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The rats were treated with a single dose of 5\u00a0mg\/kg CBD intraperitoneally 30\u00a0min before trauma. Then, the trauma were exposed to a weight of 200\u00a0g and a height of 1\u00a0m. After sacrifice, the lung tissues were removed for histopathological, immunohistochemical, biochemical, and genetic analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pulmonary injury of trauma group led to increases in tumor necrosis factor \u03b1, caspase-3, caspase-9, Bcl-2-associated X protein expressions, total oxidant status, oxidative stress index levels, and decreases in B-cell lymphoma expression and total antioxidant levels. Additionally, inflammatory cell infiltration, damage-related emphysema, pronounced hyperemia, and increased septal tissue thickness were observed histopathologically. CBD treatment ameliorated all these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CBD reduces lung damage in lung contusions caused by blunt chest trauma through its anti-inflammatory and antiapoptotic effects. More detailed studies investigating other important intracellular pathways are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00068-025-02767-0","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T09:15:15Z","timestamp":1738919715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cannabidiol protects lung against inflammation and apoptosis in a rat model of blunt chest trauma via Bax\/Bcl-2\/Cas-9 signaling pathway"],"prefix":"10.1007","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-5229","authenticated-orcid":false,"given":"Ak\u0131n S\u00fcleyman","family":"Emre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7933-0453","authenticated-orcid":false,"given":"Savran","family":"Mehtap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6351-2881","authenticated-orcid":false,"given":"Do\u011fan","family":"Cem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4411-200X","authenticated-orcid":false,"given":"\u0130lhan","family":"\u0130lter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4356-5857","authenticated-orcid":false,"given":"Arl\u0131o\u011flu","family":"Melih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5392-1626","authenticated-orcid":false,"given":"\u00d6zmen","family":"\u00d6zlem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6234-2271","authenticated-orcid":false,"given":"Sezer","family":"Serdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-0439","authenticated-orcid":false,"given":"\u00c7ama\u015f Hasan","family":"Ekrem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-6710","authenticated-orcid":false,"given":"Yazkan","family":"Rasih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"issue":"4","key":"2767_CR1","first-page":"314","volume":"3","author":"\u0130 \u0130nci","year":"1997","unstructured":"\u0130nci \u0130, \u00d6z\u00e7elik C, \u00dclk\u00fc R, Eren \u015e, Eren N, \u00d6zgen G. 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The Suleyman Demirel University local animal experimentation ethics committee approved the experimental methodology (number: 26.01.2023\/116-01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"95"}}