12\/2021, 290 patients fulfilled the inclusion criteria. Hyperoxia was dose-dependently associated with a worsened functional outcome 3\u20136 months post-injury. Regarding the first 24\u00a0h, odds ratios were 0.959 (95% confidence intervals: 0.932\u20130.990;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) for time-weighted mean PaO\n                      <jats:sub>2<\/jats:sub>\n                      and 0.955 (0.923\u20130.988;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), 0.939 (0.897\u20130.982;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), 0.923 (0.871\u20130.978;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) and 0.922 (0.858\u20130.992;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029) per mmHg above 80, 100, 120 and 150 mmHg, respectively. For exposure within 72\u00a0h, odds ratios were 0.897 (0.819\u20130.983;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020), 0.842 (0.738\u20130.961;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and 0.832 (0.705\u20130.981;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029) per mmHg per day over 100, 120 and 150 mmHg, respectively. No significant association could be established between PaO\n                      <jats:sub>2<\/jats:sub>\n                      -exposure and in-hospital mortality, GOS at discharge or the 7- and 14-day periods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort, hyperoxia within 72\u00a0h after admission was dose-dependently associated with an unfavorable neurological outcome after 3\u20136 months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00068-024-02730-5","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T11:24:35Z","timestamp":1737717875000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dose-dependent association of hyperoxia and decreased favorable outcomes in mechanically ventilated patients with traumatic brain injury, a retrospective cohort study"],"prefix":"10.1007","volume":"51","author":[{"given":"Louisa Telsche","family":"Lalla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Czorlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Schweingruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Frosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Gempt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kluge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3341-669X","authenticated-orcid":false,"given":"J\u00f6rn","family":"Grensemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"2730_CR1","doi-asserted-by":"publisher","first-page":"e932318","DOI":"10.12659\/msm.932318","volume":"27","author":"H Wu","year":"2021","unstructured":"Wu H, Gong L, Gu JC, Xing HW, Qian ZX, Mao Q. Proper partial pressure of arterial oxygen for patients with traumatic brain Injury. Med Sci Monit. 2021;27:e932318. https:\/\/doi.org\/10.12659\/msm.932318.","journal-title":"Med Sci Monit"},{"issue":"2","key":"2730_CR2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1055\/a-0948-8363","volume":"146","author":"J Grensemann","year":"2021","unstructured":"Grensemann J, Wachs C, Kluge S. Oxygen therapy in emergency and intensive care medicine. Dtsch Med Wochenschr. 2021;146(2):108\u2013. https:\/\/doi.org\/10.1055\/a-0948-8363. \u200920.","journal-title":"Dtsch Med Wochenschr"},{"issue":"1","key":"2730_CR3","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s13054-015-0996-4","volume":"19","author":"HJ Helmerhorst","year":"2015","unstructured":"Helmerhorst HJ, Schultz MJ, van der Voort PH, de Jonge E, van Westerloo DJ. Bench-to-bedside review: the effects of hyperoxia during critical illness. Crit Care. 2015;19(1):284. https:\/\/doi.org\/10.1186\/s13054-015-0996-4.","journal-title":"Crit Care"},{"key":"2730_CR4","unstructured":"Firsching R, Rickels E, Mauer UM, Sakowitz OW, Messing-J\u00fcnger M, Engelhard K et al. German S2e Guideline: Traumatic Brain Injury in adults 2015. [Available from: https:\/\/register.awmf.org\/assets\/guidelines\/008-001l_S2e_Schaedelhirntrauma_SHT_Erwachsene_2015-12-abgelaufen.pdf"},{"key":"2730_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01423-w","author":"C Hirunpattarasilp","year":"2022","unstructured":"Hirunpattarasilp C, Shiina H, Na-Ek N, Attwell D. The Effect of Hyperoxemia on neurological outcomes of adult patients: a systematic review and Meta-analysis. Neurocrit Care. 2022. https:\/\/doi.org\/10.1007\/s12028-021-01423-w.","journal-title":"Neurocrit Care"},{"issue":"15","key":"2730_CR6","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1001\/jama.2016.11993","volume":"316","author":"M Girardis","year":"2016","unstructured":"Girardis M, Busani S, Damiani E, Donati A, Rinaldi L, Marudi A, et al. Effect of conservative vs conventional oxygen therapy on Mortality among patients in an intensive care unit: the Oxygen-ICU Randomized Clinical Trial. JAMA. 2016;316(15):1583\u20139. https:\/\/doi.org\/10.1001\/jama.2016.11993.","journal-title":"JAMA"},{"issue":"2","key":"2730_CR7","doi-asserted-by":"publisher","first-page":"537","DOI":"10.3171\/2018.10.Jns18964","volume":"132","author":"AS Alali","year":"2019","unstructured":"Alali AS, Temkin N, Vavilala MS, Lele AV, Barber J, Dikmen S, et al. Matching early arterial oxygenation to long-term outcome in severe traumatic brain injury: target values. J Neurosurg. 2019;132(2):537\u201344. https:\/\/doi.org\/10.3171\/2018.10.Jns18964.","journal-title":"J Neurosurg"},{"issue":"11","key":"2730_CR8","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1001\/archsurg.2012.1560","volume":"147","author":"M Brenner","year":"2012","unstructured":"Brenner M, Stein D, Hu P, Kufera J, Wooford M, Scalea T. Association between early hyperoxia and worse outcomes after traumatic brain injury. Arch Surg. 2012;147(11):1042\u20136. https:\/\/doi.org\/10.1001\/archsurg.2012.1560.","journal-title":"Arch Surg"},{"issue":"12","key":"2730_CR9","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1089\/neu.2009.0940","volume":"26","author":"DP Davis","year":"2009","unstructured":"Davis DP, Meade W, Sise MJ, Kennedy F, Simon F, Tominaga G, et al. Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma. 2009;26(12):2217\u201323. https:\/\/doi.org\/10.1089\/neu.2009.0940.","journal-title":"J Neurotrauma"},{"issue":"8","key":"2730_CR10","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1089\/neu.2016.4753","volume":"34","author":"M Fujita","year":"2017","unstructured":"Fujita M, Oda Y, Yamashita S, Kaneda K, Kaneko T, Suehiro E, et al. Early-Stage Hyperoxia is Associated with favorable neurological outcomes and survival after severe traumatic brain Injury: a post-hoc analysis of the Brain Hypothermia Study. J Neurotrauma. 2017;34(8):1565\u201370. https:\/\/doi.org\/10.1089\/neu.2016.4753.","journal-title":"J Neurotrauma"},{"issue":"1","key":"2730_CR11","doi-asserted-by":"publisher","first-page":"e34385","DOI":"10.7759\/cureus.34385","volume":"15","author":"Z K\u0131l\u0131n\u00e7","year":"2023","unstructured":"K\u0131l\u0131n\u00e7 Z, Ayy\u0131ld\u0131z EA, Kaya E, Sahin AS. The Effect of Oxygenation on Mortality in patients with Head Injury. Cureus. 2023;15(1):e34385. https:\/\/doi.org\/10.7759\/cureus.34385.","journal-title":"Cureus"},{"issue":"3","key":"2730_CR12","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s12028-018-0553-5","volume":"29","author":"D \u00d3 Briain","year":"2018","unstructured":"\u00d3 Briain D, Nickson C, Pilcher DV, Udy AA. Early Hyperoxia in patients with traumatic brain Injury admitted to Intensive Care in Australia and New Zealand: a retrospective Multicenter Cohort Study. Neurocrit Care. 2018;29(3):443\u2013. https:\/\/doi.org\/10.1007\/s12028-018-0553-5. \u200951.","journal-title":"Neurocrit Care"},{"issue":"4","key":"2730_CR13","doi-asserted-by":"publisher","first-page":"R177","DOI":"10.1186\/cc12856","volume":"17","author":"R Raj","year":"2013","unstructured":"Raj R, Bendel S, Reinikainen M, Kivisaari R, Siironen J, L\u00e5ng M, et al. Hyperoxemia and long-term outcome after traumatic brain injury. Crit Care. 2013;17(4):R177. https:\/\/doi.org\/10.1186\/cc12856.","journal-title":"Crit Care"},{"issue":"7","key":"2730_CR14","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1136\/jnnp-2013-305505","volume":"85","author":"F Rincon","year":"2014","unstructured":"Rincon F, Kang J, Vibbert M, Urtecho J, Athar MK, Jallo J. Significance of arterial hyperoxia and relationship with case fatality in traumatic brain injury: a multicentre cohort study. J Neurol Neurosurg Psychiatry. 2014;85(7):799\u2013805. https:\/\/doi.org\/10.1136\/jnnp-2013-305505.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"2730_CR15","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1089\/neur.2022.0065","volume":"4","author":"DP Davis","year":"2023","unstructured":"Davis DP, McKnight B, Meier E, Drennan IR, Newgard C, Wang HE, et al. Higher oxygenation is Associated with Improved Survival in severe traumatic brain Injury but not traumatic shock. Neurotrauma Rep. 2023;4(1):51\u201363. https:\/\/doi.org\/10.1089\/neur.2022.0065.","journal-title":"Neurotrauma Rep"},{"issue":"6","key":"2730_CR16","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/aas.13093","volume":"62","author":"M L\u00e5ng","year":"2018","unstructured":"L\u00e5ng M, Skrifvars MB, Siironen J, Tanskanen P, Ala-Peijari M, Koivisto T, et al. A pilot study of hyperoxemia on neurological injury, inflammation and oxidative stress. Acta Anaesthesiol Scand. 2018;62(6):801\u201310. https:\/\/doi.org\/10.1111\/aas.13093.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"2","key":"2730_CR17","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s12028-022-01534-y","volume":"37","author":"J Grensemann","year":"2022","unstructured":"Grensemann J, Mader MM, Westphal M, Kluge S, Czorlich P. Hyperoxia is dose-Dependently Associated with an increase of unfavorable outcomes in ventilated patients with Aneurysmal Subarachnoid Hemorrhage: a retrospective cohort study. Neurocrit Care. 2022;37(2):523\u2013. https:\/\/doi.org\/10.1007\/s12028-022-01534-y. \u200930.","journal-title":"Neurocrit Care"},{"issue":"3","key":"2730_CR18","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/00005373-197403000-00001","volume":"14","author":"SP Baker","year":"1974","unstructured":"Baker SP, O\u2019Neill B, Haddon W Jr., Long WB. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974;14(3):187\u201396.","journal-title":"J Trauma"},{"issue":"24","key":"2730_CR19","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1001\/jama.270.24.2957","volume":"270","author":"JR Le Gall","year":"1993","unstructured":"Le Gall JR, Lemeshow S, Saulnier F. A new simplified Acute Physiology score (SAPS II) based on a European\/North American multicenter study. JAMA. 1993;270(24):2957\u201363. https:\/\/doi.org\/10.1001\/jama.270.24.2957.","journal-title":"JAMA"},{"issue":"6","key":"2730_CR20","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1227\/01.neu.0000186013.63046.6b","volume":"57","author":"AI Maas","year":"2005","unstructured":"Maas AI, Hukkelhoven CW, Marshall LF, Steyerberg EW. Prediction of outcome in traumatic brain injury with computed tomographic characteristics: a comparison between the computed tomographic classification and combinations of computed tomographic predictors. Neurosurgery. 2005;57(6):1173\u201382. https:\/\/doi.org\/10.1227\/01.neu.0000186013.63046.6b. discussion\u2013\u200982.","journal-title":"Neurosurgery"},{"issue":"7905","key":"2730_CR21","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/s0140-6736(75)92830-5","volume":"1","author":"B Jennett","year":"1975","unstructured":"Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet. 1975;1(7905):480\u20134. https:\/\/doi.org\/10.1016\/s0140-6736(75)92830-5.","journal-title":"Lancet"},{"issue":"5","key":"2730_CR22","doi-asserted-by":"publisher","first-page":"952","DOI":"10.3171\/jns.2003.98.5.0952","volume":"98","author":"S Magnoni","year":"2003","unstructured":"Magnoni S, Ghisoni L, Locatelli M, Caimi M, Colombo A, Valeriani V, et al. Lack of improvement in cerebral metabolism after hyperoxia in severe head injury: a microdialysis study. J Neurosurg. 2003;98(5):952\u20138. https:\/\/doi.org\/10.3171\/jns.2003.98.5.0952.","journal-title":"J Neurosurg"},{"issue":"2","key":"2730_CR23","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1097\/ANA.0b013e318283d350","volume":"25","author":"SR Asher","year":"2013","unstructured":"Asher SR, Curry P, Sharma D, Wang J, O\u2019Keefe GE, Daniel-Johnson J, et al. Survival advantage and PaO2 threshold in severe traumatic brain injury. J Neurosurg Anesthesiol. 2013;25(2):168\u2013. https:\/\/doi.org\/10.1097\/ANA.0b013e318283d350. \u200973.","journal-title":"J Neurosurg Anesthesiol"},{"issue":"3","key":"2730_CR24","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.annemergmed.2022.09.026","volume":"81","author":"CS Vrettou","year":"2023","unstructured":"Vrettou CS, Giannakoulis VG, Gallos P, Kotanidou A, Siempos II. Effect of different early oxygenation levels on clinical outcomes of patients presenting in the Emergency Department with severe traumatic brain Injury. Ann Emerg Med. 2023;81(3):273\u2013. https:\/\/doi.org\/10.1016\/j.annemergmed.2022.09.026. \u200981.","journal-title":"Ann Emerg Med"},{"issue":"2","key":"2730_CR25","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s12028-020-01033-y","volume":"34","author":"M Weeden","year":"2021","unstructured":"Weeden M, Bailey M, Gabbe B, Pilcher D, Bellomo R, Udy A. Functional outcomes in patients admitted to the Intensive Care Unit with Traumatic Brain Injury and exposed to Hyperoxia: a retrospective Multicentre Cohort Study. Neurocrit Care. 2021;34(2):441\u20138. https:\/\/doi.org\/10.1007\/s12028-020-01033-y.","journal-title":"Neurocrit Care"},{"issue":"2","key":"2730_CR26","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1159\/000520294","volume":"101","author":"J Gottlieb","year":"2022","unstructured":"Gottlieb J, Capetian P, Hamsen U, Janssens U, Karagiannidis C, Kluge S, et al. German S3 Guideline: Oxygen Therapy in the Acute Care of adult patients. Respiration. 2022;101(2):214\u201352. https:\/\/doi.org\/10.1159\/000520294.","journal-title":"Respiration"},{"issue":"4","key":"2730_CR27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1159\/000502157","volume":"98","author":"F Fichtner","year":"2019","unstructured":"Fichtner F, Moerer O, Weber-Carstens S, Nothacker M, Kaisers U, Laudi S. Clinical Guideline for treating Acute respiratory insufficiency with invasive ventilation and extracorporeal membrane oxygenation: evidence-based recommendations for choosing modes and setting parameters of mechanical ventilation. Respiration. 2019;98(4):357\u2013. https:\/\/doi.org\/10.1159\/000502157. \u200972.","journal-title":"Respiration"},{"key":"2730_CR28","unstructured":"Deutsche Gesellschaft f\u00fcr Unfallchirurgie e.V. S3-Leitlinie Polytrauma\/Schwerverletzen-Behandlung (AWMF Registernummer 187\u2013\u2009023), Version 4.0 (31.12.2022), available under https:\/\/register.awmf.org\/de\/leitlinien\/detail\/187-023"},{"key":"2730_CR29","doi-asserted-by":"crossref","unstructured":"Carney N, Totten AM, O\u2019Reilly C, Ullman JS, Hawryluk GWJ, Bell MJ et al. Guidelines for the management of severe traumatic brain Injury, Fourth Edition. Neurosurgery. 2017;80(1).","DOI":"10.1227\/NEU.0000000000001432"},{"key":"2730_CR30","doi-asserted-by":"publisher","unstructured":"Dellazizzo L, Demers SP, Charbonney E, Williams V, Serri K, Albert M, et al. Minimal PaO2 threshold after traumatic brain injury and clinical utility of a novel brain oxygenation ratio. J Neurosurg. 2018;1\u20139. https:\/\/doi.org\/10.3171\/2018.5.Jns18651.","DOI":"10.3171\/2018.5.Jns18651"},{"issue":"1","key":"2730_CR31","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1186\/s13054-021-03815-y","volume":"25","author":"M Singer","year":"2021","unstructured":"Singer M, Young PJ, Laffey JG, Asfar P, Taccone FS, Skrifvars MB, et al. Dangers of hyperoxia. Crit Care. 2021;25(1):440. https:\/\/doi.org\/10.1186\/s13054-021-03815-y.","journal-title":"Crit Care"},{"issue":"1","key":"2730_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.23736\/s0375-9393.19.13906-5","volume":"86","author":"S Ottolenghi","year":"2020","unstructured":"Ottolenghi S, Sabbatini G, Brizzolari A, Samaja M, Chiumello D. Hyperoxia and oxidative stress in anesthesia and critical care medicine. Minerva Anestesiol. 2020;86(1):64\u201375. https:\/\/doi.org\/10.23736\/s0375-9393.19.13906-5.","journal-title":"Minerva Anestesiol"},{"issue":"3","key":"2730_CR33","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/ALN.0b013e318280a42d","volume":"118","author":"B Blasiole","year":"2013","unstructured":"Blasiole B, Bayr H, Vagni VA, Janesko-Feldman K, Cheikhi A, Wisniewski SR, et al. Effect of hyperoxia on resuscitation of experimental combined traumatic brain injury and hemorrhagic shock in mice. Anesthesiology. 2013;118(3):649\u2013. https:\/\/doi.org\/10.1097\/ALN.0b013e318280a42d. \u200963.","journal-title":"Anesthesiology"},{"issue":"1","key":"2730_CR34","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/bja\/aex128","volume":"119","author":"AK Staehr-Rye","year":"2017","unstructured":"Staehr-Rye AK, Meyhoff CS, Scheffenbichler FT, Vidal Melo MF, G\u00e4tke MR, Walsh JL, et al. High intraoperative inspiratory oxygen fraction and risk of major respiratory complications. Br J Anaesth. 2017;119(1):140\u20139. https:\/\/doi.org\/10.1093\/bja\/aex128.","journal-title":"Br J Anaesth"},{"issue":"1","key":"2730_CR35","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/sj.jcbfm.9600319","volume":"27","author":"DP Bulte","year":"2007","unstructured":"Bulte DP, Chiarelli PA, Wise RG, Jezzard P. Cerebral perfusion response to hyperoxia. J Cereb Blood Flow Metab. 2007;27(1):69\u201375. https:\/\/doi.org\/10.1038\/sj.jcbfm.9600319.","journal-title":"J Cereb Blood Flow Metab"},{"key":"2730_CR36","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.wneu.2016.10.116","volume":"98","author":"S Sahoo","year":"2017","unstructured":"Sahoo S, Sheshadri V, Sriganesh K, Madhsudana Reddy KR, Radhakrishnan M, Umamaheswara Rao GS. Effect of Hyperoxia on Cerebral Blood Flow Velocity and Regional Oxygen Saturation in patients operated on for severe traumatic Brain Injury-the influence of cerebral blood Flow Autoregulation. World Neurosurg. 2017;98:211\u20136. https:\/\/doi.org\/10.1016\/j.wneu.2016.10.116.","journal-title":"World Neurosurg"},{"key":"2730_CR37","doi-asserted-by":"publisher","first-page":"1113386","DOI":"10.3389\/fphys.2023.1113386","volume":"14","author":"P Ciliberti","year":"2023","unstructured":"Ciliberti P, Cardim D, Giardina A, Groznik M, Ball L, Giovannini M, et al. Effects of short-term hyperoxemia on cerebral autoregulation and tissue oxygenation in acute brain injured patients. Front Physiol. 2023;14:1113386. https:\/\/doi.org\/10.3389\/fphys.2023.1113386.","journal-title":"Front Physiol"},{"key":"2730_CR38","doi-asserted-by":"publisher","first-page":"689450","DOI":"10.3389\/fmed.2021.689450","volume":"8","author":"S Busani","year":"2021","unstructured":"Busani S, Sarti M, Serra F, Gelmini R, Venturelli S, Munari E, et al. Revisited Hyperoxia Pathophysiology in the Perioperative setting: a narrative review. Front Med (Lausanne). 2021;8:689450. https:\/\/doi.org\/10.3389\/fmed.2021.689450.","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"2730_CR39","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s00101-023-01274-4","volume":"72","author":"J Stuby","year":"2023","unstructured":"Stuby J, Kaserer A, Ott S, Ruetzler K, R\u00f6ssler J. Perioperative hyperoxia-more harmful than beneficial? Anaesthesiologie. 2023;72(5):342\u20137. https:\/\/doi.org\/10.1007\/s00101-023-01274-4.","journal-title":"Anaesthesiologie"},{"issue":"1","key":"2730_CR40","doi-asserted-by":"publisher","first-page":"e26772","DOI":"10.5812\/traumamon.26772","volume":"21","author":"A Taher","year":"2016","unstructured":"Taher A, Pilehvari Z, Poorolajal J, Aghajanloo M. Effects of Normobaric Hyperoxia in Traumatic Brain Injury: a Randomized Controlled Clinical Trial. Trauma Mon. 2016;21(1):e26772. https:\/\/doi.org\/10.5812\/traumamon.26772.","journal-title":"Trauma Mon"},{"issue":"3","key":"2730_CR41","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3171\/jns.2004.101.3.0435","volume":"101","author":"CM Tolias","year":"2004","unstructured":"Tolias CM, Reinert M, Seiler R, Gilman C, Scharf A, Bullock MR. Normobaric hyperoxia\u2013induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study. J Neurosurg. 2004;101(3):435\u201344. https:\/\/doi.org\/10.3171\/jns.2004.101.3.0435.","journal-title":"J Neurosurg"},{"issue":"8","key":"2730_CR42","doi-asserted-by":"publisher","first-page":"e9964","DOI":"10.7759\/cureus.9964","volume":"12","author":"J Wiginton Jt, Brazdzionis","year":"2020","unstructured":"Wiginton Jt, Brazdzionis J, Patchana T, Dorkoski R, Miulli DE, Sweiss R, et al. Optimal partial pressure of Oxygen affects outcomes in patients with severe traumatic brain Injury. Cureus. 2020;12(8):e9964. https:\/\/doi.org\/10.7759\/cureus.9964.","journal-title":"Cureus"},{"issue":"12","key":"2730_CR43","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s00134-022-06884-x","volume":"48","author":"E Rezoagli","year":"2022","unstructured":"Rezoagli E, Petrosino M, Rebora P, Menon DK, Mondello S, Cooper DJ, et al. High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI. Intensive Care Med. 2022;48(12):1709\u201325. https:\/\/doi.org\/10.1007\/s00134-022-06884-x.","journal-title":"Intensive Care Med"},{"key":"2730_CR44","doi-asserted-by":"publisher","unstructured":"Hong WP, Hong KJ, Shin SD, Song KJ, Kim TH, Park JH, et al. Association of Flow Rate of Prehospital Oxygen Administration and clinical outcomes in severe traumatic brain Injury. J Clin Med. 2021;10(18). https:\/\/doi.org\/10.3390\/jcm10184097.","DOI":"10.3390\/jcm10184097"},{"issue":"6","key":"2730_CR45","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1007\/s12325-023-02499-w","volume":"40","author":"W Sun","year":"2023","unstructured":"Sun W, Wang L, Yuan S, Liu R, Song P, Che W, et al. Association between Percutaneous Oxygen Saturation and Mortality of patients with mild traumatic brain Injury at ICU admission: an analysis of the MIMIC-III database. Adv Ther. 2023;40(6):2773\u201383. https:\/\/doi.org\/10.1007\/s12325-023-02499-w.","journal-title":"Adv Ther"}],"container-title":["European Journal of Trauma and Emergency Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-024-02730-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00068-024-02730-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-024-02730-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:04:30Z","timestamp":1770721470000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00068-024-02730-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2730"],"URL":"https:\/\/doi.org\/10.1007\/s00068-024-02730-5","relation":{},"ISSN":["1863-9933","1863-9941"],"issn-type":[{"value":"1863-9933","type":"print"},{"value":"1863-9941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"7 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The retrospective and anonymized data collection and analyses were conducted in accordance with local government law (HmbKHG. \u00a7\u00a012) without the requirement for an ethic approval. For this type of study, formal consent is not required. The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"LTL, NS, MF, CC, KHF and JGe declare no conflicts of interests. PC and SK are delegates for the German National Guideline on Invasive Ventilation and Use of Extracorporeal Gas Exchange Procedures. JGr has received fees for articles and lectures on oxygen therapy and targets and is a Member of the Committee for Standardization and Technical Safety of the German Society for Anesthesiology and Intensive Care Medicine.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"75"}}