{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:12:54Z","timestamp":1777702374813,"version":"3.51.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"crossref","award":["#HU0001-19-2-0072, sub-award #4798"],"award-info":[{"award-number":["#HU0001-19-2-0072, sub-award #4798"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Trauma Emerg Surg"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00068-025-02819-5","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T13:09:17Z","timestamp":1742303357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The influence of hemorrhagic shock on brain perfusion in a swine model of raised intracranial pressure"],"prefix":"10.1007","volume":"51","author":[{"given":"Hossam","family":"Abdou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Treffalls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2993-6999","authenticated-orcid":false,"given":"Grzegorz","family":"Jodlowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Elansary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ptak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick F.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-8456","authenticated-orcid":false,"given":"Jonathan J.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"issue":"6 Suppl 5","key":"2819_CR1","doi-asserted-by":"publisher","first-page":"S431","DOI":"10.1097\/TA.0b013e3182755dcc","volume":"73","author":"BJ Eastridge","year":"2012","unstructured":"Eastridge BJ, Mabry RL, Seguin P, et al. Death on the battlefield (2001\u20132011): implications for the future of combat casualty care. J Trauma Acute Care Surg. 2012;73(6 Suppl 5):S431\u2013437.","journal-title":"J Trauma Acute Care Surg"},{"issue":"1 Suppl","key":"2819_CR2","first-page":"S4","volume":"71","author":"BJ Eastridge","year":"2011","unstructured":"Eastridge BJ, Hardin M, Cantrell J, et al. Died of wounds on the battlefield: causation and implications for improving combat casualty care. J Trauma. 2011;71(1 Suppl):S4\u20138.","journal-title":"J Trauma"},{"issue":"1","key":"2819_CR3","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1038\/s41598-021-81717-3","volume":"11","author":"CR Muller","year":"2021","unstructured":"Muller CR, Courelli V, Lucas A, et al. Resuscitation from hemorrhagic shock after traumatic brain injury with polymerized hemoglobin. Sci Rep. 2021;11(1):2509.","journal-title":"Sci Rep"},{"key":"2819_CR4","doi-asserted-by":"publisher","unstructured":"Large animal models of traumatic brain injury - Vink.\u2013\u20092018 - Journal of Neuroscience Research - Wiley Online Library [Internet]. [cited 2019 Aug 21];Available from: https:\/\/onlinelibrary-wiley-com.proxy-hs.researchport.umd.edu\/doi\/epdf\/https:\/\/doi.org\/10.1002\/jnr.24079","DOI":"10.1002\/jnr.24079"},{"issue":"1","key":"2819_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nurt.2009.12.001","volume":"7","author":"R Vink","year":"2010","unstructured":"Vink R, Bullock MR. Traumatic brain injury: therapeutic challenges and new directions. Neurotherapeutics. 2010;7(1):1\u20132.","journal-title":"Neurotherapeutics"},{"key":"2819_CR6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jss.2022.03.034","volume":"278","author":"H Abdou","year":"2022","unstructured":"Abdou H, Edwards J, Patel N, et al. Characterizing brain perfusion in a swine model of Raised intracranial pressure. J Surg Res. 2022;278:64\u20139.","journal-title":"J Surg Res"},{"key":"2819_CR7","doi-asserted-by":"crossref","unstructured":"Abdou H, Morrison JJ, Edwards J et al. An Estrogen (17\u03b1-ethinyl estradiol-3-sulfate) reduces mortality in a swine model of Poly trauma and hemorrhagic shock. J Trauma Acute Care Surg. Epub ahead of print 2021.","DOI":"10.1097\/TA.0000000000003434"},{"key":"2819_CR8","doi-asserted-by":"crossref","unstructured":"Edwards J, Abdou H, Patel N et al. The functional vascular anatomy of the swine for research. Vascular 2021;1708538121996500.","DOI":"10.1177\/1708538121996500"},{"key":"2819_CR9","doi-asserted-by":"crossref","unstructured":"Bonin JE, Abdou H, Edwards J et al. CT-Guided Placement of a Neuromonitoring Suite in Swine for Trauma and Resuscitation Research. Journal of Endovascular Resuscitation and Trauma Management [Internet] 2021 [cited 2021 Sep 13];5(1). Available from: https:\/\/journal.jevtm.com\/index.php\/jevtm\/article\/view\/171","DOI":"10.26676\/jevtm.v5i1.171"},{"key":"2819_CR10","doi-asserted-by":"crossref","unstructured":"Abdou H, Elansary N, Poliner D, et al. Development of a computed tomography perfusion protocol to support large animal resuscitation research. J Trauma Acute Care Surg; 2021.","DOI":"10.1097\/TA.0000000000003189"},{"key":"2819_CR11","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3389\/fneur.2017.00315","volume":"8","author":"P-O Gr\u00e4nde","year":"2017","unstructured":"Gr\u00e4nde P-O. Critical evaluation of the Lund concept for treatment of severe traumatic head injury, 25 years after its introduction. Front Neurol. 2017;8:315.","journal-title":"Front Neurol"},{"key":"2819_CR12","doi-asserted-by":"publisher","first-page":"638132","DOI":"10.3389\/fneur.2021.638132","volume":"12","author":"TM Svedung Wettervik","year":"2021","unstructured":"Svedung Wettervik TM, Lew\u00e9n A, Enblad P. Fine tuning of traumatic brain injury management in neurointensive Care\u2014Indicative observations and future perspectives. Front Neurol. 2021;12:638132.","journal-title":"Front Neurol"},{"issue":"6","key":"2819_CR13","doi-asserted-by":"publisher","first-page":"H1908","DOI":"10.1152\/ajpheart.1992.262.6.H1908","volume":"262","author":"M Ferrari","year":"1992","unstructured":"Ferrari M, Wilson DA, Hanley DF, Traystman RJ. Effects of graded hypotension on cerebral blood flow, blood volume, and mean transit time in dogs. Am J Physiol Heart Circ Physiol. 1992;262(6):H1908\u201314.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2819_CR14","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/978-1-4939-3816-2_17","volume":"1462","author":"DK Cullen","year":"2016","unstructured":"Cullen DK, Harris JP, Browne KD, et al. A Porcine model of traumatic brain injury via head rotational acceleration. Methods Mol Biol. 2016;1462:289\u2013324.","journal-title":"Methods Mol Biol"},{"issue":"1","key":"2819_CR15","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1148\/radiol.10090908","volume":"256","author":"KT Bae","year":"2010","unstructured":"Bae KT. Intravenous contrast medium administration and scan timing at CT: considerations and approaches. Radiology. 2010;256(1):32\u201361.","journal-title":"Radiology"},{"issue":"1","key":"2819_CR16","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000118718","volume":"27","author":"MA Hofman","year":"1985","unstructured":"Hofman MA. Size and shape of the cerebral cortex in mammals. I. The cortical surface. Brain Behav Evol. 1985;27(1):28\u201340.","journal-title":"Brain Behav Evol"},{"key":"2819_CR17","unstructured":"Burbridge B, Matte G, Remedios A. Complex intracranial arterial anatomy in swine is unsuitable for cerebral infarction projects.Can Assoc Radiol J. 2004 Dec;55(5):326-9"},{"key":"2819_CR18","doi-asserted-by":"crossref","unstructured":"Budohoski KP, Czosnyka M, de Riva N, et al. The relationship between cerebral blood flow autoregulation and cerebrovascular pressure reactivity after traumatic brain injury.Neurosurgery; 2012;71(3):652\u201361.","DOI":"10.1227\/NEU.0b013e318260feb1"},{"key":"2819_CR19","doi-asserted-by":"crossref","unstructured":"Klein SP, De Sloovere V, Meyfroidt G, Depreitere B. Differential Hemodynamic Response of Pial Arterioles Contributes to a Quadriphasic Cerebral Autoregulation Physiology. JAHA. 2022;11(1):e022943.","DOI":"10.1161\/JAHA.121.022943"},{"issue":"1","key":"2819_CR20","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s13054-019-2454-1","volume":"23","author":"SP Klein","year":"2019","unstructured":"Klein SP, Depreitere B, Meyfroidt G. How I monitor cerebral autoregulation. Crit Care. 2019;23(1):160. s13054-019-2454\u20131.","journal-title":"Crit Care"},{"key":"2819_CR21","doi-asserted-by":"publisher","unstructured":"Sutherland BA, Rabie T, Buchan AM. Laser Doppler Flowmetry to Measure Changes in Cerebral Blood Flow [Internet]. In: Milner R, editor. Cerebral Angiogenesis. New York, NY: Springer New York; 2014 [cited 2022 Oct 20]. pp. 237\u201348.Available from: http:\/\/link.springer.com\/https:\/\/doi.org\/10.1007\/978-1-4939-0320-7_20","DOI":"10.1007\/978-1-4939-0320-7_20"},{"issue":"1","key":"2819_CR22","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1227\/NEU.0000000000001432","volume":"80","author":"N Carney","year":"2017","unstructured":"Carney N, Totten AM, O\u2019Reilly C, et al. Guidelines for the management of severe traumatic brain injury. Fourth Ed Neurosurg. 2017;80(1):6\u201315.","journal-title":"Fourth Ed Neurosurg"},{"key":"2819_CR23","doi-asserted-by":"crossref","unstructured":"van der Pieternella H, Muller et al. Hemoglobin, hematocrit, and changes in cerebral blood flow: the second manifestations of arterial disease-Magnetic resonance study. Neurobiology of Aging. 2015;36(3)1417\u201323.","DOI":"10.1016\/j.neurobiolaging.2014.12.019"},{"key":"2819_CR24","doi-asserted-by":"publisher","first-page":"E2","DOI":"10.3171\/2018.9.FOCUS18404","volume":"45","author":"SA Shackelford","year":"2018","unstructured":"Shackelford SA, Del Junco DJ, Reade MC, et al. Association of time to craniectomy with survival in patients with severe combat-related brain injury. Neurosurg Focus. 2018;45:E2.","journal-title":"Neurosurg Focus"}],"container-title":["European Journal of Trauma and Emergency Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-025-02819-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00068-025-02819-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-025-02819-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:05:18Z","timestamp":1770721518000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00068-025-02819-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2819"],"URL":"https:\/\/doi.org\/10.1007\/s00068-025-02819-5","relation":{},"ISSN":["1863-9933","1863-9941"],"issn-type":[{"value":"1863-9933","type":"print"},{"value":"1863-9941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]},"assertion":[{"value":"27 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This work was presented at the National Neurotrauma Society Annual Meeting 2021, Virtual.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Meetings"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"137"}}